Key Publications


Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrab_ de Angelis M, Hofmann SM, Yang B, Tschöp M#, DiMarchi R, Müller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.
Cell # - Corresponding Author

García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability.


Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp M. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents.
Nature Medicine

Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrab_ de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp M. Calcineurin Links Mitochondrial Elongation with Energy Metabolism.
Cell Metabolism


Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, Dimarchi RD, Tschöp M. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.
Science Translational Medicine


Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger KM, Schriever SC, Garcia-Caceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Hrabe de Angelis M, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger PT, Zhang L, Gelfanov V, DiMarchi RD, Tschöp M. Targeted estrogen delivery reverses the metabolic syndrome.
Nature Medicine


Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp M. Melanocortin signaling in the CNS directly regulates circulating cholesterol.
Nature Neuroscience


Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp M. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents.
Nature Chemical Biology

Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp M. GOAT links dietary lipids with the endocrine control of energy balance.
Nature Medicine


Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents.


DiMarchi RD, Mayer JP, Gelfanov VM, Tschöp M. Max Bergmann award lecture: Macromolecular medicinal chemistry as applied to metabolic diseases. J Pept Sci. 2018 Jan;24(1). (IF 2.0)

Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun. 2018 Jan 18;9(1):288. (IF 12.1)

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH. Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. 2018 Jan 19. (IF 18.3)

Brandt SJ, Götz A, Tschöp MH, Müller TD. Gut hormone polyagonists for the treatment of type 2 diabetes. Peptides 2018 Feb;100:190-201. (IF 2.6)

Poher AL, Tschöp MH, Müller TD. Ghrelin regulation of glucose metabolism. Peptides 2018 Feb;100:236-242. (IF 2.6)

Pfuhlmann K, Schriever SC, Legutko B, Baumann P, Harrison L, Kabra DG, Baumgart EV, Tschöp MH, Garcia-Caceres C, Pfluger PT. Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice. J Neuroinflammation. 2018 Feb 8;15(1):35. (IF 5.1)


Zhang CJ, Bidlingmaier M, Altaye M, Page LC, D'Alessio D, Tschöp MH, Tong J. Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans. Eur J Endocrinol. 2017 Feb;176(2):123-132. (IF 4.1)

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP, Moriggl R. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes. 2017 Feb;66(2):272-286. (IF 8.7)

Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN.; WTCCC3., Heid IM, Winkler TW; GIANT., Grant SF; EGG., Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group.; Children’s Hospital of Philadelphia/Price Foundation., Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Mol Psychiatry. 2017 Feb;22(2):192-201. (IF 13.2)

Clemmensen C, Müller TD, Woods SC, Berthoud HR, Seeley RJ, Tschöp MH. Gut-Brain Cross-Talk in Metabolic Control. Cell. 2017 Feb 23;168(5):758-774. (Review) (IF 30.4)

Al Massadi O, López M, Tschöp M, Diéguez C, Nogueiras R. Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity. Trends Neurosci. 2017 Mar;40(3):167-180. (Review) (IF 11.1)

Jall S, Sachs S, Clemmensen C, Finan B, Neff F, DiMarchi RD, Tschöp MH, Müller TD, Hofmann SM. Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice. Mol Metab2017 Mar 1;6(5):440-446. (IF 6.8)

Jastroch M, Tschöp MH. Fat controls U. Science. 2017 Mar 17;355(6330):1124-1125. (IF 37.2)

Müller TD, Finan B, Clemmensen C, DiMarchi RD, Tschöp MH. The New Biology and Pharmacology of Glucagon. Physiol Rev. 2017 Apr;97(2):721-766. (Review) (IF 27.3)

Colldén G, Tschöp MH, Müller TD. Therapeutic Potential of Targeting the Ghrelin Pathway. Int J Mol Sci2017 Apr 11;18(4). pii: E798. (Review) (IF 3.2)

Fischer K, Ruiz HH, Jhun K, Finan B, Oberlin DJ, van der Heide V, Kalinovich AV, Petrovic N, Wolf Y, Clemmensen C, Shin AC, Divanovic S, Brombacher F, Glasmacher E, Keipert S, Jastroch M, Nagler J, Schramm KW, Medrikova D, Collden G, Woods SC, Herzig S, Homann D, Jung S, Nedergaard J, Cannon B, Tschöp MH, Müller TD, Buettner C. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis. Nat Med2017 May;23(5):623-630. (IF 29.9)

Kabra UD, Pfuhlmann K, Migliorini A, Keipert S, Lamp D, Korsgren O, Gegg M, Woods SC, Pfluger PT, Lickert H, Affourtit C, Tschöp MH, Jastroch M. Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes2017 May;66(5):1247-1257. Erratum. (IF 8.7)

Duncan L, Yilmaz Z, Gaspar H, Walters R, Goldstein J, Anttila V, Bulik-Sullivan B, Ripke S; Eating Disorders Working Group of the Psychiatric Genomics Consortium, Thornton L, Hinney A, Daly M, Sullivan PF, Zeggini E, Breen G, Bulik CM. Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. Am J Psychiatry. 2017 May 12:appiajp201716121402. doi: 10.1176/appi.ajp.2017.16121402. (Tschöp: collaborating author) (IF 14.2)

Yi CX, Walter M, Gao Y, Pitra S, Legutko B, Kälin S, Layritz C, García-Cáceres C, Bielohuby M, Bidlingmaier M, Woods SC, Ghanem A, Conzelmann KK, Stern JE, Jastroch M, Tschöp MH. TNFα drives mitochondrial stress in POMC neurons in obesity. Nat Commun2017 May 10;8:15143. (IF 12.1)

Varela L, Suyama S, Huang Y, Shanabrough M, Tschöp MH, Gao XB, Giordano FJ, Horvath TL. Endothelial HIF-1α Enables Hypothalamic Glucose Uptake to Drive POMC Neurons. Diabetes2017 Jun;66(6):1511-1520. (IF 8.7)

Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX. Dietary sugars, not lipids, drive hypothalamic inflammation. Mol Metab. 2017 Jun 20;6(8):897-908. eCollection 2017 Aug. (IF 6.8)

Aichler M, Borgmann D, Krumsiek J, Buck A, MacDonald PE, Fox JEM, Lyon J, Light PE, Keipert S, Jastroch M, Feuchtinger A, Mueller NS, Sun N, Palmer A, Alexandrov T, Hrabe de Angelis M, Neschen S, Tschöp MH, Walch A. N-acyl Taurines and Acylcarnitines Cause an Imbalance in Insulin Synthesis and Secretion Provoking β Cell Dysfunction in Type 2 Diabetes. Cell Metab2017 Jun 6;25(6):1334-1347.e4. (IF 18.2)

Laperrousaz E, Moullé VS, Denis RG, Kassis N, Berland C, Colsch B, Fioramonti X, Philippe E, Lacombe A, Vanacker C, Butin N, Bruce KD, Wang H, Wang Y, Gao Y, Garcia-Caceres C, Prévot V, Tschöp MH, Eckel RH, Le Stunff H, Luquet S, Magnan C, Cruciani-Guglielmacci C. Lipoprotein lipase in hypothalamus is a key regulator of body weight gain and glucose homeostasis in mice. Diabetologia2017 Jul;60(7):1314-1324. (IF 6.1)

Tschöp M, DiMarchi R. Single-Molecule Combinatorial Therapeutics for Treating Obesity and Diabetes. Diabetes. 2017 Jul;66(7):1766-1769. (IF 8.7)

Gao Y, Layritz C, Legutko B, Eichmann TO, Laperrousaz E, Moullé VS, Cruciani-Guglielmacci C, Magnan C, Luquet S, Woods SC, Eckel RH, Yi CX, Garcia-Caceres C, Tschöp MH. Disruption of Lipid Uptake in Astroglia Exacerbates Diet Induced Obesity. Diabetes. 2017 Jul 14. pii: db161278. (IF 8.7)

Schriever SC, Zimprich A, Pfuhlmann K, Baumann P, Giesert F, Klaus V, Kabra DG, Hafen U, Romanov A, Tschöp MH, Wurst W, Conrad M, Hölter SM, Vogt Weisenhorn D, Pfluger PT. Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency. Neuroscience. 2017 Aug 15;357:241-254. Epub 2017 Jun 13. (IF 3.3)

Rathjen T, Yan X, Kononenko NL, Ku MC, Song K, Ferrarese L, Tarallo V, Puchkov D, Kochlamazashvili G, Brachs S, Varela L, Szigeti-Buck K, Yi CX, Schriever SC, Tattikota SG, Carlo AS, Moroni M, Siemens J, Heuser A, van der Weyden L, Birkenfeld AL, Niendorf T, Poulet JFA, Horvath TL, Tschöp MH, Heinig M, Trajkovski M, Haucke V, Poy MN. Regulation of body weight and energy homeostasis by neuronal cell adhesion molecule 1. Nat Neurosci. 2017 Aug;20(8):1096-1103. Epub 2017 Jun 19. (IF 17.8)

Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX. Dietary sugars, not lipids, drive hypothalamic inflammation. Mol Metab. 2017 Jun 20;6(8):897-908. eCollection 2017 Aug. (IF 6.8)

Sánchez-Garrido MA, Brandt SJ, Clemmensen C, Müller TD, DiMarchi RD, Tschöp MH. GLP-1/glucagon receptor co-agonism for treatment of obesity. Diabetologia. 2017 Oct;60(10):1851-1861. Epub 2017 Jul 21. (Review) (IF 6.1)

Mayer JP, Tschöp MH, DiMarchi RD. Once Blind, Now We See GLP-1 Molecular Action. Cell Metab. 2017 Aug 1;26(2):289-291. (IF 18.2)

Frias JP, Bastyr EJ 3rd, Vignati L, Tschöp MH, Schmitt C, Owen K, Christensen RH, DiMarchi RD. The Sustained Effects of a Dual GIP/GLP-1 Receptor Agonist, NNC0090-2746, in Patients with Type 2 Diabetes. Cell Metab. 2017 Aug 1;26(2):343-352.e2. (IF 18.2)

Keipert S, Kutschke M, Ost M, Schwarzmayr T, van Schothorst EM, Lamp D, Brachthäuser L, Hamp I, Mazibuko SE, Hartwig S, Lehr S, Graf E, Plettenburg O, Neff F, Tschöp MH, Jastroch M. Long-Term Cold Adaptation Does Not Require FGF21 or UCP1. Cell Metab. 2017 Aug 1;26(2):437-446.e5. (IF 18.2)

Böttcher A, Lickert H, Tschöp M. Engineering skin with skinny genes. Cell Stem Cell. 2017 Aug 3;21(2):153-155. (IF 23.4)

Khajavi N, Biebermann H, Tschöp M, DiMarchi R. Treatment of Diabetes and Obesity by Rationally Designed Peptide Agonists Functioning at Multiple Metabolic Receptors. Endocr Dev. 2017;32:165-182. (IF 4.0)

Pfuhlmann K, Pfluger PT, Schriever SC, Müller TD, Tschöp MH, Stemmer K. Dual specificity phosphatase 6 deficiency is associated with impaired systemic glucose tolerance and reversible weight retardation in mice. PLoS One. 2017 Sep 5;12(9):e0183488. (IF 2.8)

Kälin S, Becker M, Ott VB, Serr I, Hosp F, Mollah MMH, Keipert S, Lamp D, Rohner-Jeanrenaud F, Flynn VK, Scherm MG, Nascimento LFR, Gerlach K, Popp V, Dietzen S, Bopp T, Krishnamurthy P, Kaplan MH, Serrano M, Woods SC, Tripal P, Palmisano R, Jastroch M, Blüher M, Wolfrum C, Weigmann B, Ziegler AG, Mann M, Tschöp MH, Daniel C. A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function. Cell Metab. 2017 Sep 5;26(3):475-492.e7. (Tschöp corresponding author) (IF 18.1)

Fischer IP, Irmler M, Meyer CW, Sachs SJ, Neff F, de Angelis MH, Beckers J, Tschöp MH, Hofmann SM, Ussar S. A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue. Int J Obes (Lond). Int J Obes (Lond). 2017 Sep 13. (IF 5.5)

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 2017 Sep 19. pii: S1550-4131(17)30550-8. (IF 18.2)

Kleinert M, Clemmensen C, Stemmer K, Müller TD, DiMarchi RD, Tschöp MH. Emerging Poly-Agonists for Obesity and Type 2 Diabetes. Obesity (Silver Spring). 2017 Oct;25(10):1647-1649. (IF 3.9)

Kabra UD, Pfuhlmann K, Migliorini A, Keipert S, Lamp D, Korsgren O, Gegg M, Woods SC, Pfluger PT, Lickert H, Affourtit C, Tschöp MH, Jastroch M. Erratum. Direct Substrate Delivery Into Mitochondrial Fission-Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66:1247-1257. Diabetes. 2017 Oct 12. (IF 8.7)

Keuper M, Sachs S, Walheim E, Berti L, Raedle B, Tews D, Fischer-Posovszky P, Wabitsch M, Hrabě de Angelis M, Kastenmüller G, Tschöp MH, Jastroch M, Staiger H, Hofmann SM. Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors. Mol Metab. 2017 Oct;6(10):1226-1239. (IF 6.8)

Piotrowski C, Lede V, Butthof A, Kaiser N, Hirrlinger PG, Tschöp MH, Schöneberg T, Bechmann I. Open housing drives the expression of immune response genes in the nasal mucosa, but not the olfactory bulb. PLoS One. 2017 Oct 27;12(10):e0187192. (IF 3.1)

Ryan KK, Packard AEB, Larson KR, Stout J, Fourman SM, Thompson AMK, Ludwick K, Habegger KM, Stemmer K, Itoh N, Perez-Tilve D, Tschöp MH, Seeley RJ, Ulrich-Lai YM. Dietary manipulations that induce ketosis activate the HPA axis in male rats and mice: a potential role for fibroblast growth factor-21. Endocrinology. 2017 Oct 25. (IF 4.3)

Lefort S, Tschöp MH, García-Cáceres C. A Synaptic Basis for GLP-1 Action in the Brain. Neuron. 2017 Nov 15;96(4):713-715. (IF 14.0)

Mueller KM, Hartmann K, Kaltenecker D, Vettorazzi S, Bauer M, Mauser L, Amann S, Jall S, Fischer K, Esterbauer H, Müller TD, Tschöp MH, Magnes C, Haybaeck J, Scherer T, Bordag N, Tuckermann JP, Moriggl R. Erratum. Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and HFD-Induced Obesity and Impairs the Feeding-Fasting Transition. Diabetes 2017;66:272-286. Diabetes. 2017 Nov 16. (IF 8.7)

Knerr PJ, Finan B, Gelfanov V, Perez-Tilve D, Tschöp MH, DiMarchi RD. Optimization of peptide-based polyagonists for treatment of diabetes and obesity. Bioorg Med Chem. 2017 Nov 2. pii: S0968-0896(17)31972-7. [Epub ahead of print] (IF 2.9)

Balsevich G, Häusl AS, Meyer CW, Karamihalev S, Feng X, Pöhlmann ML, Dournes C, Uribe-Marino A, Santarelli S, Labermaier C, Hafner K, Mao T, Breitsamer M, Theodoropoulou M, Namendorf C, Uhr M, Paez-Pereda M, Winter G, Hausch F, Chen A, Tschöp MH, Rein T, Gassen NC, Schmidt MV. Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function. Nat Commun. 2017 Nov 23;8(1):1725. (IF 12.1)


Clemmensen C, Müller TD, Finan B, Tschöp MH, DiMarchi R. Current and Emerging Treatment Options in Diabetes Care. Handb Exp Pharmacol. 2016;233:437-59. (IF 3.9)

Grabner GF, Eichmann TO, Wagner B, Gao Y, Farzi A, Taschler U, Radner FP, Schweiger M, Lass A, Holzer P, Zinser E, Tschöp MH, Yi CX, Zimmermann R. Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation. J Biol Chem. 2016 Jan 8;291(2):913-23. (IF 4.1)

Quarta C, Schneider R, Tschöp MH. Epigenetic ON/OFF Switches for Obesity. Cell. 2016 Jan 28;164(3):341-2. (IF 30.4)

Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT. Hypothalamic Leptin Action is Mediated by Histone Deacetylase 5. (Tschöp corresponding author) Nat Commun 2016 Feb 29;7:10782. (IF 12.1)

Garcia-Caceres C, Tschöp MH. Hypothalamic Injury: Fish oil to the Rescue! Diabetes 2016 Mar;65(3):551-3. (IF 8.7)

Tine M, Kuhl H, Teske PR, Tschöp MH, Jastroch M. Diversification and coevolution of the ghrelin/growth hormone secretagogue receptor system in vertebrates. Ecol Evol. 2016 Mar 14;6(8):2516-35. (IF 2.4)

Gomes I, Bobeck EN, Margolis EB, Gupta A, Sierra S, Fakira AK, Fujita W, Müller TD, Müller A, Tschöp MH, Kleinau G, Fricker LD, Devi LA. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425)ra43. (IF 6.5)

Huypens P, Sass S, Wu M, Dyckhoff D, Tschöp M, Theis F, Marschall S, Hrabě de Angelis M, Beckers J. Epigenetic germline inheritance of diet-induced obesity and insulin resistance. Nat Genet 2016 May;48(5):497-9. (IF 28.0)

Quarta C, Sánchez-Garrido MA, Tschöp MH, Clemmensen C. Renaissance of leptin for obesity therapy. Diabetologia. 2016 May;59(5):920-7. (IF 6.1)

Finan B, Müller TD, Clemmensen C, Perez-Tilve D, DiMarchi RD, Tschöp MH. Reappraisal of GIP Pharmacology for Metabolic Diseases. Trends Mol Med. 2016 May;22(5):359-76. (IF 10.7)

Tschöp MH, Stumvoll M, Ristow M. Opposing Effects of Antidiabetic Interventions on Malignant Growth and Metastasis. Cell Metab. 2016 Jun 14;23(6):959-960. (IF 18.2)

Tschöp MH, Finan B, Clemmensen C, Gelfanov V, Perez-Tilve D, Müller TD, DiMarchi RD. Unimolecular Polypharmacy for Treatment of Diabetes and Obesity. Cell Metab. 2016 Jul 12;24(1):51-62. (IF 18.2)

Sánchez-Garrido MA, Habegger KM, Clemmensen C, Holleman C, Müller TD, Perez-Tilve D, Li P, Agrawal AS, Finan B, Drucker DJ, Tschöp MH, DiMarchi RD, Kharitonenkov A. Fibroblast activation protein (FAP) as a novel metabolic target. Mol Metab. 2016 Jul 16;5(10):1015-24. (IF 6.8)

Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H. Identification of proliferative and mature β-cells in the islets of Langerhans. Nature. 2016 Jul 21;535(7612):430-4. (IF 40.1)

Enriori PJ, Chen W, Garcia-Rudaz MC, Grayson BE, Evans AE, Comstock SM, Gebhardt U, Müller HL, Reinehr T, Henry BA, Brown RD, Bruce CR, Simonds SE, Litwak SA, McGee SL, Luquet S, Martinez S, Jastroch M, Tschöp MH, Watt MJ, Clarke IJ, Roth CL, Grove KL, Cowley MA. α-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors. Mol Metab. 2016 Aug 5;5(10):807-22. (IF 6.8)

Müller A, Niederstadt L, Jonas W, Yi CX, Meyer F, Wiedmer P, Fischer J, Grötzinger C, Schürmann A, Tschöp M, Kleinau G, Grüters A, Krude H, Biebermann H. Ring Finger Protein 11 Inhibits Melanocortin 3 and 4 Receptor Signaling. Front Endocrinol (Lausanne). 2016 Aug 8;7:109. (IF 4.5)

Müller TD, Tschöp MH, O'Rahilly S. Metabolic Precision Medicines: Curing POMC Deficiency. Cell Metab. 2016 Aug 9;24(2):194-5. (IF 18.2)

García-Cáceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, Jastroch M, Johansson P, Ninkovic J, Yi CX, Le Thuc O, Szigeti-Buck K, Cai W, Meyer CW, Pfluger PT, Fernandez AM, Luquet S, Woods SC, Torres-Alemán I, Kahn CR, Götz M, Horvath TL, Tschöp MH. Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability. Cell. 2016 Aug 11;166(4):867-80. (IF 30.4)

Pfluger PT, Tschöp MH. Obesity: will withaferin win the war? Nat Med. 2016 Sep 7;22(9):970-1. (IF 29.9)

De Angelis M, Giesert F, Finan B, Clemmensen C, Müller TD, Vogt-Weisenhorn D, Tschöp MH, Schramm KW. Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method. J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 15;1033-1034:413-20. (IF 2.6)

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD. Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease. (Tschöp co-corresponding author) Cell. 2016 Oct 20;167(3):843-857.e14. (IF 30.4)

Hernandez-Garzón E, Fernandez AM, Perez-Alvarez A, Genis L, Bascuñana P, Fernandez de la Rosa R, Delgado M, Angel Pozo M, Moreno E, McCormick PJ, Santi A, Trueba-Saiz A, Garcia-Caceres C, Tschöp MH, Araque A, Martin ED, Torres Aleman I. The insulin-like growth factor I receptor regulates glucose transport by astrocytes. Glia. 2016 Nov;64(11):1962-71 (IF 6.2)

Vogel H, Wolf S, Rabasa C, Rodriguez-Pacheco F, Babaei CS, Stöber F, Goldschmidt J, DiMarchi RD, Finan B, Tschöp MH, Dickson SL, Schürmann A, Skibicka KP. GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight. Neuropharmacology. 2016 Nov;110(Pt A):396-406. (IF 5.0)

Tschöp M. Diabetes Type 2 Treatments. Drug Res. (Stuttg). 2016 Nov;66(S 01):S10. (IF 0.7)

Kunath N, Müller NC, Tonon M, Konrad BN, Pawlowski M, Kopczak A, Elbau I, Uhr M, Kühn S, Repantis D, Ohla K, Müller TD, Fernández G, Tschöp M, Czisch M, Steiger A, Dresler M. Ghrelin modulates encoding-related brain function without enhancing memory formation in humans. Neuroimage. 2016 Nov 15;142:465-473. (IF 5.9)

Müller V, Remus K, Hoffmann V, Tschöp MH, Meissner K. Effectiveness of a placebo intervention on visually induced nausea in women - A randomized controlled pilot study. J Psychosom Res. 2016 Dec;91:9-11. (IF 2.8)


Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH. A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. Nat Med. 2015 Jan;21(1):27-36. (IF 29.9)

Fischer K, Finan B, Clemmensen C, Van der Ploeg LH, Tschöp MH, Müller TD. The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor. Front Nutr. 2015 Jan 12;1:31. (IF N/A)

Clemmensen C, Finan B, Fischer K, Tom RZ, Legutko B, Sehrer L, Heine D, Grassl N, Meyer CW, Henderson B, Hofmann SM, Tschöp MH, Van der Ploeg LH, Müller TD. Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice. EMBO Mol Med. 2015 Feb 4;7(3):288-98. (IF 9.2)

Dinter J, Mühlhaus J, Wienchol CL, Yi CX, Nürnberg D, Morin S, Grüters A, Köhrle J, Schöneberg T, Tschöp M, Krude H, Kleinau G, Biebermann H. Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5. PLoS One. 2015 Feb 23;10(2):e0117774. (IF 2.8)

Schwenk RW, Baumeier C, Finan B, Kluth O, Brauer C, Joost HG, DiMarchi RD, Tschöp MH, Schürmann A. GLP-1-oestrogen attenuates hyperphagia and protects from beta cell failure in diabetes-prone New Zealand obese (NZO) mice. Diabetologia. 2015 Mar;58(3):604-14. (IF 6.0)

Müller TD, Nogueiras R, Andermann ML, Andrews ZB, Anker SD, Argente J, Batterham RL, Benoit SC, Bowers CY, Broglio F, Casanueva FF, D'Alessio D, Depoortere I, Geliebter A, Ghigo E, Cole PA, Cowley M, Cummings DE, Dagher A, Diano S, Dickson SL, Diéguez C, Granata R, Grill HJ, Grove K, Habegger KM, Heppner K, Heiman ML, Holsen L, Holst B, Inui A, Jansson JO, Kirchner H, Korbonits M, Laferrère B, LeRoux CW, Lopez M, Morin S, Nakazato M, Nass R, Perez-Tilve D, Pfluger PT, Schwartz TW, Seeley RJ, Sleeman M, Sun Y, Sussel L, Tong J, Thorner MO, Van der Lely AJ, Van der Ploeg LH, Zigman JM, Kojima M, Kangawa K, Smith RG, Horvath T, Tschöp MH. Ghrelin. Mol Metab. 2015 Mar 21;4(6):437-60. (IF 6.8)

Reis WL, Yi CX, Gao Y, Tschöp MH, Stern JE. Brain innate immunity regulates hypothalamic arcuate neuronal activity and feeding behavior. Endocrinology. 2015 Apr;156(4):1303-15. (IF 4.3)

Kälin S, Heppner FL, Bechmann I, Prinz M, Tschöp MH, Yi CX. Hypothalamic innate immune reaction in obesity. Nat Rev Endocrinol. 2015 Jun;11(6):339-51. (IF 18.3)

Wiedmer P, Schwarz F, Große B, Schindler N, Tuchscherer A, Russo VC, Tschöp MH, Hoeflich A. Gender-specific effects on food intake but no inhibition of age-related fat accretion in transgenic mice overexpressing human IGFBP-2 lacking the Cardin-Weintraub sequence motif. J Cell Commun Signal. 2015 Jun;9(2):143-50. (IF 4.0)

Um SH, Sticker-Jantscheff M, Chau GC, Vintersten K, Mueller M, Gangloff YG, Adams RH, Spetz JF, Elghazi L, Pfluger PT, Pende M, Bernal-Mizrachi E, Tauler A, Tschöp MH, Thomas G, Kozma SC. S6K1 controls pancreatic β cell size independently of intrauterine growth restriction. J Clin Invest. 2015 Jul 1;125(7):2736-47. (IF 12.8)

Tattikota SG, Rathjen T, Hausser J, Khedkar A, Kabra UD, Pandey V, Sury M, Wessels HH, Mollet IG, Eliasson L, Selbach M, Zinzen RP, Zavolan M, Kadener S, Tschöp MH, Jastroch M, Friedländer MR, Poy MN. miR-184 Regulates Pancreatic β-Cell Function According to Glucose Metabolism. J Biol Chem. 2015 Aug 14;290(33):20284-94. (IF 4.1)

