Publications

2021
Boer, C.G. ; ... ; Southam, L. ; Zeggini, E. ; van Meurs, J.B.J.
Genome-wide association of phenotypes based on clustering patterns of hand osteoarthritis identify WNT9A as novel osteoarthritis gene.
Ann. Rheum. Dis. 80, 367–375 (2021)
2020
Radon, K. ; ... ; Theis, F.J. ; Hoelscher, M. ; the KoCo19 collaboration group (Hasenauer, J. ; Fuchs, C. ; Castelletti, N. ; Zeggini, E. ; Laxy, M. ; Leidl, R. ; Schwettmann, L.)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19) (vol 20, 1036, 2020).
BMC Public Health 20:1335 (2020)
Neumeyer; S. ; ... ; Newcomb, P.A. ; Chang-Claude, J.
Genetic variants in the regulatory T cell related pathway and colorectal cancer prognosis.
Cancer Epidemiol. Biomarkers Prev. 29, 2719-2728 (2020)
Surendran, P. ; ... ; Müller-Nurasyid, M. ; Zeggini, E. ; Howson, J.M.M.
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals.
Nat. Genet. 52, 1314–133 (2020)
Gilly, A. ; ... ; Png, G. ; Barysenka, A. ; Fischer, I. ; Southam, L. ; Neumeyer, S. ; Rayner, N.W. ; Zeggini, E.
Whole-genome sequencing analysis of the cardiometabolic proteome.
Nat. Commun. 11:6336 (2020)
Vogelezang, S. ; ... ; Standl, M. ; Thiering, E. ; Zeggini, E. ; Verduci, E.
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
PLoS Genet. 16:e1008718 (2020)
Png, G. ; Barysenka, A. ; Gilly, A. ; Zeggini, E.
Exploring the genetic architecture of the human neurological proteome using whole genome sequencing.
Hum. Hered. 84, 220-220 (2020)
Katsoula, G. ; Southam, L. ; Steinberg, J. ; Barysenka, A. ; Zeggini, E.
A comprehensive transcriptional map of knee osteoarthritis.
Hum. Hered. 84, 213-213 (2020)
Macdonald-Dunlop, E. ; ... ; Zeggini, E. ; Wilson, J.
Genomic architecture of 184 plasma proteins in 18,884 individuals: The SCALLOP consortium.
Hum. Hered. 84, 216-217 (2020)
Haberer, G. ; Kamal, N. ; Gundlach, H. ; Fischer, I. ; Seidel, M. ; Spannagl, M. ; Schön, C.C.° ; Mayer, K.F.X.°
European maize genomes highlight intraspecies variation in repeat and gene content.
Nat. Genet. 52, 950-957 (2020)
Moll, M. ; ... ; SpiroMeta Consortium (Gieger, C. ; Karrasch, S. ; Rawal, R. ; Schulz, H. ; Zeggini, E.) ; Cho, M.H.
Chronic obstructive pulmonary disease and related phenotypes: Polygenic risk scores in population-based and case-control cohorts.
Lancet Resp. Med. 8, 696-708 (2020)
Radon, K. ; ... ; Theis, F.J. ; Hoelscher, M. ; the KoCo19 collaboration group (Hasenauer, J. ; Castelletti, N. ; Zeggini, E. ; Laxy, M. ; Leidl, R. ; Schwettmann, L.) ; the KoCo19 collaboration group (Fuchs, C.)
Protocol of a population-based prospective COVID-19 cohort study Munich, Germany (KoCo19).
BMC Public Health 20:1036 (2020)
Mennan, C. ; ... ; Zeggini, E. ; Roberts, S.
The use of technology in the subcategorisation of osteoarthritis: A delphi study approach.
Osteoarthr. Cartil. 2:100081 (2020)
Marenne, G. ; ... ; Zeggini, E. ; Farooqi, I.S.° ; Barroso, I.°
Exome sequencing identifies genes and gene sets contributing to severe childhood obesity, linking PHIP variants to repressed POMC transcription.
Cell Metab. 31, 1107-1119 (2020)
Hartley, A. ; ... ; Southam, L. ; Zeggini, E. ; Tobias, J.H.
Using multivariable mendelian randomization to estimate the BMI-independent causal effect of bone mineral density on osteoarthritis.
Osteoarthr. Cartil. 28, S402-S402 (2020)
Hatzikotoulas, K. ; ... ; Southam, L. ; Barysenka, A. ; Zeggini, E.
Large-scale genome-wide meta-anaysis provide insights for the development of new disease modifying targets for osteoarthritis.
Osteoarthr. Cartil. 28, S54-S54 (2020)
Bryois, J. ; ... ; Sullivan, P.F. ; Eating Disorders Working Group of the Psychiatric Genomics Consortium (Zeggini, E.)
Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease.
Nat. Genet. 52, 482-493 (2020)
Sedaghati-Khayat, B. ; ... ; Zeggini, E. ; van Meurs, J.B.
Polygenic risk score and its potential to improve diagnostic ability in knee and hip osteoarthritis.
Osteoarthr. Cartil. 28, S24-S24 (2020)
Wilkinson, J.M. ; Zeggini, E.
