Scientific Focus

  • ISBM develops and deploys next-generation biotechniques for molecular sensing and actuation of distributed cellular processes to reverse engineer cell-circuit function and guide future cell therapies.

    The research of ISBM focuses on three synergistic areas: 

biomolecular engineering of sensors and actuators

genetic and cellular engineering of model systems

multiscale interrogation of cell-circuit-function

Team

Image Name Job Title E-mail Telephone Building/Room
Prof. Dr. Westmeyer,
Gil Gregor
Director E-mail +49 (0) 89 3187 2123 35.32/202
Ammer,
Anja
Laboratory manager E-mail +49(0)89 3187 2157 35.32/201
Armbrust,
Niklas
Ph.D. student E-mail 3532 / 003
MD Bodea,
Silviu-Vasile
Ph.D. student E-mail +49 (0) 89 3187 49429 35.32/207
Berezin,
Oleksandr
Ph.D. student E-mail +49 (0) 89 3187 49429 35.32/207
Dr. Efremova,
Mariia
Postdoctoral Fellow E-mail +49 (0) 89 3187 43488 35.32/207
Geilenkeuser,
Julian
Master Student E-mail 35.32/003
Piovesan,
Alberto
Ph.D. student E-mail +49 (0) 89 3187 43026 35.32/208
Santl,
Tobias
Trainee 35.32/003
Scherbauer,
Thomas
HiWi E-mail 35.32/001
Ph.D., M.Sc Molecular Biotechnology Sigmund,
Felix
Group Leader E-mail +49 (0)89 3187 2217 35.32/201
Dr. Truong Diong-Jiunn,
Jeffery
Group Leader E-mail +49 (0) 89 3187 3560 3532/003
Winkler,
Stefanie
Technical Assistant E-mail +49 89 3187 43023 35.32/208

Seasonal Greetings: Stay Healthy and Safe Everyone!

We are grateful for our new ERC-COG funding!

Publications

  • Farhadi, A., Sigmund, F., Westmeyer, G.G., Shapiro, M.G. Genetically encodable materials for non-invasive biological imaging. Nature Materials (2021).  doi:10.1038/s41563-020-00883-3

    Grosch, M., Rusha, E., Ori, C., Truong, D.J.J., O'Neill, A.C., Pertek, A., Westmeyer, G.G., Drukker, M. Nucleus size and DNA accessibility are linked to the regulation of paraspeckle formation in cellular differentiation. BMC Biol. 18:42 (2020). doi:10.1186/s12915-020-00770-y

    Shams, S.F., Ghazanfari, M.R., Pettinger, S., Tavabi, A.H., Siemensmeyer, K., Smekhova, A., Dunin-Borkowski, R.E., Westmeyer, G.G., Schmitz-Antoniak, C. Structural perspective on revealing heat dissipation behavior of CoFe 2 O 4 –Pd nanohybrids: great promise for magnetic fluid hyperthermia. Phys Chem Chem Phys 22, 26728–26741. (2020)doi:10.1039/d0cp02076a

    Gabashvili, A.N., Chmelyuk, N.S., Efremova, M.V., Malinovskaya, J.A., Semkina, A.S., Abakumov, M.A. Encapsulins-bacterial protein nanocompartments: Structure, properties, and application. Biomolecules 10:966 (2020). doi:10.3390/biom10060966

    Stefanoiu, A., Page, J., Symvoulidis, P., Westmeyer, G.G., Lasser, T. Artifact-free deconvolution in light field microscopy. Optics Express 27, 31644–31666 (2019). doi:10.1364/OE.27.031644

    Sigmund, F., Pettinger,S., Kube, M., Schneider, F., Schifferer, M., Schneider, S., Efremova, M., Pujol-Martí, J., Aichler, M., Walch, A., Misgeld, T., Dietz, H., Westmeyer, G.G. Iron-Sequestering Nanocompartments as Multiplexed Electron Microscopy Gene Reporters. ACS Nano 13, 8114–8123 (2019). doi:10.1021/acsnano.9b03140

    Lauri, A., Soliman, D., Omar,M., Stelzl, A., Ntziachristos, V., Westmeyer, G.G. Whole-cell photoacoustic sensor based on pigmentrelocalization. ACS Sensors 4, 603-612 (2019). doi:10.1021/acssensors.8b01319

    Dang, K.M., Rinklin, P., Afanasenkau, D., Westmeyer, G., Schürholz, T., Wiegand, S., Wolfrum, B. Chip‐Based Heat Stimulation for Modulating Signal Propagation in HL‐1 Cell Networks. Advanced Biosystems 39, 1800138 (2018). doi:10.1002/adbi.201800138

    Sigmund, F., Massner, C., Erdmann, P., Stelzl, A., Rolbieski, H., Desai, M., Bricault, S., Wörner, T.P., Snijder, J., Geerlof, A., Fuchs, H., Hrabĕ de Angelis, M., Heck, A.J.R., Jasanoff, A., Ntziachristos, V., Plitzko J., Westmeyer, G.G. Bacterial encapsulins as orthogonal compartments for mammalian cell engineering. Nature Communications 9 (2018), DOI: 10.1038/s41467-018-04227-3

    Massner, C., Sigmund, F., Pettinger, S., Seeger, M., Hartmann, C., Ivleva, N.P., Niessner, R., Fuchs, H., Hrabě de Angelis, M., Stelzl, A., Koonakampully, N.L., Rolbieski, H., Wiedwald, U., Spasova, M., Wurst, W., Ntziachristos, V., Winklhofer, M., Westmeyer, G.G. Genetically Controlled Lysosomal Entrapment of Superparamagnetic Ferritin for Multimodal and Multiscale Imaging and Actuation with Low Tissue Attenuation. Advanced Functional Materials 13 March 2018 (2018) doi.org/10.1002/adfm.201706793

