Publications

2021

Salinno, C. ; Büttner, M. ; Cota, P. ; Tritschler, S. ; Tarquis-Medina, M. ; Bastidas-Ponce, A. ; Scheibner, K. ; Burtscher, I. ; Böttcher, A. ; Theis, F.J. ; Bakhti, M. ; Lickert, H.

CD81 marks immature and dedifferentiated pancreatic β-cells.

Mol. Metab. 49:101188 (2021)

Maya-Monteiro, C.M. ; Correâ-Da-Silva, F. ; Hofmann, S.M. ; Hesselink, M.K.C. ; la Fleur, S.E. ; Yi, C.X.

Lipid droplets accumulate in the hypothalamus of mice and humans with and without metabolic diseases.

Neuroendocrinology 111, 263-272 (2021)

Burtscher, I. ; Tarquis Medina, M. ; Schirge, S. ; Beckenbauer, J. ; Bakhti, M. ; Lickert, H.

Generation of a novel nkx6-1 venus fusion reporter mouse line.

Int. J. Mol. Sci. 22:3434 (2021)

Müller, J.A. ; Groß, R. ; Conzelmann, C. ; Krüger, J. ; Merle, U. ; Steinhart, J. ; Weil, T. ; Koepke, L. ; Bozzo, C.P. ; Read, C. ; Fois, G. ; Eiseler, T. ; Gehrmann, J. ; van Vuuren, J. ; Wessbecher, I.M. ; Frick, M. ; Costa, I.G. ; Breunig, M. ; Grüner, B. ; Peters, L. ; Schuster, M. ; Liebau, S. ; Seufferlein, T. ; Stenger, S. ; Stenzinger, A. ; MacDonald, P.E. ; Kirchhoff, F. ; Sparrer, K.M.J. ; Walther, P. ; Lickert, H. ; Barth, T.F.E. ; Wagner, M. ; Münch, J. ; Heller, S. ; Kleger, A.

SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas.

Nat. Metab. 3, 149-165 (2021)

Nasteska, D. ; Fine, N.H.F. ; Ashford, F.B. ; Cuozzo, F. ; Viloria, K. ; Smith, G. ; Dahir, A. ; Dawson, P.W.J. ; Lai, Y.C. ; Bastidas-Ponce, A. ; Bakhti, M. ; Rutter, G.A. ; Fiancette, R. ; Nano, R. ; Piemonti, L. ; Lickert, H. ; Zhou, Q. ; Akerman, I. ; Hodson, D.J.

PDX1^LOW MAFA^LOW β-cells contribute to islet function and insulin release.

Nat. Commun. 12:674 (2021)

Ansarullah ; Jain, C. ; Far, F.F. ; Homberg, S. ; Wissmiller, K. ; Gräfin von Hahn, F. ; Raducanu, A. ; Schirge, S. ; Sterr, M. ; Bilekova, S. ; Siehler, J. ; Wiener, J. ; Oppenländer, L. ; Morshedi, A. ; Bastidas-Ponce, A. ; Collden, G. ; Irmler, M. ; Beckers, J. ; Feuchtinger, A. ; Grzybek, M. ; Ahlbrecht, C. ; Feederle, R. ; Plettenburg, O. ; Müller, T.D. ; Meier, M. ; Tschöp, M.H. ; Coskun, Ü. ; Lickert, H.

Inceptor counteracts insulin signalling in β-cells to control glycaemia.

Nature 590, 326–331 (2021)

Zhang, Q. ; Delessa, C.T. ; Augustin, R. ; Bakhti, M. ; Collden, G. ; Drucker, D.J. ; Feuchtinger, A. ; García-Cáceres, C. ; Grandl, G. ; Harger, A. ; Herzig, S. ; Hofmann, S.M. ; Holleman, C.L. ; Jastroch, M. ; Keipert, S. ; Kleinert, M. ; Knerr, P.J. ; Kulaj, K. ; Legutko, B. ; Lickert, H. ; Liu, X. ; Luippold, G. ; Lutter, D. ; Malogajski, E. ; Tarquis Medina, M. ; Mowery, S.A. ; Blutke, A. ; Perez-Tilve, D. ; Salinno, C. ; Sehrer, L. ; DiMarchi, R.D. ; Tschöp, M.H. ; Stemmer, K. ; Finan, B. ; Wolfrum, C. ; Müller, T.D.

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling.

Cell Metab. 33, 833-844.e5 (2021)

Böttcher, A. ; Büttner, M. ; Tritschler, S. ; Sterr, M. ; Aliluev, A. ; Oppenländer, L. ; Burtscher, I. ; Sass, S. ; Irmler, M. ; Beckers, J. ; Ziegenhain, C. ; Enard, W. ; Schamberger, A.C. ; Verhamme, F.M. ; Eickelberg, O. ; Theis, F.J.° ; Lickert, H.°

Non-canonical Wnt/PCP signalling regulates intestinal stem cell lineage priming towards enteroendocrine and Paneth cell fates.

Nat. Cell Biol. 23, 23-31 (2021)

Bilekova, S. ; Sachs, S. ; Lickert, H.

Pharmacological targeting of endoplasmic reticulum stress in pancreatic beta cells.

Trends Pharmacol. Sci. 42, 85-95 (2021)

Siehler, J. ; Blöchinger, A. ; Akgün, M. ; Wang, X. ; Shahryari, A. ; Geerlof, A. ; Lickert, H.° ; Burtscher, I.°

Generation of a heterozygous C-peptide-mCherry reporter human iPSC line (HMGUi001-A-8).

Stem Cell Res. 50:102126 (2021)

Karlina, R. ; Lutter, D. ; Miok, V. ; Fischer, D.S. ; Altun, I. ; Schöttl, T. ; Schorpp, K.K. ; Israel, A. ; Cero, C. ; Johnson, J.W. ; Kapser-Fischer, I. ; Böttcher, A. ; Keipert, S. ; Feuchtinger, A. ; Graf, E. ; Strom, T.M. ; Walch, A.K. ; Lickert, H. ; Walzthoeni, T. ; Heinig, M. ; Theis, F.J. ; García-Cáceres, C. ; Cypess, A.M. ; Ussar, S.

Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice.

Life Sci. All. 4:e202000924 (2021)

Sachs, S. ; Niu, L. ; Geyer, P. ; Jall, S. ; Kleinert, M. ; Feuchtinger, A. ; Stemmer, K. ; Brielmeier, M. ; Finan, B. ; DiMarchi, R.D. ; Tschöp, M.H. ; Wewer Albrechtsen, N. ; Mann, M. ; Müller, T.D.° ; Hofmann, S.M.°

Plasma proteome profiles treatment efficacy of incretin dual agonism in diet-induced obese female and male mice.

Diabetes Obes. Metab. 23, 195-207 (2021)

2020

Xiong, Y. ; Scerbo, M.J. ; Seelig, A. ; Volta, F. ; O'Brien, N. ; Dicker, A. ; Padula, D. ; Lickert, H. ; Gerdes, J.M. ; Berggren, P.O.

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling.

eLife 9:e56914 (2020)

Frankó, A. ; Berti, L. ; Guirguis, A. ; Hennenlotter, J. ; Wagner, R. ; Scharpf, M.O. ; Hrabě de Angelis, M. ; Wissmiller, K. ; Lickert, H. ; Stenzl, A. ; Birkenfeld, A.L. ; Peter, A. ; Häring, H.-U. ; Lutz, S.Z. ; Heni, M.

Characterization of hormone-dependent pathways in six human prostate-cancer cell lines: A gene-expression study.

Genes 11:1174 (2020)

Lickert, H. ; Moya, N. ; Siehler, J. ; Wang, X. ; Blöchinger, A. ; Burtscher, I. ; Bakhti, M. ; Mowla, S.J.

Generation of a human iPSC line harboring a biallelic large deletion at the INK4 locus (HMGUi001-A-5).

Stem Cell Res. 47:101927 (2020)

Moya, N. ; Shahryari, A. ; Burtscher, I. ; Beckenbauer, J. ; Bakhti, M. ; Lickert, H.

