Genetic and Epigenetic Gene Regulation


Technological advances allow for an unprecedented in-depth characterization of the molecular basis of complex diseases. In particular SNP genotyping, DNA methylation assays and gene expression profiling in large cohorts have been used to identify numerous disease associated loci and genes. However, a deeper mechanistic or systems level understanding of disease processes still remains elusive in most cases.

The aim of our research is the development and application of computational and statistical tools for the identification of molecular regulatory networks underlying common diseases and the genetic and epigenetic mechanisms controlling these networks from population level DNA and multi-omics data sets. A special focus is the molecular characterization of metabolic and cardiovascular diseases, in particular diabetes and arrhythmias like atrial or ventricular fibrillation.



Regulatory networks to understand disease susceptibility from multi-OMICS data

We use cookies to improve your experience on our Website. We need cookies to continually improve our services, enable certain features, and when we embed third-party services or content, such as the Vimeo video player or Twitter feeds. In such cases, information may also be transferred to third parties. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.