Personal Details

Dr. Michael Sterr
Single Cell Core Facility Group Leader

Phone: + 49 89-3187-43152
E-mail
Building/Room: Campus Neuherberg, building 3620, room 034b

Single Cell Core Facility



Single-cell based methods are key technologies to uncover the cellular complexity of biological systems, answering important and longstanding biological questions. Single-cell genomics allows to better characterize different cell types and cellular states, identify rare cell populations, and reconstruct developmental trajectories.
 
The goal of our group is to make single-cell technology accessible to the Helmholtz Center research community. We provide all 10x Genomics applications using the Chromium Controller, including feature barcoding and multiplexing.

 

Academic and Research Activities

Since Jan 2021 

Group Leader Single Cell Core Facility

Since April 2019

Postdoc, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Neuherberg, Germany

Jan. 2013 - April 2019 PhD student, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Prof. Dr. Heiko Lickert
Project: “Transcriptional Regulation of Endocrine Cell Formation and Function in Pancreas and Intestine”
Mar. 2012 – Sept. 2012 Master thesis “Three Dimensional Structured Illumination Microscopy Studies of the Nuclear Architecture in Murine Embryonic Stem Cells and Preimplantation Embryos, Ludwig Maximilians University Munich, Prof. Dr. Thomas Cremer
Oct. 2010 – May 2011Diploma thesis “Transient and Stable Knockdown of Notch1, Delta-like 1 and Magi2 in the Insulinoma Cell Line INS-1E”, Helmholtz Zentrum München, Institute of Experimental Genetics, Prof. Dr. Martin Hrabě de Angelis
Oct. 2011 – Sept. 2012Studies of Biology,  Ludwig Maximilians University Munich
Oct. 2006 – May 2011Studies of Bioengineering, University of Applied Sciences Munich

       

Publications

Bastidas-Ponce, A., Roscioni, S.S., Burtscher, I., Bader, E., Sterr, M., Bakhti, M., and Lickert, H. (2017). Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol. Metab. 6, 524–534

Wang, X., Chen, S., Burtscher, I., Sterr, M., Hieronimus, A., Machicao, F., Staiger, H., Häring, H.-U., Lederer, G., Meitinger, T., and Lickert, H. (2016a). Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene. Stem Cell Res. 17, 273–276.

Wang, X., Chen, S., Burtscher, I., Sterr, M., Hieronimus, A., Machicao, F., Staiger, H., Häring, H.-U., Lederer, G., Meitinger, T., and Lickert, H. (2016b). Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Stem Cell Res. 17, 292–295.

Willmann, S.J., Mueller, N.S., Engert, S., Sterr, M., Burtscher, I., Raducanu, A., Irmler, M., Beckers, J., Sass, S., Theis, F.J., and Lickert, H. (2016). The global gene expression profile of the secondary transition during pancreatic development. Mech. Dev. 139, 51–64.

Cremer, T., Cremer, M., Hübner, B., Strickfaden, H., Smeets, D., Popken, J., Sterr, M., Markaki, Y., Rippe, K., and Cremer, C. (2015). The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments. FEBS Lett. 589, 2931–2943.

Smeets, D., Markaki, Y., Schmid, V.J., Kraus, F., Tattermusch, A., Cerase, A., Sterr, M., Fiedler, S., Demmerle, J., Popken, J., Leonhardt, H., Brockdorff, N., Cremer, T., Schermelleh, L., and Cremer, M. (2014). Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci. Epigenetics Chromatin 7, 8