Publications

Tritschler, S. ; Büttner, M. ; Fischer, D.S. ; Lange, M. ; Bergen, V. ; Lickert, H. ; Theis, F.J.

Concepts and limitations for learning developmental trajectories from single cell genomics.

Development 146, accepted (2019)

Gilleron, J. ; Gerdes, J.M. ; Zeigerer, A.

Metabolic regulation through the endosomal system.

Traffic, accepted (2019)

Bastidas-Ponce, A. ; Tritschler, S. ; Dony, L. ; Scheibner, K. ; Tarquis-Medina, M. ; Salinno, C. ; Schirge, S. ; Burtscher, I. ; Böttcher, A. ; Theis, F.J. ; Lickert, H. ; Bakhti, M.

Massive single-cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis.

Development, accepted (2019)

Theis, F.J. ; Lickert, H.

A map of beta-cell differentiation.

Nature 569, 342-343 (2019)

Lickert, H. ; von Hahn, F. ; Fathi, F. ; Wißmiller, K. ; Wiener, J. ; Jain, C. ; Engert, S. ; Bastidas-Ponce, A. ; Morshedi, A. ; Raducanu, A. ; Burtscher, I. ; Coskun, Ü. ; Meier, M. ; Plettenburg, O.

IGF-Receptor-Like 1 is a novel regulator of the insulin signaling pathway.

Vortrag: GRS/ GRC - IGF and Insulin System in Physiology and Disease, 09-15 March 2019, Ventura, CA. (2019)

Modic, M. ; Grosch, M. ; Rot, G. ; Schirge, S. ; Lepko, T. ; Yamazaki, T. ; Lee, F.C.Y. ; Rusha, E. ; Shaposhnikov, D. ; Palo, M. ; Merl-Pham, J. ; Cacchiarelli, D. ; Rogelj, B. ; Hauck, S.M. ; von Mering, C. ; Meissner, A. ; Lickert, H. ; Hirose, T. ; Ule, J. ; Drukker, M.

Cross-regulation between TDP-43 and paraspeckles promotes pluripotency-differentiation transition.

Mol. Cell 74, 951-965.e13 (2019)

Bakhti, M. ; Bastidas-Ponce, A. ; Lickert, H.

Sorting out fate determination.

Dev. Cell 49, 1-3 (2019)

Bakhti, M.^# ; Lickert, H.^#

Cell makeover for diabetes therapy.

Nat. Metab. 1, 312-313 (2019)

Sacco, F. ; Seelig, A. ; Humphrey, S.J. ; Krahmer, N. ; Volta, F. ; Reggio, A. ; Marchetti, P. ; Gerdes, J.M. ; Mann, M.

Phosphoproteomics reveals the GSK3-PDX1 axis as a key pathogenic signaling node in diabetic islets.

Cell Metab. 29, 1422-1432.e3 (2019)

Kluth, O. ; Stadion, M. ; Gottmann, P. ; Aga, H. ; Jähnert, M. ; Scherneck, S. ; Vogel, H. ; Krus, U. ; Seelig, A. ; Ling, C. ; Gerdes, J.M. ; Schürmann, A.

Decreased expression of cilia genes in pancreatic islets as a risk factor for type 2 diabetes in mice and humans.

Cell Rep. 26, 3027-3036.e3 (2019)

Wang, X. ; Sterr, M. ; Ansarullah ; Burtscher, I. ; Böttcher, A. ; Beckenbauer, J. ; Meitinger, T. ; Häring, H.-U. ; Staiger, H. ; Cernilogar, F.M. ; Schotta, G. ; Irmler, M. ; Beckers, J. ; Wright, C.V.E. ; Bakhti, M. ; Lickert, H.

Point mutations in the PDX1 transactivation domain impair human beta-cell development and function.

Mol. Metab. 24, 80-97 (2019)

Niu, L. ; Geyer, P.E. ; Wewer Albrechtsen, N.J. ; Gluud, L.L. ; Santos, A. ; Doll, S. ; Treit, P.V. ; Holst, J.J. ; Knop, F.K. ; Vilsbøll, T. ; Junker, A. ; Sachs, S. ; Stemmer, K. ; Müller, T.D. ; Tschöp, M.H. ; Hofmann, S.M. ; Mann, M.

Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Mol. Syst. Biol. 15:e8793 (2019)

Brennecke, P. ; Rasina, D. ; Aubi, O. ; Herzog, K. ; Landskron, J. ; Cautain, B. ; Vicente, F. ; Quintana, J. ; Mestres, J. ; Stechmann, B. ; Ellinger, B. ; Brea, J. ; Kolanowski, J.L. ; Pilarski, R. ; Orzaez, M. ; Pineda-Lucena, A. ; Laraia, L. ; Nami, F. ; Zielenkiewicz, P. ; Paruch, K. ; Hansen, E. ; von Kries, J.P. ; Neuenschwander, M. ; Specker, E. ; Bartunek, P. ; Simova, S. ; Leśnikowski, Z. ; Krauss, S. ; Lehtiö, L. ; Bilitewski, U. ; Brönstrup, M. ; Taskén, K. ; Jirgensons, A. ; Lickert, H. ; Clausen, M.H. ; Andersen, J.H. ; Vicent, M.J. ; Genilloud, O. ; Martinez, A. ; Nazaré, M. ; Fecke, W. ; Gribbon, P.

EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology.

SLAS Discov. 24, 398-413 (2019)

Sachs, S. ; Zarini, S. ; Kahn, D.E. ; Harrison, K.A. ; Perreault, L. ; Phang, T. ; Newsom, S.A. ; Strauss, A. ; Kerege, A. ; Schoen, J.A. ; Bessesen, D.H. ; Schwarzmayr, T. ; Graf, E. ; Lutter, D. ; Krumsiek, J. ; Hofmann, S.M. ; Bergman, B.C.

Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans.

Am. J. Physiol. Endocrinol. Metab. 316, E866-E879 (2019)

Norheim, F. ; Hasin-Brumshtein, Y. ; Vergnes, L. ; Chella Krishnan, K. ; Pan, C. ; Seldin, M.M. ; Hui, S.T. ; Mehrabian, M. ; Zhou, Z. ; Gupta, S. ; Parks, B.W. ; Walch, A.K. ; Reue, K. ; Hofmann, S.M. ; Arnold, A.P. ; Lusis, A.J.

Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits.