The genetic epidemiology of joint shape and the development of osteoarthritis.
Calcif. Tissue Int., DOI: 10.1007/s00223-020-00702-6 (2020)
Zeggini, E. ; ... ; Götz, M. ; Herzig, S. ; Hrabě de Angelis, M. ; Tschöp, M.H.
Biomedical research goes viral: Dangers and opportunities.
Cell 181, 1189-1193 (2020)
Munn-Chernoff, M.A. ; ... ; Hatzikotoulas, K. ; Zeggini, E. ; Agrawal, A.
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
Addict. Biol. 26:e12880 (2020)
Riveros-McKay, F. ; ... ; Zeggini, E. ; Barroso, I.
The influence of rare variants in circulating metabolic biomarkers.
PLoS Genet. 16:e1008605 (2020)
Neumeyer; S. ; ... ; Zeggini, E.
Strengthening causal inference for complex disease using molecular quantitative trait loci.
Trends Mol. Med. 26, 232-241 (2020)
Png, G. ; ... ; Zeggini, E. ; Gilly, A.
Population-wide copy number variation calling using variant call format files from 6,898 individuals.
Genet. Epidemiol. 44, 79-89 (2020)
2019
Riveros-McKay, F. ; ... ; Zeggini, E. ; Farooqi, I.S.
Genetic architecture of human thinness compared to severe obesity.
PLoS Genet. 15:e1007603 (2019)
MacInnes, S.J. ; ... ; Zeggini, E. ; Wilkinson, J.M.
The 2018 Otto Aufranc Award: How does genome-wide variation affect osteolysis risk after THA?
Clin. Orthop. Relat. Res. 477, 297-309 (2019)
Farmaki, A.-E. ; Rayner, N.W. ; Gilly, A. ; Zeggini, E. ; Dedoussis, G.
A dietary pattern with high sugar content is associated with cardiometabolic risk factors in the pomak population.
Nutrients 11:3043 (2019)
Lenk, M.# ; Wenig, M.# ; Knappe, C. ; Dey, S. ; Lang, D. ; Fischer, I. ; Mayer, K.F.X. ; Vlot, A.C.
High throughput phenotyping to optimize CRISPR/Cas9 mutation efficiency in cereal crops.
Mol. Plant Microbe Interact. 32, 20-20 (2019)
Gurdasani, D. ; ... ; Zeggini, E. ; Barroso, I.° ; Sandhu, M.S.°
Uganda Genome Resource enables insights into population history and genomic discovery in Africa.
Cell 179, 984-1002.e36 (2019)
Zeggini, E. ; ... ; Wain, L.V.
Translational genomics and precision medicine: Moving from the lab to the clinic.
Science 365, 1409-1413 (2019)
Kuchenbaecker, K. ; ... ; Gilly, A. ; Southam, L. ; Zeggini, E.
The transferability of lipid loci across African, Asian and European cohorts.
Nat. Commun. 10:4330 (2019)
Watson, H.J. ; ... ; Hatzikotoulas, K. ; Zeggini, E. ; Bulik, C.M.
Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa.
Nat. Genet. 51, 1207-1214 (2019)
Gurdasani, D. ; ... ; Zeggini, E. ; Sandhu, M.S.
Genomics of disease risk in globally diverse populations.
Nat. Rev. Genet. 20, 520–535 (2019)
Gilly, A. ; ... ; Hatzikotoulas, K. ; Zeggini, E.
Very low-depth whole-genome sequencing in complex trait association studies.
Bioinformatics 35, 2555-2561 (2019)
Zheng, J. ; ... ; Gilly, A. ; Zeggini, E. ; Tobias, J.H.
Mendelian Randomization analysis reveals a causal influence of circulating sclerostin levels on bone mineral density and fractures.
J. Bone Min. Res. 34, 1824-1836 (2019)
Flannick, J. ; ... ; Strom, T.M. ; Gieger, C. ; Meitinger, T. ; Strauch, K. ; Boehnke, M. ; GoT2D Consortium (Hrabě de Angelis, M.)
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
Nature 570, 71-76 (2019)
Hatzikotoulas, K. ; ... ; Southam, L. ; Zeggini, E.
Genome-wide analyses using uk biobank data povide new therapeutic targets for osteoarthritis.
Osteoarthr. Cartil. 27, S58-S59 (2019)
Warrington, N.M. ; ... ; Thiering, E. ; Müller-Nurasyid, M. ; Standl, M. ; Zeggini, E. ; Heinrich, J. ; Freathy, R.M.
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
Nat. Genet. 51, 804-814 (2019)
Styrkarsdottir, U.° ; ... ; Zeggini, E. ; Stefansson, K.°
GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures.
Nat. Commun. 10:2054 (2019)
Bentley, A.R.° ; ... ; Kühnel, B. ; Meitinger, T. ; Peters, A. ; Strauch, K. ; Waldenberger, M. ; Gieger, C. ; Zeggini, E. ; Cupples, L.A.°
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Nat. Genet. 51, 636-648 (2019)
Brazel, D.M. ; ... ; CHD Exome Consortium (Müller-Nurasyid, M. ; Zeggini, E.) ; Vrieze, S.