Generation of a homozygous ARX nuclear CFP (ARX(nCFP/nCFP)) reporter human iPSC line (HMGUi001-A-4).

Stem Cell Res. 46:101874 (2020)

Blöchinger, A. ; Siehler, J. ; Wißmiller, K. ; Shahryari, A. ; Burtscher, I. ; Lickert, H.

Generation of an INSULIN-H2B-Cherry reporter human iPSC line.

Stem Cell Res. 45:101797 (2020)

Mahaddalkar, P.U. ; Scheibner, K. ; Pfluger, S. ; Ansarullah ; Sterr, M. ; Beckenbauer, J. ; Irmler, M. ; Beckers, J. ; Knöbel, S. ; Lickert, H.

Generation of pancreatic β cells from CD177⁺ anterior definitive endoderm.

Nat. Biotechnol. 38, 1061–1072 (2020)

Kozak, E.L. ; Palit, S. ; Miranda Rodriguez, J.R. ; Janjic, A. ; Böttcher, A. ; Lickert, H. ; Enard, W. ; Theis, F.J. ; López-Schier, H.

Epithelial planar bipolarity emerges from Notch-mediated asymmetric inhibition of Emx2.

Curr. Biol. 30, 1142-1151 (2020)

Wiener, J. ; Kokotek, D. ; Rosowski, S. ; Lickert, H. ; Meier, M.

Preparation of single- and double-oligonucleotide antibody conjugates and their application for protein analytics.

Sci. Rep. 10:1457 (2020)

Rubey, M. ; Chhabra, N.F. ; Gradinger, D. ; Sanz-Moreno, A. ; Lickert, H. ; Przemeck, G.K.H.° ; Hrabě de Angelis, M.°

DLL1- and DLL4-mediated Notch signaling is essential for adult pancreatic islet homeostasis.

Diabetes 69, 915-926 (2020)

Cota, P. ; Helmi, S.A. ; Hsu, C. ; Rancourt, D.E.

Cytokine directed chondroblast trans-differentiation: JAK inhibition facilitates direct reprogramming of fibroblasts to chondroblasts.

Cells 9:191 (2020)

Sachs, S. ; Bastidas-Ponce, A. ; Tritschler, S. ; Bakhti, M. ; Böttcher, A. ; Sánchez-Garrido, M.A. ; Tarquis Medina, M. ; Kleinert, M. ; Fischer, K. ; Jall, S. ; Harger, A. ; Bader, E. ; Roscioni, S. ; Ussar, S. ; Feuchtinger, A. ; Yesildag, B. ; Neelakandhan, A. ; Jensen, C.B. ; Cornu, M. ; Yang, B. ; Finan, B. ; DiMarchi, R.D. ; Tschöp, M.H. ; Theis, F.J.° ; Hofmann, S.M.° ; Müller, T.D.° ; Lickert, H.°

Targeted pharmacological therapy restores β-cell function for diabetes remission.

Nat. Metab. 2, 192-209 (2020)

2019

Volta, F. ; Scerbo, M.J. ; Seelig, A. ; Wagner, R. ; O'Brien, N. ; Gerst, F. ; Fritsche, A. ; Häring, H.-U. ; Zeigerer, A. ; Ullrich, S. ; Gerdes, J.M.

Glucose homeostasis is regulated by pancreatic beta-cell cilia via endosomal EphA-processing.

Nat. Commun. 10:5686 (2019)

Salinno, C. ; Cota, P. ; Bastidas-Ponce, A. ; Tarquis Medina, M. ; Lickert, H. ; Bakhti, M.

β-cell maturation and identity in health and disease.

Int. J. Mol. Sci. 20:5417 (2019)

Kleinert, M. ; Sachs, S. ; Habegger, K.M. ; Hofmann, S.M. ; Müller, T.D.

Glucagon regulation of energy expenditure.

Int. J. Mol. Sci. 20:5407 (2019)

Bakhti, M.° ; Scheibner, K. ; Tritschler, S. ; Bastidas-Ponce, A. ; Tarquis-Medina, M. ; Theis, F.J. ; Lickert, H.°

Establishment of a high-resolution 3D modeling system for studying pancreatic epithelial cell biology in vitro.

Mol. Metab. 30, 16-29 (2019)

Shahryari, A.^#° ; Saghaeian Jazi, M. ; Mohammadi, S. ; Nikoo, H.R. ; Nazari, Z. ; Hosseini, E.S. ; Burtscher, I. ; Mowla, S.J. ; Lickert, H.^#°

Development and clinical translation of approved gene therapy products for genetic disorders.

Front. Genet. 10:868 (2019)

Wang, X. ; Malinowski, A.R. ; Beckenbauer, J. ; Siehler, J. ; Blöchinger, A. ; Meitinger, T. ; Häring, H.-U. ; Staiger, H. ; Burtscher, I. ; Lickert, H.

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Stem Cell Res. 39:101531 (2019)

Saba, R. ; Kitajima, K. ; Rainbow, L. ; Engert, S. ; Uemura, M. ; Ishida, H. ; Kokkinopoulos, I. ; Shintani, Y. ; Miyagawa, S. ; Kanai, Y. ; Kanai-Azuma, M. ; Koopman, P. ; Meno, C. ; Kenny, J. ; Lickert, H. ; Saga, Y. ; Suzuki, K. ; Sawa, Y. ; Yashiro, K.

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.

Sci. Rep. 9:11953 (2019)

Scheibner, K. ; Bakhti, M. ; Bastidas-Ponce, A. ; Lickert, H.

Wnt signaling: Implications in endoderm development and pancreas organogenesis.

Curr. Opin. Cell Biol. 61, 48-55 (2019)

Cernilogar, F.M.° ; Hasenöder, S. ; Wang, Z. ; Scheibner, K. ; Burtscher, I. ; Sterr, M. ; Smialowski, P. ; Groh, S. ; Evenroed, I.M. ; Gilfillan, G.D. ; Lickert, H.° ; Schotta, G.°

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2.

Nucleic Acids Res. 47, 9069-9086 (2019)

Tritschler, S. ; Büttner, M. ; Fischer, D.S. ; Lange, M. ; Bergen, V. ; Lickert, H.° ; Theis, F.J.°

Concepts and limitations for learning developmental trajectories from single cell genomics.

Development 146:dev170506 (2019)

Gilleron, J. ; Gerdes, J.M. ; Zeigerer, A.

Metabolic regulation through the endosomal system.

Traffic 20, 552-570 (2019)

Bastidas-Ponce, A. ; Tritschler, S. ; Dony, L. ; Scheibner, K. ; Tarquis-Medina, M. ; Salinno, C. ; Schirge, S. ; Burtscher, I. ; Böttcher, A. ; Theis, F.J. ; Lickert, H. ; Bakhti, M.

Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis.

Development 146:dev173849 (2019)

Modic, M. ; Grosch, M. ; Rot, G. ; Schirge, S. ; Lepko, T. ; Yamazaki, T. ; Lee, F.C.Y. ; Rusha, E. ; Shaposhnikov, D. ; Palo, M. ; Merl-Pham, J. ; Cacchiarelli, D. ; Rogelj, B. ; Hauck, S.M. ; von Mering, C. ; Meissner, A. ; Lickert, H. ; Hirose, T. ; Ule, J. ; Drukker, M.

Cross-regulation between TDP-43 and paraspeckles promotes pluripotency-differentiation transition.

Mol. Cell 74, 951-965.e13 (2019)

Fischer, D.S. ; Fiedler, A. ; Kernfeld, E.M. ; Genga, R.M.J. ; Bastidas-Ponce, A. ; Bakhti, M. ; Lickert, H. ; Hasenauer, J. ; Maehr, R. ; Theis, F.J.

Inferring population dynamics from single-cell RNA-sequencing time series data.

Nat. Biotechnol. 37, 461-468 (2019)

Sacco, F. ; Seelig, A. ; Humphrey, S.J. ; Krahmer, N. ; Volta, F. ; Reggio, A. ; Marchetti, P. ; Gerdes, J.M. ; Mann, M.

