Translational Diabetes

 

2020

  • Darr J, Tomar A, Lassi M, Gerlini R, Berti L, Hering A, Scheid F, Hrabě de Angelis M, Witting M, Teperino R.. iTAG-RNA isolates cell-specific transcriptional responses to environmental stimuli and identifies an RNA-based endocrine axis. Cell Rep. 30, 3183-3194.e4 (2020)

  • Randrianarisoa E, Lehn-Stefan A, Krier J, Böhm A, Heni M, Hrabě de Angelis M, Fritsche A, Häring H-U, Stefan N, Staiger H.. AMPK subunits harbor largely non-overlapping genetic determinants for body fat mass, glucose- and cholesterol metabolism. J. Clin. Endocrinol. Metab. 105, 14-25:dgz020 (2020)
  •  

 

2019

  • Jeske T; Huypens P; Stirm L; Höckele S; Wurmser CM; Böhm A; Weigert C; Staiger H; Klein C; Beckers J; Hastreiter M DEUS: An R package for accurate small RNA profiling based on differential expression of unique sequences. Bioinformatics, accepted (2019)

  • Keuper M; Berti L; Raedle B; Sachs S; Böhm A; Fritsche L; Fritsche A; Häring H-U; Hrabě de Angelis M; Jastroch M; Hofmann SM; Staiger H: Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin. Mol. Metab. 20, 28-37 (2019)

 

2018

  • Gerlini R; Berti L; Darr J; Lassi M; Brandmaier S; Fritsche L; Scheid F; Böhm A; Königsrainer A; Grallert H; Häring H-U; Hrabě de Angelis M; Staiger H; Teperino R: Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity.18, 42-50 (2018)  

  • Hoffmann C; Höckele S; Kappler L; Hrabě de Angelis M; Häring H-U; Weigert C: The effect of differentiation and TGFβ on mitochondrial respiration and mitochondrial enzyme abundance in cultured primary human skeletal muscle cells. Sci. Rep. 8:737 (2018)


 

2017

  • Frankó A; Neschen S; Rozman J; Rathkolb B; Aichler M; Feuchtinger A; Brachthäuser L; Neff F; Kovarova M; Wolf E; Fuchs H; Häring H-U; Peter A; Hrabě de Angelis M Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol. Metab. 6, 256-266 (2017)

  • Ingerslev B; Hansen JS; Hoffmann CM; Clemmesen JO; Secher NH; Scheler M; Hrabě de Angelis M; Häring H-U Pedersen BK; Weigert C; Plomgaard P: Angiopoietin-like protein 4 is an exercise-induced hepatokine in humans, regulated by glucagon and cAMP. Mol. Metab. 6, 1286-1295 (2017)

  • Keuper M; Sachs S; Walheim E; Berti L; Raedle B; Tews D; Fischer-Posovszky P; Wabitsch M; Hrabě de Angelis M; Kastenmüller G; Tschöp MH, Jastroch M; Harald Staiger H; Hofmann SM. Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors. Mol. Metab., DOI: 10.1016/j.molmet.2017.07.008 (2017)

  • Lutz SZ; Hennenlotter J; Scharpf MO; Sailer C; Fritsche L; Schmid V; Kantartzis K; Wagner R; Lehmann R; Berti L; Peter A; Staiger H; Fritsche A; Fend A; Todenhöfer T; Stenzl A; Häring H-U; Heni M: Androgen receptor overexpression in prostate cancer in type 2 diabetes. Mol. Metab. 8, 158-166:doi:10.1016/j.molmet.2017.11.013 (2017)

  • Staiger H; Keuper M; Berti L; Hrabe de Angelis M; Häring HU. Fibroblast Growth Factor 21 - Metabolic Role in Mice and Men. Endocr Rev. 2017 Jul 28. doi: 10.1210/er.2017-00016.