Exome chip meta-analysis fine maps causal variants and elucidates the genetic architecture of rare coding variants in smoking and alcohol use.
Biol. Psychiatry 85, 946-955 (2019)
Shrine, N. ; ... ; Karrasch, S. ; Gieger, C. ; Rawal, R. ; Schulz, H. ; Zeggini, E. ; Wain, L.V.
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.
Nat. Genet. 51, 481-493 (2019)
Sakornsakolpat, P. ; ... ; Cho, M.H. ; SpiroMeta Consortium (Karrasch, S. ; Gieger, C. ; Rawal, R. ; Schulz, H. ; Zeggini, E.)
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
Nat. Genet. 51, 494-505 (2019)
Tachmazidou, I. ; Hatzikotoulas, K. ; Zeggini, E.
Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.
Nat. Genet. 51, 230-236 (2019)
Justice, A.E. ; ... ; Grallert, H. ; Heid, I.M. ; Müller-Nurasyid, M. ; Strauch, K. ; North, K.E.° ; Lindgren, C.M.°
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.
Nat. Genet. 51, 452–469 (2019)
2018
Mamakou, V. ; ... ; Zeggini, E.
Combination therapy as a potential risk factor for the development of type 2 diabetes in patients with schizophrenia: the GOMAP study.
BMC Psychiatry 18:249 (2018)
Hendricks, A.E. ; ... ; Zeggini, E. ; Dupuis, J.
ProxECAT: Proxy External Controls Association Test. A new case-control gene region association test using allele frequencies from public controls.
PLoS Genet. 14:e1007591 (2018)
Steinberg, J. ; ... ; Zeggini, E.
Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.
Rheumatology 57, 1481-1489 (2018)
Casalone, E. ; ... ; Panoutsopoulou, K. ; Zeggini, E.
A novel variant in GLIS3 is associated with osteoarthritis.
Ann. Rheum. Dis. 77, 620-623 (2018)
Grarup, N. ; ... ; Zeggini, E. ; Hansen, T.
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Nat. Genet. 50, 172-174 (2018)
Zengini, E. ; ... ; Zeggini, E.
Genome-wide analyses using UK Biobank data provide insights into the genetic architecture of osteoarthritis.
Nat. Genet. 50, 549-558 (2018)
Hatzikotoulas, K. ; ... ; Zeggini, E. ; Wilkinson, J.M.
Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5.
Comm. Biol. 1:56 (2018)
Gilly, A. ; ... ; Hatzikotoulas, K. ; Zeggini, E.
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Nat. Commun. 9:5460 (2018)
Hackinger, S. ; ... ; Zeggini, E.
Evidence for genetic contribution to the increased risk of type 2 diabetes in schizophrenia.
Transl. Psychiatry 8:252 (2018)
Gilly, A. ; ... ; Hatzikotoulas, K. ; Zeggini, E.
Cohort-wide deep whole genome sequencing and the allelic architecture of complex traits.
Nat. Commun. 9:4674 (2018)
Mahajan, A. ; ... ; Gieger, C. ; Herder, C. ; Kriebel, J. ; Meitinger, T. ; Peters, A. ; Strauch, K. ; Thorand, B. ; Grallert, H. ; McCarthy, M.
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.
Nat. Genet. 50, 1505-1513 (2018)
Evangelou, E. ; ... ; Gieger, C. ; Peters, A. ; Ried, J.S. ; Caulfield, M.J.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.
Nat. Genet. 50, 1412-1425 (2018)
Juhász, A. ; ... ; Fischer, I. ; Lang, D. ; Mayer, K.F.X. ; Spannagl, M. ; Olsen, O.A.
Genome mapping of seed-borne allergens and immunoresponsive proteins in wheat.
Sci. Adv. 4:eaar8602 (2018)
van Zuydam, N.R. ; ... ; SUMMIT Investigators (Thorand, B. ; Gieger, C. ; Grallert, H. ; Ludwig, T. ; Nitz, B. ; Wang-Sattler, R. ; Zierer, A.)
A genome-wide association study of diabetic kidney disease in subjects with type 2 diabetes.
Diabetes 67, 1414-1427 (2018)
Mahajan, A.° ; ... ; Müller-Nurasyid, M. ; Kriebel, J. ; Thorand, B. ; Meitinger, T. ; Peters, A. ; Strauch, K. ; Grallert, H. ; McCarthy, M.I.°
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
Nat. Genet. 50, 559-571 (2018)
Flannick, J. ; ... ; Müller-Nurasyid, M. ; Schwarzmayr, T. ; Wieland, T. ; Kriebel, J. ; Hrabě de Angelis, M. ; Thorand, B. ; Meisinger, C. ; Peters, A. ; Huth, C. ; Ried, J.S. ; Grallert, H. ; Gieger, C. ; Illig, T. ; Strauch, K. ; Strom, T.M. ; Meitinger, T. ; McCarthy, M.I.
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Sci. Data 5:180002 (2018)
Huckins, L.M.° ; ... ; Ludolph-Donislawski, A. ; Bulik, C.M.° ; Zeggini, E.°
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa.
