Staff Details

Lorraine Southam
Senior Staff Scientist

Phone: +49 89 3187 43391
Building/Room: 3533/213




My research interests are in the genetics and genomics of complex common disease with a focus on osteoarthritis and cardiometabolic traits.


  • Cardiometabolic and musculoskeletal traits
  • Genome-wide association
  • Isolated populations
  • Functional genomics
  • Consortia

Selected Publications:

Tachmazidou, I. ; Hatzikotoulas, K. ; Zeggini, E.
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Nat. Genet. 51, 230-236 (2019)

Gilly, A. ; Southam, L. ; Zeggini, E.
Very low-depth whole-genome sequencing in complex trait association studies.
Bioinformatics 35, 2555-2561 (2019)

Gilly, A. ; Southam, L. ; Zeggini, E.
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Nat. Commun. 9:5460 (2018)

Zengini, E. ; Hatzikotoulas, K. ; … ; Southam, L. ; Zeggini, E. 
Genome-wide analyses using UK wide Biobank data provides insights into the genetic architecture of osteoarthritis.
Nat. Genet. 549-558 (2018)

Southam, L. ; Gilly, A. ; … ; Rayner, NW. ; Zeggini, E.
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.
Nat Commun. 15606 (2017)