Cell Metab. 29, 932-949.e4 (2019)

Keuper, M. ; Berti, L. ; Raedle, B. ; Sachs, S. ; Böhm, A. ; Fritsche, L. ; Fritsche, A. ; Häring, H.-U. ; Hrabě de Angelis, M. ; Jastroch, M. ; Hofmann, S.M. ; Staiger, H.

Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

Mol. Metab. 20, 28-37 (2019)

Clemmensen, C. ; Finan, B. ; Müller, T.D. ; DiMarchi, R.D. ; Tschöp, M.H. ; Hofmann, S.M.

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.

Nat. Rev. Endocrinol. 15, 90-104 (2019)

My, I. ; Laue, S. ; Dressen, M. ; Schmidt, F. ; Brade, T. ; Dorn, T. ; Goedel, A. ; Lahm, H. ; Lickert, H. ; Krane, M. ; Moretti, A. ; Laugwitz, K.L.

Primary cilium-autophagy-cell cycle axis defects impair cardiac progenitor specification in hypoplastic left heart syndrome.

Eur. Heart J. 39, 390-391 (2018)

Saito, K. ; Nobuhisa, I. ; Harada, K. ; Takahashi, S. ; Anani, M. ; Lickert, H. ; Kanai-Azuma, M. ; Kanai, Y. ; Taga, T.

Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis.

Exp. Cell Res. 365, 145-155 (2018)

Bakhti, M. ; Böttcher, A. ; Lickert, H.

Modelling the endocrine pancreas in health and disease.

Nat. Rev. Endocrinol. 15, 155-171 (2018)

Clemmensen, C. ; Jall, S. ; Kleinert, M. ; Quarta, C. ; Gruber, T. ; Reber, J. ; Sachs, S. ; Fischer, K. ; Feuchtinger, A. ; Karlas, A. ; Simonds, S.E. ; Grandl, G. ; Loher, D. ; Sanchez-Quant, E. ; Keipert, S. ; Jastroch, M. ; Hofmann, S.M. ; Nascimento, E.B.M. ; Schrauwen, P. ; Ntziachristos, V. ; Cowley, M.A. ; Finan, B. ; Müller, T.D. ; Tschöp, M.H.

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes (vol 9, 4304, 2018).

Nat. Commun. 9:4975 (2018)

Brokhman, I. ; Xu, J. ; Coles, B.L.K. ; Razavi, R. ; Engert, S. ; Lickert, H. ; Babona-Pilipos, R. ; Morshead, C.M. ; Sibley, E. ; Chen, C. ; van der Kooy, D.

Dual embryonic origin of the mammalian enteric nervous system.

Dev. Biol., accepted (2018)

Clemmensen, C. ; Jall, S. ; Kleinert, M. ; Quarta, C. ; Gruber, T. ; Reber, J. ; Sachs, S. ; Fischer, K. ; Feuchtinger, A. ; Karlas, A. ; Simonds, S.E. ; Grandl, G. ; Loher, D. ; Sanchez-Quant, E. ; Keipert, S. ; Jastroch, M. ; Hofmann, S.M. ; Nascimento, E.B.M. ; Schrauwen, P. ; Ntziachristos, V. ; Cowley, M.A. ; Finan, B.° ; Müller, T.D.° ; Tschöp, M.H.°

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Nat. Commun. 9:4304 (2018)

Stadion, M. ; Kluth, O. ; Gottmann, P. ; Aga, H. ; Krus, U. ; Gerdes, J.M. ; Ling, C. ; Schuermann, A.

The impact of cilia-genes on pancreatic beta cell replication and the risk of type 2 diabetes.

Diabetologia 61, S194-S194 (2018)

Jørgensen, M.C. ; de Lichtenberg, K.H. ; Collin, C.A. ; Klinck, R. ; Ekberg, J.H. ; Engelstoft, M.S. ; Lickert, H. ; Serup, P.

Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice.

Development 145:dev163568 (2018)

Rotter, M. ; Brandmaier, S. ; Covic, M. ; Burek, K. ; Hertel, J. ; Troll, M. ; Bader, E. ; Adam, J. ; Prehn, C. ; Rathkolb, B. ; Hrabě de Angelis, M. ; Grabe, H.J. ; Daniel, H. ; Kantermann, T. ; Harth, V. ; Illig, T. ; Pallapies, D. ; Behrens, T. ; Brüning, T. ; Adamski, J. ; Lickert, H. ; Rabstein, S. ; Wang-Sattler, R.

Night shift work affects urine metabolite profiles of nurses with early chronotype.

Metabolites 8:45 (2018)

Götz, A. ; Lehti, M. ; Donelan, E. ; Striese, C. ; Cucuruz, S. ; Sachs, S. ; Yi, C.X. ; Woods, S.C. ; Wright, S.D. ; Tschöp, M.H. ; Gao, Y. ; Hofmann, S.M.

Circulating HDL levels control hypothalamic astrogliosis via apoA-I.

J. Lipid Res. 59, 1649-1659 (2018)

Renner, S.^# ; Blutke, A.^# ; Dobenecker, B. ; Dhom, G. ; Müller, T.D. ; Finan, B. ; Clemmensen, C. ; Bernau, M. ; Novak, I. ; Rathkolb, B. ; Senf, S. ; Zöls, S. ; Roth, M. ; Götz, A. ; Hofmann, S.M. ; Hrabě de Angelis, M. ; Wanke, R. ; Kienzle, E. ; Scholz, A.M. ; DiMarchi, R. ; Ritzmann, M. ; Tschöp, M.H. ; Wolf, E.

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Mol. Metab., accepted (2018)

Scerbo, M.J. ; Volta, F. ; Seeling, A. ; O’Brien, N. ; Mann, M. ; Gerdes, J.M.

Primary cilia regulate transferrin endocytosis and iron homeostasis

Poster: 2nd German-French Conference on Diabetes Research, 19-20 April 2018 (2018)

O'Neill, A.C. ; Kyrousi, C. ; Einsiedler, M. ; Burtscher, I. ; Drukker, M. ; Markie, D.M. ; Kirk, E.P. ; Götz, M. ; Robertson, S.P. ; Cappello, S.

Mob2 insufficiency disrupts neuronal migration in the developing cortex.

Front. Cell. Neurosci. 12:57 (2018)

Wang, X. ; Sterr, M. ; Burtscher, I. ; Chen, S. ; Hieronimus, A. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Lederer, G. ; Meitinger, T. ; Cernilogar, F.M. ; Schotta, G. ; Irmler, M. ; Beckers, J. ; Hrabě de Angelis, M. ; Ray, M. ; Wright, C.V.E. ; Bakhti, M. ; Lickert, H.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.

