Staff

Prof. Dr. med. Dr. h.c. Matthias H. Tschöp
Director

Phone: +49 89 3187 2044
Building/Room: GAR / 1.03.53

 

Academic positions and career
Matthias Tschöp is the first German physician to receive the Alexander von Humboldt Professorship, the highest-endowed German research award (2012). He is Research Director of the Helmholtz Diabetes Center and Director of the Institute for Diabetes and Obesity. He is a the Director of Biomedicine of the Helmholtz Pioneer Campus. Matthias Tschöp holds the Chair of the Division of Metabolic Diseases at Technische Universität München. He is Adjunct Professor at Yale University. Matthias Tschöp is Founding Editor-in-Chief of the journal Molecular Metabolism.

Prof. Tschöp received his M.D. from Ludwig-Maximilians-Universität in Munich. In 1999 he accepted an invitation for a postdoctoral fellowship at the Eli Lilly Research Laboratories in the U.S. After establishing his independent research laboratory at the German Institute of Human Nutrition Potsdam-Rehbrücke in Germany in 2002 and 2003, he returned to Cincinnati where he led a research institute as a tenured Professor of Endocrinology and Diabetes at the University of Cincinnati Metabolic Diseases Institute. Until 2009, Prof. Tschöp was the Arthur Russell Morgan Endowed Chair of Medicine and Research Director of the University of Cincinnati’s Metabolism Center of Excellence for Diabetes and Obesity.

Research
Prof. Tschöp’s research focuses on dissecting the molecular underpinnings of diabetes and obesity in order to discover new preventive and therapeutic approaches for the metabolic syndrome. One of his areas of interest is the role of gut-brain communication as a key circuitry that regulates adiposity, glucose homeostasis and energy metabolism. Currently the IDO team is aiming to develop innovative interdisciplinary approaches in collaboration with physicists, engineers and chemists for the personalized prevention and treatment of obesity, diabetes and concomitant diseases.

Matthias Tschöp represents a unique blend of experience in clinical endocrinology (resident physician at Munich University Hospital, 1993-1998), drug discovery (postdoctoral fellow at Eli Lilly and Company Endocrine Research, 1999-2002) and basic/translational hormone research (principal investigator since 2002).  He is well recognized for his work on how gut-brain communication regulates appetite and metabolism and for combining groundbreaking discovery with translational potential.

Academic service

Matthias Tschöp has organized numerous academic conferences, including Keystone Symposia and EMBL Symposia.  In 2013 he started the Annual Helmholtz-Nature Medicine Diabetes Conference.  The 5thAnnual Helmholtz-Nature Medicine Diabetes Conference will take place in September 2017.  He currently directs several research networks including the Helmholtz Alliance ICEMED.  

Sought after as an international lecturer and active reviewer and referee for scientific journals such as Nature, Science and Cell, Dr. Tschöp also maintains international collaborations with the Rockefeller Center, Yale University, Harvard Medical School and Cambridge University, among others. Throughout his career, Professor Tschöp has worked closely with several major pharmaceutical and numerous biotechnology companies in the diabetes, obesity and cardiovascular disease space and has served as consultant on several scientific advisory boards.

Awards and recognitions (selection)
2017 Charles H. Best Lectureship and Award, University of Toronto
2017 Hansen Family Award, Bayer Foundations
2017 Honorary doctorate (Dr. h.c.), University of Leipzig
2017 Rolf Sammet Guest Professorship at Frankfurt University
2017 Geoffrey Harris Prize
2017 Endocrine Society Outstanding Innovation Award
2016 Elected Member, Academia Europaea (AE)
2016 ERC Advanced Grant (AdG). Project Acronym: HypoFlam
2016 The Victor Mutt Award
2016 European Medal of the Society for Endocrinology
2014 Paul Martini Prize, Paul Martini Foundation
2014 Linda and Jack Gill Distinguished Scientist Award, Linda and Jack Gill Center for Biomolecular Science, Indiana University.
2013 Elected member of the German National Academy of Science (Leopoldina)
2013 Elected member of the Helmholtz Think Tank, Helmholtz Association
2012 Werner-Creutzfeld-Award, German Diabetes Society
2011 Alexander von Humboldt Professorship
2011 Outstanding Scientific Achievement Award, American Diabetes Association
2010 NIH/NIDDK 60th Anniversary Scholar Award
2010 André Mayer Award, Int. Association for the Study of Obesity (IASO)
2007 Scientific Achievement Award, The Obesity Society (TOS/NAASO)

Key publications
Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger KM, Schriever SC, Garcia-Caceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Hrabe de Angelis M, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger PT, Zhang L, Gelfanov V, DiMarchi RD, Tschöp M. „Targeted estrogen delivery reverses the metabolic syndrome.“Nat Med 2012 Nov 11 doi:10.1038/nm.3009.
http://www.ncbi.nlm.nih.gov/pubmed/23142820

Perez-Tilve D, Hofmann S, Basford J, Pfluger PT, Patterson PT, Grant E, Perez-Wilson H, Granholm N, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp M. „The CNS melanocortin system directly controls circulating cholesterol.“ Nat Neurosci 2010;13(7):877-82.
http://www.ncbi.nlm.nih.gov/pubmed/20526334

Kirchner H., Gutierrez J, Pfluger PT, Morgan TA, Solenberg P, Willency J, Schuermann A, Joost HG, Jandacek R, Hale J, Heiman ML, Tschöp M. “GOAT links dietary lipids with the endocrine control of energy balance.” Nat Med 2009; 15(7):741-5.
http://www.ncbi.nlm.nih.gov/pubmed/19503064

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R and Tschöp M. “A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.” Nat Chem Biol 2009;5(10):749-57.
http://www.ncbi.nlm.nih.gov/pubmed/19597507

Tschöp M, Smiley D, Heiman ML. “Ghrelin induces adiposity in rodents."
Nature
2000. 407:908-13.
http://www.ncbi.nlm.nih.gov/pubmed/11057670

All publications
Publications of Matthias Tschöp on PubMed