Molecular Lung Carcinogenesis

Publications at PubMed: More...


Spella M, Lilis I, Pepe MA, Chen Y, Armaka M, Lamort AS, Zazara DE, Roumelioti F, Vreka M, Kanellakis NI, Wagner DE, Giannou AD, Armenis V, Arendt KA, Klotz LV, Toumpanakis D, Karavana V, Zakynthinos SG, Giopanou I, Marazioti A, Aidinis V, Sotillo R, Stathopoulos GT. “Club cells form lung adenocarcinomas and maintain the alveoli of adult mice.” Elife. 2019 May 29;8. pii: e45571. doi: 10.7554/eLife.45571

Lilis I, Ntaliarda G, Papaleonidopoulos V, Giotopoulou GA, Oplopoiou M, Marazioti A, Spella M, Marwitz S, Goldmann T, Bravou V, Giopanou I, Stathopoulos GT.” Interleukin-1β provided by KIT-competent mast cells is required for KRAS-mutant lung adenocarcinoma.” Oncoimmunology. 2019 Apr 11;8(7):1593802. doi: 10.1080/2162402X.2019.1593802. eCollection 2019.

Marazioti A, Papadia K, Kannavou M, Spella M, Basta A, de Lastic AL, Rodi M, Mouzaki A, Samiotaki M, Panayotou G, Stathopoulos GT, Antimisiaris SG.” Cellular Vesicles: New insights in engineering methods, interaction with cells and potential for brain targeting.” J Pharmacol Exp Ther. 2019 May 6. pii: jpet.119.257097. doi: 10.1124/jpet.119.257097

Merrick C, Sherrill T, Kanellakis NI, Asciak R, Stathopoulos GT, Maldonado F, Rahman NM, Blackwell T, Psallidas I.” Novel mouse model of indwelling pleural catheter in mice with malignant pleural effusion.” ERJ Open Res. 2019 May 28;5(2). pii: 00226-2018. doi: 10.1183/23120541.00226-2018.

Castelletti N, Kaiser JC, Furukawa K, Küchenhoff H, Stathopoulos GT. Risk of lung adenocarcinoma from smoking and radiation arises in distinct molecular pathways. Carcinogenesis, bgz036,

Kanellakis NI, Giannou AD, Pepe MA, Αgalioti T, Zazara DE, Giopanou I, Psallidas I, Spella M, Μarazioti A, Arendt KAM, Lamort AS, Tsaniras SC, Taraviras S, Papadaki H, Lilis I, Stathopoulos GT.Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter.Carcinogenesis. 2019 Mar 4. pii: bgz047. doi: 10.1093/carcin/bgz047

Klotz LV, Courty Y, Lindner M, Petit-Courty A, Stowasser A, Koch I, Eichhorn ME, Lilis I, Morresi-Hauf A, Arendt KAM, Pepe M, Giopanou I, Ntaliarda G, Behrend SJ, Oplopoiou M, Gissot V, Guyetant S, Marchand-Adam S, Behr J, Kaiser JC, Hatz RA, Lamort AS, Stathopoulos GT. Comprehensive clinical profiling of the Gauting locoregional lung adenocarcinoma donors.Cancer Med. 2019 Feb 25. doi: 10.1002/cam4.2031


Psallidas I, Kanellakis NI, Gerry S, Thézénas ML, Charles PD, Samsonova A, Schiller HB, Fischer R, Asciak R, Hallifax RJ, Mercer R, Dobson M, Dong T, Pavord ID, Collins GS, Kessler BM, Pass HI, Maskell N, Stathopoulos GT, Rahman NM.Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis.Lancet Oncol. 2018 Jul;19(7):930-939. doi: 10.1016/S1470-2045(18)30294-8

MaraziotiA, LilisI, VrekaM, ApostolopoulouH, KalogeropoulouA, GiopanouI, GiotopoulouGA, KrontiraAC, IliopoulouM, KanellakisNI, AgaliotiT, GiannouAD, Jones-ParisC, IwakuraY, KardamakisD, BlackwellTS, TaravirasS, SpellaM, StathopoulosGT. Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion. Nat Commun 2018;9:672

Vreka M, Lilis I, Papageorgopoulou M, Giotopoulou GA, Lianou M, Giopanou I, Kanellakis NI, Spella M, Agalioti T, Armenis V, Goldmann T, Marwitz S, Yull FE, Blackwell TS, Pasparakis M, Marazioti A, Stathopoulos GT. A requirement for ΙκΒ kinase α in KRAS-mutant lung adenocarcinoma. Cancer Res, Published OnlineFirst March 27, 2018. doi: 10.1158/0008-5472.CAN-17-1944

Marazioti A,  Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis KI,  Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M & Stathopoulos GT."Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion."NatCommun. 2018 Feb 14;9:652. doi: 10.1038/s41467-018-03051-z


Spella M, Marazioti A, Arendt KAMStathopoulos GT."RAS oncogenes direct metastasis."Mol Cell Oncol. 2017 Jul 5;4(5):e1345711. doi: 10.1080/23723556.2017.1345711. eCollection 2017.

 Agalioti T, Giannou AD, Krontira AC, Kanellakis NI, Kati D, Vreka M, Pepe M, Spella M, Lilis I, Zazara DE, Nikolouli E, Spiropoulou N, Papadakis A, Papadia K, Voulgaridis A, Harokopos V, Stamou P, Meiners S, Eickelberg O, Snyder LA, Antimisiaris SG, Kardamakis D, Psallidas I, Marazioti A, Stathopoulos GT. "Mutant KRAS promotes malignant pleural effusion formation."NatCommun. 2017 May 16;8:15205. doi: 10.1038/ncomms15205.

Giannou AD, Marazioti A, Kanellakis NI, Giopanou I, Lilis I, Zazara DE, Ntaliarda G, Kati D, Armenis V, Giotopoulou GA, Krontira AC, Lianou M, Agalioti T, Vreka M, Papageorgopoulou M, Fouzas S, Kardamakis D, Psallidas I, Spella M, Stathopoulos GT."NRAS destines tumor cells to the lungs."EMBO Mol Med. 2017 May;9(5):672-686. doi: 10.15252/emmm.201606978.