Robert Schneider: Chromatin Dynamics and Epigenetics


Ignatova V, Jansen PWTC, Baltissen MP, Vermeulen M, Schneider R (2019) The interactome of a family of potential methyltransferases in HeLa cells, Scientific Reports, 9, Article number: 6584

Campagne A, Lee MK, Zielinski D, Michaud A, Le Corre S, Dingli F, Chen H, Shahidian LZ, Vassilev I, Servant N, Loew D, Pasmant E, Postel-Vinay S, Wassef M, Margueron R. BAP1 complex promotes transcription by opposing PRC1-mediated H2A ubiquitylation. Nat Commun. 2019 Jan 21;10(1):348. doi: 10.1038/s41467-018-08255-x.

Brockers K, Schneider R. Histone H1, the forgotten histone. Epigenomics. 363-366. doi: 10.2217/epi-2019-0018. Epub 2019 Feb 22. No abstract available.  

Nakamura K, Saredi G, Becker JR, Foster BM, Nguyen NV, Beyer T, Cesa LC, Faull PA, Lukauskas S, Frimurer T, Chapman RJ, Bartke T*, and Groth A*. (2019). H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids. Nature Cell Biology 21, 311-318. *Co-corresponding authors. 


Makowski MM, Gräwe C, Foster BM, Nguyen NV, Bartke T* and Vermeulen M* (2018) Global profiling of protein-DNA and protein-nucleosome binding affinities using quantitative mass spectroscopy, Nature Communications doi: 10.1038/s41467-018-04084-0 *co-corresponding authors

Nieborak A and Schneider R (2018) Metabolic intermediates – Cellular messengers talking to chromatin modifiers, Molecular Metabolism,


Kebede, AF., Nieborak A, Zorro Shahidian L, Le Gras S, Richter F, Aguilar Gomez D, Baltissen MP, Meszaros G, de Fatima Magliarelli H, Taudt A, Margueron R, Colome-Tatche M, Ricci R, Daujat S, Vermeulen M, Mittler G, Schneider R  (2017): Histone propionylation is a novel mark of active chromatin. Nature Structural and Molecular Biology, DOI: 10.1038/nsmb.3490

Izzo A, Ziegler-Birling C, Hill PWS, Brondani L, Hajkova P, Torres-Padilla ME, Schneider R (2017) Dynamic changes in H1 subtype composition during epigenetic reprogramming, Journal of Cell Biology, DOI: 10.1083/jcb.201611012

Scahill CM, Digby Z, Sealy IM, Wojciechowska S, White RJ, Collins JE, Stemple DL, Bartke T, Mathers ME, Patton EE, Busch-Nentwich EM. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics, 13(8): e1006959

Col E, Hoghoughi N, Dufour S, Penin J, Koskas S, Faure V, Ouzounova M, Hernandez-Vargash H, Reynoird N, Daujat S, Folco E, Vigneron M, Schneider R, Verdel A, Khochbin S, Herceg Z, Caron C, Vourc'h C. 2017. Bromodomain factors of BET family are new essential actors of pericentric heterochromatin transcriptional activation in response to heat shock. Nature Sc. Rep. 7, Article number: 5418 (2017) doi:10.1038/s41598-017-05343-8

Andrew Leung, Francy-Pesek Jardim, Neda Savic, Yoan R. Monneau, Rodrigo González-Romero, Geoff Gudavicius, Jose M. Eirin-Lopez, Till Bartke, Cameron D. Mackereth, Juan Ausió & Christopher J. Nelson. 2017.  Basic surface features of nuclear FKBPs facilitate chromatin binding. Nature. Sc. Rep. 7, Article number: 3795. doi:10.1038/s41598-017-04194-7. Epub 2017 June 19.

Borgel J, Tyl M, Schiller K, Pusztai Z, Dooley CM, Deng W, Wooding C, White RJ, Warnecke T, Leonhardt H, Busch-Nentwich E, and Bartke T. 2017. KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic Acids Res. 45, 1114-1129. DOI: 10.1093/nar/gkw979. Epub 2016 October 24.

