German Mouse Clinic (GMC)

Publications 2021

Publications 2020

Publications 2019

Publications 2018

Publications 2017

Publications 2016

Publications 2015

Publications 2014

Publications 2013

Publications 2012

Klymiuk I, Kenner L, Adler T, Busch DH, Boersma A, Irmler M, Fridrich B, Gailus-Durner V, Fuchs H, Leitner N, Müller M, Kühn R, Schlederer M, Treise I, Hrabé de Angelis M, Beckers J:
Functional requirement of the mouse gene for germ cell development, interferon mediated immune response and somitogenesis
PLoS One 7:e44609 (2012)

Waltereit R, Leimer U, von Bohlen und Halbach O, Panke J, Hölter SM, Garrett L, Wittig K, Schneider M, Schmitt C, Calzada-Wack J, Neff F, Becker L, Prehn C, Kutscherjawy S, Endris V, Bacon C, Fuchs H, Gailus-Durner V, Berger S, Schönig K, Adamski J, Klopstock T, Esposito I, Wurst W, Hrabé de Angelis M, Rappold G, Wieland T, Bartsch D:
Mice present a neurodevelopmental disorder with schizophrenia-related intermediate phenotypes
Faseb J 26, 4418-4428 (2012)

Thiele F, Cohrs CM, Flor A, Lisse TS, Przemeck GKH, Horsch M, Schrewe A, Gailus-Durner V, Ivandic B, Katus, HA, Wurst W, Reisenberg C, Chaney H, Fuchs H, Hans W, Beckers J, Marini JC, Hrabé de Angelis M:
Cardiopulmonary dysfunction in the Osteogenesis imperfecta mouse model Aga2 and human patients are caused by bone-independent mechanisms
Hum Mol Genet 21, 3535-3545 (2012)

Stein C, Kling L, Proetzel G, Roopenian DC, Hrabé de Angelis M, Wolf E, Rathkolb B: Clinical chemistry of human FcRn transgenic mice
Mamm Genome 23, 259-269 (2012)

Hüttemann M, Lee I, Gao X, Pecina P, Pecinova A, Liu J, Aras S, Sommer N, Sanderson TH, Tost M, Neff F, Aguilar-Pimentel JA, Becker L, Naton B, Rathkolb B, Rozman J, Favor J, Hans W, Prehn C, Puk O, Schrewe A, Sun M, Höfler H, Adamski J, Bekeredjian R, Graw J, Adler T, Busch DH, Klingenspor M, Klopstock T, Ollert M, Wolf E, Fuchs H, Gailus-Durner V, Hrabé de Angelis M Weissmann N, Doan JW, Bassett DJ, Grossman LI: Cytochrome oxidase subunit 4 isoform 2-knockout mice show reduced enzyme activity, airway hyporeactivity, and lung pathology
Faseb J 26, 2916-2930 (2012)

Pabel J, Faust M, Prehn C, Wörlein B, Allmendinger L, Höfner, G, Wanner KT: Development of an ()-1-{2-[Tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [()-SNAP-5114] carba analogue inhibitor for murine ?-aminobutyric acid transporter type?
ChemMedChem 7, 1245-1255 (2012)

Fuchs H, Sabrautzki S, Seedorf H, Rathkolb B, Rozman J, Hans W, Schneider R, Klaften M, Hölter SM, Becker L, Klempt M, Elvert R, Wurst W, Klopstock T, Klingenspor M, Wolf E, Gailus-Durner V, Hrabé de Angelis M: Does enamelin have pleiotropic effects on organs other than the teeth? Lessons from a phenotyping screen of two enamelin-mutant mouse lines
Eur J Oral Sci 120, 269-277 (2012)

Afonso LC, Schöfer F, Hoeschen C, Caldas LVE: Dose sensitivity enhancement on polymer gel with suspended gold particles
Nukleonika 57, 467-472 (2012)

Lee AW, Hengstler H, Schwald K, Berriel-Diaz M, Loreth D Kirsch M, Kretz O, Haas CA, Hrabé de Angelis M, Herzig S, Brümmendorf T, Klingenspor M, Rathjen FG, Rozman J, Nicholson G, Cox RD, Schäfer MK: Functional inactivation of the genome-wide association study obesity gene neuronal growth regulator 1 in mice causes a body mass phenotype
PLoS One 7:e41537 (2012)

Fuchs H, Gailus-Durner V, Neschen S, Adler T, Afonso LC, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Dewert A, Fridrich B, Garrett L, Glasl L, Götz A, Hans W, Hölter SM, Horsch M, Hurt A, Janas E, Janik D, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Prehn C, Puk O, Rácz I, Räß M, Rathkolb B, Rozman J, Scheerer M, Schiller E, Schrewe A, Steinkamp R, Stöger C, Sun M, Szymczak W, Treise I, Vargas Panesso IL, Vernaleken AM, Willershäuser M, Wolff-Muscate A, Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Eickelberg O, Favor J,Graw J,Höfler H, Hoeschen C, Katus H, Klingenspor M, Klopstock T, Neff F,Ollert M, Schulz H, Stöger T, Wolf E, Wurst W ,Yildirim AO, Zimmer A, Hrabé de Angelis M: Innovations in phenotyping of mouse models in the German Mouse Clinic
Mamm Genome 23 611-622 (2012)

