Team Member

Dr. Mostafa Bakhti
Post Doc

Phone: + 49 89 3187-43153
E-mail
Building/Room: Campus Neuherberg, building 3620, room 034

 

Molecular mechanism underlying pancreas morphogenesis and differentiation

Organ development and morphogenesis is governed by extrinsic and intrinsic cues that regulate molecular programs. One of the intriguing examples is the formation of the pancreas from the primary endodermal germ layer during early mammalian embryogenesis. This glandular organ is formed by progenitor cell differentiation of endocrine cells that secrete hormones into the blood stream and exocrine cells that train the digestive enzymes via the duct into the duodenum. However, the cellular and molecular mechanisms underlying pancreas morphogenesis and differentiation are not fully elucidated. We are drawn towards understanding the molecular mechanisms that orchestrate pancreatic duct formation and tubulogenesis during mouse development. Specifically, we are interested in indentifying the mechanisms which couple tissue morphogenesis and pancreatic endocrine cell-fate specification. Understanding of these mechanisms might provide pathomechanisms of diabetes and allow new approaches in tissue engineering.

Academic and Research Activities

Since July 2013Post-doctoral training, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Munich, Germany
July 2008 - May 2013Ph.D. Cellular Neuroscience, Max Planck Institute of Experimental Medicine, Göttingen, Germany
Mar. 2007 - Feb. 2008Research assistant, Molecular Biology Unit, Pasteur Institute, Tehran, Iran
Sep. 2004 - Feb. 2007M.Sc. in Cellular and Molecular Biology, University of Tehran, Iran
Sep. 2000 - May 2004Bachelor of Science in Biology, University of Isfahan, Iran


Publications

Bastidas-Ponce A, Scheibner K, Lickert H, Bakhti M. (2017) Cellular and molecular mechanisms coordinating pancreas development. Development. 144(16):2873-2888

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. (2017) Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 26(4):620-632

Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H. Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol Metab. 2017 Mar 25;6(6):524-534.

Bader E, Migliorini A, Gegg M, Moruzzi N, Gerdes J, Roscioni SS, Bakhti M, Brandl E, Irmler M, Beckers J, Aichler M, Feuchtinger A, Leitzinger C, Zischka H, Wang-Sattler R, Jastroch M, Tschöp M, Machicao F, Staiger H, Häring HU, Chmelova H, Chouinard JA, Oskolkov N, Korsgren O, Speier S, Lickert H. Identification of proliferative and mature β-cells in the islets of Langerhans. Nature. 2016 Jul 21;535(7612):430-4.

Sun X*, Bakhti M*, Fitzner D*, Schnaars M, Kruse N, Coskun Ü, Kremser C, Willecke K, Kappos L, Kuhle J, Simons M. Quantified CSF antibody reactivity against myelin in multiple sclerosis, Ann Clin Transl Neurol. 2(12) (2015) 1116-23.

Bakhti M, Aggarwal S, Simons M. Myelin architecture: zippering membranes tightly together, Cell Mol Life Sci. 2014 Apr;71(7):1265-77

Bakhti M, Snaidero N, Schneider D, Aggarwal S, Möbius W, Janshoff A, Eckhardt M, Nave KA and Simons M. Loss of electrostatic cell-surface repulsion mediates myelin membrane adhesion and compaction in the central nervous system, Proc Natl Acad Sci U S A. 110 (8) (2013) 3143-8.

Bakhti M, Winter C and Simons M. Inhibition of myelin membrane sheath formation byoligodendrocyte-derived exosome-like vesicles, J Biol Chem. 286 (1) (2011) 787-96.

Yurlova L, Kahya N, Aggarwal S, Kaiser H-S, Chiantia S, Bakhti M, Pewzner-Jung Y, Ben-David O, Futerman AH, Brügger B and Simons M. Self-Segregation of Myelin Membrane Lipids in Model Membranes, Biophys. J. 101 (11) (2011) 2713-2720.

Fitzner D, Schnaars M, van Rossum D, Krishnamoorthy G, Dibaj P, Bakhti M, Regen T,Hanisch UK and Simons M. Selective transfer of exosomes from oligodendrocytes tomicroglia by macropinocytosis, J Cell Sci. 124(Pt 3) (2011) 447-58.

Hsu C, Morohashi Y, Yoshimura S, Manrique-Hoyos N, Jung S, Lauterbach MA, Bakhti M, Grønborg M, Möbius W, Rhee J, Barr FA and Simons M. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C, J Cell Biol. 189 (2010) 223-32.

Khazaei MR, Bakhti M. and Habibi-Rezaei M. Nicotine reduces the cytotoxic effect ofglycated proteins on microglial cells, Neurochem. Res. 35 (2010) 548-58.

Khazaei MR, Habibi-Rezaei M, Moosavi-Movahedi AA, Sarrafnejhad AA, Sabouni F and Bakhti M. Microglial cell death induced by glycated bovine serum albumin: Nitric oxideinvolvement, J.Biochem 144 (2008)197-206.

Bakhti M, Habibi-Rezaei M, Moosavi Movahedi AA, Khazaei MR. Consequential alterations in hemoglobin structure upon glycation with fructose: Prevention by acetylsalicylic acid, J. Biochem. 141 (2007) 827-833.

 

 

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