Therapeutics
Reference Number Asset Description Drug Category Lead Indication(s) Development Stage Patent Situation
PLA13A11 Ferroptosis inhibitor Small molecules Organ transplantation (liver, kidney) Late preclinical development WO 2015/007730 WO 2016/075137
PLA15A23 Therapeutic MVA-based vaccine Vaccines Hepatitis B virus (HBV) Preclinical development WO 2017/121791
PLA10A08 VLP-based prophylactic vaccine Vaccines Epstein-Barr virus (EBV) Preclinical development WO 2012/025603 WO 2017/148928
PLA18A05 Natural extract for asthma prevention Biologics Asthma Early preclinical Development PCT application filed
PLA18A07 FDA-approved drugs interfering with the adhesion forming program Small molecules Postsurgical adhesions Early preclinical Development PCT application filed
PLA15A18 TRAF6-Ubc13 inhibitor Small molecules Rheumatoid arthritis (RA) and other autoimmune diseases Lead Optimization WO 2018/050286 WO 2019/180207
PLA18A06 Combinatorial antagonism of micro RNAs Biologics Diabetes and metabolic diseases Lead Optimization WO/2020/053186
PLA13A11-2 Ferroptosis inhibitor Small molecules Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and other neurodegenerative diseases Lead Optimization WO 2015/007730 WO 2016/075137
PLA15A12 Monoclonal antibodies against IGFR-like receptors Biologics Diabetes Lead Optimization WO 2017/042242 WO 2018/138376
PLA16A06 Inhibitor of the oxysterol pathway Small molecules Chronic Obstructive Pulmonary Disease (COPD) Lead Optimization WO 2018/115319
PLA13A23 Pyrone derivatives as anti-HIV inhibitors Small molecules Human immunodeficiency virus (HIV) Lead Optimization WO 2016/162405
PLA14A04 Pyrazolopyridine derivatives inhibiting the PEX14-PEX5 interaction Small molecules Chagas disease and other trypanosomal infections Lead Optimization WO 2016/038045
PLA18A13 AVV vector for genome editing Gene therapy Duchenne muscular dystrophy (DMD) Lead Optimization Priority-establishing patent application filed
PLA17A10 Anti-CD73 monoclonal antibody Biologics Cancer Lead Optimization WO 2018/215535
PLA17A18 Microbiome modulator to treat allergic diseases Small molecules Asthma Lead Optimization US 2019/0083461 CA 2979786
PLA18A03 Proteins from a nematode parasite Biologics Chronic airway inflammation Lead Optimization WO 2019/193140
PLA14A32 Proteins from a nematode parasite Small molecules Diabetes and obesity Lead Optimization WO 2019/193140
PLA18A12 Proteins from a nematode parasite Biologics Infection diseases Hit-to-Lead Priority-establishing patent application filed