Chendeb M, Schneider R, Davidson I. and Fadloun A. 2017. Selective elimination of long INterspersed element-1 expressing tumour cells by targeted expression of the HSV-TK suicide gene. Oncotarget, DOI: 10.18632/oncotarget.16013


Saredi G, Huang H, Hammond CM, Alabert C, Bekker-Jensen S, Forne I, Reveron-Gomez N, Foster BM, Mlejnkova L, Bartke T, Cejka P, Mailand N, Imhof A, Patel D, and Groth A. 2016. H4 K20me0 marks post-replicative chromatin and recruits the TONSL-MMS22L DNA repair complex. Nature 534, 714-718

Beltran M, Yates CM, Skalska L, Dawson M, Reis FP, Viiri K, Fisher CL, Sibley CR, Foster BM, Bartke T, Ule J, and Jenner RG. 2016. The interaction of PRC2 with RNA or chromatin is mutually antagonistic. Genome Res. 26, 896-907

McBurney KL, Leung A, Choi JK, Martin BJE, Irwin NAT, Bartke T, Nelson CJ, and Howe LAJ. 2016. Divergent residues within histone H3 dictate a unique chromatin structure in S. cerevisiae. Genetics 202, 341-349

Mirabella AC, Foster BM, and Bartke T. 2016. Chromatin deregulation in disease. Chromosoma 125, 75-93

Izzo A. and Schneider R. 2016. The role of linker histone H1 modifications in the regulation of gene expression and chromatin dynamics. BBA, Gene Regulatory Mechanisms, 1859(3):486-495

Kabra DG, Pfuhlmann K, García-Cáceres C, Schriever SC, Casquero García V, Kebede AF, Fuente-Martin E, Trivedi C, Heppner K, Uhlenhaut NH, Legutko B, Kabra UD, Gao Y, Yi CX, Quarta C, Clemmensen C, Finan B, Müller TD, Meyer CW, Paez-Pereda M, Stemmer K, Woods SC, Perez-Tilve D, Schneider R, Olson EN, Tschöp MH, Pfluger PT. 2016. Hypothalamic leptin action is mediated by histone deacetylase 5. Nature Communications. 7:10782

Izzo A. Schneider R. 2016. H1 gets the genome in shape. Genome Biology. 17(1):8

Quarta C, Schneider R, Tschöp MH. 2016. Epigenetic ON/OFF switches for Obesity. Cell. 164(3): 341-342

Lawrence, M., Daujat, S. and Schneider R., 2016. Lateral thinking: how histone modifications regulate gene expression. Trends in Genetics, 32(1):42-56


Ziegler-Berling, C., Daujat, D., Schneider, R.  and Torres Padilla, ME. 2015. Dynamics of histone H3 acetylation in the nucleosome core during mouse pre-implantation development. Epigenetics, 19:0

Hergeth, S.P. and Schneider, R. 2015. The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle. EMBO reports, 16(11): 1439-1453

Cohen, I., Peleg, R., Voronov, E., Tomas, M., Tudor, C., Wegner, M., Freudenberg, M., Brodabi, L., Mittler, G., Ferrando-May, E., Dinarello, C.A., Apte, R.N. and Schneider R. 2015. The cytokine IL-1 links DNA damage signaling to inflammation. Nature Scientific Reports, 5, 14756

Kebede, A.F., Schneider, R. and Daujat, S. 2015. Novel types and sites of histone modifications emerge as players in the transcriptional regulation contest. FEBS Journal. 282(9):1658-74

Sijare, S., Geßler, A.L., Hergeth, S., Schneider R., Werner, M. and Lassmann,, S. 2015. Loss of correlation of Aurora-B and the histone H1.4S27p at specific mitotic phases in aneuploid colorectal carcinomas. Virchows Arch. 2015 Feb 14.


Di Cerbo, V., Mohn, F., Ryan, D., Montellier, E., Kacem, S., Tropberger, P., Kallis, E., Holzner, M., Horner, L., Feldmann, A., Richter, F., Bannister, A.J., Mittler, G., Michaelis, J., Khochbin, S., Feil, R., Schübeler, D., Owen-Hughes, T., Daujat, S. and Schneider R. 2014. Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription eLIFE, Mar 25;3:e01632.