Mol. Psychiatry 23, 1169-1180 (2018)
Warrington, N.M. ; ... ; Thiering, E. ; Tiesler, C.M. ; Grallert, H. ; Standl, M. ; Flexeder, C. ; Heinrich, J. ; Evans, D.M.D.° ; Lawlor, D.A.°
Maternal and fetal genetic contribution to gestational weight gain.
Int. J. Obes. 42, 755-784 (2018)
Kesselmeier, M. ; ... ; Grallert, H. ; Illig, T. ; Hinney, A.
High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation.
World J. Biol. Psychiatry 19, 187-199 (2018)
2017
Ombrello, M.J. ; ... ; Zeggini, E. ; Thomson, W.
Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: Clinical and therapeutic implications.
Ann. Rheum. Dis. 76, 906-913 (2017)
Farmaki, A.E. ; ... ; Zeggini, E. ; Dedoussis, G.
The mountainous Cretan dietary patterns and their relationship with cardiovascular risk factors: The Hellenic Isolated Cohorts MANOLIS study.
Public Health Nutr. 20, 1063-1074 (2017)
Panoutsopoulou, K. ; ... ; Zeggini, E. ; Wilkinson, J.M.
Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis.
Ann. Rheum. Dis. 76, 1199-1206 (2017)
Steinberg, J. ; ... ; Zeggini, E. ; Wilkinson, J.M.
Effects of chronic cobalt and chromium exposure after metal-on-metal hip resurfacing: An epigenome-wide association pilot study.
J. Orthop. Res. 35, 2323-2328 (2017)
Tachmazidou, I. ; ... ; Zeggini, E.
Whole-genome sequencing coupled to imputation discovers genetic signals for anthropometric traits.
Am. J. Hum. Genet. 100, 865-884 (2017)
Xu, H. ; ... ; Zeggini, E. ; Mitchell, B.D.
Familial hypercholesterolemia and type 2 diabetes in the old order amish.
Diabetes 66, 2054-2058 (2017)
Southam, L. ; ... ; Zeggini, E.
Whole genome sequencing and imputation in isolated populations identify genetic associations with medically-relevant complex traits.
Nat. Commun. 8:15606 (2017)
Marouli, E. ; ... ; Zeggini, E. ; Deloukas, P.
Evaluating the glucose raising effect of established loci via a genetic risk score.
PLoS ONE 12:e0186669 (2017)
Yilmaz, Z. ; ... ; Zeggini, E. ; Bulik, C.M.
Exploration of large, rare copy number variants associated with psychiatric and neurodevelopmental disorders in individuals with anorexia nervosa.
Psychiatr. Genet. 27, 152-158 (2017)
Steinberg, J. ; ... ; Zeggini, E.
Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis.
Sci. Rep. 7:8935 (2017)
Ng, M. ; ... ; Zeggini, E. ; Furniss, D.
A genome-wide association study of dupuytren disease reveals 17 additional variants implicated in fibrosis.
Am. J. Hum. Genet. 101, 417-427 (2017)
Xue, Y.° ; ... ; Zeggini, E.°
Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.
Nat. Commun. 8:15927 (2017)
Hackinger, S. ; ... ; Zeggini, E.
Evaluation of shared genetic aetiology between osteoarthritis and bone mineral density identifies SMAD3 as a novel osteoarthritis risk locus.
Hum. Mol. Genet. 26, 3850-3858 (2017)
Prins, B.P. ; ... ; Zeggini, E.
Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations.
Sci. Rep. 7:11008 (2017)
Hendricks, A.E. ; ... ; Zeggini, E. ; Farooqi, I.S.
Rare variant analysis of human and rodent obesity genes in individuals with severe childhood obesity.
Sci. Rep. 7:4394 (2017)
Flannick, J. ; ... ; Müller-Nurasyid, M. ; Schwarzmayr, T. ; Wieland, T. ; Kriebel, J. ; Hrabě de Angelis, M. ; Thorand, B. ; Meisinger, C. ; Peters, A. ; Huth, C. ; Ried, J.S. ; Grallert, H. ; Gieger, C. ; Illig, T. ; Strauch, K. ; Strom, T.M. ; Meitinger, T. ; McCarthy, M.I.
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Sci. Data 4:170179 (2017)
Duncan, L. ; ... ; Breen, G.° ; Bulik, C.M.° ; Eating Disorders Working Group of the Psychiatric Genomics Consortium (Wichmann, H.-E. ; Tschöp, M.H.)
Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa.
Am. J. Psychiatry 174, 850-858 (2017)
Aschard, H. ; ... ; Schulz, H. ; Rawal, R. ; Kraft, P.
Evidence for large-scale gene-by-smoking interaction effects on pulmonary function.
Int. J. Epidemiol. 46, 894-904 (2017)
Wain, L.V. ; ... ; Ried, J.S. ; Gieger, C. ; Peters, A. ; Ehret, G.B.
Novel blood pressure locus and gene discovery using genome-wide association study and expression data sets from blood and the kidney.
Hypertension 70, e4-e19 (2017)
Li, D. ; ... ; Eating Disorders Working Group of the Psychiatric Genomics Consortium (Wichmann, H.-E.) ; de Zwaan, M.
A genome-wide association study of anorexia nervosa suggests a risk locus implicated in dysregulated leptin signaling.
