Staff member

Dr. Arcangela Iuso

Phone: +49 89 3187-3568
Fax: +49 89 3187-3297
Building/Room: 3537 / 8104

Institut für Humangenetik
Ingolstädter Landstr. 1
D-85764 Neuherberg

Research interests

  • Biochemical investigation in cellular and animal models of mitochondrial disorders and Neurodegeneration with Brain Iron Accumulation (NBIA)
  • Modeling of human diseases in Drosophila melanogaster
  • Gene therapy in cellular and animal models


1. Iuso, A, Sibon OCM, Gorza M, Heim K, Organisti C, Meitinger T, Prokisch H. (2014). Impairment of Drosophila Orthologs of the Human Orphan Protein C19orf12 Induces Bang Sensitivity and Neurodegeneration. PLoS One. 9(2):e89439.

2. Kornblum C, Nicholls TJ, Haack TB, Schöler S, Peeva V, Danhauser K, Hallmann K, Zsurka G, Rorbach J, Iuso A, Wieland T, Sciacco M, Ronchi D, Comi GP, Moggio M, Quinzii CM, DiMauro S, Calvo SE, Mootha VK, Klopstock T, Strom TM, Meitinger T, Minczuk M, Kunz WS, Prokisch H. (2013) Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease. Nat Genet. 45:214-9.

3. Trentadue R, Fiore F, Massaro F, Papa F, Iuso A, Scacco S, Santacroce L, Brienza N. (2012) Induction of mitochondrial dysfunction and oxidative stress in human fibroblast cultures exposed to serum from septic patients. Life Sci. 91:237-43.

4. Haack TB, Haberberger B, Frisch EM, Wieland T, Iuso A, Gorza M, Strecker V, Graf E, Mayr JA, Herberg U, Hennermann JB, Klopstock T, Kuhn KA, Ahting U, Sperl W, Wilichowski E, Hoffmann GF, Tesarova M, Hansikova H, Zeman J, Plecko B, Zeviani M, Wittig I, Strom TM, Schuelke M, Freisinger P, Meitinger T, Prokisch H. J (2012) Molecular diagnosis in mitochondrial complex I deficiency using exome sequencing. J Med Genet. 49:277-83.

5. Danhauser K, Iuso A, Haack TB, Freisinger P, Brockmann K, Mayr JA, Meitinger T, Prokisch H. (2011). Cellular rescue-assay aids verification of causative DNA-variants in mitochondrial complex I deficiency. Mol Genet Metab. 103(2),161-6.

6. Hartig MB*, Iuso A*, Haack T*, Kmiec T, Jurkiewicz E, Heim K, Roeber S, Tarabin V, Dusi S, Krajewska-Walasek M, Jozwiak S, Hempel M, Winkelmann J, Elstner M, Oexle K, Klopstock T, Mueller-Felber W, Gasser T, Trenkwalder C, Tiranti V, Kretzschmar H, Schmitz G, Strom TM, Meitinger T, Prokisch H. (2011) Absence of an orphan mitochondrial protein, C19orf12, causes a distinct clinical subtype of neurodegeneration with brain iron accumulation. Am J Hum Genet. 89(4), 543-50. (*joint first authors).

7. Grassi FR, Ciccolella F, D'Apolito G, Papa F, Iuso A, Salzo AE, Trentadue R, Nardi GM, Scivetti M, De Matteo M, Silvestris F, Ballini A, Inchingolo F, Dipalma G, Scacco S, Tetè S. (2011) Effect of low-level laser irradiation on osteoblast proliferation and bone formation. J Biol Regul Homeost Agents. 25:603-14.

8. Haack TB, Danhauser K, Haberberger B, Hoser J, Strecker V, Boehm D, Uziel G, Lamantea E, Invernizzi F, Poulton J, Rolinski B, Iuso A, Biskup S, Schmidt T, Mewes HW, Wittig I, Meitinger T, Zeviani M, Prokisch H. (2010) Exome sequencing identifies ACAD9 mutations as a cause of complex I deficiency. Nat Genet. 42:1131-4.

9. Ahting U, Floss T, Uez N, Schneider-Lohmar I, Becker L, Kling E, Iuso A, Bender A, de Angelis MH, Gailus-Durner V, Fuchs H, Meitinger T, Wurst W, Prokisch H, Klopstock T. (2009) Neurological phenotype and reduced lifespan in heterozygous Tim23 knockout mice, the first mouse model of defective mitochondrial import. Biochim Biophys Acta. 1787:371-6.

10. Papa S, Petruzzella V, Scacco S, Sardanelli AM, Iuso A, Panelli D, Vitale R, Trentadue R, De Rasmo D, Capitanio N, Piccoli C, Papa F, Scivetti M, Bertini E, Rizza T, De Michele G. (2009) Pathogenetic mechanisms in hereditary dysfunctions of complex I of the respiratory chain in neurological diseases. Biochim Biophys Acta. 1787:502-17.

11. Piccoli C, Sardanelli A, Scrima R, Ripoli M, Quarato G, D'Aprile A, Bellomo F, Scacco S, De Michele G, Filla A, Iuso A, Boffoli D, Capitanio N, Papa S. (2008). Mitochondrial Respiratory Dysfunction in Familiar Parkinsonism Associated with PINK1 Mutation. Neurochem Res. 33(12), 2565-74.

12. Piccoli C, Scacco S, Bellomo F, Signorile A, Iuso A, Boffoli D, Scrima R, Capitanio N, Papa S. (2006) cAMP controls oxygen metabolism in mammalian cells. FEBS Lett. 580(18):4539-43.

13. Scacco, S., Petruzzella, V., Bertini, E., Iuso A., Papa, F. Bellomo, F., Signorile, A., Torraco, A., Papa. S. (2006) Mutations in structural genes of complex I associated with neurological diseases. The Italian Journal of Biochemistry: 55, 3-4.

14. Iuso A, Scacco S, Piccoli C, Bellomo F, Petruzzella V, Trentadue R, Minuto M, Ripoli M, Capitanio N, Zeviani M, Papa S (2006). Dysfunctions of cellular oxidative metabolism in patients with mutations in the NDUFS1 and NDUFS4 genes of complex I. J Biol Chem. 281(15), 10374-80.

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