Development and validation of innovative methods for aerosolized delivery of drugs to animal models and pulmonary cell systems
Further improvement of the recently developed ALICE-CLOUD technology (ALICE: Air-Liquid Interface Cell Exposure) for dosimetrically accurate and technologically simple in vitro application of liquid drugs to lung cells cultured at air-liquid interface conditions
Establishment of optical imaging techniques (fluorescence, bioluminescence) for analysis of regional distribution and bioactivity of drugs delivered to in vitro cell systems or murine lungs
Development of bioreactors for improved, cell-based drug screening under physiologically realistic conditions (e.g. air-liquid interface cell cultures; co-culture cell models; periodically stretched cells)
Preclinical targeting of (bio-)therapeutics and nano-drug-carrier systems to specific regions or cell types of the murine lung
