Genetics Unit

Aims: To develop animal models to understand human gene function and disease for internal scientific projects and external collaborations. 

The creation of animal models that mimic human conditions is a powerful tool to investigate gene function and to find better therapies. Currently, the application of CRISPR-Cas9 technology has significantly improved the possibilities of genome manipulation in animal models but also in human cells, reducing the time and the cost of the process notably.

Despite CRISPR-Cas9 is being heralded as the most feasible genome engineering technique, it is still an unpredictable technology. The introduction of precise mutation into the genome is a time-costuming process and is limited to short sequences of DNA. Animal models generated by CRISPR-Cas9 have unpredictable genotypes and require crossbreeding for the production of mouse line with expected genotypes.

The scientific objective of the group is to generate genetically modified mice in an efficient way and develop new transgenic technology to promote the progress of medical and biological science. Furthermore, the group provides expertise in the area of mouse genetics to the understanding of the metabolic basis of disease.