Research within the Institute of Epigenetics and Stem Cells aims at establishing epigenetic principles behind changes in cellular plasticity, genome reprogramming and cellular decision making. We study how the transitions in cell potency and cell fate are regulated by chromatin-mediated processes using a variety of approaches including quantitative imaging, modeling, functional genomics, computational methods and cell biology. Understanding the molecular mechanisms behind the maintenance and manipulation of cellular plasticity will have strong implications in regenerative medicine and disease, and will help in deciphering the mechanisms behind human reproduction and infertility.