Phosphoproteomics reveals the GSK3-PDX1 axis as a key pathogenic signaling node in diabetic islets.

Cell Metab. 29, 1422-1432.e3 (2019)

Kluth, O. ; Stadion, M. ; Gottmann, P. ; Aga, H. ; Jähnert, M. ; Scherneck, S. ; Vogel, H. ; Krus, U. ; Seelig, A. ; Ling, C. ; Gerdes, J.M. ; Schürmann, A.

Decreased expression of cilia genes in pancreatic islets as a risk factor for type 2 diabetes in mice and humans.

Cell Rep. 26, 3027-3036.e3 (2019)

Wang, X. ; Sterr, M. ; Ansarullah ; Burtscher, I. ; Böttcher, A. ; Beckenbauer, J. ; Meitinger, T. ; Häring, H.-U. ; Staiger, H. ; Cernilogar, F.M. ; Schotta, G. ; Irmler, M. ; Beckers, J. ; Wright, C.V.E. ; Bakhti, M. ; Lickert, H.

Point mutations in the PDX1 transactivation domain impair human beta-cell development and function.

Mol. Metab. 24, 80-97 (2019)

Niu, L. ; Geyer, P.E. ; Wewer Albrechtsen, N.J. ; Gluud, L.L. ; Santos, A. ; Doll, S. ; Treit, P.V. ; Holst, J.J. ; Knop, F.K. ; Vilsbøll, T. ; Junker, A. ; Sachs, S. ; Stemmer, K. ; Müller, T.D. ; Tschöp, M.H. ; Hofmann, S.M. ; Mann, M.

Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease.

Mol. Syst. Biol. 15:e8793 (2019)

Brennecke, P. ; Rasina, D. ; Aubi, O. ; Herzog, K. ; Landskron, J. ; Cautain, B. ; Vicente, F. ; Quintana, J. ; Mestres, J. ; Stechmann, B. ; Ellinger, B. ; Brea, J. ; Kolanowski, J.L. ; Pilarski, R. ; Orzaez, M. ; Pineda-Lucena, A. ; Laraia, L. ; Nami, F. ; Zielenkiewicz, P. ; Paruch, K. ; Hansen, E. ; von Kries, J.P. ; Neuenschwander, M. ; Specker, E. ; Bartunek, P. ; Simova, S. ; Leśnikowski, Z. ; Krauss, S. ; Lehtiö, L. ; Bilitewski, U. ; Brönstrup, M. ; Taskén, K. ; Jirgensons, A. ; Lickert, H. ; Clausen, M.H. ; Andersen, J.H. ; Vicent, M.J. ; Genilloud, O. ; Martinez, A. ; Nazaré, M. ; Fecke, W. ; Gribbon, P.

EU-OPENSCREEN: A novel collaborative approach to facilitate chemical biology.

SLAS Discov. 24, 398-413 (2019)

Sachs, S. ; Zarini, S. ; Kahn, D.E. ; Harrison, K.A. ; Perreault, L. ; Phang, T. ; Newsom, S.A. ; Strauss, A. ; Kerege, A. ; Schoen, J.A. ; Bessesen, D.H. ; Schwarzmayr, T. ; Graf, E. ; Lutter, D. ; Krumsiek, J. ; Hofmann, S.M. ; Bergman, B.C.

Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans.

Am. J. Physiol. Endocrinol. Metab. 316, E866-E879 (2019)

Norheim, F. ; Hasin-Brumshtein, Y. ; Vergnes, L. ; Chella Krishnan, K. ; Pan, C. ; Seldin, M.M. ; Hui, S.T. ; Mehrabian, M. ; Zhou, Z. ; Gupta, S. ; Parks, B.W. ; Walch, A.K. ; Reue, K. ; Hofmann, S.M. ; Arnold, A.P. ; Lusis, A.J.

Gene-by-sex interactions in mitochondrial functions and cardio-metabolic traits.

Cell Metab. 29, 932-949.e4 (2019)

Bakhti, M. ; Böttcher, A. ; Lickert, H.

Modelling the endocrine pancreas in health and disease.

Nat. Rev. Endocrinol. 15, 155-171 (2019)

Brokhman, I. ; Xu, J. ; Coles, B.L.K. ; Razavi, R. ; Engert, S. ; Lickert, H. ; Babona-Pilipos, R. ; Morshead, C.M. ; Sibley, E. ; Chen, C. ; van der Kooy, D.

Dual embryonic origin of the mammalian enteric nervous system.

Dev. Biol., DOI: 10.1016/j.ydbio.2018.11.014 (2019)

Keuper, M. ; Berti, L. ; Raedle, B. ; Sachs, S. ; Böhm, A. ; Fritsche, L. ; Fritsche, A. ; Häring, H.-U. ; Hrabě de Angelis, M. ; Jastroch, M. ; Hofmann, S.M. ; Staiger, H.

Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin.

Mol. Metab. 20, 28-37 (2019)

Clemmensen, C. ; Finan, B. ; Müller, T.D. ; DiMarchi, R.D. ; Tschöp, M.H. ; Hofmann, S.M.

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases.

Nat. Rev. Endocrinol. 15, 90-104 (2019)

2018

Saito, K. ; Nobuhisa, I. ; Harada, K. ; Takahashi, S. ; Anani, M. ; Lickert, H. ; Kanai-Azuma, M. ; Kanai, Y. ; Taga, T.

Maintenance of hematopoietic stem and progenitor cells in fetal intra-aortic hematopoietic clusters by the Sox17-Notch1-Hes1 axis.

Exp. Cell Res. 365, 145-155 (2018)

Clemmensen, C. ; Jall, S. ; Kleinert, M. ; Quarta, C. ; Gruber, T. ; Reber, J. ; Sachs, S. ; Fischer, K. ; Feuchtinger, A. ; Karlas, A. ; Simonds, S.E. ; Grandl, G. ; Loher, D. ; Sanchez-Quant, E. ; Keipert, S. ; Jastroch, M. ; Hofmann, S.M. ; Nascimento, E.B.M. ; Schrauwen, P. ; Ntziachristos, V. ; Cowley, M.A. ; Finan, B.° ; Müller, T.D.° ; Tschöp, M.H.°

Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes.

Nat. Commun. 9:4304 (2018)

Jørgensen, M.C. ; de Lichtenberg, K.H. ; Collin, C.A. ; Klinck, R. ; Ekberg, J.H. ; Engelstoft, M.S. ; Lickert, H. ; Serup, P.

Neurog3-dependent pancreas dysgenesis causes ectopic pancreas in Hes1 mutant mice.

Development 145:dev163568 (2018)

Rotter, M. ; Brandmaier, S. ; Covic, M. ; Burek, K. ; Hertel, J. ; Troll, M. ; Bader, E. ; Adam, J. ; Prehn, C. ; Rathkolb, B. ; Hrabě de Angelis, M. ; Grabe, H.J. ; Daniel, H. ; Kantermann, T. ; Harth, V. ; Illig, T. ; Pallapies, D. ; Behrens, T. ; Brüning, T. ; Adamski, J. ; Lickert, H. ; Rabstein, S. ; Wang-Sattler, R.

Night shift work affects urine metabolite profiles of nurses with early chronotype.

Metabolites 8:45 (2018)

Götz, A. ; Lehti, M. ; Donelan, E. ; Striese, C. ; Cucuruz, S. ; Sachs, S. ; Yi, C.X. ; Woods, S.C. ; Wright, S.D. ; Tschöp, M.H. ; Gao, Y. ; Hofmann, S.M.

Circulating HDL levels control hypothalamic astrogliosis via apoA-I.

J. Lipid Res. 59, 1649-1659 (2018)

Renner, S.^# ; Blutke, A.^# ; Dobenecker, B. ; Dhom, G. ; Müller, T.D. ; Finan, B. ; Clemmensen, C. ; Bernau, M. ; Novak, I. ; Rathkolb, B. ; Senf, S. ; Zöls, S. ; Roth, M. ; Götz, A. ; Hofmann, S.M. ; Hrabě de Angelis, M. ; Wanke, R. ; Kienzle, E. ; Scholz, A.M. ; DiMarchi, R. ; Ritzmann, M. ; Tschöp, M.H. ; Wolf, E.

