Previous research highlights

Nutrient sensors in metabolic control: 

  • We continue to explore the physiological roles of the stomach GOAT/ghrelin system as sensor for a lipid-rich environment that controls adaptive changes in metabolism and behavior.
  • We could reveal that NAD/NADH sensor Sirtuin1 protects against high-fat diet induced metabolic damage.

Calcineurin links mitochondrial elongation with energy metabolism:

  • We recently revealed an evolutionary conserved and environmentally controlled role of calcineurin in the adaptive regulation of body weight and energy homeostasis in flies and mice. Our work demonstrates that calcineurin ablation from skeletal muscle facilitates Drp1Ser637-hyperphosphorylation and mitochondrial elongation, enhances mitochondrial respiration, and protects from diet-induced obesity and its sequelae. Current efforts are directed towards elucidating the role of calcineurin in HFD-induced astrocytosis.
Skeletal muscle calcineurin links environmentally controlled mitochondrial fusion-fission dynamics with energy metabolism, Pfluger et al. Cell Metabolism 2015