Neuropsychiatric Diseases

Within the IDG different groups are approaching the central question of the pathoetiology of neuropsychiatric diseases from different angles using distinct experimental approaches. To do so they take advantage and closely collaborate with the groups in the genetic division of the institute.

  • There are groups focusing on the generation and comprehensive (molecular, behavioural and morphological) analysis of genetic mouse models of diseases associated genes (Neuropsychiatric Disease Modelling, Eye Diseases, CCG Neurogenetics, DZNE - neurodegeneration) in order to elucidate underlying pathomechanisms and to evaluate the influence of environment onto the disease process. Specific focus is laid on the dysregulation of oxidative stress response, mitochondrial / cytoskeletal dysfunction and the influence of a dysregulated neuroendocrinological axis.

  • The IDG also integrates groups which are dedicated to the understanding of the mechanisms underlying plasticity and regeneration in the central nervous system (Adult Neurogenesis, Neuronal Circuits in Health and Disease, Neuropsychiatric Disease Modelling). Here the focus is on understanding the molecular mechanisms involved in the generation and differentiation of new neurons as well as in the formation of neural circuits in the adult brain, since the dysregulation of these processes are significant contributors to neuropsychiatric symptoms in ageing and neurodegenerative diseases . Moreover, the understanding of the regulatory mechanisms underlying these processes will contribute to the development of regenerative and/or protective strategies for the treatment of neuropsychiatric diseases.

Read more about the different groups: