Independent Young Investigator Group Molecular Endocrinology
Aim: To understand the molecular mechanisms underlying the regulation of metabolic homeostasis by nuclear receptors and their associated transcription factors.
- Elucidating the cis-regulatory code of GR-mediated repression by analyzing transcriptional complexes assembled on inflammatory enhancers in macrophages (cutting edge genomics and proteomics);
- Screening for protein-protein interactions between the nuclear receptor and transcription factor families to determine their potential impact on the regulation of energy metabolism;
- Exploring the role of potential nuclear receptor coregulators in vivo using knockout mice;
- Investigating the influence of selected nuclear receptor family members in glucose homeostasis employing a combination of mouse genetics with next generation sequencing studies.