Translational Diabetes

Numbers fit the arrows of the Figure here.

I. Early metabolomic markers of human (malign) adipogenesis

II. Metabolomic and epigenomic profiling of human adipocytes and skeletal muscle cells differentiated in vitro

III. Generation and characterization of novel prediabetic mouse models

IV. Gene expression profiling of the human adipocytes and skeletal muscle cells

V. Validation of resulting biomarkers/mechanisms in mouse models

VI. Recovery of human material (adipose tissue, skeletal muscle, PBMC) from phenotyped and genotyped prediabetic and/or morbidly obese individuals

VII. Validation of resulting biomarkers/mechanisms in the human cohorts of the DZD e.V. (German Center for Diabetes Research)