Staropoli JF, Haliw L, Biswas S, Garrett L, Hölter SM, Becker L, Skosyrski S, Da Silva-Buttkus P, Calzada-Wack J, Neff F, Rathkolb B, Rozman J, Schrewe A, Adler T, Puk O, Sun MX, Favor J, Racz I, Bekeredjian R, Busch D H, Graw J, Klingenspor M, Klopstock T, Wolf E, Wurst W, Zimmer A, Lopez E, Harati H, Hill E, Krause DS, Guide J, Dragileva E, Gale E, Wheeler VC, Boustany RM, Brown DE, Breton S, Ruether K, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Cotman SL: Large-scale phenotyping of an accurate genetic mouse model of JNCL identifies novel early pathology outside the central nervous system
PLoS One 7:e38310 (2012)


Irmler M, Gentier RJ, Dennissen FJ, Schulz H, Bolle I, Hölter SM, Kallnik M, Cheng JJ, Klingenspor M, Rozman J, Ehrhardt N, Hermes DJ, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Meyer HE, Hopkins DA, Van Leeuwen FW, Beckers J: Long-term proteasomal inhibition in transgenic mice by UBB expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients
Acta Neuropathol 124 187-197 (2012)

Fuchs H, Neschen S, Rozman J, Rathkolb B, Wagner S, Adler T, Alfonso L, Aguilar-Pimentel JA, Becker L, Bohla A, Calzada-Wack J, Cohrs C, Frankó A, Garrett L, Glasl L, Götz A, Hagn M, Hans W, Hölter SM, Horsch M, Kahle M, Kistler M, Klein-Rodewald T, Lengger C, Ludwig T, Maier H, Marschall S, Micklich K, Möller G, Naton B, Neff F, Prehn C, Puk O, Rácz I, Räß M, Scheerer M, Schiller E, Schöfer F, Schrewe A, Steinkamp R, Stöger C, Treise I, Willershäuser M Wolff- Muscate A Zeh R, Adamski J, Beckers J, Bekeredjian R, Busch DH, Favor J, Graw J, Katus H, Klopstock T, Ollert M, Schulz H, Stöger T, Wurst W, Yildirim AÖ, Zimmer A, Wolf E, Klingenspor M, Gailus-Durner V, Hrabé de Angelis M: Mouse genetics and metabolic mouse phenotyping
In: Genetics Meets Metabolomics: from Experiment to Systems Biology : Springer 2012 85-106

Ayadi A, Birling M-C, Bottomley J, Bussel L, Fuchs H, Frayx M, Gailus-Durner V, Greenaway S, Houghton R, Karp N, Leblanc S, Lengger C,Maier H, Mallon A-M, Marschall S, Melvin D, Morgan H, Pavlovic G, Ryder E, Skarnes WC, Selloum M, Ramirez-SolisR, Sorg T, Teboul L, Vasseur L, Walling A, Weaver T, Wells S, White JK, Bradley A, Adams DJ, Steel KP, Hrabé de Angelis M, Brown SD, Herault Y: Mouse large-scale phenotyping initiatives: Overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute mouse genetics project
Mamm Genome 23 600-610 (2012)

Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, Hrabé de Angelis M, Klingenspor M, Schiöth HB, Kilimann MW: Neurobeachin a regulator of synaptic protein targeting is associated with body fat mass and feeding behavior in mice and body-mass index in humans
PLoS Genet 8:e1002568 (2012)

Radermacher KA, Wingler K, Langauser F, Altenhöfer S, Kleikers P, Hermans JJR, Hrabé de Angelis M, Kleinschnitz C, Schmidt HHHW: Neuroprotection after stroke by targeting NOX4 as a source of oxidative stress
Antioxid Redox Signal DOI:10 1089/ars 2012 4797 (2012)

Sabrautzki S, Rubio-Aliaga I, Hans W, Fuchs H, Rathkolb B, Calzada-Wack J, Cohrs CM, Klaften M, Seedorf H, Eck S, Benet-Pagès A, Favor J, Esposito I, Strom TM, Wolf E, Lorenz-Depiereux B, Hrabé de Angelis M: New mouse models for metabolic bone diseases generated by genome-wide ENU mutagenesis
Mamm Genome 23 416-430 (2012)

Eißmann M, Melzer IM, Fernández SB, Michel G, Hrabé de Angelis M, Hoefler G, Finkenwirth P, Jauch A, Schoell B, Grez M, Schmidt M, Bartholomae CC, Newrzela S, Haetscher N, Rieger MA, Zachskorn C, Mittelbronn M, Zörnig M: Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms Oncogene doi:10 1038/onc 2012 263 (2012)
Galli GG, Honnens de Lichtenberg K, Carrara M, Hans W, Wuelling M, Mentz B, Multhaupt HA, Fog CK, Jensen KT, Rappsilber J, Vortkamp A, Coulton L, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Calogero RA, Couchman JR, Lund AH: Prdm5 regulates collagen gene transcription by association with RNA polymerase II in developing bone
PLoS Genet 8:e1002711 (2012)

Kollmus H, Post R, Brielmeier M, Fernández J, Fuchs H, McKerlie C, Montoliu L, Otaegui PJ, Rebelo M, Riedesel H, Ruberte J, Sedlacek R, Hrabé de Angelis M, Schughart K: Structural and functional concepts in current mouse phenotyping and archiving facilities
J Amer Assoc Lab Anim Sci 51 418-435 (2012)

Willershäuser M, Ehrhardt N, Elvert R, Wirth EK, Schweizer U, Gailus-Durner V, Fuchs H, Hrabé de Angelis M, Rozman J, Klingenspor M: Systematic screening for mutant mouse lines with defects in body temperature regulation
In: Living in a Seasonal World Berlin Heidelberg : Springer 2012 459-469

