Nutrigenomics and Type 2 Diabetes

So far, more than 40 diabetes risk genes (or rather loci) have been identified. There are variants of these genes differing in single DNA bases due to a mutation, which is called single nucleotide polymorphism (SNP). The biological function of most diabetes risk genes and the functional consequences of the predominantly non-coding mutations are unknown, as are the metabolic and phenotypic effects of the SNPs on carriers. Moreover, there are only few easily measurable clinical parameters which can serve as a basis for the prediction of individual diabetes risk. Therefore, the CCG focuses on the following topics:

  • better understanding of the function of diabetes risk genes
  • interaction between genes and diet in persons at high diabetes risk
  • identification of novel biomarkers for early detection and intervention

Results of the above-mentioned projects will provide the basis for developing human intervention studies in which novel concepts for prevention and intervention will be tested, thus translating gained knowledge into clinical application as quickly as possible.