Biterge, B., Richter, F., Mittler, G. and Schneider R. 2014. Methylation of histone H4 at aspartate 24 by Protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis. Scientific Reports, 4:6674.

Bheda, P. and Schneider, R.  2014. Epigenetics reloaded: The single cell revolution, Trends in Cell Biology. 24(11): 712-723

Biterge, B. and Schneider, R. 2014. Histone variants: key players of chromatin. Cell & Tissue Research, 356(3), 457-66.


Tropberger, P., Pott, S., Keller, .C., Kamieniarz, K., Caron, M., Richter, F., Mittler, G., Liu, E.T., Bühler, M., Margueron, R., and Schneider, R.  2013 Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell, 152(4), 859-872.

Izzo, A., Kamieniarz, K., Ramirez, F., Noureen, N., Kind, J., Thomas, M., Van Steensel, B. and Schneider, R. 2013 The genomic landscape of the somatic linker histone subtypes H1.1 to H1.5 in human cells, Cell Reports, 3(6), 142-54.

Lange, U.C., Siebert, S., Wossidlo, M., Weiss, T., Ziegler-Birling, C., Walter, J., Torres-Padilla,  M.E., Daujat, S. and Schneider, R. 2013. Dissecting the role of H3K64me3 in the mouse pericentromeric heterochromatin pathway. Nature Communications, 4, 2233

Tropberger, P. and Schneider, R. 2013. Scratching the (lateral) surface of chromatin regulation by histone modifications Nature Structural and Molecular Biology, 20, 657-61

Di Cerbo, V, and Schneider, R.  2013. Cancers with wrong HATs: the impact of acetylation Briefings in Functional Genomics, 12(3):231-43.

Fejer, G., Wegner, M., Györy, I., Cohen, I., Engelhard, P., Voronov, E., Manke, T., Zsolt R., Dölken, L., da Costa, P.,  Branzk, N.,  Huber, M., Prasse, A., Schneider, R., Apte, R.N., Galanos, C. and Freudenberg, M.A. 2013. Self-renewing, non-transformed, GM-CSF-dependent, stable macrophage lines, a new model to study tissue macrophage functions, PNAS, 10, E2191-8.

Waldmann, T., and Schneider, R. 2013. Targeting Histone Modifications – epigenetics in cancer, Current Opinion in Cell Biology, 25, 184-189

Frangini A, Sjöberg M, Roman-Trufero M, Dharmalingam G, Haberle V, Bartke T, Lenhard B, Malumbres M, Vidal M, and Dillon D. 2013. The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes. Mol. Cell 51, 647–661

Bartke T, Borgel J, and DiMaggio PA. 2013. Proteomics in Epigenetics: New Perspectives for Cancer Research. Brief. Funct. Genomics 12, 205-218


Kamieniarz, K., Izzo, A., Dundr, M., Tropberger, P., Ozretic, L., Kirfel, J., Scheer, E., Tropel, P., Wiśniewski, J., Tora,  L., Viville, S., Buettner, R. and Schneider, R. 2012. A dual role of linker histone H1.4 Lys 34 acetylation in transcriptional activation. Genes and Development, 26, 797-802.

Ödberg, C., Izzo, A., Schneider, R., Wrange, Ö. and Belikov, S. 2012. Linker histone subtypes differ in their effect on nucleosomal spacing in vivo, Journal of Molecular Biology, 419, 183-97.

Talbert, P.B., Ahmad, K., Almouzni, G., Ausió, J., Berger, F., Bhalla, P., Bonner, W.M., Cande, Z., Chadwick, B.P., Chan, S.W.L., Cross, G.A.M., Cui, L., Dimitrov, S.I., Doenecke, D., Eirin-López, J.M., Gorovsky, M.A., Hake, S.B., Hamkalo, B.A., Holec, S., Jacobsen, S.E., Kamieniarz, K., Khochbin, K., Ladurner, A.G., Landsman, D., Latham, J.A., Loppin, B., Malik, H.S., Marzluff, W.F., Pehrson, J.R., Postberg, J., Singh, M.B., Schneider, R., Smith, M.M., Thompson, E., Torres-Padilla, M.E., Tremethick, D.J., Turner, B.M., Waterborg, J.H., Wollmann, H., Yelagandula, R., Zhu, B. and Henikoff, S. 2012. A Unified Phylogeny-based Nomenclature for Histone Variants. Epigenetics and Chromatin 5:7.

