About us

Mouse Genetics

The IDG Mouse Genetics Group generates targeted mouse mutants for internal scientific projects and external collaborations. The Large Scale Mutagenesis Team participates in the European Conditional Mouse Mutagenesis Program (EUCOMM), an international project for large scale mutagenesis to create a genome-wide resource of conditional targeted ES cells and mice. The IDG is partner in the International Knockout Mouse Consortium (IKMC), a resource for generation and distribution of mutant mouse products, and thus hosts the material distribution unit of EUCOMM, the European Mouse Mutant Cell Repository (EuMMCR). Within the national DIGTOP (From Disease Genes to Protein Pathways) project the proteomic interactions of disease-related genes in stem cells and mice are analysed. The Technology Development and Animal Model Generation teams develop new mutagenesis tools and provide infrastructure and a microinjection service for the generation of mouse mutants. The Bioinformatics team develops data infrastructures for the high-throughput analysis of mouse mutants and is involved in the modelling of genetic and protein interaction networks.

 

Neuropsychiatric Diseases

Within the IDG different groups are approaching the central question of the pathoetiology of neuropsychiatric diseases from different angles using distinct experimental approaches.

  • There are groups focusing on the generation and comprehensive (molecular, behavioural and morphological) analysis of genetic mouse models of disease-associated genes (Disease Modelling, Eye Diseases, CCG Molecular Neurogenetics, DZNE - neurodegeneration) in order to elucidate underlying pathomechanisms and to evaluate the influence of environment onto the disease process.

  • The IDG also integrates groups which are dedicated to the understanding of the mechanisms underlying plasticity and regeneration in the central nervous system (Adult Neurogenesis, Neuronal Circuits in Health and Disease, Disease Modelling).