Sci. Rep. 7:3847 (2017)
Scott, R.A. ; ... ; Grallert, H. ; Müller-Nurasyid, M. ; Ried, J.S. ; Meitinger, T. ; Thorand, B. ; Klopp, N. ; Meyer, J. ; Gieger, C. ; Strauch, K. ; McCarthy, M.I.° ; Prokopenko, I.°
An expanded genome-wide association study of type 2 diabetes in Europeans.
Diabetes 66, 2888-2902 (2017)
van den Berg, M. ; ... ; Müller-Nurasyid, M. ; Peters, A. ; Hoes, A.W. ; Waldenberger, M. ; Munroe, P.B.
Discovery of novel heart rate-associated loci using the Exome Chip.
Hum. Mol. Genet. 26, 2346-2363 (2017)
Manning, A. ; ... ; Hrabě de Angelis, M. ; Schwarzmayr, T. ; Strom, T.M. ; Wieland, T. ; Thorand, B. ; Strauch, K. ; Peters, A. ; Müller-Nurasyid, M. ; Kriebel, J. ; Illig, T. ; Grallert, H. ; Gieger, C. ; Meisinger, C. ; Meitinger, T. ; Lindgren, C.M.
A low-frequency inactivating Akt2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk.
Diabetes 66, 2019-2032 (2017)
Hinney, A. ; ... ; Jall, S. ; Müller, T.D. ; Hebebrand, J.
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index (vol 22, pg 192, 2017).
Mol. Psychiatry 22, 321-322 (2017)
Wain, L.V. ; ... ; Rawal, R. ; Schulz, H. ; Karrasch, S. ; Gieger, C. ; Tobin, M.D.
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
Nat. Genet. 49, 416-425 (2017)
2016
Iotchkova, V. ; ... ; Zeggini, E. ; Soranzo, N.
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.
Nat. Genet. 48, 1303-1312 (2016)
Haber, M. ; ... ; Zeggini, E. ; Tyler-Smith, C.
Chad genetic diversity reveals an African history marked by multiple holocene eurasian migrations.
Am. J. Hum. Genet. 99, 1316-1324 (2016)
Surendran, P. ; ... ; Müller-Nurasyid, M. ; Munroe, P.B.
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Nat. Genet. 48, 1151-1161 (2016)
Horikoshi, M. ; ... ; Thiering, E. ; Tiesler, C.M. ; Standl, M. ; Heinrich, J. ; Freathy, R.M.
Genome-wide associations for birth weight and correlations with adult disease.
Nature 538, 248-252 (2016)
Ehret, G.B. ; ... ; Petersen, A.-K. ; Döring, A. ; Illig, T. ; Klopp, N. ; Müller-Nurasyid, M. ; Peters, A. ; CHARGE-EchoGen Consortium (Wichmann, H.-E. ; Meitinger, T.) ; Munroe, P.B.
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals.
Nat. Genet. 48, 1171-1184 (2016)
McCarthy, S.# ; Das, S.# ; Kretzschmar, W.# ; Meitinger, T. ; Durbin, R. ; Abecasis, G.° ; Marchini, J.°
A reference panel of 64,976 haplotypes for genotype imputation.
Nat. Genet. 48, 1279-1283 (2016)
Kanoni, S.# ; Masca, N.G.D.# ; Stirrups, K.E.# ; Varga, T.V.# ; Warren, H.R.# ; Müller-Nurasyid, M. ; Grallert, H. ; Peters, A. ; Strauch, K. ; Waldenberger, M. ; Gieger, C. ; Deloukas, P.
Analysis with the exome array identifies multiple new independent variants in lipid loci.
Hum. Mol. Genet. 25, 4094-4106 (2016)
Fuchsberger, C.# ; Flannick, J.# ; Teslovich, T.M.# ; Mahajan, A.# ; Agarwala, V.# ; Müller-Nurasyid, M. ; Schwarzmayr, T. ; Wieland, T. ; Kriebel, J. ; Hrabě de Angelis, M. ; Thorand, B. ; Meisinger, C. ; Peters, A. ; Huth, C. ; Ried, J.S. ; Grallert, H. ; Gieger, C. ; Illig, T. ; Strauch, K. ; Strom, T.M. ; Meitinger, T. ; Boehnke, M.° ; Altshuler, D. ; McCarthy, M.I.°
The genetic architecture of type 2 diabetes.
Nature 536, 41-47 (2016)
Felix, J.F. ; ... ; Thiering, E. ; Flexeder, C. ; Tiesler, C.M. ; Heinrich, J. ; Jaddoe, V.W.
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index.
Hum. Mol. Genet. 25, 389-403 (2016)
2015
Asimit, J.L. ; ... ; GIANT Consortium (Albrecht, E. ; Gieger, C. ; Grallert, H. ; Heid, I.M. ; Illig, T. ; Müller-Nurasyid, M. ; Peters, A. ; Thorand, B. ; Wichmann, H.-E.) ; Zeggini, E. ; Barroso, I.
A Bayesian approach to the overlap analysis of epidemiologically linked traits.
