Publications

The Institute of Functional Epigenetics was established in 2016. Publication lists for each of the research teams can be found in the Research section.

2019

Sharma P, Lioutas A, Fernandez-Fuentes N, Quilez J, Carbonell-Caballero J, Wright RHG, Di Vona C, Le Dily F, Schüller R, Eick D, Oliva B, Beato M. (2019) Arginine Citrullination at the C-Terminal Domain Controls RNA Polymerase II Transcription.(2019) Mol Cell. 84-96.e7. doi: 10.1016/j.molcel.2018.10.016. Epub 2018 Nov 21 

Rohrmoser M, Kluge M, Yahia Y, Gruber-Eber A, Maqbool MA, Forné I, Krebs S, Blum H, Greifenberg AK, Geyer M, Descostes N, Imhof A, Andrau JC, Friedel CC, Eick D. (2019) MIR sequences recruit zinc finger protein ZNF768 to expressed genes. Nucleic Acids Res. 700-715. doi: 10.1093/nar/gky1148.

Nemec CM, Singh AK, Ali A, Tseng SC, Syal K, Ringelberg KJ, Ho YH, Hintermair C, Ahmad MF, Kar RK, Gasch AP, Akhtar MS, Eick D, Ansari AZ (2019). Noncanonical CTD kinases regulate RNA polymerase II in a gene-class-specific manner. Nat Chem Biol. 123-131. doi: 10.1038/s41589-018-0194-1. Epub 2018 Dec 31. 

Shah N, Decker TM, Eick D. (2019). Extension of the minimal functional unit of the RNA polymerase II CTD from yeast to mammalian cells. Biol Lett. 15(5):20190068. doi: 10.1098/rsbl.2019.0068. 

Bartke T* and Groth A. (2019). A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks. Mol. Cell. Oncol. 6, 1605820. doi: 10.1080/23723556.2019.1605820. (Invited “Author’s view” on Nakamura et al. Nat. Cell Biol. 21, 311-318. *Corresponding author. 

Ignatova VV, Jansen PWTC, Baltissen MP, Vermeulen M, Schneider R (2019) The interactome of a family of potential methyltransferases in HeLa cells, Scientific Reports, 9, Article number: 6584

Campagne A, Lee MK, Zielinski D, Michaud A, Le Corre S, Dingli F, Chen H, Shahidian LZ, Vassilev I, Servant N, Loew D, Pasmant E, Postel-Vinay S, Wassef M, Margueron R. BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation. Nat Commun. 348. doi: 10.1038/s41467-018-08255-x.

Brockers K, Schneider R. Histone H1, the forgotten histone. Epigenomics. 363-366. doi: 10.2217/epi-2019-0018. Epub 2019 Feb 22. No abstract available.

Nakamura K, Saredi G, Becker JR, Foster BM, Nguyen NV, Beyer T, Cesa LC, Faull PA, Lukauskas S, Frimurer T, Chapman RJ, Bartke T*, and Groth A*. (2019). H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nature Cell Biology 21, 311-318. doi: 10.1038/s41556-019-0282-9. *Co-corresponding authors.

2018

Eick D. (2018) Getting to grips with c-Myc. Elife. 2018 Jan 9;7. pii: e32010. doi: 10.7554/eLife.32010.

Foster BM, Stolz P, Mulholland CB, Montoya A, Kramer H, Bultmann S, and Bartke T. (2018). Critical role of the UBL domain in stimulating the E3 ubiquitin ligase activity of UHRF1 toward chromatin. Molecular Cell. 72, 739-752.e9. doi: 0.1016/j.molcel.2018.09.028.

Makowski MM, Gräwe C, Foster BM, Nguyen NV, Bartke T* and Vermeulen M* (2018)Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectroscopy, Nature Communications doi: 10.1038/s41467-018-04084-0 *co-corresponding authors

Nieborak A and Schneider R (2018) Metabolic intermediates – Cellular messengers talking to chromatin modifiers, Molecular Metabolism, doi.org/10.1016/j.molmet.2018.01.007

Nilay Shah+, Muhammad Ahmad Maqbool+, Yousra Yahia, Amal Zine El Aabidine, Cyril Esnault, Ignasi Forné, Tim-Michael Decker, David Martin, Roland Schüller, Stefan Krebs, Helmut Blum, Axel Imhof, Dirk Eick*, Jean-Christophe Andrau* (2018), Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals, Molecular Cell, Volume 69, Issue 1, 4 January 2018, Pages 48–61.e6 *co-corresponding authors +equal contribution

2017

 

Schmoller KM (2017) The phenomenology of cell size control, Current Opinion in Cell Biology, 49, 53-58

Kebede, AF., Nieborak A, Zorro Shahidian L, Le Gras S, Richter F, Aguilar Gomez D, Baltissen MP, Meszaros G, de Fatima Magliarelli H, Taudt A, Margueron R, Colome-Tatche M, Ricci R, Daujat S, Vermeulen M, Mittler G, Schneider R  (2017) Histone propionylation is a novel mark of active chromatin. Nature Structural and Molecular Biology, 24, 1048-1056 DOI: 10.1038/nsmb.3490

