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Das Institut für die Erforschung Pankreatischer Inselzellen erforscht die Krankheitsursachen des Diabetes mellitus Typ 1, Typ 2 sowie des Schwangerschaftsdiabetes. Dabei sorgen zerstörte oder in ihrer Funktion eingeschränkte Betazellen für einen erhöhten Blutzuckerspiegel. Die Wissenschaftler des IPI/PLID arbeiten daran die Mechanismen zu entschlüsseln, die die Zerstörung und/oder Funktionseinschränkung der Betazellen bedingen und versuchen darüber hinaus neue Ansätze zu entwickeln um die geschädigten bzw. zerstörten Betazellen zu ersetzen.
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Aktuelle Publikationen des Instituts
Hier finden Sie die 10 aktuellsten Publikation unseres Instituts. Sollten Sie nach älteren Veröffentlichungen suchen, folgen Sie bitte dem nachstehenden Link zu unseren Publikationen.
- Sharma et al., Convergent Losses of TLR5 Suggest Altered Extracellular Flagellin Detection in Four Mammalian Lineages. Mol Biol Evol. 2020 Jul 1;37(7):1847-1854. doi: 10.1093/molbev/msaa058.
Qadir et al., Long-term Culture of Human Pancreatic Slices as a Model to Study Real-Time Islet Regeneration. Nat Commun. 2020 Jun 29;11(1):3265. doi: 10.1038/s41467-020-17040-8.
- Thangapandi et al., Loss of hepatic Mboat7 leads to liver fibrosis. Gut. 2020 Jun 26:gutjnl-2020-320853. doi: 10.1136/gutjnl-2020-320853. Online ahead of print.
- Mirea et al., Mice Deficient in the IL-1β Activation Genes Prtn3, Elane, and Casp1 Are Protected Against the Development of Obesity-Induced NAFLD. Inflammation. 2020 Jun;43(3):1054-1064. doi: 10.1007/s10753-020-01190-4.
- Ziegler et al., Why is the presence of autoantibodies against GAD associated with a relatively slow progression to clinical diabetes? Diabetologia. 2020 May 26. doi: 10.1007/s00125-020-05175-8. Online ahead of print.
- Carrat et al., The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis. Mol Metab. 2020 May 13;40:101015. doi: 10.1016/j.molmet.2020.101015. Online ahead of print.
- Rubino et al., Bariatric and metabolic surgery during and after the COVID-19 pandemic: DSS recommendations for management of surgical candidates and postoperative patients and prioritisation of access to surgery. Lancet Diabetes Endocrinol. 2020 Jul;8(7):640-648. doi: 10.1016/S2213-8587(20)30157-1. Epub 2020 May 7.
- Kabeza et al., A qualitative study of users' experiences after 3 months: the first Rwandan diabetes self-management Smartphone application "Kir'App". Ther Adv Endocrinol Metab. 2020 Apr 27;11:2042018820914510. doi: 10.1177/2042018820914510. eCollection 2020.
- Bornstein et al., Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol. 2020 Jun;8(6):546-550. doi: 10.1016/S2213-8587(20)30152-2. Epub 2020 Apr 23.
- Panzer et al., Pancreas tissue slices from organ donors enable in situ analysis of type 1 diabetes pathogenesis. JCI Insight. 2020 Apr 23;5(8):e134525. doi: 10.1172/jci.insight.134525.