Mol. Metab. 9, 57-68 (2018)

De Castro, S.C.P. ; Hirst, C.S. ; Savery, D. ; Rolo, A.P. ; Lickert, H. ; Andersen, B. ; Copp, A.J. ; Greene, N.D.E.

Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

Dev. Biol. 435, 130-137 (2018)

Kleinert, M. ; Clemmensen, C. ; Hofmann, S.M. ; Moore, M.C. ; Renner, S. ; Woods, S.C. ; Huypens, P. ; Beckers, J. ; Hrabě de Angelis, M. ; Schürmann, A. ; Bakhti, M. ; Klingenspor, M. ; Heimann, M. ; Cherrington, A.D. ; Ristow, M. ; Lickert, H. ; Wolf, E. ; Havel, P.J. ; Müller, T.D. ; Tschöp, M.H.

Animal models of obesity and diabetes mellitus.

Nat. Rev. Endocrinol. 14, 140-162 (2018)

Fischer, I.P. ; Irmler, M. ; Meyer, C.W.E. ; Sachs, S. ; Neff, F. ; Hrabě de Angelis, M. ; Beckers, J. ; Tschöp, M.H. ; Hofmann, S.M. ; Ussar, S.

A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.

Int. J. Obes. 42, 507-517 (2018)

Lickert, H. ; Kaestner, K.H.

Islet biology.

Mol. Metab. 6, VI-VI (2017)

Tom, R.Z. ; Gao, Y. ; Schriever, S.C. ; Lutter, D. ; Yi, C.-X. ; Tschöp, M.H. ; Hofmann, S.M.

Role of neuronal fractalkine in reducing diet-induced hypothalamic inflammation.

Med. Sci. Sports Exerc. 49, 702-702 (2017)

Gao, Y. ; Vidal-Itriago, A. ; Milanova, I. ; Korpel, N.L. ; Kalsbeek, M.J. ; Tom, R.Z. ; Kalsbeek, A. ; Hofmann, S.M. ; Yi, C.X.

Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase.

Mol. Metab. 7, 155-160 (2017)

Schmitz, F. ; Burtscher, I. ; Stauber, M. ; Gossler, A. ; Lickert, H.

A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.

Genesis 55:e23073 (2017)

Götz, A. ; Jall, S. ; Tschöp, M.H. ; Müller, T.D.

Inkretinbasierte Medikamente zur Diabetes- und Adipositastherapie. Entwicklungsperspektiven.

Diabetologe 13, 505–513 (2017)

Gao, Y. ; Vidal-Itriago, A. ; Kalsbeek, M.J. ; Layritz, C. ; García-Cáceres, C. ; Tom, R.Z. ; Eichmann, T.O. ; Vaz, F.M. ; Houtkooper, R.H. ; van der Wel, N. ; Verhoeven, A.J. ; Yan, J. ; Kalsbeek, A. ; Eckel, R.H. ; Hofmann, S.M. ; Yi, C.X.

Lipoprotein lipase maintains microglial innate immunity in obesity.

Cell Rep. 20, 3034-3042 (2017)

Yamauchi, K. ; Yamazaki, M. ; Abe, M. ; Sakimura, K. ; Lickert, H. ; Kawasaki, T. ; Murakami, F. ; Hirata, T.

Netrin-1 derived from the ventricular zone, but not the floor plate, directs hindbrain commissural axons to the ventral midline.

Sci. Rep. 7:11992 (2017)

Quarta, C. ; Clemmensen, C. ; Zhu, Z. ; Yang, B. ; Joseph, S.S. ; Lutter, D. ; Yi, C.X. ; Graf, E. ; García-Cáceres, C. ; Legutko, B. ; Fischer, K. ; Brommage, R. ; Zizzari, P. ; Franklin, B.S. ; Krueger, M. ; Koch, M. ; Vettorazzi, S. ; Li, P. ; Hofmann, S.M. ; Bakhti, M. ; Bastidas-Ponce, A. ; Lickert, H. ; Strom, T.M. ; Gailus-Durner, V. ; Bechmann, I. ; Perez-Tilve, D. ; Tuckermann, J.P. ; Hrabě de Angelis, M. ; Sandoval, D.A. ; Cota, D. ; Latz, E. ; Seeley, R.J. ; Müller, T.D. ; DiMarchi, R.D. ; Finan, B.° ; Tschöp, M.H.°

Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity.

Cell Metab. 26, 620-632.e6 (2017)

Böttcher, A. ; Lickert, H.° ; Tschöp, M.H.°

Engineering skin with skinny genes.

Cell Stem Cell 21, 153-155 (2017)

Bastidas-Ponce, A. ; Scheibner, K. ; Lickert, H. ; Bakhti, M.

Cellular and molecular mechanisms coordinating pancreas development.

Development 144, 2873-2888 (2017)

Tritschler, S. ; Theis, F.J. ; Lickert, H. ; Böttcher, A.

Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.

Mol. Metab. 6, 974-990 (2017)

Icb_ML

Keuper, M. ; Sachs, S. ; Walheim, E. ; Berti, L. ; Raedle, B. ; Tews, D. ; Fischer-Posovszky, P. ; Wabitsch, M. ; Hrabě de Angelis, M. ; Kastenmüller, G. ; Tschöp, M.H. ; Jastroch, M. ; Staiger, H. ; Hofmann, S.M.

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

Mol. Metab. 6, 1226-1239 (2017)

Hockman, D. ; Burns, A. ; Schlosser, G. ; Gates, K.P. ; Jevans, B. ; Mongera, A. ; Fisher, S. ; Unlu, G. ; Knapik, E.W. ; Kaufman, C.K. ; Mosimann, C. ; Zon, L.I. ; Lancman, J.J. ; Dong, P.D. ; Lickert, H. ; Tucker, A.S. ; Baker, C.V.

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

eLife 6:e21231 (2017)

Bastidas-Ponce, A. ; Roscioni, S. ; Burtscher, I. ; Bader, E. ; Sterr, M. ; Bakhti, M. ; Lickert, H.

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells.

Mol. Metab. 6, 524-534 (2017)

Kabra, U.D. ; Pfuhlmann, K. ; Migliorini, A. ; Keipert, S. ; Lamp, D. ; Korsgren, O. ; Gegg, M. ; Woods, S.C. ; Pfluger, P.T. ; Lickert, H. ; Affourtit, C. ; Tschöp, M.H. ; Jastroch, M.