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Mol. Metab., DOI: 10.1016/j.molmet.2018.06.015 (2018)

O'Neill, A.C. ; Kyrousi, C. ; Einsiedler, M. ; Burtscher, I. ; Drukker, M. ; Markie, D.M. ; Kirk, E.P. ; Götz, M. ; Robertson, S.P. ; Cappello, S.

Mob2 insufficiency disrupts neuronal migration in the developing cortex.

Front. Cell. Neurosci. 12:57 (2018)

Wang, X. ; Sterr, M. ; Burtscher, I. ; Chen, S. ; Hieronimus, A. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Lederer, G. ; Meitinger, T. ; Cernilogar, F.M. ; Schotta, G. ; Irmler, M. ; Beckers, J. ; Hrabě de Angelis, M. ; Ray, M. ; Wright, C.V.E. ; Bakhti, M. ; Lickert, H.

Genome-wide analysis of PDX1 target genes in human pancreatic progenitors.

Mol. Metab. 9, 57-68 (2018)

De Castro, S.C.P. ; Hirst, C.S. ; Savery, D. ; Rolo, A.P. ; Lickert, H. ; Andersen, B. ; Copp, A.J. ; Greene, N.D.E.

Neural tube closure depends on expression of Grainyhead-like 3 in multiple tissues.

Dev. Biol. 435, 130-137 (2018)

Kleinert, M. ; Clemmensen, C. ; Hofmann, S.M. ; Moore, M.C. ; Renner, S. ; Woods, S.C. ; Huypens, P. ; Beckers, J. ; Hrabě de Angelis, M. ; Schürmann, A. ; Bakhti, M. ; Klingenspor, M. ; Heimann, M. ; Cherrington, A.D. ; Ristow, M. ; Lickert, H. ; Wolf, E. ; Havel, P.J. ; Müller, T.D. ; Tschöp, M.H.

Animal models of obesity and diabetes mellitus.

Nat. Rev. Endocrinol. 14, 140-162 (2018)

Fischer, I.P. ; Irmler, M. ; Meyer, C.W.E. ; Sachs, S. ; Neff, F. ; Hrabě de Angelis, M. ; Beckers, J. ; Tschöp, M.H. ; Hofmann, S.M. ; Ussar, S.

A history of obesity leaves an inflammatory fingerprint in liver and adipose tissue.

Int. J. Obes. 42, 507-517 (2018)

2017

Gao, Y. ; Vidal-Itriago, A. ; Milanova, I. ; Korpel, N.L. ; Kalsbeek, M.J. ; Tom, R.Z. ; Kalsbeek, A. ; Hofmann, S.M. ; Yi, C.X.

Deficiency of leptin receptor in myeloid cells disrupts hypothalamic metabolic circuits and causes body weight increase.

Mol. Metab. 7, 155-160 (2017)

Schmitz, F. ; Burtscher, I. ; Stauber, M. ; Gossler, A. ; Lickert, H.

A novel Cre-inducible knock-in ARL13B-tRFP fusion cilium reporter.

Genesis 55:e23073 (2017)

Götz, A. ; Jall, S. ; Tschöp, M.H. ; Müller, T.D.

Inkretinbasierte Medikamente zur Diabetes- und Adipositastherapie. Entwicklungsperspektiven.

Diabetologe 13, 505–513 (2017)

Gao, Y. ; Vidal-Itriago, A. ; Kalsbeek, M.J. ; Layritz, C. ; García-Cáceres, C. ; Tom, R.Z. ; Eichmann, T.O. ; Vaz, F.M. ; Houtkooper, R.H. ; van der Wel, N. ; Verhoeven, A.J. ; Yan, J. ; Kalsbeek, A. ; Eckel, R.H. ; Hofmann, S.M. ; Yi, C.X.

Lipoprotein lipase maintains microglial innate immunity in obesity.

Cell Rep. 20, 3034-3042 (2017)

Yamauchi, K. ; Yamazaki, M. ; Abe, M. ; Sakimura, K. ; Lickert, H. ; Kawasaki, T. ; Murakami, F. ; Hirata, T.

Netrin-1 derived from the ventricular zone, but not the floor plate, directs hindbrain commissural axons to the ventral midline.

Sci. Rep. 7:11992 (2017)

Quarta, C. ; Clemmensen, C. ; Zhu, Z. ; Yang, B. ; Joseph, S.S. ; Lutter, D. ; Yi, C.X. ; Graf, E. ; García-Cáceres, C. ; Legutko, B. ; Fischer, K. ; Brommage, R. ; Zizzari, P. ; Franklin, B.S. ; Krueger, M. ; Koch, M. ; Vettorazzi, S. ; Li, P. ; Hofmann, S.M. ; Bakhti, M. ; Bastidas-Ponce, A. ; Lickert, H. ; Strom, T.M. ; Gailus-Durner, V. ; Bechmann, I. ; Perez-Tilve, D. ; Tuckermann, J.P. ; Hrabě de Angelis, M. ; Sandoval, D.A. ; Cota, D. ; Latz, E. ; Seeley, R.J. ; Müller, T.D. ; DiMarchi, R.D. ; Finan, B.° ; Tschöp, M.H.°

Molecular integration of incretin and glucocorticoid action reverses immunometabolic dysfunction and obesity.

Cell Metab. 26, 620-632.e6 (2017)

Bastidas-Ponce, A. ; Scheibner, K. ; Lickert, H. ; Bakhti, M.

Cellular and molecular mechanisms coordinating pancreas development.

Development 144, 2873-2888 (2017)

Tritschler, S. ; Theis, F.J. ; Lickert, H. ; Böttcher, A.

Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.

Mol. Metab. 6, 974-990 (2017)

Icb_ML

Keuper, M. ; Sachs, S. ; Walheim, E. ; Berti, L. ; Raedle, B. ; Tews, D. ; Fischer-Posovszky, P. ; Wabitsch, M. ; Hrabě de Angelis, M. ; Kastenmüller, G. ; Tschöp, M.H. ; Jastroch, M. ; Staiger, H. ; Hofmann, S.M.

Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors.

Mol. Metab. 6, 1226-1239 (2017)

Hockman, D. ; Burns, A. ; Schlosser, G. ; Gates, K.P. ; Jevans, B. ; Mongera, A. ; Fisher, S. ; Unlu, G. ; Knapik, E.W. ; Kaufman, C.K. ; Mosimann, C. ; Zon, L.I. ; Lancman, J.J. ; Dong, P.D. ; Lickert, H. ; Tucker, A.S. ; Baker, C.V.

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.

eLife 6:e21231 (2017)

Bastidas-Ponce, A. ; Roscioni, S. ; Burtscher, I. ; Bader, E. ; Sterr, M. ; Bakhti, M. ; Lickert, H.

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells.

Mol. Metab. 6, 524-534 (2017)

Kabra, U.D. ; Pfuhlmann, K. ; Migliorini, A. ; Keipert, S. ; Lamp, D. ; Korsgren, O. ; Gegg, M. ; Woods, S.C. ; Pfluger, P.T. ; Lickert, H. ; Affourtit, C. ; Tschöp, M.H. ; Jastroch, M.

Direct substrate delivery into mitochondrial-fission deficient pancreatic islets rescues insulin secretion.

Diabetes 66, 1247-1257 (2017)

Ventura-Clapier, R. ; Dworatzek, E. ; Seeland, U. ; Kararigas, G. ; Francois Arnal, J. ; Brunelleschi, S. ; Carpenter, T. ; Erdmann, J. ; Franconi, F. ; Giannetta, E. ; Glezerman, M. ; Hofmann, S.M. ; Junien, C. ; Katai, M. ; Kublickiene, K. ; König, I.R. ; Majdic, G. ; Malorni, W. ; Mieth, C. ; Miller, V. ; Reynolds, R. ; Shimokawa, H. ; Tannenbaum, C. ; Maria Anna, D.U. ; Regitz-Zagrosek, V.

