EuMMCR - European Mouse Mutant Cell Repository

Human mendelian disease is caused by a variety of mutations resulting in complete loss or partial loss or gain of function under various modes of inheritance. In order to study the function of such genes in an animal model in vivo, the International Knockout Mouse Consortium (IKMC) (www.mousephenotype.org) generated mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. In total the IKMC has produced mostly conditional mutations in about 18.500 genes. The vast majority of the mutant ES cells were produced by EUCOMM and EUCOMMTOOLS, which is the European branch of IKMC. EuMMCR (European Mouse Mutant Cell Repository) has been founded as repository of EUCOMM / EUCOMMTOOLS targeting vector and mutant ES cell resource for long-term storage as well as worldwide distribution (www.eummcr.org). EuMMCR has established and implemented standard operation procedures (SOPs) to guarantee quality and maintenance of the material.

The EuMMCR repository archives mutant ES cells for 14.360 genes and conditional targeting vectors for 16.056 genes.

EuMMCR has distributed already more than 12.000 mutant ES cell clones and 1.019 conditional targeting vectors world-wide. 42% of the orders come from EU countries, 41% come from the USA and Canada and 17% from the rest or the world (e.g. Japan, China). Based on the IKMC and EuMMCR resources, more than 6.000 mutant mice have been produced by IKMC and mostly IMPC (International Mouse Phenotyping Consortium)(www.mousephenotype.org). In the EMMA / Infrafrontier repository currently 2.705 of the archived mouse lines are based on IKMC / EuMMCR material; all of them went through the IMPC phenotyping pipeline. Moreover, more than 2.100 publications referred to the use of IKMC/EUCOMM/EuMMCR material according to google scholar (July 2017). Thus, the IKMC/EUCOMM/EuMMCR resource has a major impact on the scientific community by enhancing gene function annotation.

The organization, ordering procedures, content of the resources, quality control procedures and services are described in detail at the EUMMCR website (www.eummcr.org).

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