Direct substrate delivery into mitochondrial-fission deficient pancreatic islets rescues insulin secretion.

Diabetes 66, 1247-1257 (2017)

Ventura-Clapier, R. ; Dworatzek, E. ; Seeland, U. ; Kararigas, G. ; Francois Arnal, J. ; Brunelleschi, S. ; Carpenter, T. ; Erdmann, J. ; Franconi, F. ; Giannetta, E. ; Glezerman, M. ; Hofmann, S.M. ; Junien, C. ; Katai, M. ; Kublickiene, K. ; König, I.R. ; Majdic, G. ; Malorni, W. ; Mieth, C. ; Miller, V. ; Reynolds, R. ; Shimokawa, H. ; Tannenbaum, C. ; Maria Anna, D.U. ; Regitz-Zagrosek, V.

Sex in basic research - Concepts in the cardiovascular field.

Cardiovasc. Res. 113, 711-724 (2017)

Korostylev, A.^# ; Mahaddalkar, P.U. ; Keminer, O. ; Hadian, K. ; Schorpp, K.K. ; Lickert, H.^#

A high-content small molecule screen identifies novel inducers of definitive endoderm.

Mol. Med. 6, 640-650 (2017)

Jall, S. ; Sachs, S. ; Clemmensen, C. ; Finan, B. ; Neff, F. ; DiMarchi, R.D. ; Tschöp, M.H. ; Müller, T.D.° ; Hofmann, S.M.°

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Mol. Metab. 6, 440-446 (2017)

Bardot, E. ; Calderon, D. ; Santoriello, F. ; Han, S. ; Cheung, K. ; Jadhav, B. ; Burtscher, I. ; Artap, S. ; Jain, R.K. ; Epstein, J.A. ; Lickert, H. ; Gouon-Evans, V. ; Sharp, A.J. ; Dubois, N.C.

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

Nat. Commun. 8:14428 (2017)

Tews, D. ; Fromme, T. ; Keuper, M. ; Hofmann, S.M. ; Debatin, K.M. ; Klingenspor, M. ; Wabitsch, M. ; Fischer-Posovszky, P.

Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.

Mol. Cell. Endocrinol. 443, 106-113 (2017)

Paulin, N. ; Döring, Y. ; Kooijman, S. ; Blanchet, X. ; Viola, J.R. ; de Jong, R. ; Mandl, M. ; Hendrikse, J. ; Schiener, M. ; von Hundelshausen, P. ; Vogt, A. ; Weber, C. ; Bdeir, K. ; Hofmann, S.M. ; Rensen, P.C.N. ; Drechsler, M. ; Soehnlein, O.

Human neutrophil peptide 1 Limits hypercholesterolemia-induced atherosclerosis by increasing hepatic LDL clearance.

EBioMedicine 16, 204-211 (2017)

Álvarez Hernández, E.^# ; Kahl, S. ; Seelig, A. ; Begovatz, P.^# ; Irmler, M. ; Kupriyanova, Y. ; Nowotny, J. ; Nowotny, P. ; Herder, C. ; Barosa, C. ; Carvalho, F.P. ; Rozman, J. ; Neschen, S. ; Jones, J.G. ; Beckers, J. ; Hrabě de Angelis, M. ; Roden, M.

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.

J. Clin. Invest. 127, 695-708 (2017)

Scerbo, M.J. ; Gerdes, J.M.

Bonding with beta-cells-a role for oxytocin in glucose handling.

Diabetes 66, 256-257 (2017)

Rotter, M. ; Brandmaier, S. ; Prehn, C. ; Adam, J. ; Rabstein, S. ; Gawrych, K. ; Brüning, T ; Illig, T. ; Lickert, H. ; Adamski, J. ; Wang-Sattler, R.

Stability of targeted metabolite profiles of urine samples under different storage conditions.

Metabolomics 13:4 (2017)

Volta, F. ; Gerdes, J.M.

The role of primary cilia in obesity and diabetes.

Ann. NY Acad. Sci. 1391, 71-84 (2017)

Wang, X. ; Chen, S. ; Burtscher, I. ; Sterr, M. ; Hieronimus, A. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Lederer, G. ; Meitinger, T. ; Lickert, H.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene.

Stem Cell Res. 17, 292-295 (2016)

Wang, X. ; Chen, S. ; Burtscher, I. ; Sterr, M. ; Hieronimus, A. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Lederer, G. ; Meitinger, T. ; Lickert, H.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene.

Stem Cell Res. 17, 273-276 (2016)

Bortsova, G. ; Sterr, M. ; Wang, L. ; Milletari, F. ; Navab, N. ; Böttcher, A. ; Lickert, H. ; Theis, F.J.° ; Peng, T.°

Mitosis detection in intestinal crypt images with hough forest and conditional random fields.

Lecture Notes Comp. Sci. 10019, 287-295 (2016)

Roscioni, S. ; Migliorini, A. ; Gegg, M. ; Lickert, H.

Impact of islet architecture on β-cell heterogeneity, plasticity and function.

Nat. Rev. Endocrinol. 12, 695-709 (2016)

Finan, B. ; Clemmensen, C. ; Zhu, Z. ; Stemmer, K. ; Gauthier, K. ; Müller, L. ; de Angelis, M. ; Moreth, K. ; Neff, F. ; Perez-Tilve, D. ; Fischer, K. ; Lutter, D. ; Sánchez-Garrido, M.A. ; Liu, P. ; Tuckermann, J.P. ; Malehmir, M. ; Healy, M.E. ; Weber, A. ; Heikenwälder, M. ; Jastroch, M. ; Kleinert, M. ; Jall, S. ; Brandt, S. ; Flamant, F. ; Schramm, K.-W. ; Biebermann, H. ; Döring, Y. ; Weber, C. ; Habegger, K.M. ; Keuper, M. ; Gelfanov, V. ; Liu, F. ; Köhrle, J. ; Rozman, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Hofmann, S.M. ; Yang, B. ; Tschöp, M.H. ; DiMarchi, R. ; Müller, T.D.

Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic Impact for metabolic disease.

Cell 167, 843-857.e14 (2016)

Hasenöder, S.

The role of Oct4 in murine endoderm development.

München, Technische Universität, Fakultät für Medizin, Diss., 2016, 171 S.

