Team Member

Dr. Ingo Burtscher
Deputy Director

Phone: + 49 89-3187-2063
E-mail
Building/Room: Campus Neuherberg, building 3620, room 302c

 

Project Description

During embryonic mouse development lineage segregation leading to the formation of the germ layers of ectoderm, mesoderm and endoderm, occurs during the process of gastrulation. Due to intrauterine development, the cellular and molecular processes involved in this process are poorly understood. This project utilizes ex vivo embryo culture and time-lapse fluorescent imaging technology to study the process of gastrulation in more detail. The focus is on resolving cell migration as well as morphogenetic cell changes in a time-dependent manner. Theses tools allow us to study wild type and mutant embryos with endoderm phenotypes in greater detail, deciphering the primary cause of endoderm defects. We have also elaborated this technology to monitor pancreas development in organ explant cultures.

 

Academic and Research Activities

 

Since Feb. 2005Postdoctorial Research Fellow in the Group of Dr. Heiko Lickert, Endoderm Research, Stem Cell Institute, Helmholtz Zentrum Munich
Oct 2000 – Oct 2004PhD at Queen Mary & Westfield College, University of London, Group of Prof. Dean Nizetic
Title:” Characterisation of USP25, a chromosome 21 gene potentially contributing to specific features of Down syndrome, and the effects of its overexpression on cellular structures, function & behaviour
Jan. 1998 – Jun 1999Institue of Molecular Pathology, Vienna
Group of Dr. Gerhard Christofori
Diploma Thesis: “IGF-Mediated Survival Signaling in SV-40 T Antigen-mediated Tumorigenesis”
Diploma mark: Mit Auszeichnung bestanden
Feb. 1993 – Jul. 1999Studies of Biology at University of Vienna
Genetics, Biochemistry and Microbiology
Diploma overall mark: Bestanden

Publications

Homology Arms of Targeting Vectors for Gene Insertions and Crispr/Cas9 Technology: Size Does Not Matter; Quality Control of Targeted Clones Does. Petrezselyova S, Kinsky S, Truban D, Sedlacek R, Burtscher I, Lickert H.Cell Mol Biol Lett. 2015 Nov 5. 

Flattop regulates basal body docking and positioning in mono- and multiciliated cells.Gegg M, Böttcher A, Burtscher I, Hasenoeder S, Van Campenhout C, Aichler M, Walch A, Grant SG, Lickert H. Elife. 2014 Oct 8;3. doi: 10.7554/eLife.03842.

miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.Yang D, Lutter D, Burtscher I, Uetzmann L, Theis FJ, Lickert H. Development. 2014 Feb;141(3):514-25. doi: 10.1242/dev.104232.

The Sox17CreERT2 knock-in mouse line displays spatiotemporal activation of Cre recombinase in distinct Sox17 lineage progenitors.Engert S, Burtscher I, Kalali B, Gerhard M, Lickert H. Genesis. 2013 Nov;51(11):793-802. doi: 10.1002/dvg.22714. Epub 2013 Oct 

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse.Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H. Development. 2013 Aug;140(15):3128-38. doi: 10.1242/dev.088765. Epub 2013 Jul 3.

Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation. Burtscher I, Barkey W, Lickert H. Genesis. 2013 Aug;51(8):596-604. doi: 10.1002/dvg.22404. Epub 2013 Jun 26.

Fltp(T2AiCre): a new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues.Lange A, Gegg M, Burtscher I, Bengel D, Kremmer E, Lickert H. Differentiation. 2012 Feb;83(2):S105-13. doi: 10.1016/j.diff.2011.11.003. Epub 2011 Dec 6.

The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development. Burtscher I, Barkey W, Schwarzfischer M, Theis FJ, Lickert H. Genesis. 2012 Jun;50(6):496-505. doi: 10.1002/dvg.20829. Epub 2011 Dec 27.

Pitchfork regulates primary cilia disassembly and left-right asymmetry. Kinzel D, Boldt K, Davis EE, Burtscher I, Trümbach D, Diplas B, Attié-Bitach T, Wurst W, Katsanis N, Ueffing M, Lickert H. Dev Cell. 2010 Jul 20;19(1):66-77.

Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells.
Engert S, Liao WP, Burtscher I, Lickert H. Genesis. 2009 Sep;47(9):603-10.

Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries. Liao WP, Uetzmann L, Burtscher I, Lickert H. Genesis. 2009 Jul;47(7):476-83.

Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo. Burtscher I, Lickert H. Development. 2009 Mar;136(6):1029-38.

Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation. Egea J, Erlacher C, Montanez E, Burtscher I, Yamagishi S, Hess M, Hampel F, Sanchez R, Rodriguez-Manzaneque MT, Bösl MR, Fässler R, Lickert H, Klein R. Genes Dev. 2008 Dec 1;22(23):3349-62.

A mouse line expressing Foxa2-driven Cre recombinase in node, notochord, floorplate, and endoderm. Uetzmann L, Burtscher I, Lickert H. Genesis. 2008 Oct;46(10):515-22.

Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder. Groet J, McElwaine S, Spinelli M, Rinaldi A, Burtscher I, Mulligan C, Mensah A, Cavani S, Dagna-Bricarelli F, Basso G, Cotter FE, Nizetic D. Lancet. 2003 May 10;361(9369):1617-20.

The IGF/IGF-1 receptor signaling pathway as a potential target for cancer therapy. Burtscher I, Christofori G. Drug Resist Updat. 1999 Feb;2(1):3-8.

An insulin-like growth factor-mediated, phosphatidylinositol 3' kinase-independent survival signaling pathway in beta tumor cells. Burtscher I, Compagni A, Lamm GM, Christofori G. Cancer Res. 1999 Aug 15;59(16):3923-6.

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