CPC bioArchive

Our main goals are:

     

  • the acquisition and maintenance of a comprehensive collection of biosamples, covering the key chronic lung disease areas as well as healthy controls
  • providing researchers with regulated access to biosamples and associated clinical data for high-end research projects

  • cooperating with national and international partners to explore new projects and widen our sample scope

  • core units provide tissue processing and culture, matrix genotyping, live cell imaging and immunophenotyping for sample analysis

 

Figure 1. Sample flow between the CPC BioArchive and the associated core units, Source: Helmholtz Zenntrum München, ILBD/CPC


Structure and function of the CPC bioArchive

As part of the DZL Biobanking Platform, the CPC BioArchive retrieves, manages and issues a diverse set of biological samples related to many of the major lung disease areas as well as control samples from healthy individuals. Its work is overlooked by a steering committee composed of members from all contributing institutions: the CPC and HelmholtzZentrum München (HMGU), the Klinikum der Universität München (KUM), the Ludwig-Maximilians-Universität München (LMU) and the Asklepios Fachkliniken in München-Gauting. 

Figure 2. Contributors to the CPC bioArchive , Source: Helmholtz Zentrum München, ILBD/CPC

The CPC bioArchive oversees >10,000 samples from approximately 400 neonatal CLD, 2,500 COPD, 1,500 ILD and 4,500 cases of lung cancer and 500 lung transplants. Our biological material includes native tissue, which is processed into primary cell isolates, FFPE blocks and cryo samples by the Munich Lung Tissue core unit at the CPC, blood and blood components, processed by the Immunophenotyping core unit, bronchoalveolar lavage (BAL) fluids, sputum, urine and tracheal aspirates of patient groups ranging from neonates to advanced age. All patients and their respective samples are double-pseudonymized by an external, independent identity manager to ensure the protection of patients’ personal data. Incoming samples are processed and prepared for long-term storage by our team of scientists and technicians while sample-IDs and a minimal clinical dataset are entered into an electronic database. Clinical data are stored and managed using our designated software tools, while all datasets including image data are collected in a virtual data warehouse. To ensure the responsible and traceable use of patient material and data, access to all physical samples, clinical and phenotypic information is highly regulated and subject to approval of individual research projects by the steering committee. The BioArchive thus provides an important interface and feedback tool between the CPC’s laboratory research and its translation into the clinic.

 

Figure 3. Sample & data management at the CPC bioArchive, Source: Helmholtz Zentrum München ILBD/CPC

Future Directions of the CPC bioArchive

With a growing number of highly relevant research projects the demand for biological samples is on the rise and the BioArchive continually expanding. In collaboration with other DZL locations, challenges in data management and protection are addressed and new cooperations forged. Here, the increasing digitalization facilitates both administration and exchange of the diverse biological samples and data.

 

 

 

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