Genet. Epidemiol. 39, 624-634 (2015)
Gaulton, K.J.#° ; Ferreira, T.# ; Lee, Y.# ; Raimondo, A.# ; Mägi, R.# ; Reschen, M.E.# ; Grallert, H. ; Wahl, S. ; Gieger, C. ; Klopp, N. ; Lichtner, P. ; Meyer, J. ; Müller-Nurasyid, M. ; Strauch, K. ; Thorand, B. ; Illig, T. ; Peters, A. ; McCarthy, M.I.° ; Morris, A.P.° ; DIAGRAM Consortium ()
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.
Nat. Genet. 47, 1415-1425 (2015)
Wain, L.V.# ; Shrine, N.# ; UK Brain Expression Consortium (Lamina, C. ; Rawal, R. ; Wichmann, H.-E.) ; Tobin, M.D. ; Hall, I.P.
Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): A genetic association study in UK Biobank.
Lancet Resp. Med. 3, 769-781 (2015)
Winkler, T.W.# ; Justice, A.E.# ; Graff, M.# ; Barata, L.# ; Albrecht, E. ; Müller-Nurasyid, M. ; Grallert, H. ; Illig, T. ; Thorand, B. ; Waldenberger, M. ; Gieger, C. ; Peters, A. ; CHARGE Consortium (Gieger, C. ; Meisinger, C. ; Prokisch, H. ; Wichmann, H.-E.) ; DIAGRAM Consortium (Klopp, N. ; Meyer, J.) ; Global BPgen Consortium (Döring, A.) ; ICBP Consortium (Meitinger, T.) ; Heid, I.M.° ; North, K.E.° ; Borecki, I.B.° ; Kutalik, Z.° ; Loos, R.J.°
The influence of age and sex on genetic associations with adult body size and shape: A large-scale genome-wide interaction study.
PLoS Genet. 11:e1005378 (2015)
Joshi, P.K. ; ... ; Baumbach, C. ; Meisinger, C. ; Meitinger, T. ; Strauch, K. ; Waldenberger, M. ; Gieger, C. ; Wilson, J.F.
Directional dominance on stature and cognition in diverse human populations.
Nature 523, 459-462 (2015)
Freitag, D.F. ; Müller-Nurasyid, M. ; Houlston, R.S.
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: A mendelian randomisation analysis.
Lancet Diabet. Endocrinol. 3, 243-253 (2015)
Wessel, J. ; ... ; Zeggini, E. ; Goodarzi, M.O.
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.
Nat. Commun. 6:5897 (2015)
Qi, Q.° ; ... ; Standl, M. ; Heinrich, J. ; Qi, L.°
Dietary intake, FTO genetic variants and adiposity: A combined analysis of over 16,000 children and adolescents.
Diabetes 64, 2467-2476 (2015)
Mahajan, A.# ; Sim, X.# ; Ng, H.J.# ; Lindgren, C.M.° ; Gloyn, A.L.° ; GoT2D Consortium (Hrabě de Angelis, M. ; Gieger, C. ; Grallert, H. ; Huth, C. ; Kriebel, J. ; Meisinger, C. ; Meitinger, T. ; Müller-Nurasyid, M. ; Peters, A. ; Ried, J.S. ; Strauch, K. ; Strom, T.M.)
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus.
PLoS Genet. 11:e1004876 (2015)
Locke, A.E.# ; Kahali, B.# ; Berndt, S.I.# ; Justice, A.E.# ; Pers, T.H.# ; Albrecht, E. ; Grallert, H. ; Lichtner, P. ; Müller-Nurasyid, M. ; Ried, J.S. ; Thorand, B. ; Gieger, C. ; Illig, T. ; Peters, A. ; Strauch, K. ; Wichmann, H.-E. ; Heid, I.M. ; Hirschhorn, J.N.° ; Loos, R.J.° ; Speliotes, E.K.°
Genetic studies of body mass index yield new insights for obesity biology.
Nature 518, 197-206 (2015)
Shungin, D. ; ... ; Albrecht, E. ; Grallert, H. ; Lichtner, P. ; Müller-Nurasyid, M. ; Ried, J.S. ; Thorand, B. ; Gieger, C. ; Illig, T. ; Peters, A. ; Strauch, K. ; Wichmann, H.-E. ; Heid, I.M. ; Lindgren, C.M.° ; Mohlke, K.L.°
New genetic loci link adipose and insulin biology to body fat distribution.
Nature 518, 187-196 (2015)
van der Valk, R.J.# ; Kreiner-Møller, E.# ; Kooijman, M.N.# ; Guxens, M.# ; Stergiakouli, E.# ; Thiering, E. ; Flexeder, C. ; Tiesler, C.M. ; Grallert, H. ; Jaddoe, V.W.
A novel common variant in DCST2 is associated with length in early life and height in adulthood.
Hum. Mol. Genet. 24, 1155-1168 (2015)
2014
Morris, A.P. ; ... ; DIAGRAM Consortium (Gieger, C. ; Grallert, H. ; Klopp, N. ; Illig, T. ; Müller-Nurasyid, M. ; Peters, A.)
Fine-mapping type 2 diabetes susceptibility loci with high-density imputation.
