Cranial irradiation

In a joint ongoing research project with the Gertner Institute at the Chaim Sheba Medical Center in Israel, initiated by funding from the Helmholtz Israel Cooperation in Personalized Medicine, we assess whether cranial exposure to low-moderate dose irradiation serves as potential new risk factor for the development of type 2 diabetes and the metabolic syndrome.

Our research is built upon compelling epidemiological data with an exceptionally long follow-up of more than 60 years: adolescents with the fungal scalp infection Tinea Capitis (TC) received low-moderate therapeutic doses of cranial irratiation in the 1950s and 1960s, which - according to our prelim. data - increased their risk to develop age-onset symptoms of the metabolic syndrome. With our collaborative project, we aim to confirm the epidemiological data and assess underlying mechanistic underpinnings for an increased risk to develop type 2 diabetes and the metabolic syndrome after low-moderate dose cranial irradiation.