Team Member

Xianming Wang
PhD student

Phone: +49 89 3187-43151
E-mail
Building/Room: Campus Neuherberg, building 3620, room 040a

 

Using human induced pluripotent cells to model Maturity onset diabetes of the young

Human pluripotent stem cell, either derived from the early embryo, embryonic stem (ES) cell or induced from somatic cell, induced pluripotent stem (iPS) cell can undergo self-renewal and differentiate into any cell type in the human body, thus hold great potential for clinical use in regenerative medicine. My project aims to establish models for understanding and treating MODY using induced pluripotent stem cells (iPSCs). My goals include highly efficient generating safe patient’s iPS cell, in vitro correcting its genetic defects, differentiating it into functional somatic cells for clinical use, et al.

 

Academic and Research Activities

Since Apr.2013Phd student at Helmholtz Zentrum München,/Institute for Stem Cell Research /Institute for Diabetes Research, Neuherberg, Germany
July. 2011–Feb. 2013Research Assistant at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, ChinaResearch direction: Stem Cell and Cancer
Sept. 2008–July. 2011Master in Cell Biology at University of Science and Technology of China, Hefei, ChinaMaster Thesis: Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes
Sept. 2004 –July. 2008

Bachelor in Bioscience at AnHui University, Hefei, ChinaBachelor Thesis: Physiological and biochemical changes in the sesame male sterile line during microspore development process

Publications

Wang, X., Chen, S., Burtscher, I., Sterr, M., Hieronimus, A., Machicao, F., et al., 2016. Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene. Stem Cell Research 17(2): 273–6, Doi: 10.1016/j.scr.2016.08.004

Wang, X., Chen, S., Burtscher, I., Sterr, M., Hieronimus, A., Machicao, F., et al., 2016. Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Stem Cell Research 17(2): 292–5, Doi:10.1016/j.scr.2016.08.005.

Li W *, Wang X *, Fan W *, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA. Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes. Hum Mol Genet. 2012 Jan 1;21(1):32-45. Epub 2011 Sep 23. (Co-first author)

Yang J, Cai J, Zhang Y, Wang X, Li W, Xu J, Li F, Guo X, Deng K, Zhong M, Chen Y, Lai L, Pei D, Esteban MA. Induced Pluripotent Stem Cells Can Be Used to Model the Genomic Imprinting Disorder Prader-Willi Syndrome. J Biol Chem. 2010 Dec 17;285(51):40303-11. Epub 2010 Oct 18.

Benda C, Zhou T, Wang X, Tian W, Grillari J, Tse HF, Grillari-Voglauer R, Pei D, Esteban MA. Urine as a Source of Stem Cells. Adv Biochem Eng Biotechnol. 2012 Oct 5. [Epub ahead of print]

 

 

We use cookies to improve your experience on our Website. We need cookies to continuously improve the services, to enable certain features and when embedding services or content of third parties, such as video player. By using our website, you agree to the use of cookies. We use different types of cookies. You can personalize your cookie settings here:

Show detail settings
Please find more information in our privacy statement.

There you may also change your settings later.