Diabetologia 57, S50-S51 (2014)
Boraska, V.# ; Franklin, C.S.# ; Floyd, J.A.# ; Thornton, L.M.# ; Wichmann, H.-E. ; Bulik, C.M.
A genome-wide association study of anorexia nervosa.
Mol. Psychiatry 19, 1085-1094 (2014)
Wood, A.R. ; ... ; Albrecht, E. ; Ried, J.S. ; Grallert, H. ; Illig, T. ; Klopp, N. ; Lichtner, P. ; Müller-Nurasyid, M. ; Waldenberger, M. ; Gieger, C. ; Meitinger, T. ; Peters, A. ; Strauch, K. ; Wichmann, H.-E. ; Heid, I.M. ; Visscher, P.M.° ; Hirschhorn, J.N.° ; Frayling, T.M.°
Defining the role of common variation in the genomic and biological architecture of adult human height.
Nat. Genet. 46, 1173-1186 (2014)
Huckins, L.M. ; ... ; EUMODIC Consortium (Wichmann, H.-E.) ; Tachmazidou, I.
Using ancestry-informative markers to identify fine structure across 15 populations of European origin.
Eur. J. Hum. Genet. 22, 1190-1200 (2014)
2013
Ma, R.C.° ; ... ; DIAGRAM Consortium (Huth, C. ; Grallert, H. ; Klopp, N. ; Illig, T. ; Petersen, A.-K. ; Meitinger, T. ; Thorand, B. ; Gieger, C. ; Wichmann, H.-E.) ; Jia, W.°
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.
Diabetologia 56, 1291-1305 (2013)
Fall, T. ; ... ; Ried, J.S. ; Döring, A. ; Illig, T. ; Gieger, C. ; Peters, A. ; Wichmann, H.-E. ; Ingelsson, E. ; ENGAGE Consortium ()
The role of adiposity in cardiometabolic traits: A mendelian randomization analysis.
PLoS Med. 10:e1001474 (2013)
Albrechtsen, A.# ; Grarup, N.# ; Li, Y.# ; Sparsø, T.# ; Tian, G.# ; DIAGRAM Consortium (Huth, C. ; Klopp, N. ; Petersen, A.-K. ; Grallert, H. ; Gieger, C. ; Wichmann, H.-E. ; Meitinger, T. ; Thorand, B. ; Illig, T.) ; Pedersen, O.
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes.
Diabetologia 56, 298-310 (2013)
Deloukas, P. ; ... ; Meisinger, C. ; Müller-Nurasyid, M. ; Peters, A. ; Samani, N.J.
Large-scale association analysis identifies new risk loci for coronary artery disease.
Nat. Genet. 45, 25-35 (2013)
2012
Min, J.L. ; ... ; GIANT Consortium (Heid, I.M. ; Thiering, E. ; Gieger, C. ; Grallert, H. ; Wichmann, H.-E. ; Illig, T. ; Heinrich, J. ; Peters, A.) ; Zondervan, K.T.
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes.
PLoS Genet. 8:e1002505 (2012)
Boraska, V. ; ... ; Albrecht, E. ; Heid, I.M. ; Wichmann, H.-E. ; Zeggini, E.
Genome-wide meta-analysis of common variant differences between men and women.
Hum. Mol. Genet. 21, 4805-4815 (2012)
Orozco, G. ; ... ; DIAGRAM Consortium (Gieger, C. ; Grallert, H. ; Huth, C. ; Illig, T. ; Klopp, N. ; Meitinger, T. ; Petersen, A.-K. ; Thorand, B. ; Wichmann, H.-E.)
Sex-specific differences in effect size estimates at established complex trait loci.
Int. J. Epidemiol. 41, 1376-1382 (2012)
Voight, B.F. ; ... ; Heid, I.M. ; Pfeufer, A. ; Boehnke, M.
The metabochip, a custom genotyping array for genetic studies of metabolic, cardiovascular, and anthropometric traits.
PLoS Genet. 8:e1002793 (2012)
Scott, R.A. ; ... ; Gieger, C. ; Müller-Nurasyid, M. ; Grallert, H. ; Peters, A. ; Illig, T. ; Barroso, I.
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
Nat. Genet. 44, 991-1005 (2012)
Morris, A.P. ; ... ; Grallert, H. ; Müller-Nurasyid, M. ; Meyer, J. ; Klopp, N. ; Thorand, B. ; Gieger, C. ; Peters, A. ; Illig, T. ; McCarthy, M.I.
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes.
Nat. Genet. 44, 981-990 (2012)
Taal, H.R. ; ... ; Thiering, E. ; Klopp, N. ; Müller-Nurasyid, M. ; Tiesler, C.M. ; Standl, M. ; Wichmann, H.-E. ; Flexeder, C. ; Heinrich, J. ; Wilson, J.F.
Common variants at 12q15 and 12q24 are associated with infant head circumference.
Nat. Genet. 44, 532-538 (2012)
Ikram, M.A. ; ... ; Thiering, E. ; Heinrich, J. ; CHARGE Consortium ()
Common variants at 6q22 and 17q21 are associated with intracranial volume.
Nat. Genet. 44, 539-544 (2012)
Boraska, V. ; ... ; Albrecht, E. ; Huth, C. ; Klopp, N. ; Peters, A. ; Wichmann, H.-E. ; Zeggini, E.
