Personal Details

Dr. Federico Ribaudo
Postdoc - Insulin/IGF signalling in metabolism and growth

Project description

Diabetes mellitus is a chronic metabolic disorder characterized by high blood sugar levels. The most common form of diabetes is the type 2 (T2D), characterized by peripheral insulin resistance and β-cell dysfunction. A key factor in this disorder is the dysregulation of the insulin/insulin-like growth factor (Ins/IGF) system. Indeed, insulin and IGF1 resistance in β-cell leads to Diabetes. We identified an important player in this pathway, Inceptor (Ansarullah et al. 2021) an inhibitory receptor of Insulin receptor (InsR) as well as IGF1 receptor (IGF1R). Inceptor was described to interact with INSR/IGF1R and desensitize them in a clathrin-mediated endocytosis manner. My project is to investigate the function of Inceptor by structural-functional analysis, live cell imaging and super resolution microscopy in murine and human β-cell lines. Our aim is to investigate different Inceptor domains and understand the molecular mechanism of its inhibitory function. Moreover, we aim to evaluate the intracellular trafficking of Inceptor and its role in different cellular processes, i.e. autophagy.

Academic and Research ActivitiesSince July 2021 Post Doc, Institute of Diabetes and Regeneration Research, Helmholtz Centre Munich2017 – 2021 PhD in Human Genetics, Institute of Human Genetics, Universitätsklinikum Jena, Jena, Germany2017 Junior Research Fellow, IRCCS Foundation Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy2014 - 2016 Master of Science in Medical Biotechnology and Molecular Medicine, University of Milan, Milan, ItalyThesis: “Pathogenic mechanisms related to lysosomal acid ceramidase deficit: molecular and biochemical studies in patients’ fibroblasts affected by spinal muscular atrophy with progressive myoclonic epilepsy (SMA-PME) and Farber disease.”2011 - 2014 Bachelor of Science in Medical Biotechnology, University of Milan, Milan, Italy 

Thesis: “Generation and characterization of shank1/shank3 double KO as model for Shankopathies.”

Publications1. Bartsch S, Mirzakhani K, Neubert L, Stenzel A, Ehsani M, Esmaeili M, Pungsrinont T, Kacal M, Rasa SMM, Kallenbach J, Damodaran D, Ribaudo F, Grimm MO, Neri F, Baniahmad A. Antithetic hTERT Regulation by Androgens in Prostate Cancer Cells: hTERT Inhibition Is Mediated by the ING1 and ING2 Tumor Suppressors. Cancers (Basel). 2021 Aug 10;13(16):4025. doi: 10.3390/cancers13164025. PMID: 344391792. Khundadze M*, Ribaudo F*, Hussain A, Stahlberg H, Brocke-Ahmadinejad N, Franzka P, Varga RE, Zarkovic M, Pungsrinont T, Kokal M, Ganley IG, Beetz C, Sylvester M, Hübner CA. Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. Autophagy. 2021; Online ahead of print. PMID: 33618608(* authors contributed equally)3. Khundadze M, Ribaudo F, Hussain A, Rosentreter J, Nietzsche S, Thelen M, Winter D, Hoffmann B, Afzal MA, Hermann T, de Heus C, Piskor EM, Kosan C, Franzka P, von Kleist L, Stauber T, Klumperman J, Damme M, Proikas-Cezanne T, Hübner CA. A mouse model for SPG48 reveals a block of autophagic flux upon disruption of adaptor protein complex five. Neurobiol Dis. 2019;127:419-431