Personal Details

Dr. Prisca Chapouton
Senior Scientist Insulin/IGF signalling in metabolism and growth

Phone: +49 89-3187 49250
E-mail
Building/Room: Campus Neuherberg, building 3620, room 040a

Project description

 

Located in the Pancreas, the islets of Langerhans consist of the endocrine cells α, β, δ, γ, ε, of which the abundant β-cells secrete insulin as a response to nutrients. Insulin is then transported via the blood throughout the body and promotes glucose uptake in all cells. Under diabetic conditions of type 1 or type 2,  insufficient insulin secretion or a general desensitization to insulin, respectively, lead to hyperglycemia and ensuing pathological complications.

We are interested in understanding how insulin production, secretion and signaling are regulated in β-cells. An important player in these processes is the recently characterized Inceptor (Ansarullah et al., 2021), a protein highly expressed in the pancreas and other endocrine tissues, such as the hypothalamo-pituitary-gonadal axis. In β-cells, Inceptor at the plasma membrane promotes the internalization of insulin-receptor and therefore a desensitization of insulin signaling. Its further role in the dynamic activity of β-cells appears however more complex, given its high expression in intracellular compartments. Our aim is to decipher the involvement of Inceptor in the trafficking and signaling events in β-cells at super resolution levels.

 

Academic and Research Activities

 

Since 2021   Senior scientist, group leader in Heiko Lickert´s lab, Institute of Diabetes and Regeneration Research

 

2020              Senior postdoc at the Institute of Stem Cell Research, Helmholtz Zentrum München and Biomedical Center LMU

2018-2019   Short-term research stay at the UT-Southwestern, Dallas, Texas, USA

2011-2018    Senior scientist at the Institute of Developmental Genetics and at the Sensory  Biology and Organogenesis Unit, Helmholtz Zentrum Muenchen

2002-2011   Postdoc in the lab of Laure Bally-Cuif, Helmholtz Zentrum München

1997-2001   PhD in the lab of Magdalena Götz, Max Planck Institute of Neurobiology, Martinsried

1997             Biochemistry Diploma, Freie Universität Berlin

 

Publications

 

Link to Pubmed

pubmed.ncbi.nlm.nih.gov