Genome-wide association study to identify common variants associated with brachial circumference: A meta-analysis of 14 cohorts.
PLoS ONE 7:e31369 (2012)
2011
Heid, I.M. ; ... ; Lamina, C. ; Grallert, H. ; Meitinger, T. ; Illig, T. ; Wichmann, H.-E. ; Lindgren, C.M.
Corrigendum: Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nat. Genet. 43, 1164 (2011)
Nicholson, G. ; ... ; Illig, T. ; Adamski, J. ; Suhre, K. ; Holmes, C.C.
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
PLoS Genet. 7:e1002270 (2011)
2010
Speliotes, E.K. ; ... ; Heid, I.M. ; Lamina, C. ; Thiering, E. ; Chen, C. ; Gieger, C. ; Grallert, H. ; Meitinger, T. ; Rzehak, P. ; Heinrich, J. ; Illig, T. ; Peters, A. ; Wichmann, H.-E. ; Loos, R.J.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nat. Genet. 42, 937-948 (2010)
Heid, I.M. ; ... ; Lamina, C. ; Grallert, H. ; Meitinger, T. ; Illig, T. ; Wichmann, H.-E. ; Lindgren, C.M.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nat. Genet. 42, 949-960 (2010)
Allen, H.L. ; ... ; Heid, I.M. ; Albrecht, E. ; Dixon, A.L. ; Lorentzon, M. ; Müller, M. ; Illig, T. ; Meitinger, T. ; Gieger, C. ; Hirschhorn, J.N.
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Nature 467, 832-838 (2010)
Voight, B.F. ; ... ; Huth, C. ; Grallert, H. ; Bravenboer, B, ; Gieger, C. ; Klopp, N. ; Meitinger, T. ; Petersen, A.-K. ; Thorand, B. ; van Dam, R.M. ; Wichmann, H.-E. ; Illig, T. ; McCarthy, M.I.
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
Nat. Genet. 42, 579-589 (2010)
Freathy, R.M. ; ... ; Chen, C.M. ; Tiesler, C.M. ; Heinrich, J. ; McCarthy, M.I.
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
Nat. Genet. 42, 430-435 (2010)
Scherag, A. ; ... ; Grallert, H. ; Wichmann, H.-E. ; Heinrich, J. ; Rzehak, P. ; Illig, T. ; Meyre, D.
Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups.
PLoS Genet. 6:e1000916 (2010)
Dupuis, J. ; ... ; Grallert, H. ; Gieger, C. ; Meisinger, C. ; Thorand, B. ; Wichmann, H.-E. ; Illig, T. ; Barroso, I.
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Nat. Genet. 42, 105-116 (2010)
Saxena, R. ; ... ; Grallert, H. ; Illig, T. ; Wichmann, H.-E. ; Watanabe, R.M.
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.
Nat. Genet. 42, 142-148 (2010)
2009
Newton-Cheh, C. ; ... ; Eyheramendy, S. ; Döring, A. ; Gieger, C. ; Illig, T. ; Meitinger, T. ; Pfeufer, A. ; Wichmann, H.-E. ; Munroe, P.B.
Genome-wide association study identifies eight loci associated with blood pressure.
Nat. Genet. 41, 666-676 (2009)
Nolte, I.M. ; ... ; Jamshidi, Y.
Common genetic variation near the Phospholamban gene is associated with cardiac repolarisation: Meta-analysis of three genome-wide association studies.
PLoS ONE 4:e6138 (2009)
Salanti, G. ; ... ; Grallert, H. ; Illig, T. ; Ioannidis, J.P.A.
Underlying genetic models of inheritance in established type 2 diabetes associations.
Am. J. Epidemiol. 170, 537-545 (2009)
Prokopenko, I. ; ... ; Illig, T. ; Wichmann, H.-E. ; Abecasis, G.R.
Variants in MTNR1B influence fasting glucose levels.
Nat. Genet. 41, 77-81 (2009)
Willer, C.J. ; ... ; Heid, I.M. ; Lamina, C. ; Gieger, C. ; Meitinger, T. ; Wichmann, H.-E. ; Hirschhorn, J.N.
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.
Nat. Genet. 41, 25-34 (2009)
2008
Loos, R.J. ; ... ; Heid, I.M. ; KORA Study Group () ; Lamina, C. ; Gieger, C. ; Illig, T. ; Meitinger, T. ; Wichmann, H.-E. ; Mohlke, K.L.
Common variants near MC4R are associated with fat mass, weight and risk of obesity.
Nat. Genet. 40, 768-775 (2008)
Zeggini, E. ; ... ; Grallert, H. ; Meisinger, C. ; Illig, T. ; Altshuler, D.
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes.
Nat. Genet. 40, 638-645 (2008)
2007
McCarthy, M.I. ; Zeggini, E.
Genome-wide association scans for Type 2 diabetes: New insights into biology and therapy.
Trends Pharmacol. Sci. 28, 598-601 (2007)
2006
McCarthy, M.I. ; Zeggini, E.
Genetics of type 2 diabetes.
Curr. Diab. Rep. 6, 147-54 (2006)