Chromosome dynamics and genome stability

If you would like to join Stephan's group for a Bachelor/Master/PhD project or as a Postdoc, please send your CV, motivation letter, recommendation letters and certificates as one pdf document via .

Open Positions

The Chromosome Dynamics and Genome Stability at the IES, Helmholtz Zentrum Munich, Germany, is seeking Two Postdoctoral Scientists to join our research group funded by an ERC starting grant award. Our lab aims to understand how cells accurately duplicate and process their genetic information by coordinating the fundamental processes of replication and transcription. How are these molecular activities coordinated on our chromosomes? Can some of the complexes interfere with each other at certain regions of the genome? Our ultimate goal is to understand the genetic and epigenetic principles how these fundamental processes are regulated and coordinated to work together on the genome of eukaryotic cells. 

We have recently established an in vivo system to analyze encounters between the replication fork and different types of transcriptional barriers in an inducible and localized fashion (Hamperl et al., Cell, 2017). We will use this system in combination with cell biological, genetic and proteomic assays to elucidate the mechanisms how cells respond, tolerate and resolve conflicts of the replication fork with different types of transcriptional barriers. These studies could provide insights into the many emerging links between transcription-replication conflicts and genome instability, which is observed in cancer and many other disease states. 

The successful candidate will have access to leading-edge facilities and national as well as international collaborations. The Institute is located in the heart of the Großhadern Campus of the LMU.

 Job Descriptions

  • Characterize the spatial and temporal distribution of transcription and replication complexes during conflicts. 
  • Determine the structural and mutational consequences of transcription-replication conflicts to the underlying DNA template
  • Identify factors necessary to resolve collisions between replication forks and transcription complexes
  • Establish high resolution imaging approaches to visualize and quantify the level of transcription-replication interference

 Your Qualifications 

  • PhD in Biology, Biochemistry or a related field
  • Special interest in cell biology, epigenetics and/or genome instability
  • Strong background in molecular and cellular biology
  • Outstanding motivation to participate in a competitive research program
  • Excellent communication skills in spoken and written English 
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Payment is according to standard public service salary (TVÖD). We give priority to severely disabled applicants with essentially equal qualifications. 

Please send your application with relevant documents (CV, motivation and recommendation letters) as one merged PDF to