Meyer CW, Reitmeir P, Tschöp MH. Exploration of Energy Metabolism in the Mouse Using Indirect Calorimetry: Measurement of Daily Energy Expenditure (DEE) and Basal Metabolic Rate (BMR). Curr Protoc Mouse Biol. 2015 Sep 1;5(3):205-22. (IF N/A)

Raab S, Wang H, Uhles S, Cole N, Alvarez-Sanchez R, Künnecke B, Ullmer C, Matile H, Bedoucha M, Norcross RD, Ottaway-Parker N, Perez-Tilve D, Conde Knape K, Tschöp MH, Hoener MC, Sewing S. Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. Mol Metab. 2015 Nov 1;5(1):47-56. (IF 6.8)

Pfluger PT, Kabra DG, Aichler M, Schriever SC, Pfuhlmann K, García VC, Lehti M, Weber J, Kutschke M, Rozman J, Elrod JW, Hevener AL, Feuchtinger A, Hrabě de Angelis M, Walch A, Rollmann SM, Aronow BJ, Müller TD, Perez-Tilve D, Jastroch M, De Luca M, Molkentin JD, Tschöp MH. Calcineurin Links Mitochondrial Elongation with Energy Metabolism. Cell Metab. 2015 Nov 3;22(5):838-50. (IF 18.2)

Xie TY, Ngo ST, Veldhuis JD, Jeffery PL, Chopin LK, Tschöp M, Waters MJ, Tolle V, Epelbaum J, Chen C, Steyn FJ. Effect of Deletion of Ghrelin-O-Acyltransferase on the Pulsatile Release of Growth Hormone in Mice. J Neuroendocrinol. 2015 Dec;27(12):872-86. (IF 3.5)

Lockie SH, Stefanidis A, Tschöp MH, Oldfield BJ. Combination cannabinoid and opioid receptor antagonists improves metabolic outcomes in obese mice. Mol Cell Endocrinol. 2015 Dec 5;417:10-9. (IF 3.8)


Al Massadi O, Lear PV, Muller TD, Lopez M, Dieguez C, Tschop MH, Nogueiras R. Review of novel aspects of the regulation of ghrelin secretion. Curr Drug Metab. 2014;15(4):398-413. (IF 2.7)

Garcia-Caceres C, Tschöp M. The emerging neurobiology of caloric addiction. eLife 2014;3:e01928. (IF 7.7)

Gao Y, Ottaway N, Schriever SC, Legutko B, García-Cáceres C, de la Fuente E, Mergen C, Bour S, Thaler JP, Seeley RJ, Filosa J, Stern JE, Perez-Tilve D, Schwartz MW, Tschöp MH, Yi CX. Hormones and diet, but not body weight, control hypothalamic microglial activity. Glia. 2014 Jan;62(1):17-25. (IF 6.2)

Heppner KM, Piechowski CL, Müller A, Ottaway N, Sisley S, Smiley DL, Habegger KM, Pfluger PT, Dimarchi R, Biebermann H, Tschöp MH, Sandoval DA, Perez-Tilve D. Both acyl and des-acyl ghrelin regulate adiposity and glucose metabolism via central nervous system ghrelin receptors. Diabetes. 2014 Jan;63(1):122-31. (IF 8.7)

Habegger KM, Heppner KM, Amburgy SE, Ottaway N, Holland J, Raver C, Bartley E, Müller TD, Pfluger PT, Berger J, Toure M, Benoit SC, Dimarchi RD, Perez-Tilve D, D'Alessio DA, Seeley RJ, Tschöp MH. GLP-1R responsiveness predicts individual gastric bypass efficacy on glucose tolerance in rats. Diabetes. 2014 Feb;63(2):505-13. (IF 8.7)

Keuper M, Jastroch M, Yi CX, Fischer-Posovszky P, Wabitsch M, Tschöp MH, Hofmann SM. Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J. 2014 Feb;28(2):761-70. (IF 5.5)

Aoqui C, Chmielewski S, Scherer E, Eissler R, Sollinger D, Heid I, Braren R, Schmaderer C, Megens RT, Weber C, Heemann U, Tschöp M, Baumann M. Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet. Cardiovasc Diabetol. 2014 Feb 3;13:31. (IF 4.8)

Gao Y, Tschöp MH, Luquet S. Hypothalamic tanycytes: gatekeepers to metabolic control. Cell Metab. 2014 Feb 4;19(2):173-5. (IF 18.1)

Schwartz MW, Tschöp M, Zeltser LM. A mother's influence on metabolic disorders. Nat Med. 2014 Mar;20(3):244-5. (IF 29.9)

Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Küchler D, Sehrer L, Ograjsek T, Hofmann SM, Schriever SC, Pfluger PT, Pinkstaff J, Tschöp MH, Dimarchi R, Müller TD. GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes. 2014 Apr;63(4):1422-7. (IF 8.7)

Tong J, Davis HW, Summer S, Benoit SC, Haque A, Bidlingmaier M, Tschöp MH, D'Alessio D. Acute Administration of Unacylated Ghrelin Has No Effect on Basal or Stimulated Insulin Secretion in Healthy Humans. Diabetes. 2014 Jul;63(7):2309-19. (IF 8.7)

Kim JG, Suyama S, Koch M, Jin S, Argente-Arizon P, Argente J, Liu ZW, Zimmer MR, Jeong JK, Szigeti-Buck K, Gao Y, Garcia-Caceres C, Yi CX, Salmaso N, Vaccarino FM, Chowen J, Diano S, Dietrich MO, Tschöp MH, Horvath TL. Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding. Nat Neurosci. 2014 Jul;17(7):908-10. (IF 17.8)

Habegger KM, Al-Massadi O, Heppner KM, Myronovych A, Holland J, Berger J, Yi CX, Gao Y, Lehti M, Ottaway N, Amburgy S, Raver C, Müller TD, Pfluger PT, Kohli R, Perez-Tilve D, Seeley RJ, Tschöp MH. Duodenal nutrient exclusion improves metabolic syndrome and stimulates villus hyperplasia. Gut. 2014 Aug;63(8):1238-46. (IF 16.7)

Müller TD, Tschöp MH. Play down protein to play up metabolism? J Clin Invest. 2014 Sep;124(9):3691-3. (IF 12.8)

Hernandez ED, Lee SJ, Kim JY, Duran A, Linares JF, Yajima T, Müller TD, Tschöp MH, Smith SR, Diaz-Meco MT, Moscat J. A macrophage NBR1-MEKK3 complex triggers JNK-mediated adipose tissue inflammation in obesity. Cell Metab. 2014 Sep 2;20(3):499-511. (IF 18.2)

Cansell C, Castel J, Denis RG, Rouch C, Delbes AS, Martinez S, Mestivier D, Finan B, Maldonado-Aviles JG, Rijnsburger M, Tschöp MH, DiLeone RJ, Eckel RH, la Fleur SE, Magnan C, Hnasko TS, Luquet S. Dietary triglycerides act on mesolimbic structures to regulate the rewarding and motivational aspects of feeding. Mol Psychiatry. 2014 Oct;19(10):1095-105. (IF 13.2)

Jastroch M, Morin S, Tschöp MH, Yi CX. The hypothalamic neural-glial network and the metabolic syndrome. Best Pract Res Clin Endocrinol Metab. 2014 Oct;28(5):661-71. (IF 4.5)

Ussar, S, Tschöp MH. Breaking Fat. Cell. 2014 Oct 9;159(2):238-40. (IF 30.4)

Wolf MJ, Adili A, Piotrowitz K, Abdullah Z, Boege Y, Stemmer K, Ringelhan M, Simonavicius N, Egger M, Wohlleber D, Lorentzen A, Einer C, Schulz S, Clavel T, Protzer U, Thiele C, Zischka H, Moch H, Tschöp M, Tumanov AV, Haller D, Unger K, Karin M, Kopf M, Knolle P, Weber A, Heikenwälder M. Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. Cancer Cell. 2014 Oct 13;26(4):549-64. (IF 27.4)

Morselli E, Fuente-Martin E, Finan B, Kim M, Frank A, Garcia-Caceres C, Navas CR, Gordillo R, Neinast M, Kalainayakan SP, Li DL, Gao Y, Yi CX, Hahner L, Palmer BF, Tschöp MH, Clegg DJ. Hypothalamic PGC-1α protects against high-fat diet exposure by regulating ERα. Cell Rep. 2014 Oct 23;9(2):633-45. (IF 8.3)

Mühlhaus J, Dinter J, Nürnberg D, Rehders M, Depke M, Golchert J, Homuth G, Yi CX, Morin S, Köhrle J, Brix K, Tschöp M, Kleinau G, Biebermann H. Analysis of human TAAR8 and murine Taar8b mediated signaling pathways and expression profile. Int J Mol Sci. 2014 Nov 10;15(11):20638-55. (IF 3.2)

Müller A, Leinweber B, Fischer J, Müller TD, Grüters A, Tschöp MH, Knäuper V, Biebermann H, Kleinau G. The extracellular N-terminal domain of G-protein coupled receptor 83 regulates signaling properties and is an intramolecular inverse agonist. BMC Res Notes. 2014 Dec 16;7:913. (IF 1.6)


Oelkrug R, Goetze N, Exner C, Lee Y, Ganjam GK, Kutschke M, Müller S, Stöhr S, Tschöp MH, Crichton PG, Heldmaier G, Jastroch M, Meyer CW. Brown fat in a protoendothermic mammal fuels eutherian evolution. Nat Commun. 2013;4:2140. (IF 12.1)

Müller A, Kleinau G, Piechowski CL, Müller TD, Finan B, Pratzka J, Grüters A, Krude H, Tschöp M, Biebermann H. G-protein coupled receptor 83 (GPR83) signaling determined by constitutive and zinc(II)-induced activity. PLoS One. 2013;8(1):e53347. (IF 2.8) 

Müller TD, Tschöp MH. Ghrelin - a key pleiotropic hormone-regulating systemic energy metabolism. Endocr Dev. 2013;25:91-100. (IF 4.0) 

Müller TD, Tschöp MH, Hofmann SM. Emerging Function of Fat mass and Obesity-associated protein (FTO). PloS Genet 2013;9(1):e1003223. (IF 6.1) 

Müller TD, Müller A, Yi CX, Habegger KM, Meyer CW, Gaylinn BD, Finan B, Heppner K, Trivedi C, Bielohuby M, Abplanalp W, Meyer F, Piechowski CL, Pratzka J, Stemmer K, Holland J, Hembree J, Bhardwaj N, Raver C, Ottaway N, Krishna R, Sah R, Sallee FR, Woods SC, Perez-Tilve D, Bidlingmaier M, Thorner MO, Krude H, Smiley D, Dimarchi R, Hofmann S, Pfluger PT, Kleinau G, Biebermann H, Tschöp MH. The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. Nat Commun 2013;4:1968. (IF 12.1) 

Chambers AP, Kirchner H, Wilson-Perez HE, Willency JA, Hale JE, Gaylinn BD, Thorner MO, Pfluger PT, Gutierrez JA, Tschöp MH, Sandoval DA, Seeley RJ. The effects of vertical sleeve gastrectomy in rodents are ghrelin independent. Gastroenterology. 2013 Jan;144(1):50-52.e5. (IF 18.4) 

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner KM, Hofmann S, Holland J, Küchler D, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever SC, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. p62 links β-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest. 2013 Jan;123(1):469-78. (IF 12.8) 

Lim CT, Kola B, Feltrin D, Perez-Tilve D, Tschöp MH, Grossman AB, Korbonits M. Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Mol Cell Endocrinol. 2013 Jan 30;365(2):303-8. (IF 3.8)

Heppner KM, Müller TD, Kirchner H, Perez-Tilve D, Pfluger PT, Tschöp MH, Hofmann SM. The role of ghrelin-octanoyl-acyl-transferase in thermoregulation. J Endocrinol Invest. 2013 Mar;36(3):180-4. (IF 2.6)

García-Cáceres C, Yi CX, Tschöp MH. Hypothalamic astrocytes in obesity. Endocrinol Metab Clin North Am. 2013 Mar;42(1):57-66. (IF 3.2)

Kirchner H, Heppner KM, Holland J, Kabra D, Tschöp MH, Pfluger PT. Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. PLoS One. 2013 Apr 22;8(4):e61822. (IF 2.8)

Habegger KM, Stemmer K, Cheng C, Müller TD, Heppner KM, Ottaway N, Holland J, Hembree JL, Smiley D, Gelfanov V, Krishna R, Arafat AM, Konkar A, Belli S, Kapps M, Woods SC, Hofmann SM, D'Alessio D, Pfluger PT, Perez-Tilve D, Seeley RJ, Konishi M, Itoh N, Kharitonenkov A, Spranger J, DiMarchi RD, Tschöp MH. Fibroblast growth factor 21 mediates specific glucagon actions. Diabetes. 2013 May;62(5):1453-63. (IF 8.7)

Tong J, Dave N, Mugundu GM, Davis HW, Gaylinn BD, Thorner MO, Tschöp MH, D'Alessio D, Desai PB. The pharmacokinetics of acyl, des-acyl, and total ghrelin in healthy human subjects. Eur J Endocrinol. 2013 May 2;168(6):821-8. (IF 4.1)

Harley IT, Giles DA, Pfluger PT, Burgess SL, Walters S, Hembree J, Raver C, Rewerts CL, Downey J, Flick LM, Stankiewicz TE, McAlees JW, Wills-Karp M, Balfour Sartor R, Divanovic S, Tschöp MH, Karp CL. Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice. Mol Metab. 2013 May 10;2(3):171-83. (IF 6.8)

Stemmer K, Bielohuby M, Grayson BE, Begg DP, Chambers AP, Neff C, Woods SC, Erben RG, Tschöp MH, Bidlingmaier M, Clemens TL, Seeley RJ. Roux-en-Y gastric bypass surgery but not vertical sleeve gastrectomy decreases bone mass in male rates. Endocrinology 2013 Jun;154(6):2015-24. (IF 4.3)

Tong J, Prigeon RL, Davis HW, Bidlingmaier M, Tschöp MH, D'Alessio D. Physiologic concentrations of exogenously infused ghrelin reduces insulin secretion without affecting insulin sensitivity in healthy humans. J Clin Endocrinol Metab. 2013 Jun;98(6):2536-43. (IF 5.5)

Habegger KM, Kirchner H, Yi CX, Heppner KM, Sweeney D, Ottaway N, Holland J, Amburgy S, Raver C, Krishna R, Müller TD, Perez-Tilve D, Pfluger PT, Obici S, Dimarchi RD, D'Alessio DA, Seeley RJ, Tschöp MH. GLP-1R Agonism Enhances Adjustable Gastric Banding In Diet-Induced Obese Rats. Diabetes 2013 Sep;62(9):3261-7. (IF 8.7)

Ward BP, Ottaway NL, Perez-Tilve D, Ma D, Gelfanov VM, Tschöp MH, Dimarchi RD. Peptide lipidation stabilizes structure to enhance biological function. Mol Metab. 2013 Sep 5;2(4):468-79. (IF 6.8)

Cai H, Cong WN, Daimon CM, Wang R, Tschöp MH, Sévigny J, Martin B, Maudsley S. Altered lipid and salt taste responsivity in ghrelin and GOAT null mice. PLoS One. 2013 Oct 4;8(10):e76553. (IF 2.8)

Finan B, Ma T, Ottaway N, Müller TD, Habegger KM, Heppner KM, Kirchner H, Holland J, Hembree J, Raver C, Lockie SH, Smiley DL, Gelfanov V, Yang B, Hofmann S, Bruemmer D, Drucker DJ, Pfluger PT, Perez-Tilve D, Gidda J, Vignati L, Zhang L, Hauptman JB, Lau M, Brecheisen M, Uhles S, Riboulet W, Hainaut E, Sebokova E, Conde-Knape K, Konkar A, Dimarchi RD, Tschöp MH. Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans. Sci Transl Med 2013 Oct 30;5(209):209ra151. (IF 16.8)

Bielohuby M, Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Wanke R, Tschöp MH, Seeley RJ, Bidlingmaier M. Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets. Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1059-70. (IF 4.1)

Schwartz MW, Seeley RJ, Tschöp MH, Woods SC, Morton GJ, Myers MG, D'Alessio D. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 2013 Nov 7;503(7474):59-66. (IF 40.1)

Fuente-Martin E, Garcia-Caceres C, Morselli E, Clegg DJ, Chowen JA, Finan B, Brinton RD, Tschöp MH. Estrogen, astrocytes and the neuroendocrine control of metabolism. Rev Endocr Metab Disord. 2013 Dec;14(4):331-8. (IF 5.1)

Togliatto G, Trombetta A, Dentelli P, Cotogni P, Rosso A, Tschöp MH, Granata R, Ghigo E, Brizzi MF. Unacylated ghrelin promotes skeletal muscle regeneration following hindlimb ischemia via SOD-2-mediated miR-221/222 expression. J Am Heart Assoc. 2013 Dec 5;2(6):e000376. (IF 4.9)

Stevanovic D, Trajkovic V, Müller-Lühlhoff S, Brandt E, Abplanalp W, Bumke-Vogt C, Liehl B, Wiedmer P, Janjetovic K, Starcevic V, Pfeiffer AF, Al-Hasani H, Tschöp MH, Castañeda TR. Ghrelin-induced food intake and adiposity depend on central mTORC1/S6K1 signaling. Mol Cell Endocrinol. 2013 Dec 5;381(1-2):280-90. (IF 3.8)


Kirchner H, Heppner KM, Tschöp MH. The role of ghrelin in the control of energy balance. Handb Exp Pharmacol. 2012;(209):161-84. (IF 3.9)

Rediger A, Piechowski CL, Habegger K, Grüters A, Krude H, Tschöp MH, Kleinau G, Biebermann H. MC4R dimerization in the paraventricular nucleus and GHSR/MC3R heterodimerization in the arcuate nucleus: is there relevance for body weight regulation? Neuroendocrinology. 2012;95(4):277-88. (IF 3.6)

Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, Tschöp MH. Metabolic control by S6 kinases depends on dietary lipids. PLoS One. 2012;7(3):e32631. (IF 2.8)

Riepl RL, Fischer R, Hautmann H, Hartmann G, Müller TD, Tschöp M, Toepfer M, Otto B. Influence of acute exposure to high altitude on basal and postprandial plasma levels of gastroenteropancreatic peptides. PLoS One. 2012;7(9):e44445. (IF 2.8)

Heppner KM, Müller TD, Tong J, Tschöp MH. Ghrelin in the control of energy, lipid, and glucose metabolism. Methods Enzymol. 2012;514:249-60. (IF 2.1)

Day JW, Gelfanov V, Smiley D, Carrington PE, Eiermann G, Chicchi G, Erion MD, Gidda J, Thornberry NA, Tschöp MH, Marsh DJ, SinhaRoy R, DiMarchi R, Pocai A. Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents. Biopolymers. 2012;98(5):443-50. (IF 1.9)

Betz MJ, Bielohuby M, Mauracher B, Abplanalp W, Müller HH, Pieper K, Ramisch J, Tschöp MH, Beuschlein F, Bidlingmaier M, Slawik M. Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats. PLoS One. 2012;7(6):e38997. (IF 2.8)

Yi CX, Heppner KM, Kirchner H, Tong J, Bielohuby M, Gaylinn BD, Müller TD, Bartley E, Davis HW, Zhao Y, Joseph A, Kruthaupt T, Ottaway N, Kabra D, Habegger KM, Benoit SC, Bidlingmaier M, Thorner MO, Perez-Tilve D, Tschöp MH, Pfluger PT. The GOAT-ghrelin system is not essential for hypoglycemia prevention during prolonged calorie restriction. PLoS One. 2012;7(2):e32100. (IF 2.8)

Bielohuby M, Stemmer K, Berger J, Ramisch J, Smith K, Holland J, Parks K, Pfluger PT, Habegger KM, Tschöp MH, Seeley RJ, Bidlingmaier M. Carbohydrate content of post-operative diet influences the effect of vertical sleeve gastrectomy on body weight reduction in obese rats. Obes Surg. 2012 Jan;22(1):140-51. (IF 4.0)

Thaler JP, Yi CX, Schur EA, Guyenet SJ, Hwang BH, Dietrich MO, Zhao X, Sarruf DA, Izgur V, Maravilla KR, Nguyen HT, Fischer JD, Matsen ME, Wisse BE, Morton GJ, Horvath TL, Baskin DG, Tschöp MH, Schwartz MW. Obesity is associated with hypothalamic injury in rodents and humans. J Clin Invest. 2012 Jan;122(1):153-62. (IF 13.215) Erratum in J Clin Invest. 2012 Feb 1;122(2):778 (IF 12.8)

Yi CX, Foppen E, Abplanalp W, Gao Y, Alkemade A, la Fleur SE, Serlie MJ, Fliers E, Buijs RM, Tschöp MH, Kalsbeek A. Glucocorticoid signaling in the arcuate nucleus modulates hepatic insulin sensitivity. Diabetes. 2012 Feb;61(2):339-45. (IF 8.7)

Wiedmer P, Chaudhary N, Rath M, Yi CX, Ananthakrishnan G, Nogueiras R, Wirth EK, Kirchner H, Schweizer U, Jonas W, Veyrat-Durebex C, Rohner-Jeanrenaud F, Schürmann A, Joost HG, Tschöp MH, Perez-Tilve D. The HPA axis modulates the CNS melanocortin control of liver triacylglyceride metabolism. Physiol Behav. 2012 Feb 1;105(3):791-9. (IF 2.3)

Myers MG Jr, Heymsfield SB, Haft C, Kahn BB, Laughlin M, Leibel RL, Tschöp MH, Yanovski JA. Challenges and opportunities of defining clinical leptin resistance. Cell Metab. 2012 Feb 8;15(2):150-6. (IF 18.2)

Caton SJ, Bielohuby M, Bai Y, Spangler LJ, Burget L, Pfluger P, Reinel C, Czisch M, Reincke M, Obici S, Kienzle E, Tschöp MH, Bidlingmaier M. Low-carbohydrate high-fat diets in combination with daily exercise in rats: effects on body weight regulation, body composition and exercise capacity. Physiol Behav. 2012 May 15;106(2):185-92. (IF 2.3)

Müller TD, Sullivan LM, Habegger K, Yi CX, Kabra D, Grant E, Ottaway N, Krishna R, Holland J, Hembree J, Perez-Tilve D, Pfluger PT, DeGuzman MJ, Siladi ME, Kraynov VS, Axelrod DW, DiMarchi R, Pinkstaff JK, Tschöp MH. Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21. J Pept Sci 2012 Jun;18(6);383-93. (IF 2.0) ELECTED PAPER OF THE YEAR

Tschöp MH, DiMarchi RD. Defeating Diabesity: The case for personalized combinatorial therapies. Diabetes 2012 Jun;61(6):1309-14. (IF 8.7)

Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, Horvath TL, Sinclair DA, Pfluger PT, Tschöp MH. Sirtuin 1 and Sirtuin 3: Physiological modulators of metabolism. Physiol Rev 2012 Jul;92(3):1479-514. (IF 27.3)

Czyzyk TA, Tomero-Picó A, PIntar J, McKinzie JH, Tschöp MH, Statnick MA, Nogueiras R. Mice lacking d-opioid receptors resist the development of diet-induced obesity. FASEB J 2012 Aug;26(8):3483-92. (IF 5.5)

Pfluger PT, Schriever SC, Tschöp MH. Nutropiods, hedonism in the gut? Cell Metab 2012 Aug 8;16(2):137-9. (IF 18.2)

Yi CX, Gericke M, Krüger M, Alkemade A, Kabra DG, Hanske S, Filosa J, Pfluger P, Bingham N, Woods SC, Herman J, Kalsbeek A, Baumann M, Lang R, Stern JE, Bechmann I, Tschöp MH. High calorie diet triggers hypothalamic angiopathy. Mol Metab. 2012 Aug 9;1(1-2):95-100. (IF 6.8)

Tschöp MH, Brüning JC, Horvath TL, Myers MG Jr, Neill US. Welcome to molecular metabolism! Mol Metab. 2012 Aug 16;1(1-2):1. (IF 6.8)

Yi CX, Tschöp MH, Woods SC, Hofmann SM. High-fat-diet exposure induces IgG accumulation in hypothalamic microglia. Dis Model Mech. 2012 Sep;5(5):686-90. (IF 4.7)

Yi CX, Tschöp MH. Brain-gut-adipose-tissue communication pathways at a glance. Dis Model Mech. 2012 Sep;5(5):583-7. (IF 4.7)

Tong J, D’Alessio D, Ramisch J, Davis HW, Stambrook E, Tschöp MH, Bidlingmaier M. Ghrelin stimulation of growth hormone isoforms: parallel secretion of total and 20-kDa growth hormone and relation to insulin sensitivity in healthy humans. J Clin Endocrinol Metab 2012 Sept;97(9):3366-74. (IF 5.5)

Rodgers RJ, Tschöp MH, Wilding JP. Anti-obesity drugs: past, present and future. Dis Model Mech. 2012 Sep;5(5):621-6. (IF 4.7)

Stemmer K, Perez-Tilve D, Ananthakrishnan G, Bort A, Seeley RJ, Tschöp MH, Dietrich DR, Pfluger PT. High-fat-diet-induced obesity causes an inflammatory and tumor-promoting microenvironment in the rat kidney. Dis Model Mech. 2012 Sep;5(5):627-35. (IF 4.7)

Davis JF, Schurdak JD, Magrisso IJ, Mul JD, Grayson BE, Pfluger PT, Tschöp MH, Seeley RJ, Benoit SC. Gastric bypass surgery attenuates ethanol consumption in ethanol-preferring rats. Biol Psychiatry 2012 Sept 1;72(5):354-60. (IF 11.4)

Zeltser LM, Seeley RJ, Tschöp MH. Synaptic plasticity in neuronal circuits regulating energy balance. Nat Neurosci 2012 Oct;15(10):1336-42. (IF 17.9)

Heppner KM, Chaudhary N, Müller TD, Kirchner H, Habegger KM, Ottaway N, Smiley DL, Dimarchi R, Hofmann SM, Woods SC, Siversten B, Holst B, Pfluger PT, Perez-Tilve D, Tschöp MH. Acetylation type determines ghrelin’s effects on energy homeostasis in rodents. Endocrinology 2012 Oct;153(10):4687-95. (IF 4.2)

Habegger KM, Matzke D, Ottaway N, Hembree J, Holland J, Raver C, Mansfeld J, Müller TD, Perez-Tilve D, Pfluger PT, Lee SJ, Diaz-Meco M, Moscat J, Leitges M, Tschöp MH, Hofmann SM. Role of adipose and hepatic atypical protein kinase C lambda (PKCλ) in the development of obesity and glucose intolerance. Adipocyte. 2012 Oct 1;1(4):203-14. (IF N/A)

Davis JF, Perello M, Choi DL, Magrisso IJ, Kirchner H, Pfluger PT, Tschoep M, Zigman JM, Benoit SC. GOAT induced ghrelin acylation regulates hedonic feeding. Horm Behav. 2012 Nov;62(5):598-604. (IF 3.4)

Kirchner H, Hofmann SM, Fischer-Rosinsky A, Hembree J, Abplanalp W, Ottaway N, Donelan E, Krishna R, Woods SC, Müller TD, Spranger J, Perez-Tilve D, Pfluger PT, Tschöp MH, Habegger KM. Calorie restriction chronically impairs metabolic programming in mice. Diabetes 2012 Nov;61(11):2734-42. (IF 8.7)

Lockie SH, Heppner KM, Chaudhary N, Chabenne JR, Morgan DA, Veyrat-Durebex C, Ananthakrishnan G, Rohner-Jeanrenaud F, Drucker DJ, DiMarchi R, Rahmouni K, Oldfield BJ, Tschöp MH, Perez-Tilve D. Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling. Diabetes. 2012 Nov;61(11):2753-62. (IF 8.7)

Perez-Tilve D, Davidson WS, Tschöp M, Hofmann SM. CNS regulation of plasma cholesterol. Ann Med. 2012 Nov;44(7):656-63. (IF 3.7)

Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi CX, Habegger KM, Schriever SC, Garcia-Caceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Hrabe de Angelis M, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger PT, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH. Targeted estrogen delivery reverses the metabolic syndrome. Nat Med 2012 Dec;18(12):1847-56. (IF 29.9)


Yi CX, Habegger KM, Chowen JA, Stern J, Tschöp MH. A role for astrocytes in the central control of metabolism. Neuroendocrinology. 2011;93(3):143-9. (IF 3.6)

Bielohuby M, Menhofer D, Kirchner H, Stoehr BJ, Müller TD, Stock P, Hempel M, Stemmer K, Pfluger PT, Kienzle E, Christ B, Tschöp MH, Bidlingmaier M. Induction of ketosis in rats fed low-carbohydrate, high-fat diets depends on the relative abundance of dietary fat and protein. Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E65-76. (IF 4.1)

Heppner KM, Tong J, Kirchner H, Nass R, Tschöp MH. The ghrelin O-acyltransferase-ghrelin system: a novel regulator of glucose metabolism. Curr Opin Endocrinol Diabetes Obes. 2011 Feb;18(1):50-5. (IF 3.7)

Yi CX, Kalsbeek A, Tschöp MH. Autonomic MC sets the metabolic tone. Cell Metab. 2011 Feb 2;13(2):121-3. (IF 18.2)

Patterson JT, Ottaway N, Gelfanov VM, Smiley DL, Perez-Tilve D, Pfluger PT, Tschöp MH, Dimarchi RD. A novel human-based receptor antagonist of sustained action reveals body weight control by endogenous GLP-1. ACS Chem Biol. 2011 Feb 18;6(2):135-45. (IF 5.0)

Disse E, Bussier AL, Deblon N, Pfluger PT, Tschöp MH, Laville M, Rohner-Jeanrenaud F. Systemic ghrelin and reward: effect of cholinergic blockade. Physiol Behav. 2011 Mar 28;102(5):481-4. (IF 2.3)

Castañeda TR, Nogueiras R, Müller TD, Krishna R, Grant E, Jones A, Ottaway N, Ananthakrishnan G, Pfluger PT, Chaudhary N, Solomon MB, Woods SC, Herman JP, Tschöp MH. Decreased glucose tolerance and plasma adiponectin: resistin ratio in a mouse model of post-traumatic stress disorder. Diabetologia. 2011 Apr;54(4):900-9. (IF 6.1)

Tong J, Mannea E, Aimé P, Pfluger PT, Yi CX, Castaneda TR, Davis HW, Ren X, Pixley S, Benoit S, Julliard K, Woods SC, Horvath TL, Sleeman MM, D'Alessio D, Obici S, Frank R, Tschöp MH. Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. J Neurosci. 2011 Apr 13;31(15):5841-6. (IF 6.0)

Müller TD, Tschöp MH, Jarick I, Ehrlich S, Scherag S, Herpertz-Dahlmann B, Zipfel S, Herzog W, de Zwaan M, Burghardt R, Fleischhaker C, Klampfl K, Wewetzer C, Herpertz S, Zeeck A, Tagay S, Burgmer M, Pfluger PT, Scherag A, Hebebrand J, Hinney A. Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa. J Psychiatr Res. 2011 May;45(5):706-11. (IF 4.2)

Hillman JB, Tong J, Tschop M. Ghrelin biology and its role in weight-related disorders. Discov Med. 2011 Jun;11(61):521-8. (IF 2.4)

Yi CX, Heppner K, Tschöp MH. Ghrelin in eating disorders. Mol Cell Endocrinol. 2011 Jun 20;340(1):29-34. (IF 3.8)

Yi CX, Scherer T, Tschöp MH. Cajal revisited: does the VMH make us fat? Nat Neurosci. 2011 Jun 27;14(7):806-8. (IF 17.8)

Krawczewski Carhuatanta KA, Demuro G, Tschöp MH, Pfluger PT, Benoit SC, Obici S. Voluntary exercise improves high-fat diet-induced leptin resistance independent of adiposity. Endocrinology. 2011 Jul;152(7):2655-64. (IF 4.3)

Perez-Tilve D, Habbeger KM, Tschöp MH, Hofmann SM. Neural regulation of cholesterol metabolism. Curr Opin Lipidol. 2011 Aug;22(4):283-7. (IF 4.1)

Perez-Tilve D, Heppner K, Kirchner H, Lockie SH, Woods SC, Smiley DL, Tschöp M, Pfluger P. Ghrelin-induced adiposity is independent of orexigenic effects. FASEB J. 2011 Aug;25(8):2814-22. (IF 5.5)

Seeley RJ, Tschöp MH. Uroguanylin: how the gut got another satiety hormone. J Clin Invest. 2011 Sep;121(9):3384-6. (IF 12.8)

Lockie SH, Czyzyk TA, Chaudhary N, Perez-Tilve D, Woods SC, Oldfield BJ, Statnick MA, Tschöp MH. CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice. Endocrinology 2011 Oct;152(10):3661-7. (IF 4.3)

Rudovich NN, Nikiforova VJ, Otto B, Pivovarova O, Gögebakan O, Erban A, Möhlig M, Weickert MO, Spranger J, Tschöp MH, Willmitzer L, Nauck M, Pfeiffer AF. Metabolomic linkage reveals functional interaction between glucose-dependent insulinotropic polypeptide and ghrelin in humans. Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E608-17. (IF 4.1)

Al Massadi O, Tschöp MH, Tong J. Ghrelin acylation and metabolic control. Peptides. 2011 Nov;32(11):2301-8. (IF 2.8)

Habegger KM, Grant E, Pfluger PT, Perez-Tilve D, Daugherty A, Bruemmer D, Tschöp MH, Hofmann SM. Ghrelin Receptor Deficiency does not Affect Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Null Mice. Front Endocrinol (Lausanne). 2011 Nov 2;2:67. (IF 4.480)

Rediger A, Piechowski CL, Yi CX, Tarnow P, Strotmann R, Grüters A, Krude H, Schöneberg T, Tschöp MH, Kleinau G, Biebermann H. Mutually opposite signal modulation by hypothalamic heterodimerization of ghrelin and melanocortin-3 receptors. J Biol Chem. 2011 Nov 11;286(45):39623-31. (IF 4.1)

Pfluger PT, Castañeda TR, Heppner KM, Strassburg S, Kruthaupt T, Chaudhary N, Halem H, Culler MD, Datta R, Burget L, Tschöp MH, Nogueiras R, Perez-Tilve D. Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity. Physiol Behav. 2011 Nov 30;105(1):52-61. (IF 2.3)

Wiedmer P, Strasser F, Horvath TL, Blum D, Dimarchi R, Lutz T, Schürmann A, Joost HG, Tschöp MH, Tong J. Ghrelin-induced hypothermia: a physiological basis but no clinical risk. Physiol Behav. 2011 Nov 30;105(1):43-51. (IF 2.3)

Bajzer M, Olivieri M, Haas MK, Pfluger PT, Magrisso IJ, Foster MT, Tschöp MH, Krawczewski-Carhuatanta KA, Cota D, Obici S. Cannabinoid receptor 1 (CB1) antagonism enhances glucose utilisation and activates brown adipose tissue in diet-induced obese mice. Diabetologia. 2011 Dec;54(12):3121-31. (IF 6.1)

Tschöp MH, Speakman JR, Arch JR, Auwerx J, Brüning JC, Chan L, Eckel RH, Farese RV Jr, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Müller TD, Münzberg H, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28;9(1):57-63. (IF 25.1)


Castañeda TR, Tong J, Datta R, Culler M, Tschöp MH. Ghrelin in the regulation of body weight and metabolism. Front Neuroendocrinol. 2010 Jan;31(1):44-60. (IF 10.0)

Lee SJ, Pfluger PT, Kim JY, Nogueiras R, Duran A, Pagès G, Pouysségur J, Tschöp MH, Diaz-Meco MT, Moscat J. A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis. EMBO Rep. 2010 Mar;11(3):226-32. (IF 9.0)

Tong J, Tschöp MH, Aulinger BA, Davis HW, Yang Q, Liu J, Gaylinn BD, Thorner MO, D'Alessio D, Tso P. The intestinal lymph fistula model-a novel approach to study ghrelin secretion. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G474-80. (IF 3.5)

Sutton GM, Begriche K, Kumar KG, Gimble JM, Perez-Tilve D, Nogueiras R, McMillan RP, Hulver MW, Tschöp MH, Butler AA. Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle. FASEB J. 2010 Mar;24(3):862-72. (IF 5.5)

Czyzyk TA, Nogueiras R, Lockwood JF, McKinzie JH, Coskun T, Pintar JE, Hammond C, Tschöp MH, Statnick MA. Kappa-opioid receptors control the metabolic response to a high-energy diet in mice. FASEB J. 2010 Apr;24(4):1151-9. (IF 5.5)

Tschöp J, Nogueiras R, Haas-Lockie S, Kasten KR, Castañeda TR, Huber N, Guanciale K, Perez-Tilve D, Habegger K, Ottaway N, Woods SC, Oldfield B, Clarke I, Chua S Jr, Farooqi IS, O'Rahilly S, Caldwell CC, Tschöp MH. CNS leptin action modulates immune response and survival in sepsis. J Neurosci. 2010 Apr 28;30(17):6036-47. (IF 6.0)

Pérez-Tilve D, González-Matías L, Aulinger BA, Alvarez-Crespo M, Gil-Lozano M, Alvarez E, Andrade-Olivie AM, Tschöp MH, D'Alessio DA, Mallo F. Exendin-4 increases blood glucose levels acutely in rats by activation of the sympathetic nervous system. Am J Physiol Endocrinol Metab. 2010 May;298(5):E1088-96. (IF 4.1)

Kirchner H, Tong J, Tschöp MH, Pfluger PT. Ghrelin and PYY in the regulation of energy balance and metabolism: lessons from mouse mutants. Am J Physiol Endocrinol Metab. 2010 May;298(5):E909-19. (IF 4.1)

Stefater MA, Pérez-Tilve D, Chambers AP, Wilson-Pérez HE, Sandoval DA, Berger J, Toure M, Tschöp M, Woods SC, Seeley RJ. Sleeve gastrectomy induces loss of weight and fat mass in obese rats, but does not affect leptin sensitivity. Gastroenterology. 2010 Jun;138(7):2426-36, 2436.e1-3. (IF 18.4)

Perez-Tilve D, Hofmann SM, Basford J, Nogueiras R, Pfluger PT, Patterson JT, Grant E, Wilson-Perez HE, Granholm NA, Arnold M, Trevaskis JL, Butler AA, Davidson WS, Woods SC, Benoit SC, Sleeman MW, DiMarchi RD, Hui DY, Tschöp MH. Melanocortin signaling in the CNS directly regulates circulating cholesterol. Nat Neurosci. 2010 Jul;13(7):877-82. (IF 17.8)

Romero A, Kirchner H, Heppner K, Pfluger PT, Tschöp MH, Nogueiras R. GOAT: the master switch for the ghrelin system? Eur J Endocrinol. 2010 Jul;163(1):1-8. (IF 4.1)

Labonté ED, Pfluger PT, Cash JG, Kuhel DG, Roja JC, Magness DP, Jandacek RJ, Tschöp MH, Hui DY. Postprandial lysophospholipid suppresses hepatic fatty acid oxidation: the molecular link between group 1B phospholipase A2 and diet-induced obesity. FASEB J. 2010 Jul;24(7):2516-24. (IF 5.5)

Lee SJ, Kim JY, Nogueiras R, Linares JF, Perez-Tilve D, Jung DY, Ko HJ, Hofmann SM, Drew A, Leitges M, Kim JK, Tschöp MH, Diaz-Meco MT, Moscat J. PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance. Cell Metab. 2010 Jul 7;12(1):65-77. (IF 18.2)

Heppner KM, Habegger KM, Day J, Pfluger PT, Perez-Tilve D, Ward B, Gelfanov V, Woods SC, DiMarchi R, Tschöp M. Glucagon regulation of energy metabolism. Physiol Behav. 2010 Jul 14;100(5):545-8. (IF 2.3)

Kampe J, Tschöp M, Horvath TL, Widmer P. Neuroendocrine Integration of Body Weight Regulation. Endotext [Internet]. 2010 Aug 10. (IF N/A)

Horvath TL, Sarman B, García-Cáceres C, Enriori PJ, Sotonyi P, Shanabrough M, Borok E, Argente J, Chowen JA, Perez-Tilve D, Pfluger PT, Brönneke HS, Levin BE, Diano S, Cowley MA, Tschöp MH. Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14875-80. (IF 10.0)

Tong J, Prigeon RL, Davis HW, Bidlingmaier M, Kahn SE, Cummings DE, Tschöp MH, D'Alessio D. Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes. 2010 Sep;59(9):2145-51. (IF 9.0)

Kasten KR, Tschöp J, Tschöp MH, Caldwell CC. The cannabinoid 2 receptor as a potential therapeutic target for sepsis. Endocr Metab Immune Disord Drug Targets. 2010 Sep;10(3):224-34. (IF 1.0)

Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. Am J Physiol Gastrointest Liver Physiol. 2010 Sep;299(3):G652-60. (IF 3.5)

Disse E, Bussier AL, Veyrat-Durebex C, Deblon N, Pfluger PT, Tschöp MH, Laville M, Rohner-Jeanrenaud F. Peripheral ghrelin enhances sweet taste food consumption and preference, regardless of its caloric content. Physiol Behav. 2010 Sep 1;101(2):277-81. (IF 2.3)

Shin YK, Martin B, Kim W, White CM, Ji S, Sun Y, Smith RG, Sévigny J, Tschöp MH, Maudsley S, Egan JM. Ghrelin is produced in taste cells and ghrelin receptor null mice show reduced taste responsivity to salty (NaCl) and sour (citric acid) tastants. PLoS One. 2010 Sep 14;5(9):e12729. (IF 2.8)

Müller TD, Perez-Tilve D, Tong J, Pfluger PT, Tschöp MH. Ghrelin and its potential in the treatment of eating/wasting disorders and cachexia. J Cachexia Sarcopenia Muscle. 2010 Dec;1(2):159-167. (IF 9.7)

Tschöp J, Dattilo JR, Prakash PS, Kasten KR, Tschöp MH, Caldwell CC. The leptin system: a potential target for sepsis induced immune suppression. Endocr Metab Immune Disord Drug Targets. 2010 Dec;10(4):336-47. (IF 1.0)

Habegger KM, Heppner KM, Geary N, Bartness TJ, DiMarchi R, Tschöp MH. The metabolic actions of glucagon revisited. Nat Rev Endocrinol. 2010 Dec;6(12):689-97. (IF 18.3)

Strassburg S, Pfluger PT, Chaudhary N, Tso P, Tschöp MH, Anker SD, Nogueiras R, Perez-Tilve D. Action profile of the antiobesity drug candidate oleoyl-estrone in rats. Obesity (Silver Spring). 2010 Dec;18(12):2260-7. (IF 4.4)

Barnett BP, Hwang Y, Taylor MS, Kirchner H, Pfluger PT, Bernard V, Lin YY, Bowers EM, Mukherjee C, Song WJ, Longo PA, Leahy DJ, Hussain MA, Tschöp MH, Boeke JD, Cole PA. Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science. 2010 Dec 17;330(6011):1689-92. (IF 37.2)


Caton SJ, Yinglong B, Burget L, Spangler LJ, Tschöp MH, Bidlingmaier M. Low-carbohydrate high-fat diets: regulation of energy balance and body weight regain in rats. Obesity (Silver Spring). 2009 Feb;17(2):283-9. (IF 4.4)

Votruba SB, Kirchner H, Tschöp M, Salbe AD, Krakoff J. Morning ghrelin concentrations are not affected by short-term overfeeding and do not predict ad libitum food intake in humans. Am J Clin Nutr. 2009 Mar;89(3):801-6. (IF 7.0)

Tschöp MH, Hugenholtz P, Karp CL. Getting to the core of the gut microbiome. Nat Biotechnol. 2009 Apr;27(4):344-6. (IF 41.1) 

Lockie SH, Müller TD, Tschöp MH. Coupled with uncouplers: the curious case of lifespan. Am J Physiol Endocrinol Metab. 2009 Apr;296(4):E619-20. (IF 4.1) 

Hofmann SM, Tschöp MH. Dietary sugars: a fat difference. J Clin Invest. 2009 May;119(5):1089-92. (IF 12.8) 

Nogueiras R, Pérez-Tilve D, Veyrat-Durebex C, Morgan DA, Varela L, Haynes WG, Patterson JT, Disse E, Pfluger PT, López M, Woods SC, DiMarchi R, Diéguez C, Rahmouni K, Rohner-Jeanrenaud F, Tschöp MH. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci. 2009 May 6;29(18):5916-25. (IF 6.0)

Kirchner H, Gutierrez JA, Solenberg PJ, Pfluger PT, Czyzyk TA, Willency JA, Schürmann A, Joost HG, Jandacek RJ, Hale JE, Heiman ML, Tschöp MH. GOAT links dietary lipids with the endocrine control of energy balance. Nat Med. 2009 Jul;15(7):741-5. (IF 30.0)

Tschöp J, Kasten KR, Nogueiras R, Goetzman HS, Cave CM, England LG, Dattilo J, Lentsch AB, Tschöp MH, Caldwell CC. The cannabinoid receptor 2 is critical for the host response to sepsis. J Immunol. 2009 Jul 1;183(1):499-505. (IF 4.9)

Kampe J, Tschöp MH, Hollis JH, Oldfield BJ. An anatomic basis for the communication of hypothalamic, cortical and mesolimbic circuitry in the regulation of energy balance. Eur J Neurosci. 2009 Aug;30(3):415-30. (IF 3.0)

Nogueiras R, Diaz-Arteaga A, Lockie SH, Velásquez DA, Tschop J, López M, Cadwell CC, Diéguez C, Tschöp MH. The endocannabinoid system: role in glucose and energy metabolism. Pharmacol Res. 2009 Aug;60(2):93-8. (IF 4.5)

Isken F, Weickert MO, Tschöp MH, Nogueiras R, Möhlig M, Abdelrahman A, Klaus S, Thorens B, Pfeiffer AF. Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice. Diabetologia. 2009 Oct;52(10):2159-68. (IF 6.1)

Day JW, Ottaway N, Patterson JT, Gelfanov V, Smiley D, Gidda J, Findeisen H, Bruemmer D, Drucker DJ, Chaudhary N, Holland J, Hembree J, Abplanalp W, Grant E, Ruehl J, Wilson H, Kirchner H, Lockie SH, Hofmann S, Woods SC, Nogueiras R, Pfluger PT, Perez-Tilve D, DiMarchi R, Tschöp MH. A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol. 2009 Oct;5(10):749-57. (IF 15.1)

Costanzo-Garvey DL, Pfluger PT, Dougherty MK, Stock JL, Boehm M, Chaika O, Fernandez MR, Fisher K, Kortum RL, Hong EG, Jun JY, Ko HJ, Schreiner A, Volle DJ, Treece T, Swift AL, Winer M, Chen D, Wu M, Leon LR, Shaw AS, McNeish J, Kim JK, Morrison DK, Tschöp MH, Lewis RE. KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. Cell Metab. 2009 Nov;10(5):366-78. (IF 18.2)

Andrews ZB, Erion D, Beiler R, Liu ZW, Abizaid A, Zigman J, Elsworth JD, Savitt JM, DiMarchi R, Tschoep M, Roth RH, Gao XB, Horvath TL. Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci. 2009 Nov 11;29(45):14057-65. (IF 6.0)


Müller TD, Chaudhary N, Pfluger PT, Tschöp M. The 1D1 of burning calories. Obes Facts. 2008;1(5):223-6. (IF 2.3)

Tschöp MH. There will be fat. Nat Med 2008 14:807. (IF 27.4)

Hofmann SM, Perez-Tilve D, Greer TM, Coburn BA, Grant E, Basford JE, Tschöp MH, Hui DY. Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice. Diabetes. 2008 Jan;57(1):5-12. (IF 8.7)

Strasser F, Lutz TA, Maeder MT, Thuerlimann B, Bueche D, Tschöp M, Kaufmann K, Holst B, Brändle M, von Moos R, Demmer R, Cerny T. Safety, tolerability and pharmacokinetics of intravenous ghrelin for cancer-related anorexia/cachexia: a randomised, placebo-controlled, double-blind, double-crossover study. Br J Cancer. 2008 Jan 29;98(2):300-8. (IF 6.2)

Tizzano JP, Stribling DS, Perez-Tilve D, Strack A, Frassetto A, Chen RZ, Fong TM, Shearman L, Krieter PA, Tschöp MH, Skolnick P, Basile AS. The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity. J Pharmacol Exp Ther. 2008 Mar;324(3):1111-26. (IF 3.7)

Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, Fu S, Benoit SC, Horvath T, Joost HG, Wortley KE, Sleeman MW, Tschöp MH. Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol. 2008 Mar;294(3):G610-8. (IF 3.5)

Reed JA, Benoit SC, Pfluger PT, Tschöp MH, D'Alessio DA, Seeley RJ. Mice with chronically increased circulating ghrelin develop age-related glucose intolerance. Am J Physiol Endocrinol Metab. 2008 Apr;294(4):E752-60. (IF 4.1)

Nogueiras R, Tschöp MH, Zigman JM. Central nervous system regulation of energy metabolism: ghrelin versus leptin. Ann N Y Acad Sci. 2008 Apr;1126:14-9. (IF 4.7)

Tong J, Pfluger PT, Tschöp MH. Gastric O-acyl transferase activates hunger signal to the brain. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6213-4. (IF 9.7)

López M, Lage R, Saha AK, Pérez-Tilve D, Vázquez MJ, Varela L, Sangiao-Alvarellos S, Tovar S, Raghay K, Rodríguez-Cuenca S, Deoliveira RM, Castañeda T, Datta R, Dong JZ, Culler M, Sleeman MW, Alvarez CV, Gallego R, Lelliott CJ, Carling D, Tschöp MH, Diéguez C, Vidal-Puig A. Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin. Cell Metab. 2008 May;7(5):389-99. (IF 18.2)

Nogueiras R, Rohner-Jeanrenaud F, Woods SC, Tschöp MH. The endocannabinoid system and the control of glucose homeostasis. J Neuroendocrinol. 2008 May;20 Suppl 1:147-51. (IF 3.5)

Nogueiras R, López M, Lage R, Perez-Tilve D, Pfluger P, Mendieta-Zerón H, Sakkou M, Wiedmer P, Benoit SC, Datta R, Dong JZ, Culler M, Sleeman M, Vidal-Puig A, Horvath T, Treier M, Diéguez C, Tschöp MH. Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability. Endocrinology. 2008 Jun;149(6):3009-15. (IF 4.3)

Strassburg S, Anker SD, Castaneda TR, Burget L, Perez-Tilve D, Pfluger PT, Nogueiras R, Halem H, Dong JZ, Culler MD, Datta R, Tschöp MH. Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats. Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E78-84. (IF 4.1)

Pfluger PT, Herranz D, Velasco-Miguel S, Serrano M, Tschöp MH. Sirt1 protects against high-fat diet-induced metabolic damage. Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9793-8. (IF 10.0)

Isken F, Pfeiffer AF, Nogueiras R, Osterhoff MA, Ristow M, Thorens B, Tschöp MH, Weickert MO. Deficiency of glucose-dependent insulinotropic polypeptide receptor prevents ovariectomy-induced obesity in mice. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E350-5. (IF 4.1)

Nogueiras R, Wilson H, Rohner-Jeanrenaud F, Tschöp MH. Central nervous system regulation of adipocyte metabolism. Regul Pept. 2008 Aug 7;149(1-3):26-31. (IF 1.8)

Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, Friedman JM, Tschöp MH, Shanabrough M, Cline G, Shulman GI, Coppola A, Gao XB, Horvath TL, Diano S. UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature. 2008 Aug 14;454(7206):846-51. (IF 40.1)

Perez-Tilve D, D'Alessio DA, Tschöp MH. A sweet spot for the bariatric surgeon. Cell Metab. 2008 Sep;8(3):177-9. (IF 18.2)

Nogueiras R, Veyrat-Durebex C, Suchanek PM, Klein M, Tschöp J, Caldwell C, Woods SC, Wittmann G, Watanabe M, Liposits Z, Fekete C, Reizes O, Rohner-Jeanrenaud F, Tschöp MH. Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes. 2008 Nov;57(11):2977-91. (IF 8.684)