    Myklatun, A., Lauri, A., Eder, S.H.K., Cappetta, M., Shcherbakov, D., Wurst, W., Winklhofer, M., Westmeyer, G.G. Zebrafish and medaka offer insights into the neurobehavioral correlates of vertebrate magnetoreception. Nat Commun 9, 802. (2018) doi:10.1038/s41467-018-03090-6

    Myklatun A., Cappetta M., Winklhofer M., Ntziachristos V., Westmeyer G.G. Microfluidic sorting of intrinsically magnetic cells under visual control Sci Rep. 2017; 7: 6942. (2017) doi:  10.1038/s41598-017-06946-x

    Symvoulidis P., Lauri A., Stefanoiu A., Cappetta M., Schneider S., Jia H., Stelzl A., Koch M., Perez C.C., Myklatun A., Renninger S., Chmyrov A., Lasser T., Wurst W., Ntziachristos V., Westmeyer G.G. NeuBtracker—imaging neurobehavioral dynamics in freely behaving fish, Nat Methods. 2017 Oct 2. (2017) doi: https://doi.org/10.1038/nmeth.4459

    Roberts S., Seeger M., Jiang Y., Mishra A., Sigmund F., Stelzl A., Lauri A., Symvoulidis P., Rolbieski H., Preller M., Deán Ben X.L., Razansky D., Orschmann T., Desbordes S., Vetschera P., Bach T., Ntziachristos V., Westmeyer G.G. Calcium Sensor for Photoacoustic Imaging J. Am. Chem. Soc., Just Accepted Manuscript (2017) doi: 10.1021/jacs.7b03064

    Mishra, A, Pariani, G., Oerther T., Schwaiger, M., Westmeyer, G. G. Hyperpolarized Multi-Metal 13C-Sensors for Magnetic Resonance Imaging. Anal. Chem., Article ASAP, (2016), doi: 10.1021/acs.analchem.6b03546

    Mishra A, Jiang Y., Roberts S., Ntziachristos V,. Westmeyer G. G. Near-infrared photoacoustic imaging probe responsive to calcium, Anal. Chem., Article ASAP, (2016), doi: 10.1021/acs.analchem.6b03039

    Fiallos A., Bricault S., Cai L., Worku H., Colonnese M., Westmeyer G. G., Jasanoff A. Reward magnitude tracking by neural populations in ventral striatum, NeuroImage, (2016), doi: 10.1016/j.neuroimage.2016.10.036

    Deán-Ben, X., Sela, G., Lauri, A., Kneipp, M., Ntziachristos, V., Westmeyer, G. G., Shoham S., Razansky, D. Functional optoacoustic neuro-tomography (FONT) for scalable whole-brain monitoring of calcium indicators. Light: Science & Applications,  (2016), doi: 10.1038/lsa.2016.201

    Jiang, Y., Sigmund, F., Reber, J., Deán-Ben, X. L., Glasl, S., Kneipp, M., Estrada, H., Razansky, D., Ntziachristos, V., and Westmeyer, G. G., Violacein as a genetically-controlled, enzymatically amplified and photobleaching-resistant chromophore for optoacoustic bacterial imaging, Sci Rep 5, (2015), doi: 10.1038/srep11048

    Stiel, A. C., Deán-Ben, X. L., Jiang, Y., Ntziachristos, V., Razansky, D., and Westmeyer, G. G High-contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed multispectral optoacoustic tomography Optics letters 40, 367–370 (2015), doi: 10.1364/OL.40.000367

    Westmeyer, G. G., Emer, Y., Lintelmann, J., & Jasanoff, A. MRI-Based Detection of Alkaline Phosphatase Gene Reporter Activity Using a Porphyrin Solubility Switch. Chemistry & Biology. (2014), doi: 10.1016/j.chembiol.2014.01.012

    Westmeyer, G. G., Durocher, Y., and Jasanoff, A. A secreted enzyme reporter system for MRI, Angew Chem Int Ed Engl, 49: 3909-3911 (2010), doi: 10.1002/anie.200906712

    Shapiro*, M. G., Westmeyer*, G. G., Romero, P. A., Szablowski, J. O., Kuster, B., Shah, A., Otey, C. R., Langer, R., Arnold, F. H., and Jasanoff, A. Directed evolution of a magnetic resonance imaging contrast agent for noninvasive imaging of dopamine, Nat Biotechnol 28: 264-270; (2010), doi: 10.1038/nbt.1609

    Westmeyer, G. G., and Jasanoff, A. Genetically controlled MRI contrast mechanisms and their prospects in systems neuroscience research, Magn Reson Imaging 25: 1004-1010 (2007), doi: 10.1016/j.mri.2006.11.027

    Shapiro, M. G., Atanasijevic, T., Faas, H., Westmeyer, G. G., and Jasanoff, A. Dynamic imaging with MRI contrast agents: quantitative considerations, Magn Reson Imaging 24: 449-462 (2006), doi: 10.1016/j.mri.2005.12.033

    Westmeyer, G. G., Willem, M., Lichtenthaler, S. F., Lurman, G., Multhaup, G., Assfalg-Machleidt, I., Reiss, K., Saftig, P., and Haass, C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme, J Biol Chem, 279: 53205-53212 (2006), doi: 10.1074/jbc.M410378200