Team Member

Aimee Bastidas-Ponce
PhD student

Phone: +49 89 3187-43282
E-mail
Building/Room: Campus Neuherberg, building 3620, room 034

 

Project Description

Pdx1 has been shown to play a crucial role in pancreas development as Pdx1 KO mice display pancreatic agenesis and die within a few days after birth. In adult islets Pdx1 maintains β-cell identity (Gao et al., 2014) and heterozygous Pdx1 animals develop diabetes in adulthood with glucose unresponsiveness and increased β-cell apoptotic rate (Johnson et al., 2003). Like Pdx1, Foxa2 is important for pancreas development and β-cell differentiation but also for the maintenance of mature β-cells. Both FoxA2 and Pdx1 levels appeared to be reduced in de-differentiated β-cells, as in the case of diabetes models (Russ et al., 2011; Wang et al., 2014) and heterozygous mice for both Pdx1 and Foxa2 have altered islet architecture and β-cell identity with severe consequences on insulin secretion and blood glucose levels (Shih et al., 2013). Indeed, Foxa2 and Pdx1 share important functions, such as regulation of insulin production and modulation of TFs (Gao et al., 2007; Hani, 1999; Wang et al., 2002). Although Foxa2 has been shown to drive Pdx1 expression also in differentiated β-cells (Lee et al., 2002), the interaction between FoxA2 and Pdx1 in adult β-cells and its role in β-cell pathophysiology needs to be elucidated.

 

Academic and Research Activities

Since October 2013PhD student, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Munich, Germany
Jan. 2009 - May 2013

Master in Biochemical Sciences;.Institute of Biochemestry, National Autonomous University of Mexico

Aug. 2002 - July 2007.

Bachelor in Biochemical Engineering, Autonomous University of Sinaloa, Mexico.

 

Publications:

Bastidas-Ponce A, Scheibner K, Lickert H, Bakhti M. (2017) Cellular and molecular mechanisms coordinating pancreas development. Development. 144(16):2873-2888

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. (2017) Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 26(4):620-632

Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H. Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol Metab. 2017 Mar 25;6(6):524-534.

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