Finan B, Yang B, Ottaway N, Stemmer K, Müller TD, Yi C-X, Habegger K, Schriever SC, García-Cáceres C, Kabra DG, Hembree J, Holland J, Raver C, Seeley RJ, Hans W, Irmler M, Beckers J, Hrabé de Angelis M, Tiano JP, Mauvais-Jarvis F, Perez-Tilve D, Pfluger P, Zhang L, Gelfanov V, DiMarchi RD, Tschöp MH:
Targeted estrogen delivery reverses the metabolic syndrome
Nat Med 18 1847-1856 (2012)

Pozzi B, Amodio S, Lucano C, Sciullo A, Ronzoni S, Castelletti D, Adler T, Treise I, Holmberg-Betsholtz I, Rathkolb B, Busch DH, Wolf E, Fuchs H, Gailus-Durner V, Hrabé de Angelis M, Betsholtz C, Casola S, Di Fiore PP, Offenhäuser N: The endocytic adaptor Eps15 controls marginal zone B cell numbers
PLoS One 7:e50818 (2012)

Hochrath K, Krawczyk M, Goebel R, Rathkolb B, Micklich K, Rozman J, Horsch M, Beckers J, Klingenspor M, Fuchs H, Gailus-Durner V, Wolf E, Acalovschi M, Volmer DA, Hrabé de Angelis M, Lammert F: The hepatic phosphatidylcholine transporter ABCB4 as modulator of glucose homeostasis
Faseb J 26 5081-5091 (2012)

Kühne C, Puk O, Graw J, Hrabé de Angelis M, Schütz G, Wurst W, Deussing JM: Visualizing corticotropin-releasing hormone receptor type 1 expression and neuronal connectivities in the mouse using a novel multifunctional allele J Comp Neurol 520 3150-3180 (2012)

Garrett L, Lie DC, Hrabé de Angelis M, Wurst W, Hölter SM:
Voluntary wheel running in mice increases the rate of neurogenesis without affecting anxiety-related behaviour in single tests
BMC Neurosci 13:61 (2012)

Publications 2011

  • Horsch M, Seeburg PH, Adler T, Aguilar-Pimentel JA, Becker L, Calzada-Wack J, Garrett L, Götz A, Hans W, Higuchi M, Hölter SM, Naton B, Prehn C, Puk O, Rácz I, Rathkolb B, Rozman J, Schrewe A, Adamski J, Busch DH, Esposito I, Graw J, Ivandic B, Klingenspor M, Klopstock T, Mempel M, Ollert M, Schulz H, Wolf E, Wurst W, Zimmer A, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Beckers J. Requirement of the RNA editing enzyme ADAR2 for normal physiology in mice.  J Biol Chem. 2011 Apr 5. (Epub ahead of print)
  • Abe K*, Fuchs H*, Boersma A*, Hans W*, Yu P, Kaladjiev S*, Klaften M*, Adler T*, Cazada-Wack J*, Mossbrugger I*, Rathkolb B*, Rozman J*, Prehn J*, Maraslioglu M, Kametani Y, Shimada S, Adamski J*, Busch DH, Esposito I*, Klingenspor M, Wolf E, Wurst W*, Gailus-Durner V*, Katan M, Marschall S*, Soewarto D*, Wagner S*, Hrabé de Angelis M*: A novel ENU-induced mutation in Phospholipase C gamma 2 causes inflammatory arthritis, metabolic defects, and in vitro infertility in the mouse. Arthritis Rheum.-US (Epub ahead of print) (2011)
  • Fuchs H*, Gailus-Durner V*, Adler T, Aguilar-Pimentel JA*, Becker L*, Calzada-Wack J*, Da Silva-Buttkus P*, Neff F*, Götz A*, Hans W*, Hölter SM*, Horsch M*, Kastenmüller G*, Kemter E, Lengger C*, Maier H*, Matloka M*, Möller G*, Naton B*, Prehn C*, Puk O*, Rácz I, Rathkolb B*, Römisch-Margl W*, Rozman J*, Wang-Sattler R*, Schrewe A*, Stöger C*, Tost M*, Adamski J*, Aigner B, Beckers J*, Behrendt H*, Busch DH, Esposito I*, Graw J*, Illig T*, Ivandic B, Klingenspor M, Klopstock T, Kremmer E*, Mempel M, Neschen S*, Ollert M, Schulz H*, Suhre K*, Wolf E, Wurst W*, Zimmer A, Hrabé de Angelis M*: Mouse phenotyping. Methods. 53, 120-135 (2011)
  • Lückerath K, Kirkin V, Melzer IM, Thalheimer FB, Siele D, Milani W, Adler T*, Aguilar-Pimentel A*, Horsch M*, Michel G*, Beckers J*, Busch DH, Ollert M, Gailus-Durner V*, Fuchs H*, Hrabé de Angelis M*, Staal FJT, Rajalingam K, Hueber AO, Strobl LJ, Zimber-Strobl U, Zörnig M: Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. Blood 117(2), 519-529 (2011)
  • Puk O*, Ahmad N, Wagner S*, Hrabé de Angelis M*, Graw J*: First mutation in the βA2-crystallin encoding gene is associated with small lenses and age-related cataracts. Invest Ophth Vis Sci (Epub ahead of print) (2011)
  • Saarikangas J, Mattila PK, Varjosalo M, Bovellan M, Hakanen J, Calzada-Wack J*, Tost M*, Jennen L, Rathkolb B*, Hans W*, Horsch M*, Hyvönen ME, Perälä N, Fuchs H*, Gailus-Durner V*, Esposito I*, Wolf E, Hrabé de Angelis M*, Frilander MJ, Savilahti H, Sariola H, Sainio K, Lehtonen S, Taipale J, Salminen M, Lappalainen P: Missing-in metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia. J. Cell Science 124, 1245-1255 (2011)

