News

07.01.2021

Publication announcement: TFs for TEs: the transcription factor repertoire of mammalian transposable elements

Clara Hermant published together with her PhD Supervisor Prof. Maria-Elena Torres-Padilla, the Director of the Institute for Epigenetics and Stem Cells, a review about transposable elements and the their associated transcription factors.

Hermant C and Torres-Padilla ME, 2021, Genes Dev.

Transposable elements (TEs) are elements within the genome, that are able to change the position. Nearly half of the modern genome is made up of remnants of TE insertion. Even though, their mobilization can be of harm for the genome integrity, they are also important regulatory elements, e.g. for embryonic preimplantation development. The first critical step for a successful transposition cycle is the generation of a full-length transcript. TEs have evolved cis-regulatory elements enabling them to recruit host-encoded factors driving their own, selfish transcription.

The review article focuses on the TE regulatory elements within mammalian genomes, the diversity of TE subfamilies and highlights the role of TE mobilization for spreading of transcription factor-binding sites across the genome during evolution.

References:

Hermant C, Torres-Padilla ME. (2021). TFs for TEs: the transcription factor repertoire of mammalian transposable elements. DOI: 10.1101/gad.344473.120. PMID: 33397727.