Mitarbeiter

Prof. Dr. phil. nat. Carolin Daniel
Leiterin AG Immuntoleranz

Telefon: 089 3187-2188
Fax: 089 3187-3144
E-Mail
Geb./Raum: Heidemannstraße 1

 Link zum Forscherportrait des HMGU  | Link zum Forscherportrait der Helmholtz Gemeinschaft

 Academic and Research Activities

March 2012-todayHelmholtz Zentrum Muenchen – German Research Center for Environmental Health (GmbH)
Institute of Diabetes Research, Prof. Anette-Gabriele Ziegler
Junior Group Leader ´Immunological tolerance in Typ 1 Diabetes´
August 2008- Januar 2012Dana Farber Cancer Institute, Boston, MA/USA
Department of Cancer Immunology and AIDS, Laboratory of Lymphocyte Development, Prof. Harald von Boehmer
Post-Doctoral Fellowship of the Leopoldina/National Academy of Sciences, Antigen-specific regulatory T cells: Mechanisms of conversion and suppression
Joint Appointment with Harvard Medical School, Boston, MA/USA (October 2008-Januar 2012), Prof. Harald von Boehmer
Research Fellow in Microbiology and Immunobiology (MBIB)
July 2007-July 2008Johann Wolfgang Goethe University Frankfurt, Institute of Pharmacology/Immunepharmacology, Prof. Josef Pfeilschifter
Post-Doctoral Studies, Immunoregulation by Dendritic cells and T cells
Feb. 2003-July 2007Johann Wolfgang Goethe University Frankfurt/Karolinska Institute Stockholm, Institute of Pharmaceutical Chemistry, First Department of Internal Medicine, Prof. Dieter Steinhilber/Prof. Juergen Stein
PhD Fellowship of the European Graduate School of the DFG (GRK757)
Cumulative PhD Thesis: `New immunepharmacological strategies for the treatment of inflammatory bowel disease – in vivo experiments with the TNBS- and Oxazolone-model in mice`
July 2001-July 2002Max-Planck Institute for Physiological and Clinical Research Bad Nauheim, Department of Physiology, Prof. Edgar Simon
Diploma Thesis: `Diet-induced modifications of the leptin responsitivity in C57/BL6 mice`
Oct.1997-Oct. 2002Studies of Nutrional Sciences at Justus-Liebig University Giessen
Pathophysiology, Cell Biology, Biochemistry


Prizes and Awards

2011 Juvenile Diabetes Research Foundation (JDRF)
Research Award for `Prevention of type 1 diabetes by Treg vaccination with an insulin mimetope` with Harald von Boehmer
2011Boston Area Diabetes Endocrinology Research Center (BADERC)
Research Award with Harald von Boehmer
2010Dana Farber Cancer Institute, Boston, MA/USA
Prize for the best poster presentation at the Annual Retreat of the Department for Cancer Immunology and AIDS
2008German Association for Pharmacology and Toxicology, Mainz/Germany
Fritz Kuelz Prize 2007, Recognition for an excellent experimental pharmacological achievement granted to a junior scientist
2006Rhein-Main Association of Gastroenterology
Scientific prize of the year 2006, Frankfurt/Germany
2006German Association for Digestive Diseases (DGVS), Price for the best poster presentation, Hannover/Germany
2005Grant from the Danone Institute for Nutrition, Geneva/Switzerland
2005Middle German Association for Digestive Diseases (MGG), Prize for the best poster presentation, Bad Nauheim/Germany

 

Funding ID

December 2012 Deutsches Zentrum für Diabetesforschung (DZD) Research Grant 2013
March 2012-Junior Research Group at Helmholtz Zentrum München for 5 years with tenure track option
Oct 2011-Feb 2012Leopoldina Return Fellowship
The Funding is granted to Leopoldina Post-Doctoral Fellowship who will return from abroad to Germany in order to further establish project planning, grant writing and funding applications (Post-Doc salary for up to 12 months, 20.000 Euro/year)
Aug. 2008- Aug. 2011Leopoldina Post-Doctoral Fellowship
The Post-Doctoral Funding is granted by the German Academy of Sciences to junior scientists who have demonstrated outstanding scientific excellence (40.000 Euro/year)

 

Granted Patents


U.S. Application No.: 61/354,107: Prevention of type 1 diabetes by Treg vaccination with an insulin mimetope, filed 2011 (Inventors: Carolin Daniel & Harald von Boehmer)

Professional Memberships

2012-todayMember of German Diabetes Association (DDG)
2013-todayMember of European Association for the Study of Diabetes (EASD)

 

Publications

Summary: 22 peer-reviewed papers (13 as first author) that have been cited over 360 times and 16 peer-reviewed published international conference proceedings

