Daphne Cabianca: Environment and Nuclear Organization

If you are interested in joining the group at any career stage, even if not advertised, feel free to contact  to discuss opportunities.

At the moment, we are looking for 2 PhD students, one to work on the basic mechanism through which the epigenetic reader MRG-1 promotes the spatial segregation of heterochromatin and euchromatin and the second one to explore the role of chromatin organization under environmental stress.

PhD Student to decipher the mechanism of heterochromatin spatial sequestration

We are looking for a highly motivated PhD student to join the newly established group of Dr. Daphne Cabianca, Institute of Functional Epigenetics (IFE), Helmholtz Center in Munich, Germany to decipher the mechanism of heterochromatin spatial sequestration by MRG-1 in the intestine of C. elegans. At IFE, you will find a scientifically stimulating international environment. Supported by an excellent infrastructure, you will aim to solve fundamental questions of epigenetics, molecular and organismal biology.

The spatial organization of chromatin within the nucleus enables a functional compartmentalization of the genome that mirrors changes in cell identity. Recently, we identified MRG-1 as the first component of active chromatin regulating the spatial organization of silent regions in the nematode C. elegans. 

In this project, you will contribute to identifying new players working with MRG-1 to regulate compartmentalization of chromatin. To do so, you will combine high-resolution live microscopy screens, IP-mass spec and cutting-edge molecular biology techniques like RNAseq, DamID and CRISPR-Cas9 genome editing. 

See publication: Cabianca DS, et al. Active chromatin marks drive spatial sequestration of heterochromatin in differentiated cells. Nature 2019, May;569(7758):734-739.

PhD Student to decipher the function of nuclear architecture in response to environmental stress

We are looking for a highly motivated PhD student to join the newly established group of Dr. Daphne Cabianca, Institute of Functional Epigenetics (IFE), Helmholtz Center in Munich, Germany to decipher the function of nuclear architecture in response to environmental stress. 

At IFE, you will find a scientifically stimulating international environment. Supported by an excellent infrastructure, you will aim to solve fundamental questions of epigenetics, molecular and organismal biology. 

The spatial organization of chromatin within the nucleus is not random and enables a functional compartmentalization of the genome. In our group, you will contribute to deciphering whether the spatial architecture of the genome constitutes an additional layer of epigenetic regulation. You will make use of chromatin organization mutants to determine which environmental signals (and decipher how), influence the compartmentalization of chromatin in the context of a developing organism, namely the nematode C. elegans. What are the implications of a perturbed nuclear organization by the environment for gene expression and organismal health?

To achieve our goals, we combine high-resolution live microscopy screens and cutting-edge molecular biology techniques like RNAseq, DamID and CRISPR-Cas9 genome editing.

See publication: Cabianca DS, et al. Active chromatin marks drive spatial sequestration of heterochromatin in differentiated cells. Nature 2019, May;569(7758):734-739.