June 2020: Henriette Uhlenhaut

Henriette's scientific work in one sentence

Decoding genomic mechanism governing mammalian physiology, with a special focus on nuclear hormone receptors in metabolism and innate immunity.

Short CV

Highest Level of education: 2007, PhD from the EMBL international PhD Program (Heidelberg)
Actual Position: Chair for Metabolic Programming at the TUM School of Life Sciences, and PI at the Helmholtz Diabetes Center

What is - in your opinion - your best publications?

 Quagliarini F, Mir AA, Balazs K, Wierer M, Dyar KA, Jouffe C, Makris K, Hawe J, Heinig M, Filipp FV, Barish GD, Uhlenhaut NH: “Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet”. Molecular Cell. 2019; 76 (4): 531-545.

Hemmer MC et al.: “E47 modulates hepatic glucocorticoid action”. Nature Communications. 2019; 10 (1): 306

Dyar KA et al.: “Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock”. PLOS Biology. 2018; 16 (8): e2005886.

What are your most important prizes and memberships?

Heinz Maier-Leibnitz Prize of the German Research Foundation DFG (2019)
Friedmund Neumann Preis der Scheringstiftung (2015)
ERC Starting Grant SILENCE (2014)

Editorial board member of Endocrinology; Nuclear Receptor Research
Member of the DFG review board
AcademiaNet member

5 questions about research - past, present, future

1. What are your primary tasks and responsibilities in your actual position?
Enabling everyone in the lab to make exciting and significant discoveries, teaching and training the next generation of scientists.

2. What is it that gives you pleasure and/or satisfaction the most?
See above, novel findings that explain how hormones control our lives and those moments when students or postdocs succeed and receive the recognition they deserve.

3. Which research question(s) affects you at the moment? What is its social significance?
Can we slow aging by changing nutrition and diet? How do circadian rhythms and hormone secretion control daily 24 hour rhythms? How do nuclear receptors regulate transcription? How can we translate our findings to the clinic?

4. Which publication influenced you the most?
DNA Binding of the Glucocorticoid Receptor Is Not Essential for Survival, Reichardt et al Cell 1998 ; )

5. What do you like most about the IDC?
Interactions, collaborations, translational projects, scientific environment, transcriptional mechanisms

3 questions beyond research

1. What are your experiences with reconciliation of family or private and working life?
Yes we can! To all females and young parents out there, I quote Ada Yonath: It is possible to be a great mother or grandmother and a great scientist!

2. What is the experience during your PhD you will remember all your life?
We when observed sex reversal of female mice into males, without involvement of a Y chromosome!

3. Which book and/or movie has lately affected you the most?
Lean In by Sheryl Sandberg