Peifer, M., Fernández-Cuesta, L., Sos, M.L., George, J., Kasper, L.H., Seidel, D., Plenker, D., Leenders, F., Sun, R., Zander, T., Menon, R., Koker, M., Dahmen, I., Müller, C., Di Cerbo, V., et al., Schneider, R., Büttner, R., Wolf, J., Nürnberg, P., Perner, S., Heukamp, L.C., Brindle, P., Haas, S. and Thomas, R.K. 2012. Integrative genomic analyses of somatic mutations identifies key drivers of small cell lung cancer. Nature Genetics, 44, 1104-10.

Watson AA, Mahajan P, Mertens HD, Deery MJ, Zhang W, Pham P, Du X, Bartke T, Zhang W, Edlich C, Berridge G, Chen Y, Burgess-Brown NA, Kouzarides T, Wiechens N, Owen-Hughes T, Svergund DI, Gileadi O, and Laue ED. 2012. The PHD and chromo-domains regulate the ATPase activity of the human chromatin remodeler CHD4. J. Mol. Biol. 422, 3-17.


Hergeth, S.P., Dundr, M., Tropberger, P., Zee, B.M., Garcia, B.A., Daujat, S. and Schneider, R. 2011. Isoform specific phosphorylation of human linker histone H1.4 in mitosis by Aurora B kinase, Journal of Cell Science, 124, 1623-1628.

Waldmann, T., Kappes, F., Mathew, V., Yi, J., Khodadoust, M.S., Chinnaiyan, A.M. Erhard, S., Markovitz, D.M. and Schneider, R. 2011. The DEK oncoprotein is a Su(var) that is essential for heterochromatin integrity, Genes and Development, 25, 673-678.

Cohen, I.,  Poreba, E., Kamieniarz, K. and Schneider, R. 2011. Histone modifiers in cancer – Friends or foes? Genes and Cancer, 2, 631-645.

Waldmann, T., Izzo, A., Kamieniarz, K. Richter., F., Vogler., C., Sarg, B., Lindner, H., Garcia, B.A., Nicolas, L.,Y., Mittler, G. and Schneider, R. 2011. Methylation of H2AR29 is a novel repressive PRMT6 target, Epigenetics and Chromatin, 4:11.

Bartke T and Kouzarides T. 2011. Decoding the chromatin modification landscape. Cell Cycle 10, 182


Weiss, T., Hergeth, S., Zeissler, U., Izzo, A. Tropberger, P., Zee, B.M., Dundr, M., Garcia, B., Daujat, S. and Schneider, R. 2010. Histone H1 variant-specific lysine methylation by G9a/KMT1C and Glp1/KMT1D, Epigenetics and Chromatin, 3,7.

Infantino, S., Waldmann, T. , Benz., B., Jung, M., Schneider, R. and Reth, M. 2010. Arginine methylation of the B-cell antigen receptor promotes differentiation, Journal of Experimental Medicine, 5, 112-117.

Lange, U.C. and Schneider, R. 2010. What an epigenome remembers, BioEssays, 32, 659-668.

Izzo, A. and Schneider, R. 2010. Chatting histone modifications in mammals, Briefings in Functional Genomics, 9, 429-443.

Plazas-Mayorca, M.D., Bloom, J.S.,  Zeissler, U., Leroy, G., Young, N.L., DiMaggio, P., Krugylak, L., Schneider, R. and Garcia, B.A. 2010. Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown, Molecular Biosystems, 6, 1719-1729.