Adam, J. ; Brandmaier, S. ; Leonhardt, J. ; Scheerer, M.F. ; Mohney, R.P. ; Xu, T. ; Bi, J. ; Rotter, M. ; Troll, M. ; Chi, S. ; Heier, M. ; Herder, C. ; Rathmann, W.G. ; Giani, G. ; Adamski, J. ; Illig, T. ; Strauch, K. ; Li, Y. ; Gieger, C. ; Peters, A. ; Suhre, K. ; Ankerst, D.P. ; Meitinger, T. ; Hrabě de Angelis, M. ; Roden, M. ; Neschen, S. ; Kastenmüller, G. ; Wang-Sattler, R.

Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.

Diabetes 65, 3776-3785 (2016)

Bergamini, C. ; Moruzzi, N. ; Volta, F. ; Faccioli, L. ; Gerdes, J.M. ; Mondardini, M.C. ; Fato, R.

Role of mitochondrial complex I and protective effect of CoQ10 supplementation in propofol induced cytotoxicity.

J. Bioenerg. Biomembr. 48, 413-423 (2016)

Migliorini, A. ; Roscioni, S. ; Lickert, H.

Targeting insulin-producing beta cells for regenerative therapy.

Diabetologia 59, 1838-1842 (2016)

Bader, E.^# ; Migliorini, A.^# ; Gegg, M. ; Moruzzi, N. ; Gerdes, J.M. ; Roscioni, S. ; Bakhti, M. ; Brandl, E. ; Irmler, M. ; Beckers, J. ; Aichler, M. ; Feuchtinger, A. ; Leitzinger, C. ; Zischka, H. ; Wang-Sattler, R. ; Jastroch, M. ; Tschöp, M.H. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Chmelova, H. ; Chouinard, J.A. ; Oskolkov, N. ; Korsgren, O. ; Speier, S. ; Lickert, H.

Identification of proliferative and mature β-cells in the islets of Langerhans.

Nature 535, 430-434 (2016)

Hoppe, P.S. ; Schwarzfischer, M. ; Loeffler, D. ; Kokkaliaris, K.D. ; Hilsenbeck, O. ; Moritz, N. ; Endele, M. ; Filipczyk, A. ; Gambardella, A. ; Ahmed, N. ; Etzrodt, M. ; Coutu, D.L. ; Rieger, M.A. ; Marr, C. ; Strasser, M. ; Schauberger, B. ; Burtscher, I. ; Ermakova, O. ; Bürger, A. ; Lickert, H. ; Nerlov, C. ; Theis, F.J. ; Schroeder, T.

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Nature 535, 299-302 (2016)

Icb_qscd

Klancic, T. ; Woodward, L. ; Hofmann, S.M. ; Fisher, E.A.

High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties.

Mol. Metab. 5, 321-327 (2016)

Haensel, I. ; Rotter, M. ; Lauffer, F. ; Biedermann, T. ; Zink, A.

The impact of gliding on the prevalence of non-melanoma skin cancer and its precursors - a cross-sectional study among male pilots of glider aircrafts in Bavaria.

Exp. Dermatol. 25, E16 (2016)

Preusse, M. ; Theis, F.J. ; Müller, N.S.

miTALOS v2: Analyzing tissue specific microRNA function.

PLoS ONE 11:e0151771 (2016)

Icb_rene

Jung, B. ; Messias, A.C. ; Schorpp, K.K. ; Geerlof, A. ; Schneider, G. ; Saur, D. ; Hadian, K. ; Sattler, M. ; Wanker, E.E. ; Hasenöder, S. ; Lickert, H.

Novel small molecules targeting ciliary transport of smoothened and oncogenic Hedgehog pathway activation.

Sci. Rep. 6:22540 (2016)

Rotter, M. ; Nigg, C.R. ; Renda, G.A. ; Novotny, R.

Acculturation is not related to physical activity stage of change for children in Hawai'i.

Hawaii J. Med. Public Health 75, 35-41 (2016)

Jung, B. ; Padula, D. ; Burtscher, I. ; Landerer, C. ; Lutter, D. ; Theis, F.J. ; Messias, A.C. ; Geerlof, A. ; Sattler, M. ; Kremmer, E. ; Boldt, K. ; Ueffing, M. ; Lickert, H.

Pitchfork and Gprasp2 target smoothened to the primary cilium for Hedgehog pathway activation.

PLoS ONE 11:e0149477 (2016)

Willmann, S.^# ; Müller, N.S.^# ; Engert, S. ; Sterr, M. ; Burtscher, I. ; Raducanu, A. ; Irmler, M. ; Beckers, J. ; Sass, S. ; Theis, F.J. ; Lickert, H.

The global gene expression profile of the secondary transition during pancreatic development.

Mech. Dev. 139, 51-64 (2016)

Icb_rene

Icb_VLN

Icb_LungSys

Icb_Latent Causes

Petrezselyova, S. ; Kinsky, S. ; Truban, D. ; Sedlacek, R. ; Burtscher, I. ; Lickert, H.

Homology arms of targeting vectors for gene insertions and Crispr/Cas9 technology: Size does not matter; quality control of targeted clones does.

Cell. Mol. Biol. Lett. 20, 773-787 (2016)

Schlüssel, E. ; Migliorini, A. ; Bader, E. ; Lickert, H.

Diabetes mellitus: Zelluläre Plastizität und Perspektiven für die regenerative Therapie.

For. Med. Exz. Med. 5, 43-47 (2015)

Johansson, E. ; Andersson, L.B. ; Örnros, J. ; Carlsson, T. ; Ingeson-Carlsson, C. ; Liang, S. ; Dahlberg, J. ; Jansson, S.A. ; Parrillo, L. ; Zoppoli, P. ; Barila, G.O. ; Altschuler, D.L. ; Padula, D. ; Lickert, H. ; Fagman, H. ; Nilsson, M.

Revising the embryonic origin of thyroid C cells in mice and humans.

Development 142, 3519-3528 (2015)

Preusse, M. ; Marr, C. ; Saunders, S. ; Maticzka, D. ; Lickert, H. ; Backofen, R. ; Theis, F.J.

SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins.

RNA Biol. 12, 998-1009 (2015)

Icb_qscd

Carvalho, L.A. ; Gerdes, J.M. ; Strell, C. ; Wallace, G.R. ; Martins, J.O.

Interplay between the endocrine system and immune cells.

Biomed Res. Int. 2015:986742 (2015)

Schmitz, F. ; Roscioni, S. ; Lickert, H.