Sutton GM, Perez-Tilve D, Nogueiras R, Fang J, Kim JK, Cone RD, Gimble JM, Tschöp MH, Butler AA. The melanocortin-3 receptor is required for entrainment to meal intake. J Neurosci. 2008 Nov 26;28(48):12946-55. (IF 6.0)

Davis JF, Tracy AL, Schurdak JD, Tschöp MH, Lipton JW, Clegg DJ, Benoit SC. Exposure to elevated levels of dietary fat attenuates psychostimulant reward and mesolimbic dopamine turnover in the rat. Behav Neurosci. 2008 Dec;122(6):1257-63. (IF 2.5)


Nogueiras R, Pfluger P, Tovar S, Arnold M, Mitchell S, Morris A, Perez-Tilve D, Vázquez MJ, Wiedmer P, Castañeda TR, DiMarchi R, Tschöp M, Schurmann A, Joost HG, Williams LM, Langhans W, Diéguez C. Effects of obestatin on energy balance and growth hormone secretion in rodents. Endocrinology. 2007 Jan;148(1):21-6. (IF 4.3)

Pfluger PT, Kampe J, Castaneda TR, Vahl T, D'Alessio DA, Kruthaupt T, Benoit SC, Cuntz U, Rochlitz HJ, Moehlig M, Pfeiffer AF, Koebnick C, Weickert MO, Otto B, Spranger J, Tschöp MH. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab. 2007 Feb;92(2):583-8. (IF 5.5)

Tschöp MH, Hui DY, Horvath TL. Diet-induced leptin resistance: the heart of the matter. Endocrinology. 2007 Mar;148(3):921-3. (IF 4.3)

Otto B, Cuntz U, Otto C, Heldwein W, Riepl RL, Tschöp MH. Peptide YY release in anorectic patients after liquid meal. Appetite. 2007 May;48(3):301-4. (IF 3.4)

Sakkou M, Wiedmer P, Anlag K, Hamm A, Seuntjens E, Ettwiller L, Tschöp MH, Treier M. A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior. Cell Metab. 2007 Jun;5(6):450-63. (IF 18.2)

Nitsche H, Nitsche M, Sudi K, Tschöp M, Zotter H, Weinhand G, Froehlich-Reiterer E, Gallistl S, Pirker M, Borkenstein M. Ghrelin-an indicator for fat oxidation in obese children and adolescents during a weight reduction program. J Pediatr Endocrinol Metab. 2007 Jun;20(6):719-23. (IF 1.2)

Jürgens HS, Neschen S, Ortmann S, Scherneck S, Schmolz K, Schüler G, Schmidt S, Blüher M, Klaus S, Perez-Tilve D, Tschöp MH, Schürmann A, Joost HG. Development of diabetes in obese, insulin-resistant mice: essential role of dietary carbohydrate in beta cell destruction. Diabetologia. 2007 Jul;50(7):1481-9. (IF 6.1)

Inge TH, Pfluger P, Zeller M, Rose SR, Burget L, Sundararajan S, Daniels SR, Tschöp MH. Gastric bypass surgery for treatment of hypothalamic obesity after craniopharyngioma therapy. Nat Clin Pract Endocrinol Metab. 2007 Aug;3(8):606-9. (IF 7.5)

Nomiyama T, Perez-Tilve D, Ogawa D, Gizard F, Zhao Y, Heywood EB, Jones KL, Kawamori R, Cassis LA, Tschöp MH, Bruemmer D. Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest. 2007 Oct;117(10):2877-88. (IF 12.8)

Joost HG, Tschöp MH. NO to obesity: does nitric oxide regulate fat oxidation and insulin sensitivity? Endocrinology. 2007 Oct;148(10):4545-7. (IF 4.3)

Wiedmer P, Nogueiras R, Broglio F, D'Alessio D, Tschöp MH. Ghrelin, obesity and diabetes. Nat Clin Pract Endocrinol Metab. 2007 Oct;3(10):705-12. (IF 7.5)

Tschöp MH, Ravussin E. Am Peptide YY: obesity's cause and cure? J Physiol Endocrinol Metab. 2007 Nov;293(5):E1131-3. (IF N/A)

Nogueiras R, Wiedmer P, Perez-Tilve D, Veyrat-Durebex C, Keogh JM, Sutton GM, Pfluger PT, Castaneda TR, Neschen S, Hofmann SM, Howles PN, Morgan DA, Benoit SC, Szanto I, Schrott B, Schürmann A, Joost HG, Hammond C, Hui DY, Woods SC, Rahmouni K, Butler AA, Farooqi IS, O'Rahilly S, Rohner-Jeanrenaud F, Tschöp MH. The central melanocortin system directly controls peripheral lipid metabolism. J Clin Invest. 2007 Nov;117(11):3475-88. (IF 12.8)

Wortley KE, Garcia K, Okamoto H, Thabet K, Anderson KD, Shen V, Herman JP, Valenzuela D, Yancopoulos GD, Tschöp MH, Murphy A, Sleeman MW. Peptide YY regulates bone turnover in rodents. Gastroenterology. 2007 Nov;133(5):1534-43. (IF 18.4)

Hofmann SM, Zhou L, Perez-Tilve D, Greer T, Grant E, Wancata L, Thomas A, Pfluger PT, Basford JE, Gilham D, Herz J, Tschöp MH, Hui DY. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest. 2007 Nov;117(11):3271-82. (IF 12.8)

Davis JF, Melhorn SJ, Shurdak JD, Heiman JU, Tschöp MH, Clegg DJ, Benoit SC. Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats. Physiol Behav. 2007 Dec 5;92(5):924-30. (IF 2.3)


Spranger J, Verma S, Göhring I, Bobbert T, Seifert J, Sindler AL, Pfeiffer A, Hileman SM, Tschöp M, Banks WA. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes. 2006 Jan;55(1):141-7. (IF 7.0)

Seeley RJ, Tschöp M. How diabetes went to our heads. Nat Med. 2006 Jan;12(1):47-9. (IF 30.0)

Biebermann H, Castañeda TR, van Landeghem F, von Deimling A, Escher F, Brabant G, Hebebrand J, Hinney A, Tschöp MH, Grüters A, Krude H. A role for beta-melanocyte-stimulating hormone in human body-weight regulation. Cell Metab. 2006 Feb;3(2):141-6. (IF 18.2)

Perez-Tilve D, Nogueiras R, Mallo F, Benoit SC, Tschoep M. Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism. Endocrine. 2006 Feb;29(1):61-71. (IF 3.1)

Perez-Tilve D, Stern JE, Tschöp M. The brain and the metabolic syndrome: not a wireless connection. Endocrinology. 2006 Mar;147(3):1136-9. (IF 4.3)

Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, Horvath B, Gaskin FS, Nonaka N, Jaeger LB, Banks WA, Morley JE, Pinto S, Sherwin RS, Xu L, Yamada KA, Sleeman MW, Tschöp MH, Horvath TL. Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci. 2006 Mar;9(3):381-8. (IF 17.8)

Jürgens HS, Schürmann A, Kluge R, Ortmann S, Klaus S, Joost HG, Tschöp MH. Hyperphagia, lower body temperature, and reduced running wheel activity precede development of morbid obesity in New Zealand obese mice. Physiol Genomics. 2006 Apr 13;25(2):234-41. (IF 3.0)

Sanna B, Brandt EB, Kaiser RA, Pfluger P, Witt SA, Kimball TR, van Rooij E, De Windt LJ, Rothenberg ME, Tschop MH, Benoit SC, Molkentin JD. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7327-32. (IF 10.0)

Cota D, Tschöp MH, Horvath TL, Levine AS. Cannabinoids, opioids and eating behavior: the molecular face of hedonism? Brain Res Rev. 2006 Jun;51(1):85-107. (IF 6.0)

Nogueiras R, Perez-Tilve D, Wortley KE, Tschöp M. Growth hormone secretagogue (ghrelin-) receptors--a complex drug target for the regulation of body weight. CNS Neurol Disord Drug Targets. 2006 Jun;5(3):335-43. (IF 2.5)

Theander-Carrillo C, Wiedmer P, Cettour-Rose P, Nogueiras R, Perez-Tilve D, Pfluger P, Castaneda TR, Muzzin P, Schürmann A, Szanto I, Tschöp MH, Rohner-Jeanrenaud F. Ghrelin action in the brain controls adipocyte metabolism. J Clin Invest. 2006 Jul;116(7):1983-93. (IF 12.8)

Tschöp MH, Castaneda TR, Woods SC. The brain is getting ready for dinner. Cell Metab. 2006 Oct;4(4):257-8. (IF 18.2)

Kampe J, Wiedmer P, Pfluger PT, Castaneda TR, Burget L, Mondala H, Kerr J, Liaw C, Oldfield BJ, Tschöp MH, Bagnol D. Effect of central administration of QRFP(26) peptide on energy balance and characterization of a second QRFP receptor in rat. Brain Res. 2006 Nov 13;1119(1):133-49. (IF 2.7)

Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. J Clin Invest. 2006 Dec;116(12):3229-39. (IF 12.8)

Tschöp M, Thomas G. Fat fuels insulin resistance through Toll-like receptors. Nat Med. 2006 Dec;12(12):1359-61. (IF 29.9)

Menyhért J, Wittmann G, Hrabovszky E, Szlávik N, Keller E, Tschöp M, Liposits Z, Fekete C. Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus. Brain Res. 2006 Dec 13;1125(1):31-6. (IF 2.7)


Benoit SC, Tschöp MH. PYY3-36 "monkeys around" with energy balance. Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R358-9. (IF 3.0)

Rudovich NN, Dick D, Moehlig M, Otto B, Spranger J, Rochlitz HJ, Ristow M, Tschoep M, Pfeiffer AF. Ghrelin is not suppressed in hyperglycemic clamps by gastric inhibitory polypeptide and arginine. Regul Pept. 2005 Apr 15;127(1-3):95-9. (IF 1.8)

Castañeda TR, Jürgens H, Wiedmer P, Pfluger P, Diano S, Horvath TL, Tang-Christensen M, Tschöp MH. Obesity and the neuroendocrine control of energy homeostasis: the role of spontaneous locomotor activity. J Nutr. 2005 May;135(5):1314-9. (IF 4.1)

Otto B, Spranger J, Benoit SC, Clegg DJ, Tschöp MH. The many faces of ghrelin: new perspectives for nutrition research? Br J Nutr. 2005 Jun;93(6):765-71. (IF 3.7)

Jürgens H, Haass W, Castañeda TR, Schürmann A, Koebnick C, Dombrowski F, Otto B, Nawrocki AR, Scherer PE, Spranger J, Ristow M, Joost HG, Havel PJ, Tschöp MH. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res. 2005 Jul;13(7):1146-56. (IF 2.6)

Otto B, Tschöp M, Frühauf E, Heldwein W, Fichter M, Otto C, Cuntz U. Postprandial ghrelin release in anorectic patients before and after weight gain. Psychoneuroendocrinology. 2005 Jul;30(6):577-81. (IF 4.8)

Arafat MA, Otto B, Rochlitz H, Tschöp M, Bähr V, Möhlig M, Diederich S, Spranger J, Pfeiffer AF. Glucagon inhibits ghrelin secretion in humans. Eur J Endocrinol. 2005 Sep;153(3):397-402. (IF 4.1)

Proulx K, Cota D, Castañeda TR, Tschöp MH, D'Alessio DA, Tso P, Woods SC, Seeley RJ. Mechanisms of oleoylethanolamide-induced changes in feeding behavior and motor activity. Am J Physiol Regul Integr Comp Physiol. 2005 Sep;289(3):R729-37. (IF 3.0)

Theisen FM, Gebhardt S, Brömel T, Otto B, Heldwein W, Heinzel-Gutenbrunner M, Krieg JC, Remschmidt H, Tschöp M, Hebebrand J. A prospective study of serum ghrelin levels in patients treated with clozapine. J Neural Transm (Vienna). 2005 Oct;112(10):1411-6. (IF 2.4)

Boggiano MM, Chandler PC, Oswald KD, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Schindler M, Arndt K, Rudolf K, Mark M, Schoelch C, Joost HG, Klaus S, Thöne-Reineke C, Benoit SC, Seeley RJ, Beck-Sickinger AG, Koglin N, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Ortmann S, Castañeda TR, Tschöp M. PYY3-36 as an anti-obesity drug target. Obes Rev. 2005 Nov;6(4):307-22. (IF 7.9)

Nogueiras R, Tschöp M. Biomedicine. Separation of conjoined hormones yields appetite rivals. Science. 2005 Nov 11;310(5750):985-6. (IF 37.2)


Meyer CW, Korthaus D, Jagla W, Cornali E, Grosse J, Fuchs H, Klingenspor M, Roemheld S, Tschöp M, Heldmaier G, De Angelis MH, Nehls M. A novel missense mutation in the mouse growth hormone gene causes semidominant dwarfism, hyperghrelinemia, and obesity. Endocrinology. 2004 May;145(5):2531-41. (IF 4.3)