Vogler, C., Huber, C., Waldmann, T., Braun, L., Chassignet, I.,  Dundr, M., Gernot Längst, G. and  Schneider, R. 2010. Histone H2A C-terminus regulates chromatin dynamics, remodelling and histone H1 binding, PLOS Genetics, 6(12), e1001234.

Tropberger, P. and Schneider, R. 2010. Going global- histone modifications in the globular domain of H3. Epigenetics, 5, 112-117.

Bartke T, Vermeulen M, Xhemalce B, Robson SC, Mann M, and Kouzarides T. 2010. Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell 143, 470-484.





Daujat, S., Weiss, T., Mohn, F., Lange, U.C., Ziegler-Birling, C., Zeissler, U., Lappe, M., Schübeler, D., Torres-Padilla, M.E. and Schneider, R. 2009. H3 lysine 64 methylation is a novel heterochromatic mark dynamically remodelled during epigenetic reprogramming. Nature Structural and Molecular Biology, 16, 777-781.

Kamieniarz, K. and Schneider R. 2009. Novel tools to tackle protein acetylation. Chemistry & Biology, 16, 10-27-1029.


Hajkova, P., Waldmann, T., Ancelin, K., Lange, U.C., Lacoste, N., Cesari, F., Lee, C., Almouzni, G., Schneider, R. and Surani, A. 2008 Chromatin dynamics during epigenetic reprogramming in the mouse germ lineNature, 452, 877-881.

Izzo, A., Kamienariaz, K. and Schneider, R. 2008. The histone H1 family: specific members, specific functions?. Biol. Chem., 389, 333-343.

Laue, K., Daujat, S., Plaster, N., Roehl, H.H., Schneider, R and Hammerschmidt, M.  2008. The multi-domain protein Brpf1, binds histones and is required for hox gene expression and segmental identity. Development 135, 1935-1946.

Lange, U.C., Adams, D.J., Lee, C., Barton, S., Bradley A., Schneider, R and Surani A. 2008. Normal germline establishment in mice carrying  deletions in the lfitm/Fragilis gene family custer. Molecular and Cellular Biology, 15, 4688-96


Wissmann, M., Yin, N., Muller, J.M., Greschik, H., Fodor, B.D., Jenuwein, T., Vogler, C., Schneider, R., Gunther, T., Buettner, R., Metzger, E. and Schule R. 2007. Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nature Cell Biology, 9, 347-53

Schneider, R. and Grosschedl, R. 2007. Dynamics of nuclear architecture, genome organisation and gene expression. Genes and Development, 21, 3027-3043.


Ancelin, K., Lange, U.C., Hajkova, P., Schneider, R. and Surani, A. 2006 Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells. Nature Cell Biology., 8, 623-630.

Schneider, R. 2006. ChIPing histones. Proceedings of AACR, 97, 379-386.


Metzger, E., Wissmann, M., Yin, N., Müller, J.M., Schneider, R., Peters, A., Günther, T., Buettner, R., and Schule, R. 2005. LSD1 demethylates repressive histone marks to promote androgen receptor dependent transcription. Nature, 437, 436-439.

Daujat, S., Zeissler, U., Waldmann, T., Happel, N. and Schneider, R. 2005. HP1 binds specifically to Lys26-methylated H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding Journal of Biological Chemistry, 280, 38090-5.

Bannister, A.J., Schneider R., Myers, F., Thorne, A., Crane-Robinson, C. and Kouzarides, T. 2005 Spatial distribution of Di- and tri-methyl lysine 36 of histone H3 at active genes. Journal of Biological Chemistry., 280, 17732-6.


Schneider, R., Bannister, A.J., Myers, F., Thorne, A., Crane-Robinson, C. and Kouzarides, T. 2004. Histone H3 lysine 4 methylation patterns in higher eukaryotic genes. Nature Cell Biology., 6, 73-77.

Schneider, R., Bannister, A.J., Weise, C. and Kouzarides, T. 2004. Direct binding of INHAT to H3 tails disrupted by modifications. Journal of Biological Chemistry, 279, 23859-62.