 

2016

  • Berti L; Hartwig S; Irmler M; Rädle B; Siegel-Axel D; Beckers J; Lehr S; Al-Hasani H; Häring HU; Hrabě de Angelis M; Staiger H. Impact of fibroblast growth factor 21 on the secretome of human perivascular preadipocytes and adipocytes: A targeted proteomics approach. Arch. Physiol. Biochem. 122, 281-288 (2016)

  • Böhm A; Hoffmann C; Irmler M; Schneeweiss P; Schnauder G; Sailer C; Schmid V; Hudemann J; Machann J; Schick F; Beckers J; Hrabě de Angelis M; Staiger H; Fritsche A; Stefan N; Nieß AM; Häring HU; Weigert C. TGFβ contributes to impaired exercise response by suppression of mitochondrial key regulators in skeletal muscle. Diabetes 65, 2849-2861 (2016)

  • Walford GA; Gustafsson S; Rybin D; Stancáková A; Chen H; Liu CT; Hong J: Jensen RA; Rice K; Morris AP; Mägi R; Tönjes A; Prokopenko I; Kleber ME; Delgado G; Silbernagel G; Jackson AU; Appel EV; Grarup N; Lewis JP; Montasser M; Landenvall C; Staiger H; Luan J; Frayling TM; Weedon MN; Xie W; Morcillo S; Martinez-Larrad MT; Biggs ML; Chen YDI; Corbatón-Anchuelo A; Færch K; Zumaquero JM; Goodarzi MO; Kizer JR; Koistinen HA; Leong A; Lind L; Lindgren C; Machicao F; Manning AK; Martín-Núñez GM; Rojo-Martínez G; Rotter JI; Siscovick DS; Zmuda JM; Zhang Z; Serrano-Rios M; Smith U; Soriguer F; Hansen T; Jørgensen TJ; Linnenberg A; Pedersen O; Walker M; Langenberg C; Scott RA; Wareham NJ; Fritsche A; Häring H-U; Stefan N; Groop L; O'Connell JR; Boehnke M; Bergman RN; Collins FS; Mohlke KL; Tuomilehto J; Marz W; Kovacs P; Stumvoll M; Psaty BM; Kuusisto J; Laakso M; Meigs JB; Dupuis J; Ingelsson E; Florez JC Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci. Diabetes 65, 3200-3211 (2016)  

  • Wang X; Chen S; Burtscher I; Sterr M; Hieronimus A; Machicao F; Staiger H; Häring H-U; Lederer G; Meitinger T; Lickert H Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Stem Cell Res., 292-295 (2016)

  • Wang X; Chen S; Burtscher I; Sterr M; Hieronimus A; Machicao F; Staiger H; Häring H-U; Lederer G; Meitinger T; Lickert H Generation of a human induced pluripotent stem cell (iPSC) line from a patient carrying a P33T mutation in the PDX1 gene. Stem Cell Res. 17, 273-276 (2016)

  • Xu G; Hansen JS; Zhao XJ; Chen S; Hoene M; Wang XL; Clemmesen JO; Secher NH; Häring H-U; Pedersen BK; Lehmann R; Weigert C; Plomgaard P Liver and muscle contribute differently to the plasma acylcarnitine pool during fasting and exercise in humans. J. Clin. Endocrinol. Metab. 101, 5044-5052 (2016)

 

2015

  • Berti L; Irmler M; Zdichavsky M; Meile T; Böhm A; Stefan N ; Fritsche A; Beckers J; Königsrainer A; Häring H-U; Hrabě de Angelis M; Staiger H Fibroblast growth factor 21 is elevated in metabolically unhealthy obesity and affects lipid deposition, adipogenesis, and adipokine secretionof human abdominal subcutaneous adipocytes. Mol. Metab. 4, 519-527 (2015)

  • Häring H-U; Hrabě de Angelis M; Joost HG; Roden M; Schürmann A; Solimena M 5 Jahre erfolgreiche translationale Forschung - Deutsches Zentrum für Diabetesforschung. Diabetes akt. 13, 58-62 (2015)

  • Hansen  JS; Zhao X; Irmler M; Liu X; Hoene M; Scheler M; Li Y; Beckers J; Hrabě de Angelis M; Häring H-U; Pedersen BK; Lehmann R; Xu G; Plomgaard; P Weigert C. Type 2 diabetes alters metabolic and transcriptional signatures of glucose and amino acid metabolism during exercise and recovery. Diabetologia 58, 1845-1854 (2015)

  • Scheler M; Hrabě de Angelis M; Al-Hasani H; Häring H-U; Weigert C; Lehr S Methods for proteomics-based analysis of the human muscle secretome using an in vitro exercise model. Methods Mol. Biol. 1295, 55-64 (2015) 
  •  