Publications 2010

  • Aguilar-Pimentel JA*, Alessandrini F*, Huster KM*, Jakob T, Schulz H*, Behrendt H*, Ring J*, Hrabé de Angelis M*, Busch DH*, Mempel M*, Ollert M: Specific CD8 T cells in IgE-mediated allergy correlate with allergen dose and allergic phenotype. Am. J. Respir. Crit. Care. Med. 181, 7-16 (2010)
  • Braulke LJ, Heldmaier G, Berriel Diaz M, Rozman J*, Exner C: Seasonal changes of myostatin expression and its relation to body mass acclimation in the Djungarian hamster. J. Exp. Zool. 31A, 548-556 (2010)
  • Deussing JM, Breu J, Kühne C, Kallnik M*, Bunck M, Glasl L*, Yen YC, Schmidt MV, Zurmühlen R, Vogl AM, Gailus-Durner V*, Fuchs H*, Hölter SM*, Wotjak CT, Landgraf R, Hrabé de Angelis M*, Holsboer F, Wurst W*: Urocortin 3 modulates social discrimination abilities via corticotropin-releasing hormone receptor type 2. J. Neurosci. 30, 9103-9116 (2010)
  • Hesse D, Dunn M, Heldmaier G, Klingenspor M, Rozman J*: Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity. Physiol. Behav. 99, 370-380 (2010)
  • Kemter E, Rathkolb B*, Bankir L, Schrewe A*, Hans W*, Landbrecht C, Klaften M*, Ivandic B, Fuchs H*, Gailus-Durner V*, Hrabé de Angelis M*, Wolf E, Wanke R, Aigner B: Mutation of the Na+-K+-2Cl‾ cotransporter NKCC2 in mice is associated with severe polyuria and a urea-selective concentrating defect without hyperreninemia. Am. J. Physiol. Renal. Physiol. 298, F1405-F1415 (2010)
  • Kleinschnitz C, Grund H, Wingler K, Armitage ME, Jones E, Mittal M, Barit D, Schwarz T, Geis C, Kraft P, Barthel K, Schuhmann MK, Herrmann AM, Meuth SG, Stoll G, Meurer S, Schrewe A*, Becker L*, Gailus-Durner V*, Fuchs H*, Klopstock T, Hrabé de Angelis M*, Jandeleit-Dahm K, Shah AM, Weissmann N, Schmidt HH: Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration. PLoS Biol. 8:e1000479 (2010)
  • Meyer CW, Willershäuser M*, Jastroch M, Rourke BC, Fromme T, Oelkrug R, Heldmaier G, Klingenspor M: Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice. Am. J. Physiol.-Regul. Integr. Comp. Physiol. 299, R1396-R1406 (2010)
  • Morgan H, Beck T, Blake A, Gates H, Adams N, Debouzy G, Leblanc S, Lengger C*, Maier H*, Melvin D, Meziane H, Richardson D, Wells S, White J, Wood J, Hrabé de Angelis M*, Brown S, Hancock JM, Mallon AM: EuroPhenome: A repository for high-throughput mouse phenotyping data. Nucleic Acids Res. 38, D577-D585 (2010)
  • Pham TT*, Giesert F*, Rothig A*, Floss T*, Kallnik M*, Weindl K*, Hölter SM*, Ahting U*, Prokisch H*, Becker L*, Klopstock T, Hrabé de Angelis M*, Beyer K, Gorner K, Kahle PJ, Vogt-Weisenhorn DM*, Wurst W*: DJ-1-deficient mice show less TH-positive neurons in the ventral tegmental area and exhibit non-motoric behavioural impairments. Genes Brain Behav. 9, 305-317 (2010)
  • Rosemann M*, Ivashkevich A*, Favor J*, Dalke C*, Hölter SM*, Becker L*, Rácz I, Bolle I*, Klempt M*, Rathkolb B*, Kalaydjiev S*, Adler T*, Aguilar A*, Hans W*, Horsch M*, Rozman J*, Calzada-Wack J*, Kunder S*, Naton B*, Gailus-Durner V*, Fuchs H*, Schulz H*, Beckers J*, Busch DH, Burbach JP, Smidt MP, Quintanilla-Martinez L*, Esposito I*, Klopstock T, Klingenspor M, Ollert M, Wolf E, Wurst W*, Zimmer A, Hrabé de Angelis M*, Atkinson M*, Heinzmann U*, Graw J*: Microphthalmia, parkinsonism, and enhanced nociception in Pitx3(416insG) mice. Mamm. Genome 21, 13-27 (2010)
  • Schofield PN, Eppig J, Huala E, Hrabé de Angelis M*, Harvey M, Davidson D, Weaver T, Brown S, Smedley D, Rosenthal N, Schughart K, Aidinis V, Tocchini-Valentini G, Hancock JM: Sustaining the data and bioresource commons. Science 330, 592-593 (2010)
  • Shimokawa N, Haglund K, Hölter SM*, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J*, Hoeller D, Qiu CH, Londono MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher SW, Wolfer DP, Ehrhardt N*, Heuchel R, Nezis I, Brech A, Schmidt MHH, Fuchs H*, Gailus-Durner V*, Klingenspor M, Bogler O, Wurst W*, Deller T, Hrabé de Angelis M*, Dikic I: CIN85 regulates dopamine receptor endocytosis and governs behaviour in mice. EMBO J. 29, 2421-2432 (2010)
  • Tocchetti A, Soppo CBE, Zani F, Bianchi F, Gagliani MC, Pozzi B, Rozman J*, Elvert R*, Ehrhardt N*, Rathkolb B*, Mörth C*, Horsch M*, Fuchs H*, Gailus-Durner V*, Beckers J*, Klingenspor M, Wolf E, Hrabé de Angelis M*, Scanziani E, Tacchetti C, Scita G, Di Fiore PP, Offenhäuser N: Loss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in mice. PLoS One 5:e9468 (2010)
  • Vegiopoulos A, Müller-Decker K, Strzoda D, Schmitt I, Chichelnitskiy E, Ostertag A*, Diaz MB, Rozman J*, Hrabé de Angelis M*, Nüsing RM, Meyer CW, Wahli W*, Klingenspor M*, Herzig S: Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 328, 1158-1161 (2010)
  • Wurst W*, Hrabé de Angelis M*: Systematic phenotyping of mouse mutants. Nat. Biotechnol. 28, 684-685 (2010)
  • Yin R*, Tian F*, Frankenberger B*, Hrabé de Angelis M*, Stöger T*:B Selection and evaluation of stable housekeeping genes for gene expression normalization in carbon nanoparticle-induced acute pulmonary inflammation in mice. Biochem. Biophys. Res. Commun. 399, 531-536 (2010)