Repurposing an osteoporosis drug for β cell regeneration in diabetic patients.

Cell Metab. 22, 58-59 (2015)

Stoy, C. ; Sundaram, A. ; Rios Garcia, M. ; Wang, X. ; Seibert, O. ; Zota, A. ; Wendler, S. ; Männle, D. ; Hinz, U. ; Sticht, C. ; Muciek, M. ; Gretz, N. ; Rose, A.J. ; Greiner, V. ; Hofmann, T.G. ; Bauer, A. ; Hoheisel, J. ; Berriel Diaz, M. ; Gaida, M.M. ; Werner, J. ; Schafmeier, T. ; Strobel, O.° ; Herzig, S.°

Transcriptional co-factor Transducin Beta-Like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.

EMBO Mol. Med. 7, 1048-1062 (2015)

Roscioni, S. ; Heerspink, H.J.

New nonabsorbable potassium-exchange resins in hyperkalaemia.

Nat. Rev. Nephrol. 11, 205-206 (2015)

Migliorini, A. ; Lickert, H.

Beyond association: A functional role for Tcf7l2 in β-cell development.

Mol. Metab. 4, 365-366 (2015)

Clemmensen, C. ; Finan, B. ; Fischer, K. ; Tom, R.Z. ; Legutko, B. ; Sehrer, L. ; Heine, D. ; Grassl, N. ; Meyer, C.W. ; Henderson, B. ; Hofmann, S.M. ; Tschöp, M.H. ; van der Ploeg, L.H.T. ; Müller, T.D.

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

EMBO Mol. Med. 7, 288-298 (2015)

Hofmann, S.M. ; Havel, P.J.

The good, the bad, and the unknown: Fructose and FGF21.

Mol. Metab. 4, 1-2 (2015)

Padula, D.

Functional analysis of Pitchfork and G-protein coupled associated sorting protein 2 in the mouse.

München, Technische Universität, Fakultät für Medizin, Diss., 2014, 177 S.

van de Laar, E. ; Clifford, M. ; Hasenöder, S. ; Kim, B. ; Wang, D. ; Lee, S. ; Paterson, J. ; Vu, N.M. ; Waddell, T.K. ; Keshavjee, S. ; Tsao, M.S. ; Ailles, L. ; Moghal, N.

Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.

Respir. Res. 15:1513 (2014)

Goldman, O.^# ; Han, S.^# ; Hamou, W. ; Jodon de Villeroche, V. ; Uzan, G. ; Lickert, H. ; Gouon-Evans, V.

Endoderm generates endothelial cells during liver development.

Stem Cell Rep. 3, 556-565 (2014)

Gerdes, J.M. ; Christou-Safina, S. ; Xiong, Y. ; Moede, T. ; Moruzzi, N. ; Karlsson-Edlund, P. ; Leibiger, B. ; Leibiger, I. ; Ostenson, C.G. ; Beales, P. ; Berggren, P.O.

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.

Nat. Commun. 5:5308 (2014)

Gegg, M. ; Böttcher, A. ; Burtscher, I. ; Hasenöder, S. ; van Campenhout, C.A. ; Aichler, M. ; Walch, A.K. ; Grant, S.G. ; Lickert, H.

Flattop regulates basal body docking and positioning in mono- and multiciliated cells.

eLife 3:e03842 (2014)

Matthes, M.^# ; Preusse, M.^# ; Zhang, J.^# ; Schechter, J. ; Mayer, D. ; Lentes, B. ; Theis, F.J. ; Prakash, N. ; Wurst, W.° ; Trümbach, D.°

Mouse IDGenes: A reference database for genetic interactions in the developing mouse brain.

Database 2014:bau083 (2014)

Icb_rene

Moruzzi, N. ; Del Sole, M. ; Fato, R. ; Gerdes, J.M. ; Berggren, P.O. ; Bergamini, C. ; Brismar, K.

Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: Metabolic and osmotic effects.

Int. J. Biochem. Cell Biol. 53, 66-76 (2014)

Gegg, M.

Identification and characterization of the novel planar cell polarity gene Flattop (Fltp).

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014, 163 S.

Engert, S.

Epigenetic and transcriptional regulation of early mouse development.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2014

Worzfeld, T. ; Swiercz, J.M. ; Sentürk, A. ; Genz, B. ; Korostylev, A. ; Deng, S. ; Xia, J.J. ; Hoshino, M. ; Epstein, J.A. ; Chan, A.M. ; Vollmar, B. ; Acker-Palmer, A. ; Kuner, R. ; Offermanns, S.

Genetic dissection of plexin signaling in vivo.

Proc. Natl. Acad. Sci. U.S.A. 111, 2194-2199 (2014)

Migliorini, A. ; Bader, E. ; Lickert, H.

Islet cell plasticity and regeneration.

Mol. Metab. 3, 268–274 (2014)

Yang, D.^# ; Lutter, D.^# ; Burtscher, I. ; Uetzmann, L. ; Theis, F.J.° ; Lickert, H.°

miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.

Development 141, 514-525 (2014)

Icb_Latent Causes

Icb_ML

Clemmensen, C. ; Chabenne, J. ; Finan, B. ; Sullivan, L. ; Fischer, K. ; Küchler, D. ; Sehrer, L. ; Ograjsek, T. ; Hofmann, S. ; Schriever, S.C. ; Pfluger, P.T. ; Pinkstaff, J.K. ; Tschöp, M.H.° ; DiMarchi, R.° ; Müller, T.D.

GLP-1/glucagon co-agonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet.

Diabetes 63, 1422-1427 (2014)

Keuper, M.^# ; Jastroch, M.^# ; Yi, C.-X. ; Fischer-Posovszky, P. ; Wabitsch, M. ; Tschöp, M.H. ; Hofmann, S.M.

Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions.

FASEB J. 28, 761-770 (2014)

Bakhti, M.° ; Aggarwal, S. ; Simons, M.°

Myelin architecture: Zippering membranes tightly together.