Sex in basic research - Concepts in the cardiovascular field.

Cardiovasc. Res. 113, 711-724 (2017)

Korostylev, A.^# ; Mahaddalkar, P.U. ; Keminer, O. ; Hadian, K. ; Schorpp, K.K. ; Lickert, H.^#

A high-content small molecule screen identifies novel inducers of definitive endoderm.

Mol. Med. 6, 640-650 (2017)

Jall, S. ; Sachs, S. ; Clemmensen, C. ; Finan, B. ; Neff, F. ; DiMarchi, R.D. ; Tschöp, M.H. ; Müller, T.D.° ; Hofmann, S.M.°

Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice.

Mol. Metab. 6, 440-446 (2017)

Bardot, E. ; Calderon, D. ; Santoriello, F. ; Han, S. ; Cheung, K. ; Jadhav, B. ; Burtscher, I. ; Artap, S. ; Jain, R.K. ; Epstein, J.A. ; Lickert, H. ; Gouon-Evans, V. ; Sharp, A.J. ; Dubois, N.C.

Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential.

Nat. Commun. 8:14428 (2017)

Tews, D. ; Fromme, T. ; Keuper, M. ; Hofmann, S.M. ; Debatin, K.M. ; Klingenspor, M. ; Wabitsch, M. ; Fischer-Posovszky, P.

Teneurin-2 (TENM2) deficiency induces UCP1 expression in differentiating human fat cells.

Mol. Cell. Endocrinol. 443, 106-113 (2017)

Paulin, N. ; Döring, Y. ; Kooijman, S. ; Blanchet, X. ; Viola, J.R. ; de Jong, R. ; Mandl, M. ; Hendrikse, J. ; Schiener, M. ; von Hundelshausen, P. ; Vogt, A. ; Weber, C. ; Bdeir, K. ; Hofmann, S.M. ; Rensen, P.C.N. ; Drechsler, M. ; Soehnlein, O.

Human neutrophil peptide 1 Limits hypercholesterolemia-induced atherosclerosis by increasing hepatic LDL clearance.

EBioMedicine 16, 204-211 (2017)

Álvarez Hernández, E.^# ; Kahl, S. ; Seelig, A. ; Begovatz, P.^# ; Irmler, M. ; Kupriyanova, Y. ; Nowotny, J. ; Nowotny, P. ; Herder, C. ; Barosa, C. ; Carvalho, F.P. ; Rozman, J. ; Neschen, S. ; Jones, J.G. ; Beckers, J. ; Hrabě de Angelis, M. ; Roden, M.

Acute dietary fat intake initiates alterations in energy metabolism and insulin resistance.

J. Clin. Invest. 127, 695-708 (2017)

Rotter, M. ; Brandmaier, S. ; Prehn, C. ; Adam, J. ; Rabstein, S. ; Gawrych, K. ; Brüning, T ; Illig, T. ; Lickert, H. ; Adamski, J. ; Wang-Sattler, R.

Stability of targeted metabolite profiles of urine samples under different storage conditions.

Metabolomics 13:4 (2017)

Volta, F. ; Gerdes, J.M.

The role of primary cilia in obesity and diabetes.

Ann. NY Acad. Sci. 1391, 71-84 (2017)

2016

Wang, X. ; Chen, S. ; Burtscher, I. ; Sterr, M. ; Hieronimus, A. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Lederer, G. ; Meitinger, T. ; Lickert, H.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene.

Stem Cell Res. 17, 292-295 (2016)

Wang, X. ; Chen, S. ; Burtscher, I. ; Sterr, M. ; Hieronimus, A. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Lederer, G. ; Meitinger, T. ; Lickert, H.

Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene.

Stem Cell Res. 17, 273-276 (2016)

Bortsova, G. ; Sterr, M. ; Wang, L. ; Milletari, F. ; Navab, N. ; Böttcher, A. ; Lickert, H. ; Theis, F.J.° ; Peng, T.°

Mitosis detection in intestinal crypt images with hough forest and conditional random fields.

Lect. Notes Comput. Sc. 10019, 287-295 (2016)

Roscioni, S. ; Migliorini, A. ; Gegg, M. ; Lickert, H.

Impact of islet architecture on β-cell heterogeneity, plasticity and function.

Nat. Rev. Endocrinol. 12, 695-709 (2016)

Finan, B. ; Clemmensen, C. ; Zhu, Z. ; Stemmer, K. ; Gauthier, K. ; Müller, L. ; de Angelis, M. ; Moreth, K. ; Neff, F. ; Perez-Tilve, D. ; Fischer, K. ; Lutter, D. ; Sánchez-Garrido, M.A. ; Liu, P. ; Tuckermann, J.P. ; Malehmir, M. ; Healy, M.E. ; Weber, A. ; Heikenwälder, M. ; Jastroch, M. ; Kleinert, M. ; Jall, S. ; Brandt, S. ; Flamant, F. ; Schramm, K.-W. ; Biebermann, H. ; Döring, Y. ; Weber, C. ; Habegger, K.M. ; Keuper, M. ; Gelfanov, V. ; Liu, F. ; Köhrle, J. ; Rozman, J. ; Fuchs, H. ; Gailus-Durner, V. ; Hrabě de Angelis, M. ; Hofmann, S.M. ; Yang, B. ; Tschöp, M.H. ; DiMarchi, R. ; Müller, T.D.

Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic Impact for metabolic disease.

Cell 167, 843-857.e14 (2016)

Adam, J. ; Brandmaier, S. ; Leonhardt, J. ; Scheerer, M.F. ; Mohney, R.P. ; Xu, T. ; Bi, J. ; Rotter, M. ; Troll, M. ; Chi, S. ; Heier, M. ; Herder, C. ; Rathmann, W.G. ; Giani, G. ; Adamski, J. ; Illig, T. ; Strauch, K. ; Li, Y. ; Gieger, C. ; Peters, A. ; Suhre, K. ; Ankerst, D.P. ; Meitinger, T. ; Hrabě de Angelis, M. ; Roden, M. ; Neschen, S. ; Kastenmüller, G. ; Wang-Sattler, R.

Metformin effect on non-targeted metabolite profiles in patients with type 2 diabetes and multiple murine tissues.

Diabetes 65, 3776-3785 (2016)

Bergamini, C. ; Moruzzi, N. ; Volta, F. ; Faccioli, L. ; Gerdes, J.M. ; Mondardini, M.C. ; Fato, R.

Role of mitochondrial complex I and protective effect of CoQ10 supplementation in propofol induced cytotoxicity.

J. Bioenerg. Biomembr. 48, 413-423 (2016)

Migliorini, A. ; Roscioni, S. ; Lickert, H.

Targeting insulin-producing beta cells for regenerative therapy.

Diabetologia 59, 1838-1842 (2016)

Bader, E.^# ; Migliorini, A.^# ; Gegg, M. ; Moruzzi, N. ; Gerdes, J.M. ; Roscioni, S. ; Bakhti, M. ; Brandl, E. ; Irmler, M. ; Beckers, J. ; Aichler, M. ; Feuchtinger, A. ; Leitzinger, C. ; Zischka, H. ; Wang-Sattler, R. ; Jastroch, M. ; Tschöp, M.H. ; Machicao, F. ; Staiger, H. ; Häring, H.-U. ; Chmelova, H. ; Chouinard, J.A. ; Oskolkov, N. ; Korsgren, O. ; Speier, S. ; Lickert, H.

Identification of proliferative and mature β-cells in the islets of Langerhans.

Nature 535, 430-434 (2016)

Hoppe, P.S. ; Schwarzfischer, M. ; Loeffler, D. ; Kokkaliaris, K.D. ; Hilsenbeck, O. ; Moritz, N. ; Endele, M. ; Filipczyk, A. ; Gambardella, A. ; Ahmed, N. ; Etzrodt, M. ; Coutu, D.L. ; Rieger, M.A. ; Marr, C. ; Strasser, M. ; Schauberger, B. ; Burtscher, I. ; Ermakova, O. ; Bürger, A. ; Lickert, H. ; Nerlov, C. ; Theis, F.J. ; Schroeder, T.

Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios.

Nature 535, 299-302 (2016)

Icb_qscd

Klancic, T. ; Woodward, L. ; Hofmann, S.M. ; Fisher, E.A.

High density lipoprotein and metabolic disease: Potential benefits of restoring its functional properties.

Mol. Metab. 5, 321-327 (2016)

Preusse, M. ; Theis, F.J. ; Müller, N.S.

miTALOS v2: Analyzing tissue specific microRNA function.

PLoS ONE 11:e0151771 (2016)

Icb_rene

Jung, B. ; Messias, A.C. ; Schorpp, K.K. ; Geerlof, A. ; Schneider, G. ; Saur, D. ; Hadian, K. ; Sattler, M. ; Wanker, E.E. ; Hasenöder, S. ; Lickert, H.

Novel small molecules targeting ciliary transport of smoothened and oncogenic Hedgehog pathway activation.

Sci. Rep. 6:22540 (2016)

Rotter, M. ; Nigg, C.R. ; Renda, G.A. ; Novotny, R.

Acculturation is not related to physical activity stage of change for children in Hawai'i.

Hawaii J. Med. Public Health 75, 35-41 (2016)

Jung, B. ; Padula, D. ; Burtscher, I. ; Landerer, C. ; Lutter, D. ; Theis, F.J. ; Messias, A.C. ; Geerlof, A. ; Sattler, M. ; Kremmer, E. ; Boldt, K. ; Ueffing, M. ; Lickert, H.

Pitchfork and Gprasp2 target smoothened to the primary cilium for Hedgehog pathway activation.

PLoS ONE 11:e0149477 (2016)

Willmann, S.^# ; Müller, N.S.^# ; Engert, S. ; Sterr, M. ; Burtscher, I. ; Raducanu, A. ; Irmler, M. ; Beckers, J. ; Sass, S. ; Theis, F.J. ; Lickert, H.

The global gene expression profile of the secondary transition during pancreatic development.

Mech. Dev. 139, 51-64 (2016)

Icb_rene

Icb_VLN

Icb_LungSys

Icb_Latent Causes

Petrezselyova, S. ; Kinsky, S. ; Truban, D. ; Sedlacek, R. ; Burtscher, I. ; Lickert, H.

Homology arms of targeting vectors for gene insertions and Crispr/Cas9 technology: Size does not matter; quality control of targeted clones does.

Cell. Mol. Biol. Lett. 20, 773-787 (2016)

2015

Schlüssel, E. ; Migliorini, A. ; Bader, E. ; Lickert, H.

Diabetes mellitus: Zelluläre Plastizität und Perspektiven für die regenerative Therapie.

For. Med. Exz. Med. 5, 43-47 (2015)

Johansson, E. ; Andersson, L.B. ; Örnros, J. ; Carlsson, T. ; Ingeson-Carlsson, C. ; Liang, S. ; Dahlberg, J. ; Jansson, S.A. ; Parrillo, L. ; Zoppoli, P. ; Barila, G.O. ; Altschuler, D.L. ; Padula, D. ; Lickert, H. ; Fagman, H. ; Nilsson, M.

Revising the embryonic origin of thyroid C cells in mice and humans.

Development 142, 3519-3528 (2015)

Preusse, M. ; Marr, C. ; Saunders, S. ; Maticzka, D. ; Lickert, H. ; Backofen, R. ; Theis, F.J.

SimiRa: A tool to identify coregulation between microRNAs and RNA-binding proteins.

RNA Biol. 12, 998-1009 (2015)

Icb_qscd

Schmitz, F. ; Roscioni, S. ; Lickert, H.

Repurposing an osteoporosis drug for β cell regeneration in diabetic patients.

Cell Metab. 22, 58-59 (2015)

Stoy, C. ; Sundaram, A. ; Rios Garcia, M. ; Wang, X. ; Seibert, O. ; Zota, A. ; Wendler, S. ; Männle, D. ; Hinz, U. ; Sticht, C. ; Muciek, M. ; Gretz, N. ; Rose, A.J. ; Greiner, V. ; Hofmann, T.G. ; Bauer, A. ; Hoheisel, J. ; Berriel Diaz, M. ; Gaida, M.M. ; Werner, J. ; Schafmeier, T. ; Strobel, O.° ; Herzig, S.°

Transcriptional co-factor Transducin Beta-Like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy.

EMBO Mol. Med. 7, 1048-1062 (2015)

Roscioni, S. ; Heerspink, H.J.

New nonabsorbable potassium-exchange resins in hyperkalaemia.

Nat. Rev. Nephrol. 11, 205-206 (2015)

Clemmensen, C. ; Finan, B. ; Fischer, K. ; Tom, R.Z. ; Legutko, B. ; Sehrer, L. ; Heine, D. ; Grassl, N. ; Meyer, C.W. ; Henderson, B. ; Hofmann, S.M. ; Tschöp, M.H. ; van der Ploeg, L.H.T. ; Müller, T.D.

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

EMBO Mol. Med. 7, 288-298 (2015)

2014

van de Laar, E. ; Clifford, M. ; Hasenöder, S. ; Kim, B. ; Wang, D. ; Lee, S. ; Paterson, J. ; Vu, N.M. ; Waddell, T.K. ; Keshavjee, S. ; Tsao, M.S. ; Ailles, L. ; Moghal, N.

Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.

Respir. Res. 15:1513 (2014)

Goldman, O.^# ; Han, S.^# ; Hamou, W. ; Jodon de Villeroche, V. ; Uzan, G. ; Lickert, H. ; Gouon-Evans, V.

Endoderm generates endothelial cells during liver development.

Stem Cell Rep. 3, 556-565 (2014)

Gerdes, J.M. ; Christou-Safina, S. ; Xiong, Y. ; Moede, T. ; Moruzzi, N. ; Karlsson-Edlund, P. ; Leibiger, B. ; Leibiger, I. ; Ostenson, C.G. ; Beales, P. ; Berggren, P.O.

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents.

Nat. Commun. 5:5308 (2014)

Gegg, M. ; Böttcher, A. ; Burtscher, I. ; Hasenöder, S. ; van Campenhout, C.A. ; Aichler, M. ; Walch, A.K. ; Grant, S.G. ; Lickert, H.

Flattop regulates basal body docking and positioning in mono- and multiciliated cells.

eLife 3:e03842 (2014)

statConAck

Matthes, M.^# ; Preusse, M.^# ; Zhang, J.^# ; Schechter, J. ; Mayer, D. ; Lentes, B. ; Theis, F.J. ; Prakash, N. ; Wurst, W.° ; Trümbach, D.°

Mouse IDGenes: A reference database for genetic interactions in the developing mouse brain.

Database 2014:bau083 (2014)

Icb_rene

Moruzzi, N. ; Del Sole, M. ; Fato, R. ; Gerdes, J.M. ; Berggren, P.O. ; Bergamini, C. ; Brismar, K.

Short and prolonged exposure to hyperglycaemia in human fibroblasts and endothelial cells: Metabolic and osmotic effects.

Int. J. Biochem. Cell Biol. 53, 66-76 (2014)

Worzfeld, T. ; Swiercz, J.M. ; Sentürk, A. ; Genz, B. ; Korostylev, A. ; Deng, S. ; Xia, J.J. ; Hoshino, M. ; Epstein, J.A. ; Chan, A.M. ; Vollmar, B. ; Acker-Palmer, A. ; Kuner, R. ; Offermanns, S.

Genetic dissection of plexin signaling in vivo.

Proc. Natl. Acad. Sci. U.S.A. 111, 2194-2199 (2014)

Migliorini, A. ; Bader, E. ; Lickert, H.

Islet cell plasticity and regeneration.

Mol. Metab. 3, 268–274 (2014)

Yang, D.^# ; Lutter, D.^# ; Burtscher, I. ; Uetzmann, L. ; Theis, F.J.° ; Lickert, H.°

miR-335 promotes mesendodermal lineage segregation and shapes a transcription factor gradient in the endoderm.