Publications 2009

  • Abe K*, Klaften M*, Narita A, Kimura T, Imai K, Kimura M, Rubio-Aliaga I*, Wagner S*, Jakob T, Hrabé de Angelis M*: Genome-wide search for genes that modulate inflammatory arthritis caused by Ali18 mutation in mice. Mamm. Genome 20, 152-161 (2009)
  • Aigner B, Rathkolb B*, Klaften M*, Sedlmeier R, Klempt M*, Wagner S*, Michel D*, Mayer U, Klopstock T, Hrabé de Angelis M*, Wolf E: Generation of N-ethyl-N-nitrosourea-induced mouse mutants with deviations in plasma enzyme activities as novel organ-specific disease models. Exp. Physiol. 94, 412-421 (2009)
  • Aigner B, Rathkolb B*, Klempt M*, Wagner S*, Michel D*, Hrabé de Angelis M*, Wolf E: N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels. J. Biomed. Sci. 16, (2009)
  • Ahting U*, Floss T*, Uez N*, Schneider-Lohmar I*, Becker L*, Kling E*, Iuso A*, Bender A, Hrabé de Angelis M*, Gailus-Durner V*, Fuchs H*, Meitinger T*, Wurst W*, Prokisch H*, Klopstock T*: Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim. Biophys. Acta 1787, 371-376 (2009)
  • Beckers J*, Wurst W*, Hrabé de Angelis M*: Towards better mouse models: Enhanced genotypes, systemic phenotyping and envirotype modelling. Nat. Rev. Genet. 10, 371-380 (2009)
  • Enard W, Gehre S, Hammerschmidt K, Hölter SM*, Blass T, Somel M, Brückner MK, Schreiweis C, Winter C, Sohr R, Becker L*, Wiebe V, Nickel B, Giger T, Müller U, Groszer M, Adler T*, Aguilar A*, Bolle I*, Calzada-Wack J*, Dalke C*, Ehrhardt N*, Favor J*, Fuchs H*, Gailus-Durner V*, Hans W*, Hölzlwimmer G*, Javaheri A*, Kalaydjiev S, Kallnik M*, Kling E*, Kunder S*, Moßbrugger I*, Naton B*, Rácz I, Rathkolb B*, Rozman J*, Schrewe A*, Busch DH, Graw J*, Ivandic B, Klingenspor M, Klopstock T, Ollert M, Quintanilla-Martinez L*, Schulz H*, Wolf E, Wurst W*, Zimmer A, Fisher SE, Morgenstern R, Arendt T, Hrabé de Angelis M*, Fischer J, Schwarz J, Pääbo S: A humanized version of Foxp2 affects cortico-basal ganglia circuits in mice. Cell 137, 961-971 (2009)
  • Fuchs H*, Gailus-Durner V*, Adler T*, Aguilar Pimentel JA*, Becker L*, Bolle I*, Brielmeier M*, Calzada-Wack J*, Dalke C*, Ehrhardt N*, Fasnacht N, Ferwagner B*, Frischmann U, Hans W*, Hölter SM*, Hölzlwimmer G*, Horsch M*, Javaheri A, Kallnik M*, Kling E*, Lengger C*, Maier H*, Mossbrugger I*, Mörth C*, Naton B*, Nöth U*, Pasche B, Prehn C*, Przemeck GKH*, Puk O*, Rácz I, Rathkolb B*, Rozman J*, Schäble K*, Schreiner R, Schrewe A*, Sina C, Steinkamp R*, Thiele F*, Willershäuser M*, Zeh R*, Adamski J*, Busch DH, Beckers J*, Behrendt H, Daniel H, Esposito I*, Favor J*, Graw J*, Heldmaier G, Höfler H*, Ivandic B, Katus H, Klingenspor M, Klopstock T, Lengeling A, Mempel M, Müller W, Neschen S*, Ollert M, Quintanilla-Martinez L*, Rosenstiel P, Schmidt J*, Schreiber S, Schughart K, Schulz H*, Wolf E, Wurst W*, Zimmer A, Hrabé de Angelis M*: The German Mouse Clinic: A platform for systemic phenotype analysis of mouse models. Curr. Pharm. Biotechnol. 10, 236-243 (2009)
  • Grzmil P, Konietzko J, Boehm D, Hoelter SM*, Aguilar A*, Javaheri A*, Kalaydjiev S*, Adler T*, Bolle I, Adham I, Dixkens C, Wolf S, Fuchs H*, Gailus-Durner V*, Wurst W*, Ollert M, Busch D, Schulz H*, Hrabé de Angelis M*, Burfeind P*: Targeted disruption of the mouse Npal3 gene leads to deficits in behavior, increased IgE levels, and impaired lung function. Cytogenet. Genome Res. 125, 186-200 (2009)