Otto B, Tschöp M, Cuntz U. Letter to the Editor: Similar fasting ghrelin levels in binge eating/purging anorexia nervosa and restrictive anorexia nervosa. Psychoneuroendocrinology. 2004 Jun;29(5):692-3. (IF 4.8)

Horvath TL, Diano S, Tschöp M. Brain circuits regulating energy homeostasis. Neuroscientist. 2004 Jun;10(3):235-46. (IF 7.4)

van der Lely AJ, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev. 2004 Jun;25(3):426-57. (IF 15.7)

Salbe AD, Tschöp MH, DelParigi A, Venti CA, Tataranni PA. Negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake. J Clin Endocrinol Metab. 2004 Jun;89(6):2951-6. (IF 5.5)

Teff KL, Elliott SS, Tschöp M, Kieffer TJ, Rader D, Heiman M, Townsend RR, Keim NL, D'Alessio D, Havel PJ. Dietary fructose reduces circulating insulin and leptin, attenuates postprandial suppression of ghrelin, and increases triglycerides in women. J Clin Endocrinol Metab. 2004 Jun;89(6):2963-72. (IF 5.5)

Otto B, Tschöp M, Heldwein W, Pfeiffer AF, Diederich S. Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans. Eur J Endocrinol. 2004 Jul;151(1):113-7. (IF 4.1)

Tschöp M, Castañeda TR, Joost HG, Thöne-Reineke C, Ortmann S, Klaus S, Hagan MM, Chandler PC, Oswald KD, Benoit SC, Seeley RJ, Kinzig KP, Moran TH, Beck-Sickinger AG, Koglin N, Rodgers RJ, Blundell JE, Ishii Y, Beattie AH, Holch P, Allison DB, Raun K, Madsen K, Wulff BS, Stidsen CE, Birringer M, Kreuzer OJ, Schindler M, Arndt K, Rudolf K, Mark M, Deng XY, Whitcomb DC, Halem H, Taylor J, Dong J, Datta R, Culler M, Craney S, Flora D, Smiley D, Heiman ML. Physiology: does gut hormone PYY3-36 decrease food intake in rodents? Nature. 2004 Jul 8;430(6996):1 p following 165. (IF 40.1)

Helmling S, Maasch C, Eulberg D, Buchner K, Schröder W, Lange C, Vonhoff S, Wlotzka B, Tschöp MH, Rosewicz S, Klussmann S. Inhibition of ghrelin action in vitro and in vivo by an RNA-Spiegelmer. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13174-9. (IF 10.0)

Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL, Tschöp M. Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology. 2004 Oct;145(10):4645-52. (IF 4.2)


Horvath TL, Diano S, Tschöp M. Ghrelin in hypothalamic regulation of energy balance. Curr Top Med Chem. 2003;3(8):921-7. (IF 2.6)

Horvath TL, Castañeda T, Tang-Christensen M, Pagotto U, Tschöp MH. Ghrelin as a potential anti-obesity target. Curr Pharm Des. 2003;9(17):1383-95. (IF 2.6)

Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML, Garcia-Segura LM, Nillni EA, Mendez P, Low MJ, Sotonyi P, Friedman JM, Liu H, Pinto S, Colmers WF, Cone RD, Horvath TL. The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron. 2003 Feb 20;37(4):649-61. (IF 14.0)

Gambineri A, Pagotto U, Tschöp M, Vicennati V, Manicardi E, Carcello A, Cacciari M, De Iasio R, Pasquali R. Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome. J Endocrinol Invest. 2003 Jul;26(7):629-34. (IF 2.6)

Cota D, Marsicano G, Tschöp M, Grübler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thöne-Reineke C, Ortmann S, Tomassoni F, Cervino C, Nisoli E, Linthorst AC, Pasquali R, Lutz B, Stalla GK, Pagotto U. The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest. 2003 Aug;112(3):423-31. (IF 12.8)

Bunt JC, Salbe AD, Tschöp MH, DelParigi A, Daychild P, Tataranni PA. Cross-sectional and prospective relationships of fasting plasma ghrelin concentrations with anthropometric measures in pima Indian children. J Clin Endocrinol Metab. 2003 Aug;88(8):3756-61. (IF 5.5)

Spranger J, Ristow M, Otto B, Heldwein W, Tschöp M, Pfeiffer AF, Möhlig M. Post-prandial decrease of human plasma ghrelin in the absence of insulin. J Endocrinol Invest. 2003 Aug;26(8):RC19-22. (IF 2.6)

Tschöp M, Arlt W, Anker S, Ristow M [Perspectives on the medical-academic younger generation in Germany]. Urologe A. 2003 Sep;42(9):1290-3. (IF 0.3)

Pagotto U, Gambineri A, Pelusi C, Genghini S, Cacciari M, Otto B, Castañeda T, Tschöp M, Pasquali R. Testosterone replacement therapy restores normal ghrelin in hypogonadal men. J Clin Endocrinol Metab. 2003 Sep;88(9):4139-43. (IF 5.5)

Al-Hasani H, Tschöp MH, Cushman SW. Two birds with one stone: novel glucokinase activator stimulates glucose-induced pancreatic insulin secretion and augments hepatic glucose metabolism. Mol Interv. 2003 Oct;3(7):367-70. (IF 12.1)


Tschöp M, Statnick MA, Suter TM, Heiman ML. GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein. Endocrinology. 2002 Feb;143(2):558-68. (IF 4.3)

Tschöp M, Heiman ML. Overview of rodent models for obesity research. Curr Protoc Neurosci. 2002 Feb; Chapter 9:Unit 9.10. (IF N/A)

Muccioli G, Tschöp M, Papotti M, Deghenghi R, Heiman M, Ghigo E. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol. 2002 Apr 12;440(2-3):235-54. (IF 2.9)

Cuntz U, Frühauf E, Wawarta R, Tschöp M, Folwaczny C, Riepl R, Lehnert P, Fichter M, Otto B. A role for the novel weight-regulating hormone ghrelin in anorexia nervosa. Am Clin Lab. 2002 May;21(4):22-3. (IF 0.8)

Wu Z, Bidlingmaier M, Liu C, De Souza EB, Tschöp M, Morrison KM, Strasburger CJ. Quantification of the soluble leptin receptor in human blood by ligand-mediated immunofunctional assay. J Clin Endocrinol Metab. 2002 Jun;87(6):2931-9. (IF 5.5)

Ukkola O, Ravussin E, Jacobson P, Pérusse L, Rankinen T, Tschöp M, Heiman ML, Leon AS, Rao DC, Skinner JS, Wilmore JH, Sjöström L, Bouchard C. Role of ghrelin polymorphisms in obesity based on three different studies. Obes Res. 2002 Aug;10(8):782-91. (IF 2.6)

Banks WA, Tschöp M, Robinson SM, Heiman ML. Extent and direction of ghrelin transport across the blood-brain barrier is determined by its unique primary structure. J Pharmacol Exp Ther. 2002 Aug;302(2):822-7. (IF 3.7)

Tschöp M, Flora DB, Mayer JP, Heiman ML. Hypophysectomy prevents ghrelin-induced adiposity and increases gastric ghrelin secretion in rats. Obes Res. 2002 Oct;10(10):991-9. (IF 2.6)

Ott V, Fasshauer M, Dalski A, Meier B, Perwitz N, Klein HH, Tschöp M, Klein J. Direct peripheral effects of ghrelin include suppression of adiponectin expression. Horm Metab Res. 2002 Nov-Dec;34(11-12):640-5. (IF 2.3)

Pagotto U, Gambineri A, Vicennati V, Heiman ML, Tschöp M, Pasquali R. Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels. J Clin Endocrinol Metab. 2002 Dec;87(12):5625-9. (IF 5.5)

DelParigi A, Tschöp M, Heiman ML, Salbe AD, Vozarova B, Sell SM, Bunt JC, Tataranni PA. High circulating ghrelin: a potential cause for hyperphagia and obesity in prader-willi syndrome. J Clin Endocrinol Metab. 2002 Dec;87(12):5461-4. (IF 5.5)

Möhlig M, Spranger J, Otto B, Ristow M, Tschöp M, Pfeiffer AF. Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans. J Endocrinol Invest. 2002 Dec;25(11):RC36-8. (IF 2.6)


Bidlingmaier M, Tschoep M. Immunoassay measurements of leptin. Methods Mol Biol. 2001;155:323-30. (IF 0.8)

Tschöp M, Heiman ML. Rodent obesity models: an overview. Exp Clin Endocrinol Diabetes. 2001;109(6):307-19. (IF 1.7)

Tschöp M, Morrison KM. Weight loss at high altitude. Adv Exp Med Biol. 2001;502:237-47. (IF 2.0)

Folwaczny C, Chang JK, Tschöp M. Ghrelin and motilin: two sides of one coin? Eur J Endocrinol. 2001 Apr;144(4):R1-3. (IF 4.1)

Tschöp M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, Heiman ML. Circulating ghrelin levels are decreased in human obesity. Diabetes. 2001 Apr;50(4):707-9. (IF 8.7)

Tschöp M, Wawarta R, Riepl RL, Friedrich S, Bidlingmaier M, Landgraf R, Folwaczny C. Post-prandial decrease of circulating human ghrelin levels. J Endocrinol Invest. 2001 Jun;24(6):RC19-21. (IF 2.6)

Ravussin E, Tschöp M, Morales S, Bouchard C, Heiman ML. Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins. J Clin Endocrinol Metab. 2001 Sep;86(9):4547-51. (IF 5.5)

Horvath TL, Diano S, Sotonyi P, Heiman M, Tschöp M. Minireview: ghrelin and the regulation of energy balance--a hypothalamic perspective. Endocrinology. 2001 Oct;142(10):4163-9. (IF 4.3)

Otto B, Cuntz U, Fruehauf E, Wawarta R, Folwaczny C, Riepl RL, Heiman ML, Lehnert P, Fichter M, Tschöp M. Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur J Endocrinol. 2001 Nov;145(5):669-73. (IF 4.1)


Hartmann G, Tschöp M, Fischer R, Bidlingmaier C, Riepl R, Tschöp K, Hautmann H, Endres S, Toepfer M. High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein. Cytokine. 2000 Mar;12(3):246-52. (IF 3.5)

Tschöp M, Strasburger CJ, Töpfer M, Hautmann H, Riepl R, Fischer R, Hartmann G, Morrison K, Appenzeller M, Hildebrandt W, Biollaz J, Bärtsch P. Influence of hypobaric hypoxia on leptin levels in men. Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S151. (IF N/A)

Tschöp M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature. 2000 Oct 19;407(6806):908-13. (IF 40.1)

Tschöp M, Lahner H, Feldmeier H, Grasberger H, Morrison KM, Janssen OE, Attanasio AF, Strasburger CJ. Effects of growth hormone replacement therapy on levels of cortisol and cortisol-binding globulin in hypopituitary adults. Eur J Endocrinol. 2000 Dec;143(6):769-73. (IF 4.1)


Folwaczny C, Riepl R, Tschöp M, Landgraf R. Gastrointestinal involvement in patients with diabetes mellitus: Part I (first of two parts). Epidemiology, pathophysiology, clinical findings. Z Gastroenterol. 1999 Sep;37(9):803-15. (IF 1.6)

Folwaczny C, Riepl R, Tschöp M, Landgraf R. Gastrointestinal involvement in patients with diabetes mellitus: Part II (second of two parts). Diagnostic procedures, pharmacological and nonpharmacological therapy. Z Gastroenterol. 1999 Sep;37(9):817-26. (IF 1.6)

Tschöp M, Pflaum CD, Strasburger CJ, Gärtner R, Schopohl J. [21-year old patient with a pituitary microadenoma and gynecomastia of recent onset]. Internist (Berl). 1999 Dec;40(12):1327-32. (IF 0.4)


Tschöp M, Folwaczny C, Schindlbeck N, Loeschke K. [Megaloblastic anemia due to inadequate nutrition]. Dtsch Med Wochenschr. 1997 Jun 20;122(25-26):820-4. (IF 0.6)

Alkadhi H, Tschöp M, Marschang A, Langenmayer I, Feucht HE, Strasburger CJ. [A 35-year old male patient with fever and painful swelling of the pectoral glands following a short visit to Sri Lanka]. Dtsch Med Wochenschr. 1998 Jan 30;123(5):114-8. (IF 0.6)

Butenandt O, Jocham A, Schwarz HP, Sperlich M, Tschöp M. Childhood onset of GH deficiency: reassessment of GH status and effects of substitution. Growth Horm IGF Res. 1998 Feb;8 Suppl A:9-13. (IF 1.8)

Tschöp M, Behre HM, Nieschlag E, Dressendörfer RA, Strasburger CJ. A time-resolved fluorescence immunoassay for the measurement of testosterone in saliva: monitoring of testosterone replacement therapy with testosterone buciclate. Clin Chem Lab Med. 1998 Apr;36(4):223-30. (IF 3.4)

Toepfer M, Hartmann G, Schlosshauer M, Hautmann H, Tschöp M, Fischer R, Huber RM. Adrenomedullin: a player at high altitude? Chest. 1998 May;113(5):1428. (IF 6.0)

Tschöp M, Strasburger CJ, Hartmann G, Biollaz J, Bärtsch P. Raised leptin concentrations at high altitude associated with loss of appetite. Lancet. 1998 Oct 3;352(9134):1119-20. (IF 47.8)

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