Development 141, 514-525 (2014)

Icb_Latent Causes

Icb_ML

Clemmensen, C. ; Chabenne, J. ; Finan, B. ; Sullivan, L. ; Fischer, K. ; Küchler, D. ; Sehrer, L. ; Ograjsek, T. ; Hofmann, S. ; Schriever, S.C. ; Pfluger, P.T. ; Pinkstaff, J.K. ; Tschöp, M.H.° ; DiMarchi, R.° ; Müller, T.D.

GLP-1/glucagon co-agonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet.

Diabetes 63, 1422-1427 (2014)

Keuper, M.^# ; Jastroch, M.^# ; Yi, C.-X. ; Fischer-Posovszky, P. ; Wabitsch, M. ; Tschöp, M.H. ; Hofmann, S.M.

Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions.

FASEB J. 28, 761-770 (2014)

Bakhti, M.° ; Aggarwal, S. ; Simons, M.°

Myelin architecture: Zippering membranes tightly together.

Cell. Mol. Life Sci. 71, 1265-1277 (2014)

2013

Finan, B.^# ; Ma, T.^# ; Ottaway, N. ; Müller, T.D. ; Habegger, K.M. ; Heppner, K.M. ; Kirchner, H. ; Holland, J. ; Hembree, J. ; Raver, C. ; Lockie, S.H. ; Smiley, D.L. ; Gelfanov, V. ; Yang, B. ; Hofmann, S. ; Bruemmer, D. ; Drucker, D.J. ; Pfluger, P.T. ; Perez-Tilve, D. ; Gidda, J. ; Vignati, L. ; Zhang, L. ; Hauptman, J.B. ; Lau, M. ; Brecheisen, M. ; Uhles, S. ; Riboulet, W. ; Hainaut, E. ; Sebokova, E. ; Conde-Knape, K. ; Konkar, A. ; DiMarchi, R.D.° ; Tschöp, M.H.°

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans.

Sci. Transl. Med. 5:209ra151 (2013)

Habegger, K.M. ; Donelan, E. ; Abplanalp, W. ; Al-Massadi, O. ; Habegger, K.M. ; Weber, J. ; Ress, C. ; Mansfeld, J. ; Somvanshi, S. ; Trivedi, C. ; Keuper, M. ; Ograjsek, T. ; Striese, C. ; Cucuruz, S. ; Pfluger, P.T. ; Krishna, R. ; Gordon, S.M. ; Silva, R.A. ; Luquet, S. ; Castel, J. ; Martinez, S. ; D'Alessio, D. ; Davidson, W.S. ; Hofmann, S.M.

High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice.

Circulation 128, 2364-2371 (2013)

Engert, S. ; Burtscher, I. ; Kalali, B. ; Gerhard, M. ; Lickert, H.

The Sox17^CreERT2 knock-in mouse line displays spatiotemporal activation of Cre recombinase in distinct Sox17 lineage progenitors.

Genesis 51, 793-802 (2013)

Filipczyk, A. ; Gkatzis, K. ; Fu, J. ; Hoppe, P.S. ; Lickert, H. ; Anastassiadis, K. ; Schroeder, T.

Biallelic expression of nanog protein in mouse embryonic stem cells.

Cell Stem Cell 13, 12-13 (2013)

Rinck, A.^# ; Preusse, M.^# ; Laggerbauer, B. ; Lickert, H. ; Engelhardt, S.° ; Theis, F.J.°

The human transcriptome is enriched for miRNA-binding sites located in cooperativity-permitting distance.

RNA Biol. 10, 1125-1135 (2013)

Icb_rene

Icb_InKoMBio_RNA

Icb_BioSysNet

Modzelewska, K. ; Lauritzen, A. ; Hasenöder, S. ; Brown, L. ; Georgiou, J. ; Moghal, N.

Neurons refine the Caenorhabditis elegans body plan by directing axial patterning by Wnts.

PLoS Biol. 11:e1001465 (2013)

Engert, S. ; Burtscher, I. ; Liao, W.P. ; Dulev, S. ; Schotta, G. ; Lickert, H.

Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse.

Development 140, 3128-3138 (2013)

Burtscher, I. ; Barkey, W. ; Lickert, H.

Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation.

Genesis 51, 596-604 (2013)

Müller, T.D.^# ; Müller, A.^# ; Yi, C.-X.^# ; Habegger, K.M. ; Meyer, C.W. ; Gaylinn, B.D. ; Finan, B. ; Heppner, K. ; Trivedi, C. ; Bielohuby, M. ; Abplanalp, W. ; Meyer, F. ; Piechowski, C.L. ; Pratzka, J. ; Stemmer, K. ; Holland, J. ; Hembree, J. ; Bhardwaj, N. ; Raver, C. ; Ottaway, N. ; Krishna, R. ; Sah, R. ; Sallee, F.R. ; Woods, S.C. ; Perez-Tilve, D. ; Bidlingmaier, M. ; Thorner, M.O. ; Krude, H. ; Smiley, D. ; DiMarchi, R. ; Hofmann, S. ; Pfluger, P.T. ; Kleinau, G. ; Biebermann, H. ; Tschöp, M.H.

The orphan receptor Gpr83 regulates systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms.

Nat. Commun. 4:1968 (2013)

Habegger, K.M. ; Stemmer, K. ; Cheng, C. ; Müller, T.D. ; Heppner, K.M. ; Ottaway, N. ; Holland, J. ; Hembree, J.L. ; Smiley, D. ; Gelfanov, V. ; Krishna, R. ; Arafat, A.M. ; Konkar, A. ; Belli, S. ; Kapps, M. ; Woods, S.C. ; Hofmann, S.M. ; D'Alessio, D. ; Pfluger, P.T. ; Perez-Tilve, D. ; Seeley, R.J. ; Konishi, M. ; Itoh, N. ; Kharitonenkov, A. ; Spranger, J. ; DiMarchi, R.D. ; Tschöp, M.H.

Fibroblast growth factor 21 mediates specific glucagon actions.

Diabetes 62, 1453-1463 (2013)

Müller, T.D. ; Tschöp, M.H. ; Hofmann, S.M.

Emerging function of fat mass and obesity-associated protein (FTO).

PLoS Genet. 9:e1003223 (2013)

Müller, T.D. ; Lee, S.J. ; Jastroch, M. ; Kabra, D. ; Stemmer, K. ; Aichler, M. ; Abplanalp, B. ; Ananthakrishnan, G. ; Bhardwaj, N. ; Collins, S. ; Divanovic, S. ; Endele, M. ; Finan, B. ; Gao, Y. ; Habegger, K.M. ; Hembree, J. ; Heppner, K.M. ; Hofmann, S. ; Holland, J. ; Küchler, D. ; Kutschke, M. ; Krishna, R. ; Lehti, M. ; Oelkrug, R. ; Ottaway, N. ; Perez-Tilve, D. ; Raver, C. ; Walch, A.K. ; Schriever, S.C. ; Speakman, J. ; Tseng, Y.H. ; Diaz-Meco, M. ; Pfluger, P.T. ; Moscat, J. ; Tschöp, M.H.

P62 links β-adrenergic input to mitochondrial function and thermogenesis.

J. Clin. Invest. 123, 469-478 (2013)

2012

Lickert, H. ; van Campenhout, C.A.

Evolution of the Discs large gene family provides new insights into the establishment of apical epithelial polarity and the etiology of mental retardation.

Commun. Integr. Biol. 5, 287-290 (2012)

Wang-Sattler, R. ; Yu, Z. ; Herder, C. ; Messias, A.C. ; Floegel, A. ; He, Y. ; Heim, K. ; Campillos, M.J. ; Holzapfel, C. ; Thorand, B. ; Grallert, H. ; Xu, T. ; Bader, E. ; Huth, C. ; Mittelstraß, K. ; Döring, A. ; Meisinger, C. ; Gieger, C. ; Prehn, C. ; Römisch-Margl, W. ; Carstensen, M. ; Xie, L. ; Yamanaka-Okumura, H. ; Xing, G. ; Ceglarek, U. ; Thiery, J. ; Giani, G. ; Lickert, H. ; Lin, X. ; Li, Y. ; Boeing, H. ; Joost, H.-G. ; Hrabě de Angelis, M. ; Rathmann, W. ; Suhre, K. ; Prokisch, H. ; Peters, A. ; Meitinger, T. ; Roden, M. ; Wichmann, H.-E. ; Pischon, T. ; Adamski, J. ; Illig, T.

