Instrumentation

The LTQ Orbitrap XL is a hybrid mass spectrometer combining the LTQ linear ion trap with the orbitrap technology. It enables sensitive and reliable detection and identification of proteins in complex mixtures. The LTQ Orbitrap XL supports a variety of different fragmentation techniques and can be utilized in a very flexible manner for comprehensive analytical strategies including PTM analytics and quantitative proteomic approaches (SILAC, ICPL and Label-free).

A typical workflow (Top 10) for protein identifications from a complex mixture (adapted from Thermofisher).