News

23.05.2019

Publication: Genome-lamina interactions are established de novo in the early mouse embryo

© Helmholtz Zentrum München Individual embryonic cells are depicted through their cellular membranes (green). The small inner cercle depicts the nuclear lamina, where the genome becomes attached.

The architecture of the DNA-protein complexes that make up the genome in each cell nucleus regulates the course of early embryonic development. Researchers from Maria Elena Torres-Padilla's group at the Institute of Epigenetics and Stem Cells, in collaboration with the Hubrecht Institute, have now shown that this architecture is not inherited, but must be assembled new – in a process that is regulated largely by epigenetic mechanisms. The new study appears in the journal Nature.

For the full Press Release see here

Original publication: Borsos M, Perricone SM et al. (2019): Genome-lamina interactions are established de novo in the early mouse embryo. Nature. DOI: 10.1038/s41586-019-1233-0