 

2014

  • Böhm A; Halama A; Meile T; Zdichavsky M; Lehmann R; Weigert C; Fritsche A; Stefan N; Königsrainer A; Häring H-U; Hrabé de Angelis M; Adamski J; Staiger H. Metabolic signatures of cultured human adipocytes from metabolically healthy versus unhealthy obese individuals. PLoS ONE 9:e93148 (2014)

  • Hartwig S; Raschke S; Knebel B; Scheler M; Irmler M; Passlack W; Muller S; Hanisch FG; Franz T; Li X; Dicken HD; Eckardt K; Beckers J; de Angelis MH; Weigert C; Häring HU; Al-Hasani H; Ouwens DM; Eckel J; Kotzka J; Lehr S. Secretome profiling of primary human skeletal muscle cells. Biochim. Biophys. Acta-Proteins Proteom. 1844, 1011-1017 (2013)

  • Heni M; Kullmann S; Ketterer C; Guthoff M; Bayer M; Staiger H; Machicao F; Häring H-U; Preissl H; Veit R; Fritsche A Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults. Hum. Brain Mapp. 35, 918–928 (2014)

  • Heni M; Kullmann S; Veit R; Ketterer C; Frank S; Machicao F; Staiger H; Häring H-U; Preissl H; Fritsche A Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli in the prefrontal cortex. Mol. Metab. 3, 109-113 (2014)

  • Ketterer C; Heni M; Stingl KT; Tschritter O; Linder K; Wagner R; Machicao F; Häring H-U; Preissl H; Staiger H; Fritsche A Polymorphism rs3123554 in CNR2 reveals gender-specific effects on body weight and affects loss of body weight and cerebral insulin action. Obesity 22, 925-931 (2014)

  • Wagner R; Heni M; Linder K; Ketterer C; Peter A; Böhm A; Hatziagelaki E; Stefan N; Staiger H; Häring H-U; Fritsche A Age-dependent association of serum prolactin with glycaemia and insulin sensitivity in humans. Acta Diabetol. 51, 71-78 (2014)

  • Wagner R; Staiger H; Ullrich S; Stefan N; Fritsche A; Häring H-U Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol. Metab. 3, 261-267 (2014)

 

2013

  •  Boehm AA; Halama A; Adamski J; Häring H-U; Hrabé de Angelis M; Staiger H Metabolic profiling of cultured human adipocytes from metabolically malign versus benign obese individuals. Diabetologia 56, S331 (2013)

  • Heni M; Kullmann S; Veit R; Ketterer C; Machicao F; Staiger H; Häring H-U; Preissl H; Fritsche A Variation in the obesity risk gene FTO determines the postprandial cerebral processing of food stimuli. Diabetologia 56, S294 (2013)

  • Heni M; Wagner R; Ketterer C; Böhm A; Linder K; Machicao F; Machann J; Schick F; Hennige AM; Stefan N; Häring H-U; Fritsche A; Staiger H Genetic variation in NR1H4 encoding the bile acid receptor FXR determines fasting glucose and free fatty acid levels in humans. J. Clin. Endocrinol. Metab. 98, E1224-E1229 (2013)

  • Lehmann R; Franken H; Dammeier S; Rosenbaum L; Kantartzis K; Peter A; Tell A; Adam P; Li J; Xu G; Königsrainer A; Machann J; Schick F; Hrabé de Angelis M; Schwab M; Staiger H; Schleicher E; Gastaldelli A; Fritsche A; Häring H-U; Stefan N Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver. Diabetes Care 36, 2331-2338 (2013)

  • Ordelheide A-M; Gerst F; Rothfuss O; Heni M; Haas C; Thielker I; Herzberg-Schäfer S; Böhm A; Machicao F; Ullrich S; Stefan N; Fritsche A; Häring H-U; Staiger H Nor-1, a novel incretin-responsive regulator of insulin genes and insulin secretion. Mol. Metab. 2, 243-255 (2013)

  • Scheler M; Irmler M; Lehr S; Hartwig S; Staiger H; Al-Hasani H; Beckers J; Hrabé de Angelis M; Häring HU; Weigert C Cytokine response of primary human myotubes in an in vitro exercise model. Am. J. Physiol.-Cell Physiol. 305, C877-C886 (2013)

