Publications

2018

Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation. Fuenzalida-Werner JP, Janowski R, Mishra K, Weidenfeld I, Niessing D, Ntziachristos V, Stiel AC. J Struct Biol. 2018 Oct 1. pii: S1047-8477(18)30273-9. doi: 10.1016/j.jsb.2018.09.013.

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs. Węglarz-Tomczak E, Talma M, Giurg M, Westerhoff HV, Janowski R, Mucha A. Oncotarget. 2018 Jun 29;9(50):29365-29378. doi: 10.18632/oncotarget.25532. eCollection 2018 Jun 29.

A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor. Tretter JY, Schorpp K, Luxenburger E, Trambauer J, Steiner H, Hadian K, Gires O, Niessing D. J Biol Chem. 2018 Jun 8;293(23):8994-9005. doi: 10.1074/jbc.RA118.002776. Epub 2018 Apr 26.

Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation. Hofweber M, Hutten S, Bourgeois B, Spreitzer E, Niedner-Boblenz A, Schifferer M, Ruepp MD, Simons M, Niessing D, Madl T, Dormann D. Cell. 2018 Apr 19;173(3):706-719.e13. doi: 10.1016/j.cell.2018.03.004.

Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein JE, Brenner S, Klein J, Jeridi A, Hoffmann A, Lee E, Dianzani U, Willemsen R, Feederle R, Reiche K, Hackermüller J, Leonhardt H, Sharma S, Niessing D, Heissmeyer V. Nat Commun. 2018 Jan 19;9(1):299. doi: 10.1038/s41467-017-02582-1.

mRNA transport in fungal top models. Niessing D, Jansen RP, Pohlmann T, Feldbrügge M. Wiley Interdiscip Rev RNA. 2018 Jan;9(1). doi: 10.1002/wrna.1453. Epub 2017 Oct 10. Review.

PURA syndrome: clinical delineation and genotype-phenotype study in 32 individuals with review of published literature. Reijnders MRF, Janowski R, Alvi M, Self JE, van Essen TJ, Vreeburg M, Rouhl RPW, Stevens SJC, Stegmann APA, Schieving J, Pfundt R, van Dijk K, Smeets E, Stumpel CTRM, Bok LA, Cobben JM, Engelen M, Mansour S, Whiteford M, Chandler KE, Douzgou S, Cooper NS, Tan EC, Foo R, Lai AHM, Rankin J, Green A, Lönnqvist T, Isohanni P, Williams S, Ruhoy I, Carvalho KS, Dowling JJ, Lev DL, Sterbova K, Lassuthova P, Neupauerová J, Waugh JL, Keros S, Clayton-Smith J, Smithson SF, Brunner HG, van Hoeckel C, Anderson M, Clowes VE, Siu VM, Ddd Study T, Selber P, Leventer RJ, Nellaker C, Niessing D, Hunt D, Baralle D. J Med Genet. 2018 Feb;55(2):104-113. doi: 10.1136/jmedgenet-2017-104946. Epub 2017 Nov 2.

 

2017

Evidence for Complex Formation of the Bacillus cereus Haemolysin BL Components in Solution. Tausch F, Dietrich R, Schauer K, Janowski R, Niessing D, Märtlbauer E, Jessberger N. Toxins (Basel). 2017 Sep 16;9(9). pii: E288. doi: 10.3390/toxins9090288.

Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator. Schlundt A, Buchner S, Janowski R, Heydenreich T, Heermann R, Lassak J, Geerlof A, Stehle R, Niessing D, Jung K, Sattler M. Sci Rep. 2017 Apr 21;7(1):1051. doi: 10.1038/s41598-017-01031-9.

Molecular architecture and dynamics of ASH1 mRNA recognition by its mRNA-transport complex. Edelmann FT, Schlundt A, Heym RG, Jenner A, Niedner-Boblenz A, Syed MI, Paillart JC, Stehle R, Janowski R, Sattler M, Jansen RP, Niessing D. Nat Struct Mol Biol. 2017 Feb;24(2):152-161. doi: 10.1038/nsmb.3351.

 

 

2016

Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4. Janowski R, Scanu S, Niessing D, Madl T. Acta Crystallogr F Struct Biol Commun. 2016 Oct 1;72(Pt 10):743-749.

Roquin recognizes a non-canonical hexaloop structure in the 3'-UTR of Ox40. Janowski R, Heinz GA, Schlundt A, Wommelsdorf N, Brenner S, Gruber AR, Blank M, Buch T, Buhmann R, Zavolan M, Niessing D, Heissmeyer V, Sattler M. Nat Commun. 2016 Mar 24;7:11032. doi: 10.1038/ncomms11032

RNA recognition by Roquin in posttranscriptional gene regulation. Schlundt A, Niessing D, Heissmeyer V, Sattler M. Wiley Interdiscip Rev RNA. 2016 Jul;7(4):455-69. doi: 10.1002/wrna.1333. Review.

