Team Member

Ciro Salinno
PhD student

Phone: + 49 89-3187-43134
E-mail
Building/Room: Campus Neuherberg, building 3620, room 020b

 

Longitudinal analysis of pancreatic endocrine heterogeneity in mouse

The development of the endocrine compartment of the pancreas has not been completely dissected yet. Understanding the mechanisms underlying the final step of maturation of the islets of Langerhans could generate novel therapeutic approaches for diabetes and improve the current protocol for the differentiation of β-cells from stem cells. Using our Fltp reporter mouse line and the innovative technology of single cell RNA sequencing (scRNAseq) we aim to pinpoint the key signaling pathways that determine the acquisition of the mature phenotype of the islets of Langerhans. Furthermore, we want to unveil the mechanisms underlying the establishment and maintenance of the heterogeneity of the islets of Langerhans throughout the life.

 

Academic and Research Activities

Since Oct.  2016

PhD student, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Prof. Dr. Heiko Lickert

Oct. 2013 - Oct. 2015

Master's degree in Medical Biotechnologies and Molecular Medicine, University of Bari, Italy Master Thesis: Transient inhibition of islet VEGF-A signaling boosts beta cell proliferation and restores glucose tolerance (Prof. H. Heimberg, Vrije Universiteit Brussel)

Sep. 2009- Oct. 2013

Bachelor's degree in Medical and Pharmaceutical Biotechnologies. University of Bari, Italy Bachelor Thesis: Live Imaging Technology for the characterization of a Lamin A mutant (Prof. M. Svelto, University of Bari)

 

Publications

1. Salinno C, Cota P, Bastidas-Ponce A, Tarquis-Medina M, Lickert H, Bakhti M. β-Cell Maturation and Identity in Health and Disease. M. Int J Mol Sci, Oct 30;20(21). pii: E5417, (2019)

2. Bastidas-Ponce A, Tritschler S, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Böttcher A, Theis FJ, Lickert H, Bakhti M. Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development, 146:dev173849, (2019)

3. Staels W, Heremans Y, Leuckx G, Van Gassen N, Salinno C, De Groef S, Cools M, Keshet E, Dor Y, Heimberg H, De Leu N. Conditional Islet Hypovascularisation Does Not Preclude Beta Cell Expansion During Pregnancy in Mice. Diabetologia, 60 (6), 1051-1056, (2017)