  • Staiger H; Böhm A; Scheler M; Berti L; Machann J; Schick F; Machicao F; Fritsche A; Stefan N; Weigert C; Krook A; Häring H-U; Hrabé de Angelis M. Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning’ factor Irisin, determines insulin sensitivity. PLoS One 8:e61903 (2013)

  • Wagner R; Thorand B; Osterhoff MA; Müller G;Böhm A; Meisinger C; Kowall B; Rathmann W; Kronenberg F; Staiger H; Stefan N; Roden M; Schwarz PE; Pfeiffer AF; Häring H-U; Fritsche A Family history of diabetes is associated with higher risk for prediabetes: A multicentre analysis from the German Center for Diabetes Research. Diabetologia 56, 2176-2180 (2013)

  • Wolf M; Chen S; Zhao X; Scheler M, Irmler M; Staiger H; Beckers J; Hrabé de Angelis M; Fritsche A; Häring H-U; Schleicher ED; Xu G; Lehmann R; Weigert C Production and release of acylcarnitines by primary myotubes reflect the differences in fasting fat oxidation of the donors. J. Clin. Endocrinol. Metab., DOI:10.1210/jc.2012-3976 (2013)

 

2012

  • Böhm A, Ordelheide A-M, Machann J;Heni M, Ketterer C, Machicao F, Schick F, Stefan N, Fritsche A, Häring H-U, Staiger H. Common genetic variation in the locus determines overall adiposity, obesity-related insulin resistance, and circulating leptin levels. PLoS One 7:e34035 (2012)

  • Floegel A, Stefan  N, Yu Z, Mühlenbruch K, Drogan D, Joost H-G, Fritsch A, Häring H-U, Hrabé de Angelis M, Peters A, Roden M, Prehn C, Wang-Sattler R, Illig T, Schulze M, Adamski J, Boing H, Pischon T Identification of serum metabolites associated with risk of type 2 diabetes using a targeted metabolomic approach. Diabetes 62. 639-648 (2012)

  • Hatziagelaki E; Wagner R; Kantartzis K; Heni M; Linder K; Ketterer C; Machicao F; Stefan N; Staiger H; Häring H-U; Fritsche A Insulin resistant phenotype of polycystic ovary syndrome does not seem to be caused by variation in FTO. Horm. Metab. Res. 44, 810-813 (2012)

  • Heni M, Hennenlotter J, Scharpf M, Lutz, SZ, Schwentner C, Todenhöfer T, Schilling D, Kühs U, Gerber V, Machicao F, Staiger H, Häring H-U, Stenzl A Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and -2 are differentially expressed in prostate cancer. PLoS ONE 7:e50953 (2012)

  • Heni M; Kullmann, S., Ketterer, C.*, Guthoff, M.*, Linder, K.*, Wagner, R.*, Stingl, K.T.*, Veit, R.*, Staiger, H., Häring, H.-U., Preissl, H., Fritsche, A.: Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions. Diabetologia 55, 1773-1782 (2012)

  • Rittig K; Dolderer JH; Balletshofer B; Machann J; Schick F; Meile T; Küper M; Stock UA; Staiger H; Machicao F; Schaller HE; Königsrainer A; Häring H-U; Siegel-Axel DI The secretion pattern of perivascular fat cells is different from that of subcutaneous and visceral fat cells. 55, 1514-1525 (2012)

  • Sartorius T, Heni M, Tschritter O, Preissl H, Hopp S, Fritsche A, Lievertz PS, Gertler A, Berthou F, Taouis M, Staiger H, Häring H-U, Hennige AM Leptin affects insulin action in astrocytes and impairs insulin-mediated physical activity. Cell. Physiol. Biochem. 30, 238-246 (2012)

  • Sartorius T, Staiger H, Ketterer C, Heni M, Machicao F, Guilherme A, Grallert HH, Schulze MB, Boeing H, Stefan N, Fritsche A, Czech MP, Häring H-U Association of common genetic variants in the MAP4K4 locus with prediabetic traits in humans. PLoS ONE 7:e47647 (2012)

