PLA13A11 |
Ferroptosis inhibitor |
Small molecules |
Organ transplantation (liver, kidney) |
Late preclinical development |
WO 2015/007730 WO 2016/075137 |
PLA15A23 |
Therapeutic MVA-based vaccine |
Vaccines |
Hepatitis B virus (HBV) |
Preclinical development |
WO 2017/121791 |
PLA10A08 |
VLP-based prophylactic vaccine |
Vaccines |
Epstein-Barr virus (EBV) |
Preclinical development |
WO 2012/025603 WO 2017/148928 |
PLA18A05 |
Natural extract for asthma prevention |
Biologics |
Asthma |
Early preclinical Development |
PCT application filed |
PLA18A07 |
FDA-approved drugs interfering with the adhesion forming program |
Small molecules |
Postsurgical adhesions |
Early preclinical Development |
PCT application filed |
PLA15A18 |
TRAF6-Ubc13 inhibitor |
Small molecules |
Rheumatoid arthritis (RA) and other autoimmune diseases |
Lead Optimization |
WO 2018/050286 WO 2019/180207 |
PLA18A06 |
Combinatorial antagonism of micro RNAs |
Biologics |
Diabetes and metabolic diseases |
Lead Optimization |
WO/2020/053186 |
PLA13A11-2 |
Ferroptosis inhibitor |
Small molecules |
Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD) and other neurodegenerative diseases |
Lead Optimization |
WO 2015/007730 WO 2016/075137 |
PLA15A12 |
Monoclonal antibodies against IGFR-like receptors |
Biologics |
Diabetes |
Lead Optimization |
WO 2017/042242 WO 2018/138376 |
PLA16A06 |
Inhibitor of the oxysterol pathway |
Small molecules |
Chronic Obstructive Pulmonary Disease (COPD) |
Lead Optimization |
WO 2018/115319 |
PLA13A23 |
Pyrone derivatives as anti-HIV inhibitors |
Small molecules |
Human immunodeficiency virus (HIV) |
Lead Optimization |
WO 2016/162405 |
PLA14A04 |
Pyrazolopyridine derivatives inhibiting the PEX14-PEX5 interaction |
Small molecules |
Chagas disease and other trypanosomal infections |
Lead Optimization |
WO 2016/038045 |
PLA18A13 |
AVV vector for genome editing |
Gene therapy |
Duchenne muscular dystrophy (DMD) |
Lead Optimization |
Priority-establishing patent application filed |
PLA17A10 |
Anti-CD73 monoclonal antibody |
Biologics |
Cancer |
Lead Optimization |
WO 2018/215535 |
PLA17A18 |
Microbiome modulator to treat allergic diseases |
Small molecules |
Asthma |
Lead Optimization |
US 2019/0083461 CA 2979786 |
PLA18A03 |
Proteins from a nematode parasite |
Biologics |
Chronic airway inflammation |
Lead Optimization |
WO 2019/193140 |
PLA14A32 |
Proteins from a nematode parasite |
Small molecules |
Diabetes and obesity |
Lead Optimization |
WO 2019/193140 |
PLA18A12 |
Proteins from a nematode parasite |
Biologics |
Infection diseases |
Hit-to-Lead |
Priority-establishing patent application filed |