Team Member

Dr. Silvia Schirge
Post Doc

Phone: +49 89-187-4733
E-mail
Building/Room: Campus Neuherberg, building 3620, room 034b

 

Functional analysis of endoderm development


The early mammalian embryo consists of three primary germ layers: the ectoderm, the mesoderm and the endoderm which will form all embryonic structures. We focus on the endoderm which gives rise to the gastrointestinal tract and its associated organs, such as lung, liver and pancreas. We are interested in factors and pathways which regulate endoderm development and its specification. For this purpose we generated endoderm-specific Cre mouse lines to identify tissues and organs which derive from endoderm progenitor cells and to inactivate genes of interest within the endoderm to understand the mechanisms involved in endoderm formation and organ specification.

 

Academic and Research Activities

Oct. 2003 – Mar. 2009 Studies of Biology at Ludwigs-Maximilians- Universtität Würzburg
Developmental and Cell biology, Physiological chemistry and Genetics
(Diploma overall mark: 1.0)
May. 2008 – Mar. 2009HelmholtzZentrum München
Institute of stem cell research, Dr. Heiko Lickert
Diploma Thesis: “Characterization of the Sox17-2A-iCre mouse line” (mark: 1.0)
Apr 2009- Sep. 2014

HelmholtzZentrum München
Institute of stem cell research/ Institute of Diabetes and Regeneration Research, Neuherberg, Germany Dr. Heiko Lickert
Phd Thesis: “Epigenetic and transcriptional regulation of early mouse development” Supervisor: Prof. Dr. Heiko Lickert

Since Sep. 2014Postdoc, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany

 

Publications

Engert S, Burtscher I, Liao WP, Dulev S, Schotta G, Lickert H. Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development. 2013 Aug;140(15):3128-38. doi: 10.1242/dev.088765. Epub 2013 Jul 3.

Engert S, Burtscher I, Kalali B, Gerhard M, Lickert H. The Sox17CreERT2 knock-in mouse line displays spatiotemporal activation of Cre recombinase in distinct Sox17 lineage progenitors. Genesis. 2013 Nov;51(11):793-802. doi: 10.1002/dvg.22714. Epub 2013 Oct

Willmann SJ, Mueller NS, Engert S, Sterr M, Burtscher I, Raducanu A, Irmler M, Beckers J, Sass S, Theis FJ, Lickert H. The global gene expression profile of the secondary transiion during pancreatic development. Mech Dev. 2016 Feb;139:51-64. doi: 10.1016/j.mod.2015.11.004. Epub 2015 Nov 28

Engert, S., et al., Sox17-2A-iCre: a knock-in mouse line expressing Cre recombinase in endoderm and vascular endothelial cells. Genesis, 2009. 47(9): p. 603-10.

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