  • Wörmann K, Walker A, Moritz F, Forcisi S, Tziotis D, Lucio D, Lucio M, Heinzmann SS, Adamski J, Lehmann R, Häring H-U, Schmitt-Kopplin P  Revolution in der Diabetesdiagnostik dank -omics: Biomarker mittels Metabolomics. Diabetes Aktuell 10. 129-133 (2012)

 

2011

  • Kantartzis K, Machann J, Schick F, Rittig K, Machicao F, Fritsche A, Häring HU, Stefan N. Effects of a lifestyle intervention in metabolically benign and malign obesity. Diabetologia. 2011 Apr;54(4):864-8. Peter A, Cegan A, Wagner S, Elcnerova M, Königsrainer A, Königsrainer I, Häring HU, Schleicher ED, Stefan N. Relationships between hepatic stearoyl-CoA desaturase-1 activity and mRNA expression with liver fat content in humans. Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E321-6.

 

2010

  • Peter A; Kantartzis K; Machann J; Schick F; Staiger H; Machicao F; Schleicher E; Fritsche A; Häring HU; Stefan N Relationships of circulating sex hormone-binding globulin with metabolic traits in humans. Diabetes. 2010 Dec;59(12):3167-73.

  • Heni M; Ketterer C; Thamer C; Herzberg-Schäfer SA; Guthoff M; Stefan N; Machicao F; Staiger H; Fritsche A; Häring HU Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. Diabetes. 2010 Dec;59(12):3247-52.

  • Lucio M; Fekete A; Weigert C; Wägele B; Zhao X; Chen J; Fritsche A; Häring H-U; Schleicher ED; Xu G; Schmitt-Kopplin P; Lehmann R Insulin sensitivity is reflected by characteristic metabolic fingerprints--a Fourier transform mass spectrometric non-targeted metabolomics approach. PLoS One. 2010 Oct 15;5(10):e13317.

  • Hu C; Hoene M; Zhao X; Häring HU; Schleicher E; Lehmann R; Han X; Xu G; Weigert C Lipidomics analysis reveals efficient storage of hepatic triacylglycerides enriched in unsaturated fatty acids after one bout of exercise in mice. PLoS One. 2010 Oct 13;5(10):e13318.

  • Thamer C; Machann J; Staiger H; Müssig K; Schwenzer N; Ludescher B; Machicao F; Claussen C; Fritsche A; Schick F; Stefan N; Häring HU Interscapular fat is strongly associated with insulin resistance. J Clin Endocrinol Metab. 2010 Oct;95(10):4736-42.

  • Zhao X; Fritsche J; Wang J; Chen J; Rittig K; Schmitt-Kopplin P; Fritsche A, Häring H-U; Schleicher ED, Xu G, Lehmann R. Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits. Metabolomics. 2010 Sep;6(3):362-374.

  • Hoene M; Franken H; Fritsche L; Lehmann R; Pohl AK; Häring HU; Zell A; Schleicher ED; Weigert C Activation of the mitogen-activated protein kinase (MAPK) signalling pathway in the liver of mice is related to plasma glucose levels after acute exercise. Diabetologia. 2010 Jun;53(6):1131-41.

  • Hennige AM; Heni M; Machann J; Staiger H; Sartorius T; Hoene M; Lehmann R; Weigert C; Peter A; Bornemann A; Kroeber S; Pujol A; Franckhauser S; Bosch F; Schick F; Lammers R; Häring H-U Enforced expression of protein kinase C in skeletal muscle causes physical inactivity, fatty liver and insulin resistance in the brain. J Cell Mol Med. 2010 Apr;14(4):903-13.

  • Heni M; Machann J; Staiger H; Schwenzer NF; Peter A; Schick F; Claussen CD; Stefan N; Häring H-U; Fritsche A Pancreatic fat is negatively associated with insulin secretion in individuals with impaired fasting glucose and/or impaired glucose tolerance: a nuclear magnetic resonance study. Diabetes Metab Res Rev. 2010 Mar;26(3):200-5.

  • Hennige AM; Ranta F; Heinzelmann I; Düfer M; Michael D; Braumüller H; Lutz SZ; Lammers R; Drews G; Bosch F; Häring HU; Ullrich S Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction. Diabetes. 2010 Jan;59(1):119-27.