1. Weigmann B, Franke RK and Daniel C, Immunotherapy in Autoimmune Type 1 Diabetes, The Review of Diabetes Studies 2013, in press.
2. von Boehmer H and Daniel C, Therapeutic opportunities for manipulating Tregs in autoimmunity and cancer, Nat Rev. Drug Discovery 2013, 12:51-63.
3. Weigmann B and Daniel C, Treg vaccination with a strong agonistic insulin mimetope, Curr Diab Rep. 2012, 12(5):463-70.
4. Gerlach K, Daniel C, Lehr HA, Nikolaev A, Gerlach T, Atreya R, Rose-John S, Neurath MF, Weigmann B. Transcription factor NFATc2 controls the emergence of colon cancer associated with IL-6 dependent colitis. Cancer Res. 2012, 72(17):4340-50.
5. Daniel C, and von Boehmer H. Extrathymic generation of regulatory T cells – chances and challenges for prevention of autoimmune disease. Adv Immunol 2011, 112: 177-213.
6. Daniel C, and von Boehmer, H. Extra-thymically induced regulatory T cells: do they have potential in disease prevention? Semin Immunol 2011; 23(6):440-7.
7. Daniel C, Weigmann B, Bronson R and von Boehmer H. Prevention of type 1 diabetes in mice by tolerogenic vaccination with a strong agonist insulin mimetope. J Exp Med 2011; 208(7):1501-10.
8. Daniel C, Ploegh H and von Boehmer H. Antigen-specific induction of regulatory T cells in vivo and in vitro. Methods Mol Biol. 2011; 707:173-185.
9. Daniel C, Wennhold K, Kim HJ and von Boehmer H. Enhancement of antigen-specific Treg-vaccination in vivo. PNAS 2010, 107(37):16246-51.
10. Nolting J., Daniel C, Reuter S, Stuelten C, Li P, Sucov H, Kim BG, Letterio JJ, Kretschmer K, Kim HJ and von Boehmer H. Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokines. J Exp Med 2009, 206:2131-2139.
11. Daniel C, Nolting J, and von Boehmer H. Mechanisms of self non-self discrimination and possible clinical relevance. Immunotherapy 2009, 1(4):631-644.
12. Daniel C, Sartory NA, Zahn N, Radeke HH, Stein J, Immunemodulatory treatment of TNBS colitis with calcitriol is associated with a change of Th1/Th17 to a Th2 and regulatory T cell profile, J Pharmacol Exp Ther 2008, 324:23-33.
13. Daniel C, Sartory NA, Zahn N, Geisslinger G, Radeke HH, Stein J, FTY720 ameliorates Th1-mediated colitis in mice by directly affecting the functional activity of CD4+CD25+ regulatory T cells, J Immunol 2007, 178(4), 2458-2468.
14. Daniel C, Sartory NA, Zahn N, Schmidt R, Geisslinger G, Radeke HH, Stein J, FTY720 ameliorates oxazolone colitis in mice by affecting T helper type 2 functions via the IL-1 receptor related protein T1/ST2, Mol Immunol 2007, 44, 3305-3316.
15. Schneider D, Liaw L, Daniel C, Athanasopoulos AN, Herrman M, Preissner KT, Nawroth PP, Chavakis T, Inhibition of breast cancer cell adhesion and bone metastasis by the extracellular adherence protein of Staphylococcus aureus, Biochem Biophys Res Commun 2007, 357(1), 282-288.
16. Daniel C, Schroeder O, Zahn N, Steinhilber D, Stein J, The TGF-Smad 3-signalling pathway is involved in butyrate-mediated Vitamin D receptor expression, J Cell Biochem 2007, 102(6):1420-31.
17. Berriel Diaz M, Eiden S, Daniel C, Steinbrueck A, Schmidt I, Effects of periodic intake of a high-caloric diet on body mass and leptin resistance. Physiol Behav 2006, 88(1-2):191-200.
18. Daniel C, Radeke HH, Sartory NA, Zahn N, Zuegel U, Steinmeyer A, Stein J, The new low calcemic vitamin D analog 22-ene-25-oxa-vitamin D prominently ameliorates Th1-mediated colitis in mice. J Pharmacol Exp Ther 2006, 319(2):622-631.
19. Schroder O, Turak S, Daniel C, Gaschott T, Stein J, Upregulation of 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase by butyrate in Caco-2 cells. Word Journal Gastroenterol 2005, 11, 7136-7141.
20. Daniel C, Schlauch T, Zuegel U, Steinmeyer A, Radeke HH, Steinhilber D, Stein J, 22-ene-25-oxa-vitamin D, a new vitamin D analog with profound immunosuppressive capacities. Eur J Clin Invest 2005, 35, 343-349.
21. Daniel C, Schroeder O, Zahn N, Gaschott T, P38 MAPK is involved in Butyrate-induced vitamin D receptor expression. Biochem Biophys Res Commun 2004, 324, 1220-1226.
22. Eiden S, Daniel C, Steinbrueck A, Schmidt I, Simon E, Salmon calcitonin – a potent inhibitor of food intake in states of impaired leptin signalling in laboratory rodents. J Physiol 2002, 541:1041-8.

  
  
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