About us

Vision

Our vision is to improve the quality of life for patients suffering from chronic neuropsychiatric diseases such as Dementia, Parkinson’s Diseases and Amyotrophic Lateral Sclerosis.

Since genetic predisposition is a major risk factor for common diseases we also contribute large scale to the functional annotation of the mammalian genome

Mission

Our mission is to contribute to the functional annotation of the mouse genome by performing large scale mutagenesis and develop and implement continuously new genome editing technologies in order to improve preclinical disease models.

The IDG Genetics groups

The IDG Genetics groups develops and implements the latest genome editing technologies to generate mouse mutants for internal scientific projects and external collaborations. The IDG coordinated the European Conditional Mouse Mutagenesis Program (EUCOMM) and EUCOMMTOOLs project and was founding partner of the International Knockout Mouse Consortium (IKMC) aiming to provide and distribute mutant mouse material for all genes. Thus, providing tools to functionally annotate all mammalian genes to contribute to the formation of an encyclopaedia of mammalian life. All mutant resources are distributed by the European Mouse Mutant Cell Repository (EuMMCR, www.eummcr.org). The Genetic Technology team develops and implements new genome editing tools for generating state of the art animal and human induced pluripotent (iPSCs) stem cell models. The Bioinformatic Team provides data infrastructures for high-throughput functional network analysis underlying disease mechanisms to generate novel hypothesis which are subsequently experimentally validated.

Within the IDG different groups are approaching the central question of the pathoetiology of neuropsychiatric disease from different angles using distinct experimental approaches. Several groups are focusing on the generation and comprehensive (molecular and morphological) analysis of genetic mouse models of disease-associated genes (disease modelling, eye diseases, neurodegeneration (collaboration with the DZNE) in order to elucidate underlying pathomechanisms and to evaluate the influence of environment, life style and ageing on the disease processes.

The IDG also integrates teams which are dedicated to understand molecular and cellular mechanisms underlying cell plasticity, regeneration and cellular protection in the central nervous system (Redox signalling, Stem cells).

Neuropsychiatric Diseases

Within the IDG different groups are approaching the central question of the pathoetiology of neuropsychiatric diseases from different angles using distinct experimental approaches.

  • There are groups focusing on the generation and comprehensive (molecular, behavioural and morphological) analysis of genetic mouse models of disease-associated genes (Disease Modelling, Eye Diseases, CCG Molecular Neurogenetics, DZNE - neurodegeneration) in order to elucidate underlying pathomechanisms and to evaluate the influence of environment onto the disease process.

  • The IDG also integrates groups which are dedicated to the understanding of the mechanisms underlying plasticity and regeneration in the central nervous system (Adult Neurogenesis, Neuronal Circuits in Health and Disease, Disease Modelling).

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