  • Isensee J, Meoli L, Zazzu V, Nabzdyk C, Witt H, Soewarto D*, Effertz K, Fuchs H*, Gailus-Durner V*, Busch D, Adler T*, Hrabé de Angelis M*, Irgang M, Otto C, Noppinger PR: Expression pattern of G Protein-coupled receptor 30 in LacZ reporter mice. Endocrinology 150, 1722-1730 (2009)
  • Kemter E, Rathkolb B*, Rozman J*, Hans W*, Schrewe A*, Landbrecht C, Klaften M*, Ivandic B, Fuchs H*, Gailus-Durner V*, Klingenspor M, Hrabé de Angelis M*, Wolf E, Wanke R, Aigner B: Novel missense mutation of uromodulin in mice causes renal dysfunction with alterations in urea handling, energy, and bone metabolism. Am. J. Physiol. Renal Physiol. 297, F1391-F1398 (2009)
  • Khasawneh J, Schulz MD, Walch A*, Rozman J*, Hrabé de Angelis M*, Klingenspor M, Buck A, Schwaiger M, Saur D, Schmid RM, Klöppel G, Sipos B, Greten FR, Arkan MC: Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion. Proc. Natl. Acad. Sci. U.S.A. 106, 3354-3359 (2009)
  • Klonisch T, Glogowska A, Gratao AA, Grzech M, Nistor A, Torchia M, Weber E, Hrabé de Angelis M*, Rathkolb B*, Hoang-Vu C, Wolf E, Schneider MR: The C-terminal cytoplasmic domain of human proEGF is a negative modulator of body and organ weights in transgenic mice. FEBS Lett. 583, 1349-1357 (2009)
  • Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H*, Gailus-Durner V*, Hulme H, Iraqi F, Kemp S, Rathkolb B*, Wolf E, Hrabé de Angelis M*, Roshandel D, Naessens J: Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLoS ONE 4:e5170 (2009)
  • Puk O*, Dalke C*, Calzada-Wack J*, Ahmad N*, Klaften M*, Wagner S*, Hrabé de Angelis M*, Graw J*: Reduced corneal thickness and enlarged anterior chamber in a novel ColVIIIa2(G257D) mutant mouse. Invest. Ophthalmol. Vis. Sci. 50, 5653-5661 (2009)
  • Puk O*, Esposito I*, Söker T*, Löster J*, Budde B, Nürnberg P, Michel-Soewarto D*, Fuchs H*, Wolf E, Hrabé de Angelis M*, Graw J*: A new Fgf10 mutation in the mouse leads to atrophy of the harderian gland and slit-eye phenotype in heterozygotes: A novel model for dry-eye disease? Invest. Ophthalmol. Vis. Sci. 50, 4311-4318 (2009)
  • Rathkolb B*, Noyes HA, Brass A, Dark P, Fuchs H*, Gailus-Durner V*, Gibson J, Hrabé de Angelis M*, Ogugo M, Iraqi F, Kemp SJ, Naessens J, Pope ME, Wolf E, Agaba M: Clinical chemistry of congenic mice with quantitative trait loci for predicted responses to Trypanosoma congolense infection. Infect. Immun. 77, 3948-3957 (2009)
  • Rubio-Aliaga I*, Przemeck GKH*, Fuchs H*, Gailus-Durner V*, Adler T*, Hans W*, Horsch M*, Rathkolb B*, Rozman J*, Schrewe A*, Wagner S*, Hoelter SM*, Becker L*, Klopstock T, Wurst W*, Wolf E, Klingenspor M, Ivandic BT, Busch DH, Beckers J*, Hrabé de Angelis M*: Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS ONE 4:e6054 (2009)
  • Schofield PN, Bubela T, Weaver T, Portilla L, Brown SD, Hancock JM, Einhorn D, Tocchini-Valentini G, Hrabé de Angelis M*, Rosenthal N, et. al.: Post-publication sharing of data and tools. Nature 461, 171-173 (2009)
  • Wirth EK, Roth S, Blechschmidt C, Hölter SM*, Becker L*, Rácz I*, Zimmer A, Klopstock T, Gailus-Durner V*, Fuchs H*, Wurst W*, Naumann T, Bräuer A, Hrabé de Angelis M*, Köhrle J, Grüters A, Schweizer U: Neuronal 3',3,5-triiodothyronine (T2) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T2 transporter mutated in Allan-Herndon-Dudley syndrome. J. Neurosci. 29, 9439-9449 (2009)

