Team Member

Sandra Pfluger
PhD student

E-mail
Building/Room: Campus Neuherberg, building 3620, room 020b

 

Endocrine differentiation from human pluripotent stem cells

 

Type 1 diabetes (T1D) results from the autoimmune destruction of insulin-producing beta cells in the islets of Langerhans of the pancreas. Despite increasing knowledge about the immunological aspects of the disease and insights into development and regeneration of beta cells there is no cure available. To date, the only effective treatments for T1D are either lifelong intensive insulin therapy or transplantation of cadaveric pancreatic islets. However, the lack of donor organs and the obligatory suppression of the recipient’s immune system are major drawbacks associated with islet transplantation. The generation of insulin-producing pancreatic beta cells from human pluripotent stem cells (hPSCs) in vitro would provide an unparalleled source for transplantation therapies and is therefore of major interest. The scientific object of my PhD thesis is to get mechanistic insight into the signaling pathways and downstream targets that control expansion of pancreatic progenitors derived from hPSCs and their differentiation into endocrine cells

Academic and Research Activities

Since Sept. 2017

PhD student – Institute of Diabetes and Regeneration Research, Helmholtz Zentrum Munich, Germany

Oct. 2014 – Aug. 2017Master of Science in Molecular and Applied Biotechnology - RWTH Aachen, Germany
Sept. 2010 - Oct. 2014Bachelor of Science in Biotechnology - FH Aachen University of Applied Sciences, Germany

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