Proteasome Function in Chronic Lung Disease

1. Regulation of proteasome expression and function in normal and diseased lung (Asthma, Fibrosis, COPD, aging lung)

2. Effect of cigarette smoke on proteasome function and antigen processing:

  • Modification of proteasome and alteration of activity?
  • Generation of altered antigens?
  • Role of immunoproteasome?   

3. Proteasome as a therapeutic target for lung disease:

  • Inhalative application of proteasome inhibitors for therapeutic use in cell and mouse models of lung cancer and pulmonary fibrosis. More...
  • Development of smart nanoparticle-based delivery methods for targeted delivery of proteasome inhibitors. More...