Publications 2008

  • Abe K*, Wechs S*, Kalaydjiev S*, Franz TJ*, Busch DH*, Fuchs H*, Soewarto D*, Behrendt H*, Wagner S*, Jakob T*, Hrabé de Angelis M*: Novel lymphocyte-independent mechanisms to initiate inflammatory arthritis via bone marrow-derived cells of Ali18 mutant mice. Rheumatology 47, 292-300 (2008)
  • Aigner B, Rathkolb B*, Herbach N, Hrabé de Angelis M*, Wanke R, Wolf E: Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am. J. Physiol. Endocrinol. Metab. 294, E232-40 (2008)
  • Bender A*, Beckers J*, Schneider I, Hölter SM*, Haack T*, Ruthsatz T, Vogt-Weisenhorn DM*, Becker L*, Genius J*, Rujescu D*, Irmler M*, Mijalski T*, Mader M, Quintanilla-Martinez L*, Fuchs H*, Gailus-Durner V*, Hrabé de Angelis M*, Wurst W*, Schmid J, Klopstock T: Creatine improves health and survival of mice. Neurobiol. Aging 29, 1404-1411 (2008)
  • Fuchs H*, Lisse T*, Hans W*, Abe K*, Thiele F*, Gailus-Durner V*, Hrabé de Angelis M*: Phenotypic characterization of mouse models for bone-related diseases in the German Mouse Clinic. J. Musculoskelet. Neuronal. Interact. 8, 13-14 (2008)
  • Hölter SM*, Dalke C*, Kallnik M*, Becker L*, Horsch M*, Schrewe A*, Favor J*, Klopstock T, Beckers J*, Ivandic B, Gailus-Durner V*, Fuchs H*, Hrabé de Angelis M*, Graw J*, Wurst W*: 'Sighted C3H' mice - a tool for analysing the influence of vision on mouse behaviour? Front. Biosci. 13, 5810-5823 (2008)
  • Lisse TS*, Thiele F*, Fuchs H*, Hans W*, Przemeck GKH*, Abe K*, Rathkolb B*, Quintanilla-Martinez L, Hölzlwimmer G, Helfrich M, Wolf E, Ralston SH, Hrabé de Angelis M*: ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet. 4:e7 (2008)
  • Horsch M*, Schädler S*, Gailus-Durner V*, Fuchs H*, Meyer H, Hrabé de Angelis M*, Beckers J*: Systematic gene expression profiling of mouse model series reveals coexpressed genes. Proteomics 8, 1248-1256 (2008)
  • Maier H*, Lengger C*, Simic B, Fuchs H*, Gailus-Durner V*, Hrabé de Angelis M*: MausDB: An open source application for phenotype data and mouse colony management in large-scale mouse phenotyping projects. BMC Bioinformatics 9:169 (2008)
  • Puk O*, Dalke C*, Hrabé de Angelis M*, Graw J*: Variation of the response to the optokinetic drum among various strains of mice. Front. Biosci. 13, 6269-6275 (2008)
  • Puk O*, Löster J*, Dalke C*, Soewarto D*, Fuchs H*, Budde B, Nürnberg P, Wolf E, Hrabé de Angelis M*, Graw J*: Mutation in a novel connexin-like gene (Gjf1) in the mouse affects early lens development and causes a variable small-eye phenotype. Invest. Ophthalmol. Vis. Sci. 49, 1525-1532 (2008)
  • Schmidt S, Gawlik V, Hölter SM*, Augustin R, Scheepers A, Behrens M, Wurst W*, Gailus-Durner V*, Fuchs H*, Hrabé de Angelis M*, Kluge R, Joost HG, Schürmann A: Deletion of glucose transporter GLUT8 in mice increases locomotor activity. Behav. Genet. 38, 396‑406 (2008)
  • Söker T*, Dalke C*, Puk O*, Floss T*, Becker L*, Bolle I, Favor J*, Hans W*, Hölter SM*, Horsch M*, Kallnik M*, Kling E*, Mörth C*, Schrewe A*, Stigloher C*, Topp S*, Gailus-Durner V*, Naton B*, Beckers J*, Fuchs H*, Ivandic B, Klopstock T, Schulz H*, Wolf E, Wurst W*, Bally-Cuif L*, Hrabé de Angelis M*, Graw J*: Pleiotropic effects in Eya3 knockout mice. BMC Dev. Biol. 8:118 (2008)

Publications 2007

  • Aigner B, Rathkolb B*, Herbach N, Kemter E, Schessl C, Klaften M*, Klempt M*, Hrabé de Angelis M*, Wanke R, Wolf E: Screening for increased plasma urea levels in a large-scale ENU mouse mutagenesis project reveals kidney disease models. Am. J. Physiol. Renal Physiol. 292, 1560-1567 (2007)
  • Aigner B, Rathkolb B*, Mohr M*, Klempt M*, Hrabé de Angelis M*, Wolf E: Generation of ENU-induced mouse mutants with hypocholesterolemia: Novel tools for dissecting plasma lipoprotein homeostasis. Lipids 42, 731-737 (2007
  • Hancock JM, Adams NC, Aidinis V, Blake A, Blake JA, Bogue M, Brown SDM, Chesler E, Davidson D, Duran C, Eppig JT, Gailus-Durner V*, Gates H, Gkoutos GV, Greenaway S, Hrabé de Angelis M*, Kollias G, Leblanc S, Lee K, Lengger C*, Maier H*, Mallon AM, Masuya H, Melvin DG, Muller W, Parkinson H, Proctor G, Reuveni E, Schofield P, Shukla A, Smith C, Toyoda T, Vasseur L, Wakana S, Walling A, White J, Wood J, Zouberakis M: Integration of mouse phenome data resources. Mamm. Genome 18, 157-163 (2007)
  • Herbach N, Rathkolb B*, Kemter E, Pichl L, Klaften M*, Hrabé de Angelis M*, Halban P A, Wolf E, Aigner B, Wanke R: Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes 56, 1268-1276 (2007)
  • Kallnik M*, Elvert R*, Ehrhardt N*, Kissling D*, Mahabir E*, Welzl G*, Faus-Kessler T*, Hrabé de Angelis M*, Wurst W*, Schmidt J*, Hölter SM*: Impact of IVC housing on emotionality and fear learning in male C3HeB/FeJ and C57BL/6J mice. Mamm. Genome 18, 173-186 (2007)
  • Meyer CW, Elvert R*, Scherag A, Ehrhardt N*, Gailus-Durner V*, Fuchs H*, Schäfer H, Hrabé de Angelis M*, Klingenspor M: Power matters in closing the phenotyping gap. Naturwissenschaften 94, 401-406 (2007)
  • Rubio-Aliaga I*, Soewarto D*, Wagner S*, Klaften M*, Fuchs H*, Kalaydjiev S*, Busch DH, Klempt M*, Rathkolb B*, Wolf E, Abe K*, Zeiser S*, Przemeck GKH*, Beckers J*, Hrabé de Angelis M*: A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse. Genetics 175, 1451-1463 (2007)
  • Seedorf H, Klaften M*, Fuchs H*, Seedorf U, Hrabé de Angelis M*: A mutation in the enamelin gene in a mouse model. J. Dent. Res. 86, 764-768 (2007)
  • Vauti F, Goller T, Beine R, Becker L*, Klopstock T, Hölter SM*, Wurst W*, Fuchs H*, Gailus-Durner V*, Hrabé de Angelis M*, Arnold H-H: The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour. Gene 389, 174-185 (2007)