Cell. Mol. Life Sci. 71, 1265-1277 (2014)

Finan, B.^# ; Ma, T.^# ; Ottaway, N. ; Müller, T.D. ; Habegger, K.M. ; Heppner, K.M. ; Kirchner, H. ; Holland, J. ; Hembree, J. ; Raver, C. ; Lockie, S.H. ; Smiley, D.L. ; Gelfanov, V. ; Yang, B. ; Hofmann, S. ; Bruemmer, D. ; Drucker, D.J. ; Pfluger, P.T. ; Perez-Tilve, D. ; Gidda, J. ; Vignati, L. ; Zhang, L. ; Hauptman, J.B. ; Lau, M. ; Brecheisen, M. ; Uhles, S. ; Riboulet, W. ; Hainaut, E. ; Sebokova, E. ; Conde-Knape, K. ; Konkar, A. ; DiMarchi, R.D.° ; Tschöp, M.H.°

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Sci. Transl. Med. 5:209ra151 (2013)

Habegger, K.M. ; Donelan, E. ; Abplanalp, W. ; Al-Massadi, O. ; Habegger, K.M. ; Weber, J. ; Ress, C. ; Mansfeld, J. ; Somvanshi, S. ; Trivedi, C. ; Keuper, M. ; Ograjsek, T. ; Striese, C. ; Cucuruz, S. ; Pfluger, P.T. ; Krishna, R. ; Gordon, S.M. ; Silva, R.A. ; Luquet, S. ; Castel, J. ; Martinez, S. ; D'Alessio, D. ; Davidson, W.S. ; Hofmann, S.M.

High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.

Circulation 128, 2364-2371 (2013)

Engert, S. ; Burtscher, I. ; Kalali, B. ; Gerhard, M. ; Lickert, H.

The Sox17^CreERT2 knock-in mouse line displays spatiotemporal activation of Cre recombinase in distinct Sox17 lineage progenitors.

Genesis 51, 793-802 (2013)

Filipczyk, A. ; Gkatzis, K. ; Fu, J. ; Hoppe, P.S. ; Lickert, H. ; Anastassiadis, K. ; Schroeder, T.

Biallelic expression of nanog protein in mouse embryonic stem cells.

Cell Stem Cell 13, 12-13 (2013)

Lickert, H.

Betatrophin fuels β cell proliferation: First step toward regenerative therapy?

Cell Metab. 18, 5-6 (2013)

Rinck, A.^# ; Preusse, M.^# ; Laggerbauer, B. ; Lickert, H. ; Engelhardt, S.° ; Theis, F.J.°

The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance.

RNA Biol. 10, 1125-1135 (2013)

Icb_rene

Icb_InKoMBio_RNA

Icb_BioSysNet

Modzelewska, K. ; Lauritzen, A. ; Hasenöder, S. ; Brown, L. ; Georgiou, J. ; Moghal, N.

Neurons refine the Caenorhabditis elegans body plan by directing axial patterning by Wnts.

PLoS Biol. 11:e1001465 (2013)

Engert, S. ; Burtscher, I. ; Liao, W.P. ; Dulev, S. ; Schotta, G. ; Lickert, H.

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse.

Development 140, 3128-3138 (2013)

Burtscher, I. ; Barkey, W. ; Lickert, H.

Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation.

Genesis 51, 596-604 (2013)

Müller, T.D.^# ; Müller, A.^# ; Yi, C.-X.^# ; Habegger, K.M. ; Meyer, C.W. ; Gaylinn, B.D. ; Finan, B. ; Heppner, K. ; Trivedi, C. ; Bielohuby, M. ; Abplanalp, W. ; Meyer, F. ; Piechowski, C.L. ; Pratzka, J. ; Stemmer, K. ; Holland, J. ; Hembree, J. ; Bhardwaj, N. ; Raver, C. ; Ottaway, N. ; Krishna, R. ; Sah, R. ; Sallee, F.R. ; Woods, S.C. ; Perez-Tilve, D. ; Bidlingmaier, M. ; Thorner, M.O. ; Krude, H. ; Smiley, D. ; DiMarchi, R. ; Hofmann, S. ; Pfluger, P.T. ; Kleinau, G. ; Biebermann, H. ; Tschöp, M.H.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Nat. Commun. 4:1968 (2013)

Habegger, K.M. ; Stemmer, K. ; Cheng, C. ; Müller, T.D. ; Heppner, K.M. ; Ottaway, N. ; Holland, J. ; Hembree, J.L. ; Smiley, D. ; Gelfanov, V. ; Krishna, R. ; Arafat, A.M. ; Konkar, A. ; Belli, S. ; Kapps, M. ; Woods, S.C. ; Hofmann, S.M. ; D'Alessio, D. ; Pfluger, P.T. ; Perez-Tilve, D. ; Seeley, R.J. ; Konishi, M. ; Itoh, N. ; Kharitonenkov, A. ; Spranger, J. ; DiMarchi, R.D. ; Tschöp, M.H.

Fibroblast growth factor 21 mediates specific glucagon actions.

Diabetes 62, 1453-1463 (2013)

Müller, T.D. ; Tschöp, M.H. ; Hofmann, S.M.

Emerging function of fat mass and obesity-associated protein (FTO).

PLoS Genet. 9:e1003223 (2013)

Müller, T.D. ; Lee, S.J. ; Jastroch, M. ; Kabra, D. ; Stemmer, K. ; Aichler, M. ; Abplanalp, B. ; Ananthakrishnan, G. ; Bhardwaj, N. ; Collins, S. ; Divanovic, S. ; Endele, M. ; Finan, B. ; Gao, Y. ; Habegger, K.M. ; Hembree, J. ; Heppner, K.M. ; Hofmann, S. ; Holland, J. ; Küchler, D. ; Kutschke, M. ; Krishna, R. ; Lehti, M. ; Oelkrug, R. ; Ottaway, N. ; Perez-Tilve, D. ; Raver, C. ; Walch, A.K. ; Schriever, S.C. ; Speakman, J. ; Tseng, Y.H. ; Diaz-Meco, M. ; Pfluger, P.T. ; Moscat, J. ; Tschöp, M.H.

P62 links β-adrenergic input to mitochondrial function and thermogenesis.

J. Clin. Invest. 123, 469-478 (2013)

Lickert, H. ; van Campenhout, C.A.

Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.

Commun. Integr. Biol. 5, 287-290 (2012)

Wang-Sattler, R. ; Yu, Z. ; Herder, C. ; Messias, A.C. ; Floegel, A. ; He, Y. ; Heim, K. ; Campillos, M.J. ; Holzapfel, C. ; Thorand, B. ; Grallert, H. ; Xu, T. ; Bader, E. ; Huth, C. ; Mittelstraß, K. ; Döring, A. ; Meisinger, C. ; Gieger, C. ; Prehn, C. ; Römisch-Margl, W. ; Carstensen, M. ; Xie, L. ; Yamanaka-Okumura, H. ; Xing, G. ; Ceglarek, U. ; Thiery, J. ; Giani, G. ; Lickert, H. ; Lin, X. ; Li, Y. ; Boeing, H. ; Joost, H.-G. ; Hrabě de Angelis, M. ; Rathmann, W. ; Suhre, K. ; Prokisch, H. ; Peters, A. ; Meitinger, T. ; Roden, M. ; Wichmann, H.-E. ; Pischon, T. ; Adamski, J. ; Illig, T.