 

2009

  • Rittig K, Thamer C, Haupt A, Machann J, Peter A, Balletshofer B, Fritsche A, Häring HU, Stefan N High plasma fetuin-A is associated with increased carotid intima-media thickness in a middle-aged population. Atherosclerosis. 2009 Dec;207(2):341-2. </il>

  • Fisher E, Stefan N, Saar K, Drogan D, Schulze MB, Fritsche A, Joost HG, Häring HU, Hubner N, Boeing H, Weikert C Association of AHSG gene polymorphisms with fetuin-A plasma levels and cardiovascular diseases in the EPIC-Potsdam study. Circ Cardiovasc Genet. 2009 Dec;2(6):607-13.

  • Kantartzis K, Peter A, Machicao F, Machann J, Wagner S, Königsrainer I, Königsrainer A, Schick F, Fritsche A, Häring HU, Stefan N. Dissociation between fatty liver and insulin resistance in humans carrying a variant of the patatin-like phospholipase 3 gene. Diabetes. 2009 Nov;58(11):2616-23

  • Peter A, Weigert C, Staiger H, Machicao F, Schick F, Machann J, Stefan N, Thamer C, Häring HU, Schleicher E. Individual stearoyl-coa desaturase 1 expression modulates endoplasmic reticulum stress and inflammation in human myotubes and is associated with skeletal muscle lipid storage and insulin sensitivity in vivo. Diabetes. 2009 Aug;58(8):1757-65.

  • Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A. A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia. 2009 Jun;52(6):1075-82.

  • Haupt A, Guthoff M, Schäfer SA, Kirchhoff K, Machicao F, Gallwitz B, Staiger H, Stefan N, Fritsche A, Häring HU. The inhibitory effect of recent type 2 diabetes risk loci on insulin secretion is modulated by insulin sensitivity. J Clin Endocrinol Metab. 2009 May;94(5):1775-80.

  • Kantartzis K, Machicao F, Machann J, Schick F, Fritsche A, Häring HU, Stefan N. The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans. Clin Sci (Lond). 2009 Mar;116(6):531-7.
  •  

  • Staiger H, Haas C, Machann J, Werner R, Weisser M, Schick F, Machicao F, Stefan N, Fritsche A, Häring HU Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans. Diabetes. 2009 Mar;58(3):579-89.

  • Haupt A, Staiger H, Schäfer SA, Kirchhoff K, Guthoff M, Machicao F, Gallwitz B, Stefan N, Häring HU, Fritsche A. The risk allele load accelerates the age-dependent decline in beta cell function. Diabetologia. 2009 Mar;52(3):457-62.

  • Zhao X, Peter A, Fritsche J, Elcnerova M, Fritsche A, Häring HU, Schleicher ED, Xu G, Lehmann R. Changes of the plasma metabolome during an oral glucose tolerance test: is there more than glucose to look at? Am J Physiol Endocrinol Metab. 2009 Feb;296(2):E384-93.

  • Hoene M, Lehmann R, Hennige AM, Pohl AK, Häring HU, Schleicher ED, Weigert C. Acute regulation of metabolic genes and insulin receptor substrates in the liver of mice by one single bout of treadmill exercise. J Physiol. 2009 Jan 15;587(Pt 1):241-52.

 

2008

  • Weikert C, Stefan N, Schulze MB, Pischon T, Berger K, Joost HG, Häring HU, Boeing H, Fritsche A. Plasma fetuin-a levels and the risk of myocardial infarction and ischemic stroke. Circulation. 2008 Dec 9;118(24):2555-62.

  • Böhm A, Staiger H, Hennige AM, Haas C, Machicao F, Häring HU. Effect of insulin detemir, compared to human insulin, on 3T3-L1 adipogenesis. Regul Pept. 2008 Nov 29;151(1-3):160-3./li>

  • Rittig K, Staib K, Machann J, Böttcher M, Peter A, Schick F, Claussen C, Stefan N, Fritsche A, Häring HU, Balletshofer B. Perivascular fatty tissue at the brachial artery is linked to insulin resistance but not to local endothelial dysfunction. Diabetologia. 2008 Nov;51(11):2093-9.