Novel biomarkers for pre-diabetes identified by metabolomics.

Mol. Syst. Biol. 8:615 (2012)

Raducanu, A. ; Lickert, H.

Understanding pancreas development for β-cell repair and replacement therapies.

Curr. Diab. Rep. 12, 481-489 (2012)

Gardiner, J.R. ; Jackson, A.L. ; Gordon, J. ; Lickert, H. ; Manley, N.R. ; Basson, M.A.

Localised inhibition of FGF signalling in the third pharyngeal pouch is required for normal thymus and parathyroid organogenesis.

Development 139, 3456-3466 (2012)

Horn, S. ; Kobberup, S. ; Jorgensen, M.C. ; Kalisz, M. ; Klein, T. ; Kageyama, R. ; Gegg, M. ; Lickert, H. ; Lindner, J. ; Magnuson, M.A. ; Kong, Y.Y. ; Serup, P. ; Ahnfelt-Ronne, J. ; Jensen, J.N.

Mind bomb 1 is required for pancreatic β-cell formation.

Proc. Natl. Acad. Sci. U.S.A. 109, 7356-7361 (2012)

Rothova, M. ; Thompson, H. ; Lickert, H. ; Tucker, A.S.

Lineage tracing of the endoderm during oral development.

Dev. Dyn. 241, 1183-1191 (2012)

Burtscher, I. ; Barkey, W. ; Schwarzfischer, M. ; Theis, F.J. ; Lickert, H.

The Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development.

Genesis 50, 496-505 (2012)

Lange, A. ; Gegg, M. ; Burtscher, I. ; Bengel, D. ; Kremmer, E. ; Lickert, H.

Fltp^T2AiCre: A new knock-in mouse line for conditional gene targeting in distinct mono- and multiciliated tissues.

Differentiation 83, S105-S113 (2012)

Simon, C. ; Lickert, H. ; Götz, M. ; Dimou, L.

Sox10-iCreER^T2 : A mouse line to inducibly trace the neural crest and oligodendrocyte lineage.

Genesis 50, 506-515 (2012)

2011

Frauer, C. ; Rottach, A. ; Meilinger, D. ; Bultmann, S. ; Fellinger, K. ; Hasenöder, S. ; Wang, M. ; Qin, W. ; Söding, J. ; Spada, F. ; Leonhardt, H.

Different binding properties and function of CXXC zinc finger domains in Dnmt1 and Tet1.

PLoS ONE 6:e16627 (2011)

van Campenhout, C.A. ; Eitelhuber, A. ; Gloeckner, C.J. ; Giallonardo, P. ; Gegg, M. ; Oller, H. ; Grant, S.G. ; Krappmann, D. ; Ueffing, M. ; Lickert, H.

Dlg3 trafficking and apical tight junction formation is regulated by Nedd4 and Nedd4-2 E3 ubiquitin ligases.

Dev. Cell 21, 479-491 (2011)

PROT-CF

Simrick, S. ; Lickert, H. ; Basson, M.A.

Sprouty genes are essential for the normal development of epibranchial ganglia in the mouse embryo.

Dev. Biol. 358, 147-155 (2011)

David, R. ; Jarsch, V.B. ; Schwarz, F. ; Nathan, P. ; Gegg, M. ; Lickert, H. ; Franz, W.M.

Induction of MesP1 by Brachyury(T) generates the common multipotent cardiovascular stem cell.

Cardiovasc. Res. 92, 115-122 (2011)

Chow, J.C. ; Watson, J.G. ; Robles, J. ; Wang, X. ; Chen, L.W. ; Trimble, D.L. ; Kohl, S.D. ; Tropp, R.J. ; Fung, K.K.

Quality assurance and quality control for thermal/optical analysis of aerosol samples for organic and elemental carbon.

Anal. Bioanal. Chem. 401, 3141-52 (2011)

2010

Glasmacher, E. ; Höfig, K.P. ; Vogel, K.U. ; Rath, N. ; Du, L. ; Wolf, C. ; Kremmer, E. ; Wang, X. ; Heissmeyer, V.

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression.

Nat. Immunol. 11, 725-733 (2010)

PROT-CF

Wenzlau, J.M. ; Walter, M.C. ; Gardner, T.J. ; Frisch, L.M. ; Yu, L. ; Eisenbarth, G.S. ; Ziegler, A.-G. ; Davidson, H.W. ; Hutton, J.C.

Kinetics of the post-onset decline in zinc transporter 8 autoantibodies in type 1 diabetic human subjects.

J. Clin. Endocrinol. Metab. 95, 4712-9 (2010)

2008

Hofmann, S.M. ; Perez-Tilve, D. ; Greer, T.M. ; Coburn, B.A. ; Grant, E. ; Basford, J.E. ; Tschöp, M.H. ; Hui, D.Y.

Defective lipid delivery modulates glucose tolerance and metabolic response to diet in apolipoprotein E-deficient mice.

Diabetes 57, 5-12 (2008)

2007

Nogueiras, R. ; Wiedmer, P. ; Perez-Tilve, D. ; Veyrat-Durebex, C. ; Keogh, J.M. ; Sutton, G.M. ; Pfluger, P.T. ; Castañeda, T.R. ; Neschen, S. ; Hofmann, S.M. ; Howles, P.N. ; Morgan, D.A. ; Benoit, S.C. ; Szanto, I. ; Schrott, B. ; Schürmann, A. ; Joost, H.G. ; Hammond, C. ; Hui, D.Y. ; Woods, S.C. ; Rahmouni, K. ; Butler, A.A. ; Farooqi, I.S. ; O'Rahilly, S. ; Rohner-Jeanrenaud, F. ; Tschöp, M.H.

The central melanocortin system directly controls peripheral lipid metabolism.

J. Clin. Invest. 117, 3475-3488 (2007)

Hofmann, S.M. ; Zhou, L. ; Perez-Tilve, D. ; Greer, T. ; Grant, E. ; Wancata, L. ; Thomas, A. ; Pfluger, P.T. ; Basford, J.E. ; Gilham, D. ; Herz, J. ; Tschöp, M.H. ; Hui, D.Y.

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.

J. Clin. Invest. 117, 3271-3282 (2007)

2004

von Both, I. ; Silvestri, C. ; Erdemir, T. ; Lickert, H. ; Walls, J.R. ; Henkelman, R.M. ; Rossant, J. ; Harvey, R.P. ; Attisano, L. ; Wrana, J.L.

Foxh1 is essential for development of the anterior heart field.

Dev. Cell 7, 331-345 (2004)

Ben Abdelkhalek, H ; Beckers, A. ; Burkhardt, H ; Ceolin, M ; Rivera-Pomar, R

The mouse homeobox gene Not is required for caudal notochord development and affected 1725 by the truncate mutation

Genes Dev. 18, 1725-1736 (2004)

Lickert, H. ; Takeuchi, J.K. ; von Both, I. ; Walls, J.R. ; McAuliffe, F. ; Adamson, S.L. ; Henkelman, R.M. ; Wrana, J.L. ; Rossant, J. ; Bruneau, B.G.

Baf60c is essential for function of BAF chromatin remodelling complexes in heart development.

Nature 432, 107-112 (2004)

2003

Kunath, T. ; Gish, G. ; Lickert, H. ; Jones, N. ; Pawson, T. ; Rossant, J.

Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype.

Nat. Biotechnol. 21, 559-561 (2003)

2002

Lickert, H. ; Kutsch, S. ; Kanzler, B. ; Tamai, Y. ; Taketo, M.M. ; Kemler, R.

Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.

Dev. Cell 3, 171-181 (2002)

Lickert, H. ; Kemler, R.

Functional analysis of cis-regulatory elements controlling initiation and maintenance of early Cdx1 gene expression in the mouse.