Cuthbert, G.L., Daujat, S., Snowden, A.W., Erdjument-Bromage, H., Hagiwara, T., Yamada, M., Schneider, R., Gregory, P.D., Tempst , P., Bannister, A.J. and Kouzarides, T. 2004. Histone deimination antagonizes arginine methylation. Cell, 118, 545-53.


Erhardt, S., Su, I., Schneider, R., Barton, S., Bannister, A.J., Jenuwein, T., Kouzarides, T., Trarakhovsky, A and Surani, M.A. 2003 Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development, 130, 4235-4248

Santos-Rosa, H., Schneider R., Bernstein, B.E., Karabeston, N., Morillon, A., Weise, C., Schreiber, S.L., Mellor, J., and Kouzarides, T. 2003 Methylation of histone H3 K4 mediates association of Isw1 ATPase with chromatin. Molecular Cell, 12, 1325-32.

Auner, H., Buckle, M., Deufel, A., Kutateladze, T., Lazarus, L., Muskhelishvili, G., Pemberton, I., Schneider, R. and Travers A.A. 2003 Mechanism of transcriptional activation by FIS: Role of promoter structure and DNA topology, Journal of Molecular Biology, 331, 331-344.


Schneider, R. and Bannister, A.J. 2002. Protein N-methyltransferase assays in the study of gene transcription. Methods, 26, 226-232.

Bernstein, B.E., Humphrey, E.L., Erlich, R., Schneider, R., Bouman, P. , Liu J.S., Kouzarides, T. and Schreiber, S.L. 2002. Methylation of histone H3 Lys 4 in coding regions of active genes. PNAS, 99, 8695-8700.

Schneider, R., Bannister A.J. and Kouzarides, T. 2002. Unsafe SETs: histone methyltransferases and cancer. Trends in Biochemical Sciences., 27, 396-402.

Bannister, A.J., Schneider, R. and Kouzarides, T. 2002. Histone methylation.Dynamic or static? Cell, 109, 801-806.

Santos-Rosa,  H., Schneider,  R.,  Bannister,  A.J, Sherriff,  J., Bernstein, B.E., Schreiber, S., Mellor J. and Kouzarides, T. 2002. Lysine Tri-methylation in active genes extends histone code. Nature, 419, 407-11.


Nielsen, S.J., Schneider, R., Bauer, U.M., Morrison, A. , O’Carroll, D., Cleary, M., Jenuwein, T., Herrera, T. and Kouzarides, T. 2001. RB targets histone H3 methylation and HP1 to promoters. Nature, 412, 561-565.

Travers, A.A., Schneider, R. and Muskhelishvili, G. 2001. DNA supercoiling and transcription in Escherichia coli – the FIS connection. Biochemie, 83, 213-217.

Schneider, R., Lurz, R., Lüder, G., Travers, A.A. and Muskhelishvili, G. 2001. An architectural role of the Escherichia coli chromatin protein FIS in organising DNA, Nucleic Acids Research, 29, 5107-14.

Nasser, W., Schneider, R., Travers,  A.A. and Muskhelishvili, G. 2001. CRP modulates fis transcription by alternate formation of activating and repressing nucleoprotein complexes, Journal of Biological Chemistry, 276, 17878-86.


Zechiedrich, E.L., Khodursky, A.B., Bachellier, S., Schneider, R., Lilly, D.M.J. and Cozzarelli, N.R. 2000. Roles of topoisomerases in maintaining steady-state supercoiling in E. coli. Journal of Biological Chemistry, 275, 8103-8113.

Schneider, R., Travers, A.A. and Muskhelishvili, G. 2000. The expression of the Escherichia coli fis gene is modulated by negative supercoiling of DNA. Mol. Microbiol., 38, 167-175.

1997 - 1999

Schneider, R., Kutateladze, T., Travers, A.A. and Muskhelishvili, G. 1999. A DNA architectural protein couples cellular physiology and DNA supercoiling in Escherichia coli. Molecular Microbiology, 34, 953-964.

Schneider, R., Travers, A.A. and Muskhelishvili, G. 1997. FIS modulates growth-phase dependent topological transitions of DNA in E. coli. Molecular Microbiology, 26, 519-530.