  • Stefan N, Fritsche A, Weikert C, Boeing H, Joost HG, Häring HU, Schulze MB. Plasma fetuin-A levels and the risk of type 2 diabetes. Diabetes. 2008 Oct;57(10):2762-7.

  • Stefan N, Kantartzis K, Machann J, Schick F, Thamer C, Rittig K, Balletshofer B, Machicao F, Fritsche A, Häring HU. Identification and characterization of metabolically benign obesity in humans. Arch Intern Med. 2008 Aug 11;168(15):1609-16.

  • Peter A, Weigert C, Staiger H, Rittig K, Cegan A, Lutz P, Machicao F, Häring HU, Schleicher E. Induction of stearoyl-CoA desaturase protects human arterial endothelial cells against lipotoxicity. Am J Physiol Endocrinol Metab. 2008 Aug;295(2):E339-49.

  • Stefan N, Peter A, Cegan A, Staiger H, Machann J, Schick F, Claussen CD, Fritsche A, Häring HU, Schleicher E. Low hepatic stearoyl-CoA desaturase 1 activity is associated with fatty liver and insulin resistance in obese humans. Diabetologia. 2008 Apr;51(4):648-56.

  • Kirchhoff K, Machicao F, Haupt A, Schäfer SA, Tschritter O, Staiger H, Stefan N, Häring HU, Fritsche A. Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia. 2008 Apr;51(4):597-601.

  • Thamer C, Machann J, Stefan N, Schäfer SA, Machicao F, Staiger H, Laakso M, Böttcher M, Claussen C, Schick F, Fritsche A, Häring HU. Variations in PPARD determine the change in body composition during lifestyle intervention: a whole-body magnetic resonance study. J Clin Endocrinol Metab. 2008 Apr;93(4):1497-500.

  • Hennige AM, Staiger H, Wicke C, Machicao F, Fritsche A, Häring HU, Stefan N. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS One. 2008 Mar 12;3(3):e1765.

  • Chen J, Zhao X, Fritsche J, Yin P, Schmitt-Kopplin P*, Wang W, Lu X, Häring HU*, Schleicher ED, Lehmann R, Xu G. Practical approach for the identification and isomer elucidation of biomarkers detected in a metabonomic study for the discovery of individuals at risk for diabetes by integrating the chromatographic and mass spectrometric information. Anal Chem. 2008 Feb 15;80(4):1280-9.

  • Staiger H, Machicao F, Schäfer SA, Kirchhoff K, Kantartzis K, Guthoff M, Silbernagel G, Stefan N, Häring HU, Fritsche A. Polymorphisms within the novel type 2 diabetes risk locus MTNR1B determine beta-cell function. PLoS One. 2008;3(12):e3962.

 

2007

    Tschritter O, Preissl H, Yokoyama Y, Machicao F, Häring HU, Fritsche A Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans. Diabetologia. 2007 Dec;50(12):2602-3.

    Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia. 2007 Dec;50(12):2443-50.

    Stefan N, Thamer C, Staiger H, Machicao F, Machann J, Schick F, Venter C, Niess A, Laakso M, Fritsche A, Häring HU Genetic variations in PPARD and PPARGC1A determine mitochondrial function and change in aerobic physical fitness and insulin sensitivity during lifestyle intervention. J Clin Endocrinol Metab. 2007 May;92(5):1827-33.

 

2006

  • Tschritter O, Preissl H, Hennige AM, Stumvoll M, Porubska K, Frost R, Marx H, Klösel B, Lutzenberger W, Birbaumer N, Häring HU, Fritsche A. The cerebrocortical response to hyperinsulinemia is reduced in overweight humans: a magnetoencephalographic study. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12103-8.

  • Stefan N, Hennige AM, Staiger H, Machann J, Schick F, Kröber SM, Machicao F, Fritsche A, Häring HU. Alpha2-Heremans-Schmid glycoprotein/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans. Diabetes Care. 2006 Apr;29(4):853-7.

  • Weigert C, Hennige AM, Lehmann R, Brodbeck K, Baumgartner F, Schaüble M, Häring HU, Schleicher ED. Direct cross-talk of interleukin-6 and insulin signal transduction via insulin receptor substrate-1 in skeletal muscle cells. J Biol Chem. 2006 Mar 17;281(11):7060-7.