Structural basis of nucleic-acid recognition and double-strand unwinding by the essential neuronal protein Pur-alpha. Weber J, Bao H, Hartlmüller C, Wang Z, Windhager A, Janowski R, Madl T, Jin P, Niessing D. Elife. 2016 Jan 8;5. pii: e11297. doi: 10.7554/eLife.11297.

Inhibition of Canonical NF-κB Signaling by a Small Molecule Targeting NEMO-Ubiquitin Interaction. Vincendeau M, Hadian K, Messias AC, Brenke JK, Halander J, Griesbach R, Greczmiel U, Bertossi A, Stehle R, Nagel D, Demski K, Velvarska H, Niessing D, Geerlof A, Sattler M, Krappmann D. Sci Rep. 2016 Jan 7;6:18934. doi: 10.1038/srep18934.

Spiroepoxytriazoles Are Fumagillin-like Irreversible Inhibitors of MetAP2 with Potent Cellular Activity. Morgen M, Jöst C, Malz M, Janowski R, Niessing D, Klein CD, Gunkel N, Miller AK. ACS Chem Biol. 2016 Apr 15;11(4):1001-11. doi: 10.1021/acschembio.5b00755.

 

2015

ASH1 mRNP-core factors form stable complexes in absence of cargo RNA at physiological conditions. Edelmann FT, Niedner A, Niessing D. RNA Biol. 2015;12(3):233-7. doi: 10.1080/15476286.2015.1017217.

 

2014

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation. Schlundt A, Heinz GA, Janowski R, Geerlof A, Stehle R, Heissmeyer V, Niessing D, Sattler M. Nat Struct Mol Biol. 2014 Aug;21(8):671-8. doi: 10.1038/nsmb.2855.

Of social molecules: The interactive assembly of ASH1 mRNA-transport complexes in yeast. Niedner A, Edelmann FT, Niessing D. RNA Biol. 2014;11(8):998-1009. doi: 10.4161/rna.29946. Review.

mRNA transport meets membrane traffic. Jansen RP, Niessing D, Baumann S, Feldbrügge M. Trends Genet. 2014 Sep;30(9):408-17. doi: 10.1016/j.tig.2014.07.002. Review.

Production of pure and functional RNA for in vitro reconstitution experiments. Edelmann FT, Niedner A, Niessing D. Methods. 2014 Feb;65(3):333-41. doi: 10.1016/j.ymeth.2013.08.034. Review.

 

2013

In vitro reconstitution of an mRNA-transport complex reveals mechanisms of assembly and motor activation. Heym RG, Zimmermann D, Edelmann FT, Israel L, Ökten Z, Kovar DR, Niessing D. J Cell Biol. 2013 Dec 23;203(6):971-84. doi: 10.1083/jcb.201302095.

Structural insights into the globular tails of the human type v myosins Myo5a, Myo5b, And Myo5c. Velvarska H, Niessing D. PLoS One. 2013 Dec 10;8(12):e82065. doi: 10.1371/journal.pone.0082065.

Role of Loc1p in assembly and reorganization of nuclear ASH1 messenger ribonucleoprotein particles in yeast. Niedner A, Müller M, Moorthy BT, Jansen RP, Niessing D. Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):E5049-58. doi: 10.1073/pnas.1315289111.

Purification, crystallization and preliminary crystallographic analysis of the globular domain of the human type V myosin Myo5a. Velvarska H, Niessing D. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Nov;69(Pt 11):1220-3. doi: 10.1107/S1744309113025578.

Structural features of Argonaute-GW182 protein interactions. Pfaff J, Hennig J, Herzog F, Aebersold R, Sattler M, Niessing D, Meister G. Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):E3770-9. doi: 10.1073/pnas.1308510110.

 

2012
Purification, crystallization and preliminary crystallographic analysis of Kar9p from Saccharomyces cerevisiae. Hüls D, Niessing D. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Oct 1;68(Pt 10):1251-4. doi: 10.1107/S1744309112036342.

Assembly of mRNA-protein complexes for directional mRNA transport in eukaryotes--an overview. Jansen RP, Niessing D. Curr Protein Pept Sci. 2012 Jun;13(4):284-93. Review.

Drosophila Pur-α binds to trinucleotide-repeat containing cellular RNAs and translocates to the early oocyte. Aumiller V, Graebsch A, Kremmer E, Niessing D, Förstemann K. RNA Biol. 2012 May;9(5):633-43. doi: 10.4161/rna.19760.

 

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