Gressel S, Schwalb B, Decker TM, Qin W, Leonhardt H, Eick D, Cramer P. (2017) CDK9-dependent RNA polymerase II pausing controls transcription initiation, Elife, 6, pii: e29736

Chandler-Brown D*, Schmoller KM*, Winetraub Y, Skotheim JM (2017) The Adder Phenomenon Emerges from Independent Control of Pre- and Post-Start Phases of the Budding Yeast Cell Cycle, Current Biology, 27-18, 2774-2783. http://dx.doi.org/10.1016/j.cub.2017.08.015 *equal contribution

Izzo A, Ziegler-Birling C, Hill PWS, Brondani L, Hajkova P, Torres-Padilla ME, Schneider R (2017) Dynamic changes in H1 subtype composition during epigenetic reprogramming, Journal of Cell Biology, DOI: 10.1083/jcb.201611012

Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE, Busch-Nentwich EM. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics, 13(8): e1006959

Col E, Hoghoughi N, Dufour S, Penin J, Koskas S, Faure V, Ouzounova M, Hernandez-Vargash H, Reynoird N, Daujat S, Folco E, Vigneron M, Schneider R, Verdel A, Khochbin S, Herceg Z, Caron C, Vourc'h C. 2017. Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock. Sci Rep. 7, doi:10.1038/s41598-017-05343-8

Decker TM, Kluge M, Krebs S, Shah N, Blum H, Friedel CC, Eick D. (2017) Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1. Sci Rep. 7(1):1684. doi: 10.1038/s41598-017-01943-6.

Andrew Leung, Francy-Pesek Jardim, Neda Savic, Yoan R. Monneau, Rodrigo González-Romero, Geoff Gudavicius, Jose M. Eirin-Lopez, Till Bartke, Cameron D. Mackereth, Juan Ausió & Christopher J. Nelson. 2017.  Basic surface features of nuclear FKBPs facilitate chromatin binding. Sci Rep. 7, doi:10.1038/s41598-017-04194-7.

Nemec CM, Yang F, Gilmore JM, Hintermair C, Ho YH, Tseng SC, Heidemann M, Zhang Y, Florens L, Gasch AP, Eick D, Washburn MP, Varani G, Ansari AZ. (2017) Different phosphoisoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner. Proc Natl Acad Sci U S A.;114(20):E3944-E3953. doi:10.1073/pnas.1700128114.

Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich E, and Bartke T. 2017. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic Acids Res. 45, 1114-1129. DOI: 10.1093/nar/gkw979.

Chendeb M, Schneider R, Davidson I. and Fadloun A. 2017. Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene. Oncotarget, DOI: 0.18632/oncotarget.16013

2016

Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reveron-Gomez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel D, and Groth A. 2016. H4 K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. Nature 534, 714-718

Beltran M, Yates CM, Skalska L, Dawson M, Reis FP, Viiri K, Fisher CL, Sibley CR, Foster BM, Bartke T, Ule J, and Jenner RG. 2016. The interaction of PRC2 with RNA or chromatin is mutually antagonistic. Genome Res. 26, 896-907

McBurney KL, Leung A, Choi JK, Martin BJE, Irwin NAT, Bartke T, Nelson CJ, and Howe LAJ. 2016. Divergent residues within histone H3 dictate a unique chromatin structure in S. cerevisiae. Genetics 202, 341-349

Schüller R, Eick D. (2016) Getting Access to Low-Complexity Domain Modifications. Trends Biochem Sci.;41(11):894-897. doi: 10.1016/j.tibs.2016.05.010.

Burger K, Eick D. (2016) A Nonradioactive Assay to Measure Production and Processing of Ribosomal RNA by 4sU-Tagging. Methods Mol Biol.;1455:121-31. doi: 10.1007/978-1-4939-3792-9_10.

Hintermair C, Voß K, Forné I, Heidemann M, Flatley A, Kremmer E, Imhof A, Eick D. (2016) Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression. Sci Rep.;6:27401. doi: 10.1038/srep27401.

Schüller R, Forné I, Straub T, Schreieck A, Texier Y, Shah N, Decker TM, Cramer P, Imhof A, Eick D. (2016) Heptad-Specific Phosphorylation of RNA Polymerase II CTD. Mol Cell.;61(2):305-14. doi: 10.1016/j.molcel.2015.12.003.

Mirabella AC, Foster BM, and Bartke T. 2016. Chromatin deregulation in disease. Chromosoma 125, 75-93

Izzo A. and Schneider R. 2016. The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics. BBA, Gene Regulatory Mechanisms, 1859(3):486-495

Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT. 2016. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature Communications. 7:10782

Izzo A. Schneider R. 2016. H1 gets the genome in shape. Genome Biology. 17(1):8

Quarta C, Schneider R, Tschöp MH. 2016. Epigenetic ON/OFF switches for Obesity. Cell. 164(3): 341-342

Lawrence, M., Daujat, S. and Schneider R., 2016. Lateral thinking: how histone modifications regulate gene expression. Trends in Genetics, 32(1):42-56

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