New Safeguard for Cellular Identity

In a recent work led by the laboratory of Anne Dejean (Institut Pasteur, Paris) published in the journal Cell Stem Cell, the Torres-Padilla lab (Institute of Epigenetics & Stem Cells, HMGU) contributed with the discovery that sumoylation – that is the addition of a small chemical group to proteins- inhibits reprogramming of mouse pluripotent stem cells towards the 2-cell-like state.  Overall, the work shows that SUMO functions as a tether on distinct chromatin types in mouse embryonic fibroblasts and embryonic stem cells to stabilize occupancy of protein substrate complexes on key cell-identity genes, thus preserving the somatic and pluripotent states.

For the original publication please go here.