Personal Details

Dr. Aimee Bastidas-Ponce
Post Doc - Beta cell development and regeneration

Phone: +49 89 3187-43282
E-mail
Building/Room: Campus Neuherberg, building 3620, room 034

 

Project Description

Dissecting the molecular mechanisms underlying endocrine cell formation and function

 

The pancreatic endocrine compartment regulates glucose homeostasis by secreting hormones into the blood stream. Despite the efforts, the formation of endocrine cells during pancreas development has been not yet fully understood. I combine mouse genetics with cutting edge technologies such as primary pancreatic culture, single cell RNA sequencing and confocal imaging to provide novel insight into the gene regulatory programs and factors regulating endocrine cell induction, specification and maturation. Disclosing and describing new determinants or factors involved in pancreatic endocrinogenesis will enrich the understanding of this complex process to then be translated to regenerative therapies.

 

Academic and Research Activities

Since October 2013PhD student, Helmholtz Zentrum München, Institute of Diabetes and Regeneration Research, Munich, Germany
Jan. 2009 - May 2013

Master in Biochemical Sciences;.Institute of Biochemestry, National Autonomous University of Mexico

Aug. 2002 - July 2007.

Bachelor in Biochemical Engineering, Autonomous University of Sinaloa, Mexico.

 

Publications:

Sachs S*, Bastidas-Ponce A*, Tritschler S*, Bakthi M, Böttcher A, Sánchez-Garrido MA, Tarquis-Medina M, Kleinert M, Fischer K, Jall S, Harger A, Bader E, Roscioni S, Ussar S, Feuchtinger A, Yesildag B, Neelakandhan A, Jensen CB, Cornu M, Yang B, Finan B, DiMarchi R, Tschöp MH, Theis F, Hofmann SM, Müller TD, Lickert H. Targeted pharmacological therapy restores β-cell function for diabetes remission. Nat Met. 2020 Feb. 

Salinno C, Cota P, Bastidas-Ponce A, Tarquis-Medina M, Lickert H, Bakhti M. β-Cell Maturation and Identity in Health and Disease. Int J Mol Sci. 2019 Oct 30;20(21).

Scheibner K, Bakhti M, Bastidas-Ponce A and Heiko Lickert. Wnt signaling: implications in endoderm development and pancreas organogenesis. Curr Opin Cell Biol. 2019 Aug 1;61:48-55.

Bastidas-Ponce A*, Tritschler S*, Dony L, Scheibner K, Tarquis-Medina M, Salinno C, Schirge S, Burtscher I, Böttcher A, Theis FJ, Lickert H, Bakhti M. Comprehensive single cell mRNA profiling reveals a detailed roadmap for pancreatic endocrinogenesis. Development. 2019 Jun 17;146(12). (*First authors).

Bakhti M, Bastidas-Ponce A, Lickert H. Sorting out fate determination. Dev Cell. 2019 Apr 8;49(1):1-3. 

Fischer DS, Fiedler AK, Kernfeld EM, Genga RMJ, Bastidas-Ponce A, Bakhti M, Lickert H, Hasenauer J, Maehr R, Theis FJ. Inferring population dynamics from single-cell RNA-sequencing time series data. Nat Biotechnol. 2019 Apr;37(4):461-468.

Guerrero-Flores G, Bastidas-Ponce A, Collazo-Navarrete O, Guerra-Crespo M, Covarrubias L. Functional determination of the differentiation potential of ventral mesencephalic neural precursor cells during dopaminergic neurogenesis. Dev Biol. 2017 Sep 1;429(1):56-70.

Bastidas-Ponce A*, Scheibner K*, Lickert H, Bakhti M. Cellular and molecular mechanisms coordinating pancreas development. Development. 2017 Aug 15;144(16):2873-2888. Review. (*First authors).

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH. (2017) Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity. Cell Metab. 26(4):620-632

Bastidas-Ponce A, Roscioni SS, Burtscher I, Bader E, Sterr M, Bakhti M, Lickert H. Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells. Mol Metab. 2017 Mar 25;6(6):524-534.

Awards

DZD Award 2016