Novel biomarkers for pre-diabetes identified by metabolomics.

Mol. Syst. Biol. 8:615 (2012)

Raducanu, A. ; Lickert, H.

Understanding pancreas development for β-cell repair and replacement therapies.

Curr. Diab. Rep. 12, 481-489 (2012)

Gardiner, J.R. ; Jackson, A.L. ; Gordon, J. ; Lickert, H. ; Manley, N.R. ; Basson, M.A.

Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis.

Development 139, 3456-3466 (2012)

Horn, S. ; Kobberup, S. ; Jorgensen, M.C. ; Kalisz, M. ; Klein, T. ; Kageyama, R. ; Gegg, M. ; Lickert, H. ; Lindner, J. ; Magnuson, M.A. ; Kong, Y.Y. ; Serup, P. ; Ahnfelt-Ronne, J. ; Jensen, J.N.

Mind bomb 1 is required for pancreatic β-cell formation.

Proc. Natl. Acad. Sci. U.S.A. 109, 7356-7361 (2012)

Rothova, M. ; Thompson, H. ; Lickert, H. ; Tucker, A.S.

Lineage tracing of the endoderm during oral development.

Dev. Dyn. 241, 1183-1191 (2012)

Burtscher, I. ; Barkey, W. ; Schwarzfischer, M. ; Theis, F.J. ; Lickert, H.

The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development.

Genesis 50, 496-505 (2012)

Lange, A. ; Gegg, M. ; Burtscher, I. ; Bengel, D. ; Kremmer, E. ; Lickert, H.

Fltp^T2AiCre: A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues.

Differentiation 83, S105-S113 (2012)

Simon, C. ; Lickert, H. ; Götz, M. ; Dimou, L.

Sox10-iCreER^T2 : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.

Genesis 50, 506-515 (2012)

Frauer, C. ; Rottach, A. ; Meilinger, D. ; Bultmann, S. ; Fellinger, K. ; Hasenöder, S. ; Wang, M. ; Qin, W. ; Söding, J. ; Spada, F. ; Leonhardt, H.

Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1.

PLoS ONE 6:e16627 (2011)

van Campenhout, C.A. ; Eitelhuber, A. ; Gloeckner, C.J. ; Giallonardo, P. ; Gegg, M. ; Oller, H. ; Grant, S.G. ; Krappmann, D. ; Ueffing, M. ; Lickert, H.

Dlg3 trafficking and apical tight junction formation is regulated by Nedd4 and Nedd4-2 E3 ubiquitin ligases.

Dev. Cell 21, 479-491 (2011)

PROT-CF

Simrick, S. ; Lickert, H. ; Basson, M.A.

Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo.

Dev. Biol. 358, 147-155 (2011)

David, R. ; Jarsch, V.B. ; Schwarz, F. ; Nathan, P. ; Gegg, M. ; Lickert, H. ; Franz, W.M.

Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell.

Cardiovasc. Res. 92, 115-122 (2011)

Chow, J.C. ; Watson, J.G. ; Robles, J. ; Wang, X. ; Chen, L.W. ; Trimble, D.L. ; Kohl, S.D. ; Tropp, R.J. ; Fung, K.K.

Quality assurance and quality control for thermal/optical analysis of aerosol samples for organic and elemental carbon.

Anal. Bioanal. Chem. 401, 3141-52 (2011)

Glasmacher, E. ; Höfig, K.P. ; Vogel, K.U. ; Rath, N. ; Du, L. ; Wolf, C. ; Kremmer, E. ; Wang, X. ; Heissmeyer, V.

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.

Nat. Immunol. 11, 725-733 (2010)

PROT-CF

Wenzlau, J.M. ; Walter, M.C. ; Gardner, T.J. ; Frisch, L.M. ; Yu, L. ; Eisenbarth, G.S. ; Ziegler, A.-G. ; Davidson, H.W. ; Hutton, J.C.

Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

J. Clin. Endocrinol. Metab. 95, 4712-9 (2010)

Bengel, D.

Die Identifikation und Charakterisierung neuer Spemann/Mangold Organisatorgene.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2009, 170 S.

Imhof, S.

Endoderm lineage labelling using BAC reporter constructs in ES cells and mouse embryos.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2009, 166 S.

Uetzmann, L.

Differentiation of the endoderm lineage in the murine system.

München, Technische Universität, Fakultät Wissenschaftszentrum Weihenstephan, Diss., 2009, 138 S.

von Both, I. ; Silvestri, C. ; Erdemir, T. ; Lickert, H. ; Walls, J.R. ; Henkelman, R.M. ; Rossant, J. ; Harvey, R.P. ; Attisano, L. ; Wrana, J.L.

Foxh1 is essential for development of the anterior heart field.

Dev. Cell 7, 331-345 (2004)

Ben Abdelkhalek, H ; Beckers, A. ; Burkhardt, H ; Ceolin, M ; Rivera-Pomar, R

The mouse homeobox gene Not is required for caudal notochord development and affected 1725 by the truncate mutation

Genes Dev. 18, 1725-1736 (2004)

Lickert, H. ; Takeuchi, J.K. ; von Both, I. ; Walls, J.R. ; McAuliffe, F. ; Adamson, S.L. ; Henkelman, R.M. ; Wrana, J.L. ; Rossant, J. ; Bruneau, B.G.

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.

Nature 432, 107-112 (2004)

Wehrle, C. ; Lickert, H. ; Kemler, R.

Wnt Signaling in Development. Handbook of Cell Signaling (Volume 1-3)

2003.

Kunath, T. ; Gish, G. ; Lickert, H. ; Jones, N. ; Pawson, T. ; Rossant, J.

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

Nat. Biotechnol. 21, 559-561 (2003)

Lickert, H. ; Kutsch, S. ; Kanzler, B. ; Tamai, Y. ; Taketo, M.M. ; Kemler, R.

Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.

Dev. Cell 3, 171-181 (2002)

Lickert, H. ; Kemler, R.