Team Member

Michael Sterr
PhD student

Phone: + 49 89-3187-43152
E-mail
Building/Room: Campus Neuherberg, building 3620, room 034

 

Epigenetic Regulation of the Neuroendocrine Lineage Decision in the Small Intestine

The epithelium of the small intestine is arranged in crypt-villus domains. At the base of each crypt reside intestinal stem cells (ISC) that give rise to all cell types of the small intestine. Along with the absorptive enterocytes, the intestine also contains endocrine cells that secrete hormones such as GLP-1 that plays an important role in glucose metabolism. In the intestine, the transcription factor Foxa2 is differentially expressed in ISCs and endocrine precursor cells, suggesting a role in the specification of the endocrine lineage. The aim of the project is to gain insight into the differentiation of the intestinal stem cells towards the endocrine lineage. In particular, the role of Foxa2 in the epigenetic mechanisms, governing this cell fate decision is investigated.

Academic and Research Activities

Since Jan. 2013 PhD student, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Prof. Dr. Heiko Lickert
Project: “Epigenetic Regulation of the Neuroendocrine Lineage Decision in the Small Intestine”
Mar. 2012 – Sept. 2012 Master thesis “Three Dimensional Structured Illumination Microscopy Studies of the Nuclear Architecture in Murine Embryonic Stem Cells and Preimplantation Embryos, Ludwig Maximilians University Munich, Prof. Dr. Thomas Cremer
Oct. 2010 – May 2011Diploma thesis “Transient and Stable Knockdown of Notch1, Delta-like 1 and Magi2 in the Insulinoma Cell Line INS-1E”, Helmholtz Zentrum München, Institute of Experimental Genetics, Prof. Dr. Martin Hrabě de Angelis
Oct. 2011 – Sept. 2012Studies of Biology,  Ludwig Maximilians University Munich
Oct. 2006 – May 2011Studies of Bioengineering, University of Applied Sciences Munich

       

Publications

 

Bastidas-Ponce, A., Roscioni, S.S., Burtscher, I., Bader, E., Sterr, M., Bakhti, M., and Lickert, H. (2017). Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol. Metab. 6, 524–534

Wang, X., Chen, S., Burtscher, I., Sterr, M., Hieronimus, A., Machicao, F., Staiger, H., Häring, H.-U., Lederer, G., Meitinger, T., and Lickert, H. (2016a). Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene. Stem Cell Res. 17, 273–276.

Wang, X., Chen, S., Burtscher, I., Sterr, M., Hieronimus, A., Machicao, F., Staiger, H., Häring, H.-U., Lederer, G., Meitinger, T., and Lickert, H. (2016b). Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Stem Cell Res. 17, 292–295.

Willmann, S.J., Mueller, N.S., Engert, S., Sterr, M., Burtscher, I., Raducanu, A., Irmler, M., Beckers, J., Sass, S., Theis, F.J., and Lickert, H. (2016). The global gene expression profile of the secondary transition during pancreatic development. Mech. Dev. 139, 51–64.

Cremer, T., Cremer, M., Hübner, B., Strickfaden, H., Smeets, D., Popken, J., Sterr, M., Markaki, Y., Rippe, K., and Cremer, C. (2015). The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments. FEBS Lett. 589, 2931–2943.

Smeets, D., Markaki, Y., Schmid, V.J., Kraus, F., Tattermusch, A., Cerase, A., Sterr, M., Fiedler, S., Demmerle, J., Popken, J., Leonhardt, H., Brockdorff, N., Cremer, T., Schermelleh, L., and Cremer, M. (2014). Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics Chromatin 7, 8

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