Team Member

Ciro Salinno
PhD student

Phone: + 49 89-3187-43134
E-mail
Building/Room: Campus Neuherberg, building 3620, room 020b

 

Beta cell heterogeneity impact on pathogenesis and progression of Type 1 Diabetes (T1D)

Type 1 diabetes (T1D) is the autoimmune-mediated form of diabetes mellitus (DM) that accounts for 5-10% of all cases of DM. The disease at onset affects mostly children and determines an absolute necessity of insulin therapy due to the destruction of the pancreatic beta cell mass. In this project we would like to investigate whether the subpopulations observed among beta cells, using the novel marker Fltp, has an impact on the pathogenesis and progression of the disease. In order to do this, we will generate a transgenic mouse model (NOD-FltpZV/+), and in collaboration with partners from the Immunology department, we will try to isolate and characterize a possible immunological-resistant beta cell subpopulation.

 

Academic and Research Activities

Since Oct.  2016

PhD student, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Prof. Dr. Heiko Lickert

Oct. 2013 - Oct. 2015

Master's degree in Medical Biotechnologies and Molecular Medicine, University of Bari, Italy Master Thesis: Transient inhibition of islet VEGF-A signaling boosts beta cell proliferation and restores glucose tolerance (Prof. H. Heimberg, Vrije Universiteit Brussel)

Sep. 2009- Oct. 2013

Bachelor's degree in Medical and Pharmaceutical Biotechnologies. University of Bari, Italy Bachelor Thesis: Live Imaging Technology for the characterization of a Lamin A mutant (Prof. M. Svelto, University of Bari)

 

 

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