Publications 2006

  • Abe K*, Fuchs H*, Lisse T*, Hans W*, Hrabé de Angelis M*: New ENU-induced semidominant mutation, Ali18, causes inflammatory arthritis, dermatitis and osteoporosis in the mouse. Mamm. Genome 17, 915-926 (2006)
  • del Barco Barrantes I, Montero-Pedrazuela A, Guadano-Ferraz A, Obregon MJ, de Mena RM, Gailus-Durner V*, Fuchs H*, Franz TJ*, Kalaydjiev S*, Klempt M*, Hölter SM*, Rathkolb B*, Reinhard C*, de Escobar GM, Bernal J, Busch DH, Wurst W*, Wolf E, Schulz H*, Shtrom S, Greiner E, Hrabé de Angelis M*, Westphal H, Niehrs C: Generation and characterization of dickkopf3 mutant mice. Mol. Cell. Biol. 26, 2317-2326 (2006)
  • Galy B, Hölter SM*, Klopstock T, Ferring D, Becker L*, Kaden S, Wurst W*, Gröne H-J, Hentze MW: Iron homeostasis in the brain: Complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat. Genet. 38, 967-969 (2006)
  • Klempt M*, Rathkolb B*, Fuchs E, Hrabé de Angelis M*, Wolf E, Aigner B: Genotype-specific environmental impact on the variance of blood values in inbred and F1 hybrid mice. Mamm. Genome 17, 93-102 (2006)
  • Puk O*, Dalke C*, Favor J*, Hrabé de Angelis M*, Graw J*: Variations of eye size parameters among different strains of mice. Mamm. Genome 17, 851-857 (2006)
  • Schneider I*, Tirsch WS*, Faus-Keßler T*, Becker L*, Kling E*, Busse R-L A*, Bender A, Feddersen B, Tritschler J*, Fuchs H*, Gailus-Durner V*, Englmeier KH*, Hrabé de Angelis M*, Klopstock T*: Systematic, standardized and comprehensive neurological phenotyping of inbred mice strains in the German Mouse Clinic. J. Neurosci. Methods 157, 82-90 (2006)

Bookchapters

  • Gailus-Durner V*, Naton B*, Adler T*, Afonso L*, Aguilar Pimentel A, Becker L*, Calzada-Wack J*, da Silva-Buttkus P, Hans W*, Horsch M*, Kahle M*, Lengger C*, Ludwig T*, Maier H*, Micklich K*, Möller G*, Neff F*, Neschen S*, Prehn C*, Rathkolb B*, Rozman J*, Schiller E*, Schrewe A*, Scheerer M*, Schöfer F*, Steinkamp R*, Stöger C*, Thiele F*, Tost M*, Treise I*, Willershäuser M*, Zeh R*, Adamski J*, Bekeredjian R*, Beckers J*, Esposito I*, Höfler H*, Katus H*, Klingenspor M*, Klopstock T*, Ollert M*, Wolf E*, Busch DH*, Fuchs H*, Hrabé de Angelis M*, The German Mouse Clinic – Running an Open Access Platform. In C. Brakebusch, T. Pihlajaniemi (eds.), Mouse as a Model Organism, ISBN 978-94-007-0749-8, Springer Science+Business Media B.V. (2011) in press
  • Brown S, Lad H, Green E, Gkoutos G, Gates H, Hrabé de Angelis M* and members of the EUMORPHIA consortium*. EUMORPHIA and the European mouse phenotyping resource for standardized screen (EMPReSS). In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 309-320
  • Dalke C*, Puk O*, Neuhäuser-Klaus A*, Favor J*, Graw J*. Eye disorders. In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 283-310
  • Fuchs H*, Lisse T*, Abe K*, Hrabé de Angelis M*. Screening for bone and cartilage phenotypes in mice. In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 35-86
  • Jakob T*, Alessandrini F*, Gutermuth J*, Köllisch G*, Javaheri A*, Aguilar A*, Ring J, Ollert M, Behrendt. Phenotyping Allergy in the Laboratory Mouse. In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 253-282
  • Kalaydjiev S*, Franz T*, Busch DH. Mouse Phenotyping: Immunology. In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 237-252
  • Klempt M*, Rathkolb B*, Aigner B, Wolf E. Clinical chemical screen. In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 87-108
  • Rácz I, Zimmer A. Animal models of nociception. In: Standards of Mouse Model Phenotyping. Edited by M. Hrabé de Angelis, P. Chambon, S. Brown; WILEY-VCH, Weinheim, 2006, ISBN: 3-527-31031-2, pp 221-236